Development and validation of algorithms to identify patients with chronic kidney disease and related chronic diseases across the Northern Territory, Australia

• Published in: BMC nephrology Vol. 23; no. 1; pp. 320 - 12
• Main Authors: Chen, Winnie, Abeyaratne, Asanga, Gorham, Gillian, George, Pratish, Karepalli, Vijay, Tran, Dan, Brock, Christopher, Cass, Alan
• Format: Journal Article
• Language: English
• Published: London BioMed Central 23.09.2022; BioMed Central Ltd; Springer Nature B.V; BMC
• Subjects: Algorithms; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - complications; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - epidemiology; Chronic diseases; Chronic illnesses; Chronic kidney disease; Clinical decision making; Codes; Comorbidity; Diabetes; Diabetes Mellitus; Diagnostic accuracy; Electronic health records; Electronic medical records; Electronic phenotype; Epidemiology; Epidermal growth factor receptors; Genotype & phenotype; Health services; Humans; Hypertension; Hypertension - complications; Hypertension - diagnosis; Hypertension - epidemiology; Internal Medicine; Kidney diseases; Kidney Failure, Chronic - complications; Laboratories; Medicine; Medicine & Public Health; Nephrology; Northern Territory - epidemiology; Patients; Primary care; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - diagnosis; Renal Insufficiency, Chronic - epidemiology; Renal replacement therapy; Northern Territory; Australia; Hypertension; Validation; Diagnostic accuracy; Chronic diseases; Chronic kidney disease; Diabetes; Electronic phenotype; Electronic health records
• ISSN: 1471-2369; 1471-2369
• DOI: 10.1186/s12882-022-02947-9

Background Electronic health records can be used for population-wide identification and monitoring of disease. The Territory Kidney Care project developed algorithms to identify individuals with chronic kidney disease (CKD) and several commonly comorbid chronic diseases. This study aims to describe the development and validation of our algorithms for CKD, diabetes, hypertension, and cardiovascular disease. A secondary aim of the study was to describe data completeness of the Territory Kidney Care database. Methods The Territory Kidney Care database consolidates electronic health records from multiple health services including public hospitals ( n  = 6) and primary care health services (> 60) across the Northern Territory, Australia. Using the database ( n  = 48,569) we selected a stratified random sample of patients ( n  = 288), which included individuals with mild to end-stage CKD. Diagnostic accuracy of the algorithms was tested against blinded manual chart reviews. Data completeness of the database was also described. Results For CKD defined as CKD stage 1 or higher (eGFR of any level with albuminuria or persistent eGFR < 60 ml/min/1.73 2 , including renal replacement therapy) overall algorithm sensitivity was 93% (95%CI 89 to 96%) and specificity was 73% (95%CI 64 to 82%). For CKD defined as CKD stage 3a or higher (eGFR < 60 ml/min/1.73 2 ) algorithm sensitivity and specificity were 93% and 97% respectively. Among the CKD 1 to 5 staging algorithms, the CKD stage 5 algorithm was most accurate with > 99% sensitivity and specificity. For related comorbidities – algorithm sensitivity and specificity results were 75% and 97% for diabetes; 85% and 88% for hypertension; and 79% and 96% for cardiovascular disease. Conclusions We developed and validated algorithms to identify CKD and related chronic diseases within electronic health records. Validation results showed that CKD algorithms have a high degree of diagnostic accuracy compared to traditional administrative codes. Our highly accurate algorithms present new opportunities in early kidney disease detection, monitoring, and epidemiological research.