Effect of rhPDGF-BB on bone turnover during periodontal repair
Purpose: Growth factors such as platelet‐derived growth factor (PDGF) exert potent effects on wound healing including the regeneration of periodontia. Pyridinoline cross‐linked carboxyterminal telopeptide of type I collagen (ICTP) is a well‐known biomarker of bone turnover, and as such is a potentia...
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| Published in | Journal of clinical periodontology Vol. 33; no. 2; pp. 135 - 140 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Munksgaard International Publishers
01.02.2006
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0303-6979 1600-051X 1600-051X |
| DOI | 10.1111/j.1600-051X.2005.00870.x |
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| Abstract | Purpose: Growth factors such as platelet‐derived growth factor (PDGF) exert potent effects on wound healing including the regeneration of periodontia. Pyridinoline cross‐linked carboxyterminal telopeptide of type I collagen (ICTP) is a well‐known biomarker of bone turnover, and as such is a potential indicator of osseous metabolic activity. The objective of this study was to evaluate the release of the ICTP into the periodontal wound fluid (WF) following periodontal reconstructive surgery using local delivery of highly purified recombinant human PDGF (rhPDGF)‐BB.
Methods: Forty‐seven human subjects at five treatment centres possessing chronic severe periodontal disease were monitored longitudinally for 24 weeks following PDGF regenerative surgical treatment. Severe periodontal osseous defects were divided into one of three groups and treated at the time of surgery with either: β‐tricalcium phosphate (TCP) osteoconductive scaffold alone (active control), β‐TCP+0.3 mg/ml of rhPDGF‐BB, or β‐TCP+1.0 mg/ml of rhPDGF‐BB. WF was harvested and analysed for local ICTP levels by radioimmunoassay. Statistical analysis was performed using analysis of variance and an area under the curve analysis (AUC).
Results: The 0.3 and 1.0 mg/ml PDGF‐BB treatment groups demonstrated increases in the amount of ICTP released locally for up to 6 weeks. There were statistically significant differences at the week 6 time point between β‐TCP carrier alone group versus 0.3 mg/ml PDGF‐BB group (p<0.05) and between β‐TCP alone versus the 1.0 mg/ml PDGF‐BB‐treated lesions (p<0.03). The AUC analysis revealed no statistical differences amongst groups.
Conclusion: This study corroborates the release of ICTP as a measure of active bone turnover following local delivery of PDGF‐BB to periodontal osseous defects. The amount of ICTP released from the WF revealed an early increase for all treatment groups. Data from this study suggests that when PDGF‐BB is delivered to promote periodontal tissue engineering of tooth‐supporting osseous defects, there is a direct effect on ICTP released from the wound. |
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| AbstractList | Purpose: Growth factors such as platelet‐derived growth factor (PDGF) exert potent effects on wound healing including the regeneration of periodontia. Pyridinoline cross‐linked carboxyterminal telopeptide of type I collagen (ICTP) is a well‐known biomarker of bone turnover, and as such is a potential indicator of osseous metabolic activity. The objective of this study was to evaluate the release of the ICTP into the periodontal wound fluid (WF) following periodontal reconstructive surgery using local delivery of highly purified recombinant human PDGF (rhPDGF)‐BB.
Methods: Forty‐seven human subjects at five treatment centres possessing chronic severe periodontal disease were monitored longitudinally for 24 weeks following PDGF regenerative surgical treatment. Severe periodontal osseous defects were divided into one of three groups and treated at the time of surgery with either: β‐tricalcium phosphate (TCP) osteoconductive scaffold alone (active control), β‐TCP+0.3 mg/ml of rhPDGF‐BB, or β‐TCP+1.0 mg/ml of rhPDGF‐BB. WF was harvested and analysed for local ICTP levels by radioimmunoassay. Statistical analysis was performed using analysis of variance and an area under the curve analysis (AUC).
Results: The 0.3 and 1.0 mg/ml PDGF‐BB treatment groups demonstrated increases in the amount of ICTP released locally for up to 6 weeks. There were statistically significant differences at the week 6 time point between β‐TCP carrier alone group versus 0.3 mg/ml PDGF‐BB group (p<0.05) and between β‐TCP alone versus the 1.0 mg/ml PDGF‐BB‐treated lesions (p<0.03). The AUC analysis revealed no statistical differences amongst groups.
Conclusion: This study corroborates the release of ICTP as a measure of active bone turnover following local delivery of PDGF‐BB to periodontal osseous defects. The amount of ICTP released from the WF revealed an early increase for all treatment groups. Data from this study suggests that when PDGF‐BB is delivered to promote periodontal tissue engineering of tooth‐supporting osseous defects, there is a direct effect on ICTP released from the wound. Growth factors such as platelet-derived growth factor (PDGF) exert potent effects on wound healing including the regeneration of periodontia. Pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) is a well-known biomarker of bone turnover, and as such is a potential indicator of osseous metabolic activity. The objective of this study was to evaluate the release of the ICTP into the periodontal wound fluid (WF) following periodontal reconstructive surgery using local delivery of highly purified recombinant human PDGF (rhPDGF)-BB.PURPOSEGrowth factors such as platelet-derived growth factor (PDGF) exert potent effects on wound healing including the regeneration of periodontia. Pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) is a well-known biomarker of bone turnover, and as such is a potential indicator of osseous metabolic activity. The objective of this study was to evaluate the release of the ICTP into the periodontal wound fluid (WF) following periodontal reconstructive surgery using local delivery of highly purified recombinant human PDGF (rhPDGF)-BB.Forty-seven human subjects at five treatment centres possessing chronic severe periodontal disease were monitored longitudinally for 24 weeks following PDGF regenerative surgical treatment. Severe periodontal osseous defects were divided into one of three groups and treated at the time of surgery with either: beta-tricalcium phosphate (TCP) osteoconductive scaffold alone (active control), beta-TCP+0.3 mg/ml of rhPDGF-BB, or beta-TCP+1.0 mg/ml of rhPDGF-BB. WF was harvested and analysed for local ICTP levels by radioimmunoassay. Statistical analysis was performed using analysis of variance and an area under the curve analysis (AUC).METHODSForty-seven human subjects at five treatment centres possessing chronic severe periodontal disease were monitored longitudinally for 24 weeks following PDGF regenerative surgical treatment. Severe periodontal osseous defects were divided into one of three groups and treated at the time of surgery with either: beta-tricalcium phosphate (TCP) osteoconductive scaffold alone (active control), beta-TCP+0.3 mg/ml of rhPDGF-BB, or beta-TCP+1.0 mg/ml of rhPDGF-BB. WF was harvested and analysed for local ICTP levels by radioimmunoassay. Statistical analysis was performed using analysis of variance and an area under the curve analysis (AUC).The 0.3 and 1.0 mg/ml PDGF-BB treatment groups demonstrated increases in the amount of ICTP released locally for up to 6 weeks. There were statistically significant differences at the week 6 time point between beta-TCP carrier alone group versus 0.3 mg/ml PDGF-BB group (p<0.05) and between beta-TCP alone versus the 1.0 mg/ml PDGF-BB-treated lesions (p<0.03). The AUC analysis revealed no statistical differences amongst groups.RESULTSThe 0.3 and 1.0 mg/ml PDGF-BB treatment groups demonstrated increases in the amount of ICTP released locally for up to 6 weeks. There were statistically significant differences at the week 6 time point between beta-TCP carrier alone group versus 0.3 mg/ml PDGF-BB group (p<0.05) and between beta-TCP alone versus the 1.0 mg/ml PDGF-BB-treated lesions (p<0.03). The AUC analysis revealed no statistical differences amongst groups.This study corroborates the release of ICTP as a measure of active bone turnover following local delivery of PDGF-BB to periodontal osseous defects. The amount of ICTP released from the WF revealed an early increase for all treatment groups. Data from this study suggests that when PDGF-BB is delivered to promote periodontal tissue engineering of tooth-supporting osseous defects, there is a direct effect on ICTP released from the wound.CONCLUSIONThis study corroborates the release of ICTP as a measure of active bone turnover following local delivery of PDGF-BB to periodontal osseous defects. The amount of ICTP released from the WF revealed an early increase for all treatment groups. Data from this study suggests that when PDGF-BB is delivered to promote periodontal tissue engineering of tooth-supporting osseous defects, there is a direct effect on ICTP released from the wound. Purpose: Growth factors such as platelet-derived growth factor (PDGF) exert potent effects on wound healing including the regeneration of periodontia. Pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) is a well-known biomarker of bone turnover, and as such is a potential indicator of osseous metabolic activity. The objective of this study was to evaluate the release of the ICTP into the periodontal wound fluid (WF) following periodontal reconstructive surgery using local delivery of highly purified recombinant human PDGF (rhPDGF)-BB. Methods: Forty-seven human subjects at five treatment centres possessing chronic severe periodontal disease were monitored longitudinally for 24 weeks following PDGF regenerative surgical treatment. Severe periodontal osseous defects were divided into one of three groups and treated at the time of surgery with either: beta -tricalcium phosphate (TCP) osteoconductive scaffold alone (active control), beta -TCP+0.3 mg-ml of rhPDGF-BB, or beta -TCP+1.0 mg-ml of rhPDGF-BB. WF was harvested and analysed for local ICTP levels by radioimmunoassay. Statistical analysis was performed using analysis of variance and an area under the curve analysis (AUC). Results: The 0.3 and 1.0 mg-ml PDGF-BB treatment groups demonstrated increases in the amount of ICTP released locally for up to 6 weeks. There were statistically significant differences at the week 6 time point between beta -TCP carrier alone group versus 0.3 mg-ml PDGF-BB group (p<0.05) and between beta -TCP alone versus the 1.0 mg-ml PDGF-BB-treated lesions (p<0.03). The AUC analysis revealed no statistical differences amongst groups. Conclusion: This study corroborates the release of ICTP as a measure of active bone turnover following local delivery of PDGF-BB to periodontal osseous defects. The amount of ICTP released from the WF revealed an early increase for all treatment groups. Data from this study suggests that when PDGF-BB is delivered to promote periodontal tissue engineering of tooth-supporting osseous defects, there is a direct effect on ICTP released from the wound. Growth factors such as platelet-derived growth factor (PDGF) exert potent effects on wound healing including the regeneration of periodontia. Pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) is a well-known biomarker of bone turnover, and as such is a potential indicator of osseous metabolic activity. The objective of this study was to evaluate the release of the ICTP into the periodontal wound fluid (WF) following periodontal reconstructive surgery using local delivery of highly purified recombinant human PDGF (rhPDGF)-BB. Forty-seven human subjects at five treatment centres possessing chronic severe periodontal disease were monitored longitudinally for 24 weeks following PDGF regenerative surgical treatment. Severe periodontal osseous defects were divided into one of three groups and treated at the time of surgery with either: beta-tricalcium phosphate (TCP) osteoconductive scaffold alone (active control), beta-TCP+0.3 mg/ml of rhPDGF-BB, or beta-TCP+1.0 mg/ml of rhPDGF-BB. WF was harvested and analysed for local ICTP levels by radioimmunoassay. Statistical analysis was performed using analysis of variance and an area under the curve analysis (AUC). The 0.3 and 1.0 mg/ml PDGF-BB treatment groups demonstrated increases in the amount of ICTP released locally for up to 6 weeks. There were statistically significant differences at the week 6 time point between beta-TCP carrier alone group versus 0.3 mg/ml PDGF-BB group (p<0.05) and between beta-TCP alone versus the 1.0 mg/ml PDGF-BB-treated lesions (p<0.03). The AUC analysis revealed no statistical differences amongst groups. This study corroborates the release of ICTP as a measure of active bone turnover following local delivery of PDGF-BB to periodontal osseous defects. The amount of ICTP released from the WF revealed an early increase for all treatment groups. Data from this study suggests that when PDGF-BB is delivered to promote periodontal tissue engineering of tooth-supporting osseous defects, there is a direct effect on ICTP released from the wound. Purpose: Growth factors such as platelet‐derived growth factor (PDGF) exert potent effects on wound healing including the regeneration of periodontia. Pyridinoline cross‐linked carboxyterminal telopeptide of type I collagen (ICTP) is a well‐known biomarker of bone turnover, and as such is a potential indicator of osseous metabolic activity. The objective of this study was to evaluate the release of the ICTP into the periodontal wound fluid (WF) following periodontal reconstructive surgery using local delivery of highly purified recombinant human PDGF (rhPDGF)‐BB. Methods: Forty‐seven human subjects at five treatment centres possessing chronic severe periodontal disease were monitored longitudinally for 24 weeks following PDGF regenerative surgical treatment. Severe periodontal osseous defects were divided into one of three groups and treated at the time of surgery with either: β ‐tricalcium phosphate (TCP) osteoconductive scaffold alone (active control), β ‐TCP+0.3 mg/ml of rhPDGF‐BB, or β ‐TCP+1.0 mg/ml of rhPDGF‐BB. WF was harvested and analysed for local ICTP levels by radioimmunoassay. Statistical analysis was performed using analysis of variance and an area under the curve analysis (AUC). Results: The 0.3 and 1.0 mg/ml PDGF‐BB treatment groups demonstrated increases in the amount of ICTP released locally for up to 6 weeks. There were statistically significant differences at the week 6 time point between β ‐TCP carrier alone group versus 0.3 mg/ml PDGF‐BB group ( p <0.05) and between β ‐TCP alone versus the 1.0 mg/ml PDGF‐BB‐treated lesions ( p <0.03). The AUC analysis revealed no statistical differences amongst groups. Conclusion: This study corroborates the release of ICTP as a measure of active bone turnover following local delivery of PDGF‐BB to periodontal osseous defects. The amount of ICTP released from the WF revealed an early increase for all treatment groups. Data from this study suggests that when PDGF‐BB is delivered to promote periodontal tissue engineering of tooth‐supporting osseous defects, there is a direct effect on ICTP released from the wound. |
| Author | Jin, Qiming Cooke, Jason W. Miller, Sarah E. McClain, Pamela K. Lynch, Samuel E. McGuire, Michael K. McAllister, Bradley S. Giannobile, William V. Sarment, David P. Kao, Richard T. |
| AuthorAffiliation | 7 Department of Biomedical Engineering, College of Engineering, University of Michigan, MI, USA 5 Private Practice, Portland Implant Dentistry, Portland, OR, USA 6 BioMimetic Pharmaceuticals Inc., Franklin, TN, USA 2 Private Practice, Perio Health Professionals, Houston, TX, USA 1 Department of Periodontics and Oral Medicine, Center for Craniofacial Regeneration and Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, Ann Arbor, MI, USA 3 Private Practice, Cupertino, CA, USA 4 Private Practice, Aurora, CO, USA |
| AuthorAffiliation_xml | – name: 2 Private Practice, Perio Health Professionals, Houston, TX, USA – name: 6 BioMimetic Pharmaceuticals Inc., Franklin, TN, USA – name: 7 Department of Biomedical Engineering, College of Engineering, University of Michigan, MI, USA – name: 1 Department of Periodontics and Oral Medicine, Center for Craniofacial Regeneration and Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, Ann Arbor, MI, USA – name: 5 Private Practice, Portland Implant Dentistry, Portland, OR, USA – name: 3 Private Practice, Cupertino, CA, USA – name: 4 Private Practice, Aurora, CO, USA |
| Author_xml | – sequence: 1 givenname: David P. surname: Sarment fullname: Sarment, David P. organization: Department of Periodontics and Oral Medicine, Center for Craniofacial Regeneration and Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, Ann Arbor, MI, USA – sequence: 2 givenname: Jason W. surname: Cooke fullname: Cooke, Jason W. organization: Department of Periodontics and Oral Medicine, Center for Craniofacial Regeneration and Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, Ann Arbor, MI, USA – sequence: 3 givenname: Sarah E. surname: Miller fullname: Miller, Sarah E. organization: Department of Periodontics and Oral Medicine, Center for Craniofacial Regeneration and Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, Ann Arbor, MI, USA – sequence: 4 givenname: Qiming surname: Jin fullname: Jin, Qiming organization: Department of Periodontics and Oral Medicine, Center for Craniofacial Regeneration and Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, Ann Arbor, MI, USA – sequence: 5 givenname: Michael K. surname: McGuire fullname: McGuire, Michael K. organization: Private Practice, Perio Health Professionals, Houston, TX, USA – sequence: 6 givenname: Richard T. surname: Kao fullname: Kao, Richard T. organization: Private Practice, Cupertino, CA, USA – sequence: 7 givenname: Pamela K. surname: McClain fullname: McClain, Pamela K. organization: Private Practice, Aurora, CO, USA – sequence: 8 givenname: Bradley S. surname: McAllister fullname: McAllister, Bradley S. organization: Private Practice, Portland Implant Dentistry, Portland, OR, USA – sequence: 9 givenname: Samuel E. surname: Lynch fullname: Lynch, Samuel E. organization: BioMimetic Pharmaceuticals Inc., Franklin, TN, USA – sequence: 10 givenname: William V. surname: Giannobile fullname: Giannobile, William V. organization: Department of Periodontics and Oral Medicine, Center for Craniofacial Regeneration and Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, Ann Arbor, MI, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16441739$$D View this record in MEDLINE/PubMed |
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| References | Al-Shammari, K. F., Giannobile, W. V., Aldredge, W. A., Iacono, V. J., Eber, R. M., Wang, H. L. & Oringer, R. J. (2001) Effect of non-surgical periodontal therapy on C-telopeptide pyridinoline cross-links (ICTP) and interleukin-1 levels. Journal of Periodontology 72, 1045-1051. Cooke, J. W., Sarment, D. P., Whitesman, L. A., Miller, S. E., Jin, Q., Lynch, S. E. & Giannobile, W. V. Effect of platelet derived growth factor on mediators of periodontal wound repair. Tissue Engineering, in press. Nevins, M., Giannobile, W. V., McGuire, M. K., Kao, R. T., Mellonig, J. T., Hinrichs, J. E., McAllister, B. S., Murphy, K. S., McClain, P. K., Nevins, M. L., Paquette, D. W., Han, T. H., Reddy, M. S., Lavin, P. T., Genco, R. J. & Lynch, S. E. (2005) Platelet-derived growth factor (rhPDGF-BB) Stimulates bone fill and rate of attachment level gain: results of a large multi-center randomized controlled trial. Journal of Periodontology 76, 2205-2215. Parkar, M. H., Kuru, L., Giouzeli, M. & Olsen, I. (2001) Expression of growth-factor receptors in normal and regenerating human periodontal cells. Archives of Oral Biology 46, 275-284. Golub, L. M., Lee, H. M., Greenwald, R. A., Ryan, M. E., Sorsa, T., Salo, T. & Giannobile, W. V. (1997) A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflammation Research 46, 310-319. Matsuda, N., Lin, W. L., Kumar, N. M., Cho, M. I. & Genco, R. J. (1992) Mitogenic, chemotactic, and synthetic responses of rat periodontal ligament fibroblastic cells to polypeptide growth factors in vitro. Journal of Periodontology 63, 515-525. Mumford, J. H., Carnes, D. L., Cochran, D. L. & Oates, T. W. (2001) The effects of platelet-derived growth factor-BB on periodontal cells in an in vitro wound model. Journal of Periodontology 72, 331-340. Oringer, R. J., Palys, M. D., Iranmanesh, A., Fiorellini, J. P., Haffajee, A. D., Socransky, S. S. & Giannobile, W. V. (1998) C-telopeptide pyridinoline cross-links (ICTP) and periodontal pathogens associated with endosseous oral implants. Clinical Oral Implants Research 9, 365-373. Giannobile, W. V., Hernandez, R. A., Finkelman, R. D., Ryan, S., Kiritsy, C. P., D'Andrea, M. & Lynch, S. E. (1996) Comparative effects of platelet-derived growth factor-BB and insulin-like growth factor-I, individually and in combination, on periodontal regeneration in Macaca fascicularis. Journal of Periodontal Research 31, 301-312. McAllister, B., Leeb-Lundberg, F. & Olsen, M. S. (1993) Bradykinin inhibition of epidermal growth factor and platelet-derived growth factor-induced DNA synthesis in human fibroblasts. American Journal of Physiology 265, C477-C484. Cho, M. I., Lin, W. L. & Genco, R. J. (1995) Platelet-derived growth factor-modulated guided tissue regenerative therapy. Journal of Periodontology 66, 522-530. Green, R. J., Usui, M. L., Hart, C. E., Ammons, W. F. & Narayanan, A. S. (1997) Immunolocalization of platelet-derived growth factor A and B chains and PDGF-alpha and beta receptors in human gingival wounds. Journal of Periodontal Research 32, 209-214. Talonpoika, J. T. & Hämaläinen, M. M. (1994) Type I collagen carboxyterminal telopeptide in human gingival crevicular fluid in different clinical conditions and after periodontal treatment. Journal of Clinical Periodontology 21, 320-326. Giannobile, W. V. (1996) Periodontal tissue engineering by growth factors. Bone 19, 23S-37S. Palys, M. D., Haffajee, A. D., Socransky, S. S. & Giannobile, W. V. (1998) Relationship between C-telopeptide pyridinoline cross-links (ICTP) and putative periodontal pathogens in periodontitis. Journal of Clinical Periodontology 25, 865-871. Shibutani, T., Murahashi, Y., Tsukada, E., Iwayama, Y. & Heersche, J. N. (1997) Experimentally induced periodontitis in beagle dogs causes rapid increases in osteoclastic resorption of alveolar bone. Journal of Periodontology 68, 385-391. Lynch, S. E., Williams, R. C., Polson, A. M., Howell, T. H., Reddy, M. S., Zappa, U. E. & Antoniades, H. N. (1989) A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration. Journal of Clinical Periodontology 16, 545-548. Calvo, M. S., Eyre, D. R. & Gundberg, C. M. (1996) Molecular basis and clinical application of biological markers of bone turnover. Endocrine Review 17, 333-368. Lynch, S. E., de Castilla, G. R., Williams, R. C., Kiritsy, C. P., Howell, T. H., Reddy, M. S. & Antoniades, H. N. (1991) The effects of short-term application of a combination of platelet-derived and insulin-like growth factors on periodontal wound healing. Journal of Periodontology 62, 458-467. Eyre, D. (1987) Collagen cross-linking amino acids. Methods in Enzymology 144, 115-139. Giannobile, W. V., Al-Shammari, K. F. & Sarment, D. P. (2003) Matrix molecules and growth factors as indicators of periodontal disease activity. Periodontology 2000 31, 125-134. Nevins, M., Camelo, M., Nevins, M. L., Schenk, R. K. & Lynch, S. E. (2003) Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone. Journal of Periodontology 74, 1282-1292. Taba, M. Jr., Kinney, J., Kim, A. S. & Giannobile, W. V. (2005) Diagnostic biomarkers for oral and periodontal diseases. Dental Clinics of North America 49, 551-571. Risteli, J., Elomaa, I., Niemi, S., Novamo, A. & Risteli, L. (1993) Radioimmunoassay for the pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen: a new serum marker of bone collagen degradation. Clinical Chemistry 39, 635-640. Giannobile, W. V., Lynch, S. E., Denmark, R. G., Paquette, D. W., Fiorellini, J. P. & Williams, R. C. (1995) Crevicular fluid osteocalcin and pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) as markers of rapid bone turnover in periodontitis. A pilot study in beagle dogs. Journal of Clinical Periodontology 22, 903-910. Charles, P., Mosekilde, L., Risteli, L., Risteli, J. & Eriksen, E. F. (1994) Assessment of bone remodeling using biochemical indicators of type I collagen synthesis and degradation: relation to calcium kinetics. Bone and Mineral 24, 81-94. Last, J. A., Armstrong, L. G. & Reiser, K. M. (1990) Biosynthesis of collagen crosslinks. International Journal of Biochemistry 22, 559-564. Gapski, R., Barr, J. L., Sarment, D. P., Layher, M. G., Socransky, S. S. & Giannobile, W. V. (2004) Effect of systemic matrix metalloproteinase inhibition on periodontal wound repair: a proof of concept trial. Journal of Periodontology 75, 441-452. Oringer, R. J., Al-Shammari, K. F., Aldrege, W. A., Iacono, V. J., Eber, R. M., Wang, H. L., Berwald, B., Nejat, R. & Giannobile, W. V. (2002) Effect of locally delivered minocycline microspheres on markers of bone resorption. Journal of Periodontology 73, 835-842. Giannobile, W. V., Finkelman, R. D. & Lynch, S. E. (1994) Comparison of canine and non-human primate animal models for periodontal regenerative therapy: results following a single administration of PDGF/IGF-I. Journal of Periodontology 65, 1158-1168. Howell, T. H., Fiorellini, J. P., Paquette, D. W., Offenbacher, S., Giannobile, W. V. & Lynch, S. E. (1997) A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease. Journal of Periodontology 68, 1186-1193. Eriksen, E. F., Charles, P., Melsen, F., Mosekilde, L., Risteli, L. & Risteli, J. (1993) Serum markers of type I collagen formation and degradation in metabolic bone disease: correlation with bone histomorphometry. Journal of Bone and Mineral Research 8, 127-132. Eastell, R., Robins, S. P., Colwell, T., Assiri, A. M., Riggs, B. L. & Russell, R. G. (1993) Evaluation of bone turnover in type I osteoporosis using biochemical markers specific for both bone formation and bone resorption. Osteoporosis International 3, 255-260. Narayanan, A. S. & Page, R. C. (1983) Connective tissues of the periodontium: a summary of current work. Collagen and Related Research 3, 33-64. 1993; 8 2001; 72 1996; 17 1987; 144 1996; 19 1983; 3 2002; 73 1997; 46 1997; 68 1994; 24 2005; 49 2001; 46 2003; 74 1993; 3 2003; 31 1996; 31 1994; 65 1998; 25 1994; 21 1993; 265 2004; 75 1990; 22 1993; 39 1997; 32 1995; 66 1995; 22 1991; 62 2005; 76 1989; 16 1998; 9 1992; 63 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_9_1 e_1_2_7_8_1 Cooke J. W. (e_1_2_7_6_1) e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_12_1 e_1_2_7_11_1 e_1_2_7_10_1 e_1_2_7_26_1 e_1_2_7_27_1 e_1_2_7_28_1 e_1_2_7_29_1 Risteli J. (e_1_2_7_32_1) 1993; 39 Calvo M. S. (e_1_2_7_3_1) 1996; 17 e_1_2_7_30_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_24_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_20_1 |
| References_xml | – reference: Cho, M. I., Lin, W. L. & Genco, R. J. (1995) Platelet-derived growth factor-modulated guided tissue regenerative therapy. Journal of Periodontology 66, 522-530. – reference: Gapski, R., Barr, J. L., Sarment, D. P., Layher, M. G., Socransky, S. S. & Giannobile, W. V. (2004) Effect of systemic matrix metalloproteinase inhibition on periodontal wound repair: a proof of concept trial. Journal of Periodontology 75, 441-452. – reference: Calvo, M. S., Eyre, D. R. & Gundberg, C. M. (1996) Molecular basis and clinical application of biological markers of bone turnover. Endocrine Review 17, 333-368. – reference: Giannobile, W. V., Hernandez, R. A., Finkelman, R. D., Ryan, S., Kiritsy, C. P., D'Andrea, M. & Lynch, S. E. (1996) Comparative effects of platelet-derived growth factor-BB and insulin-like growth factor-I, individually and in combination, on periodontal regeneration in Macaca fascicularis. Journal of Periodontal Research 31, 301-312. – reference: Mumford, J. H., Carnes, D. L., Cochran, D. L. & Oates, T. W. (2001) The effects of platelet-derived growth factor-BB on periodontal cells in an in vitro wound model. Journal of Periodontology 72, 331-340. – reference: Palys, M. D., Haffajee, A. D., Socransky, S. S. & Giannobile, W. V. (1998) Relationship between C-telopeptide pyridinoline cross-links (ICTP) and putative periodontal pathogens in periodontitis. Journal of Clinical Periodontology 25, 865-871. – reference: Last, J. A., Armstrong, L. G. & Reiser, K. M. (1990) Biosynthesis of collagen crosslinks. International Journal of Biochemistry 22, 559-564. – reference: Giannobile, W. V., Finkelman, R. D. & Lynch, S. E. (1994) Comparison of canine and non-human primate animal models for periodontal regenerative therapy: results following a single administration of PDGF/IGF-I. Journal of Periodontology 65, 1158-1168. – reference: Golub, L. M., Lee, H. M., Greenwald, R. A., Ryan, M. E., Sorsa, T., Salo, T. & Giannobile, W. V. (1997) A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflammation Research 46, 310-319. – reference: Al-Shammari, K. F., Giannobile, W. V., Aldredge, W. A., Iacono, V. J., Eber, R. M., Wang, H. L. & Oringer, R. J. (2001) Effect of non-surgical periodontal therapy on C-telopeptide pyridinoline cross-links (ICTP) and interleukin-1 levels. Journal of Periodontology 72, 1045-1051. – reference: Talonpoika, J. T. & Hämaläinen, M. M. (1994) Type I collagen carboxyterminal telopeptide in human gingival crevicular fluid in different clinical conditions and after periodontal treatment. Journal of Clinical Periodontology 21, 320-326. – reference: Eyre, D. (1987) Collagen cross-linking amino acids. Methods in Enzymology 144, 115-139. – reference: Cooke, J. W., Sarment, D. P., Whitesman, L. A., Miller, S. E., Jin, Q., Lynch, S. E. & Giannobile, W. V. Effect of platelet derived growth factor on mediators of periodontal wound repair. Tissue Engineering, in press. – reference: Giannobile, W. V., Al-Shammari, K. F. & Sarment, D. P. (2003) Matrix molecules and growth factors as indicators of periodontal disease activity. Periodontology 2000 31, 125-134. – reference: Howell, T. H., Fiorellini, J. P., Paquette, D. W., Offenbacher, S., Giannobile, W. V. & Lynch, S. E. (1997) A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease. Journal of Periodontology 68, 1186-1193. – reference: Oringer, R. J., Al-Shammari, K. F., Aldrege, W. A., Iacono, V. J., Eber, R. M., Wang, H. L., Berwald, B., Nejat, R. & Giannobile, W. V. (2002) Effect of locally delivered minocycline microspheres on markers of bone resorption. Journal of Periodontology 73, 835-842. – reference: Taba, M. Jr., Kinney, J., Kim, A. S. & Giannobile, W. V. (2005) Diagnostic biomarkers for oral and periodontal diseases. Dental Clinics of North America 49, 551-571. – reference: Nevins, M., Camelo, M., Nevins, M. L., Schenk, R. K. & Lynch, S. E. (2003) Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone. Journal of Periodontology 74, 1282-1292. – reference: Eastell, R., Robins, S. P., Colwell, T., Assiri, A. M., Riggs, B. L. & Russell, R. G. (1993) Evaluation of bone turnover in type I osteoporosis using biochemical markers specific for both bone formation and bone resorption. Osteoporosis International 3, 255-260. – reference: Eriksen, E. F., Charles, P., Melsen, F., Mosekilde, L., Risteli, L. & Risteli, J. (1993) Serum markers of type I collagen formation and degradation in metabolic bone disease: correlation with bone histomorphometry. Journal of Bone and Mineral Research 8, 127-132. – reference: Charles, P., Mosekilde, L., Risteli, L., Risteli, J. & Eriksen, E. F. (1994) Assessment of bone remodeling using biochemical indicators of type I collagen synthesis and degradation: relation to calcium kinetics. Bone and Mineral 24, 81-94. – reference: Giannobile, W. V. (1996) Periodontal tissue engineering by growth factors. Bone 19, 23S-37S. – reference: Lynch, S. E., de Castilla, G. R., Williams, R. C., Kiritsy, C. P., Howell, T. H., Reddy, M. S. & Antoniades, H. N. (1991) The effects of short-term application of a combination of platelet-derived and insulin-like growth factors on periodontal wound healing. Journal of Periodontology 62, 458-467. – reference: Shibutani, T., Murahashi, Y., Tsukada, E., Iwayama, Y. & Heersche, J. N. (1997) Experimentally induced periodontitis in beagle dogs causes rapid increases in osteoclastic resorption of alveolar bone. Journal of Periodontology 68, 385-391. – reference: Narayanan, A. S. & Page, R. C. (1983) Connective tissues of the periodontium: a summary of current work. Collagen and Related Research 3, 33-64. – reference: Nevins, M., Giannobile, W. V., McGuire, M. K., Kao, R. T., Mellonig, J. T., Hinrichs, J. E., McAllister, B. S., Murphy, K. S., McClain, P. K., Nevins, M. L., Paquette, D. W., Han, T. H., Reddy, M. S., Lavin, P. T., Genco, R. J. & Lynch, S. E. (2005) Platelet-derived growth factor (rhPDGF-BB) Stimulates bone fill and rate of attachment level gain: results of a large multi-center randomized controlled trial. Journal of Periodontology 76, 2205-2215. – reference: Parkar, M. H., Kuru, L., Giouzeli, M. & Olsen, I. (2001) Expression of growth-factor receptors in normal and regenerating human periodontal cells. Archives of Oral Biology 46, 275-284. – reference: Lynch, S. E., Williams, R. C., Polson, A. M., Howell, T. H., Reddy, M. S., Zappa, U. E. & Antoniades, H. N. (1989) A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration. Journal of Clinical Periodontology 16, 545-548. – reference: McAllister, B., Leeb-Lundberg, F. & Olsen, M. S. (1993) Bradykinin inhibition of epidermal growth factor and platelet-derived growth factor-induced DNA synthesis in human fibroblasts. American Journal of Physiology 265, C477-C484. – reference: Giannobile, W. V., Lynch, S. E., Denmark, R. G., Paquette, D. W., Fiorellini, J. P. & Williams, R. C. (1995) Crevicular fluid osteocalcin and pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) as markers of rapid bone turnover in periodontitis. A pilot study in beagle dogs. Journal of Clinical Periodontology 22, 903-910. – reference: Green, R. J., Usui, M. L., Hart, C. E., Ammons, W. F. & Narayanan, A. S. (1997) Immunolocalization of platelet-derived growth factor A and B chains and PDGF-alpha and beta receptors in human gingival wounds. Journal of Periodontal Research 32, 209-214. – reference: Matsuda, N., Lin, W. L., Kumar, N. M., Cho, M. I. & Genco, R. J. (1992) Mitogenic, chemotactic, and synthetic responses of rat periodontal ligament fibroblastic cells to polypeptide growth factors in vitro. Journal of Periodontology 63, 515-525. – reference: Oringer, R. J., Palys, M. D., Iranmanesh, A., Fiorellini, J. P., Haffajee, A. D., Socransky, S. S. & Giannobile, W. V. (1998) C-telopeptide pyridinoline cross-links (ICTP) and periodontal pathogens associated with endosseous oral implants. Clinical Oral Implants Research 9, 365-373. – reference: Risteli, J., Elomaa, I., Niemi, S., Novamo, A. & Risteli, L. (1993) Radioimmunoassay for the pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen: a new serum marker of bone collagen degradation. Clinical Chemistry 39, 635-640. – volume: 9 start-page: 365 year: 1998 end-page: 373 article-title: C‐telopeptide pyridinoline cross‐links (ICTP) and periodontal pathogens associated with endosseous oral implants publication-title: Clinical Oral Implants Research – volume: 65 start-page: 1158 year: 1994 end-page: 1168 article-title: Comparison of canine and non‐human primate animal models for periodontal regenerative therapy publication-title: Journal of Periodontology – volume: 74 start-page: 1282 year: 2003 end-page: 1292 article-title: Periodontal regeneration in humans using recombinant human platelet‐derived growth factor‐BB (rhPDGF‐BB) and allogenic bone publication-title: Journal of Periodontology – volume: 63 start-page: 515 year: 1992 end-page: 525 article-title: Mitogenic, chemotactic, and synthetic responses of rat periodontal ligament fibroblastic cells to polypeptide growth factors in vitro publication-title: Journal of Periodontology – volume: 76 year: 2005 article-title: Platelet‐derived growth factor (rhPDGF‐BB) Stimulates bone fill and rate of attachment level gain publication-title: Journal of Periodontology – volume: 49 start-page: 551 year: 2005 end-page: 571 article-title: Diagnostic biomarkers for oral and periodontal diseases publication-title: Dental Clinics of North America – volume: 46 start-page: 310 year: 1997 end-page: 319 article-title: A matrix metalloproteinase inhibitor reduces bone‐type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis publication-title: Inflammation Research – volume: 68 start-page: 1186 year: 1997 end-page: 1193 article-title: A phase I/II clinical trial to evaluate a combination of recombinant human platelet‐derived growth factor‐BB and recombinant human insulin‐like growth factor‐I in patients with periodontal disease publication-title: Journal of Periodontology – volume: 16 start-page: 545 year: 1989 end-page: 548 article-title: A combination of platelet‐derived and insulin‐like growth factors enhances periodontal regeneration publication-title: Journal of Clinical Periodontology – volume: 66 start-page: 522 year: 1995 end-page: 530 article-title: Platelet‐derived growth factor‐modulated guided tissue regenerative therapy publication-title: Journal of Periodontology – volume: 46 start-page: 275 year: 2001 end-page: 284 article-title: Expression of growth‐factor receptors in normal and regenerating human periodontal cells publication-title: Archives of Oral Biology – volume: 72 start-page: 1045 year: 2001 end-page: 1051 article-title: Effect of non‐surgical periodontal therapy on C‐telopeptide pyridinoline cross‐links (ICTP) and interleukin‐1 levels publication-title: Journal of Periodontology – volume: 3 start-page: 255 year: 1993 end-page: 260 article-title: Evaluation of bone turnover in type I osteoporosis using biochemical markers specific for both bone formation and bone resorption publication-title: Osteoporosis International – volume: 24 start-page: 81 year: 1994 end-page: 94 article-title: Assessment of bone remodeling using biochemical indicators of type I collagen synthesis and degradation publication-title: Bone and Mineral – volume: 3 start-page: 33 year: 1983 end-page: 64 article-title: Connective tissues of the periodontium publication-title: Collagen and Related Research – volume: 68 start-page: 385 year: 1997 end-page: 391 article-title: Experimentally induced periodontitis in beagle dogs causes rapid increases in osteoclastic resorption of alveolar bone publication-title: Journal of Periodontology – volume: 32 start-page: 209 year: 1997 end-page: 214 article-title: Immunolocalization of platelet‐derived growth factor A and B chains and PDGF‐alpha and beta receptors in human gingival wounds publication-title: Journal of Periodontal Research – volume: 21 start-page: 320 year: 1994 end-page: 326 article-title: Type I collagen carboxyterminal telopeptide in human gingival crevicular fluid in different clinical conditions and after periodontal treatment publication-title: Journal of Clinical Periodontology – volume: 8 start-page: 127 year: 1993 end-page: 132 article-title: Serum markers of type I collagen formation and degradation in metabolic bone disease publication-title: Journal of Bone and Mineral Research – volume: 17 start-page: 333 year: 1996 end-page: 368 article-title: Molecular basis and clinical application of biological markers of bone turnover publication-title: Endocrine Review – volume: 144 start-page: 115 year: 1987 end-page: 139 article-title: Collagen cross‐linking amino acids publication-title: Methods in Enzymology – volume: 31 start-page: 301 year: 1996 end-page: 312 article-title: Comparative effects of platelet‐derived growth factor‐BB and insulin‐like growth factor‐I, individually and in combination, on periodontal regeneration in publication-title: Journal of Periodontal Research – volume: 22 start-page: 903 year: 1995 end-page: 910 article-title: Crevicular fluid osteocalcin and pyridinoline cross‐linked carboxyterminal telopeptide of type I collagen (ICTP) as markers of rapid bone turnover in periodontitis. 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| Snippet | Purpose: Growth factors such as platelet‐derived growth factor (PDGF) exert potent effects on wound healing including the regeneration of periodontia.... Purpose: Growth factors such as platelet‐derived growth factor (PDGF) exert potent effects on wound healing including the regeneration of periodontia.... Growth factors such as platelet-derived growth factor (PDGF) exert potent effects on wound healing including the regeneration of periodontia. Pyridinoline... Purpose: Growth factors such as platelet-derived growth factor (PDGF) exert potent effects on wound healing including the regeneration of periodontia.... |
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| SubjectTerms | Adult Aged Alveolar Bone Loss - surgery Becaplermin Bone Regeneration - drug effects Bone Substitutes - therapeutic use Calcium Phosphates - therapeutic use collagen telopeptides Collagen Type I - analysis Female Follow-Up Studies growth factors Guided Tissue Regeneration, Periodontal Humans Longitudinal Studies Male Middle Aged Peptides - analysis Periodontal Diseases - surgery periodontal regeneration periodontal wound repair Platelet-Derived Growth Factor - therapeutic use Proto-Oncogene Proteins c-sis Recombinant Proteins Regeneration - drug effects tissue engineering Wound Healing - drug effects |
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| Title | Effect of rhPDGF-BB on bone turnover during periodontal repair |
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