磷脂酰肌醇蛋白聚糖3在肝癌治疗中的应用进展

肝癌是常见恶性肿瘤之一,传统的肝癌治疗方法各自存在局限性。磷脂酰肌醇蛋白聚糖（GPC）3是一种细胞膜表面的硫酸乙酰肝素蛋白多糖,参与调控个体发育、细胞增殖和分化等过程,是一种肝癌特异性癌胚抗原。GPC3在肝癌发生、发展中的作用机制已成为研究热点。GPC3不仅在肝癌诊断方面有独特价值,在肝癌治疗方面更有重要作用。介绍了应用GPC3瘤苗、GPC3抗体、GPC3基因及靶向等治疗手段,为肝癌治疗提供了新的思路。...

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Bibliographic Details
Published in临床肝胆病杂志 Vol. 33; no. 7; pp. 1369 - 1372
Main Author 任志忠 张跃伟
Format Journal Article
LanguageChinese
Published 遵义医学院,贵州 遵义,563000 2017
Subjects
治疗
磷脂酰肌醇蛋白聚糖类
综述
肝肿瘤
肝肿瘤
治疗
therapy
review
磷脂酰肌醇蛋白聚糖类
liver neoplasms
综述
glypicans
Online AccessGet full text
ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2017.07.037

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Summary:肝癌是常见恶性肿瘤之一,传统的肝癌治疗方法各自存在局限性。磷脂酰肌醇蛋白聚糖（GPC）3是一种细胞膜表面的硫酸乙酰肝素蛋白多糖,参与调控个体发育、细胞增殖和分化等过程,是一种肝癌特异性癌胚抗原。GPC3在肝癌发生、发展中的作用机制已成为研究热点。GPC3不仅在肝癌诊断方面有独特价值,在肝癌治疗方面更有重要作用。介绍了应用GPC3瘤苗、GPC3抗体、GPC3基因及靶向等治疗手段,为肝癌治疗提供了新的思路。
Bibliography:Liver cancer is one of the most common malignant tumors in the world,and traditional liver cancer treatment methods have their own limitations.Glypican-3（GPC3） is a cell-surface heparan sulfate proteoglycan and is involved in the regulation of individual development and cell proliferation and differentiation.It is also a hepatoma-specific carcinoembryonic antigen.The mechanism of action of GPC3 in the development and progression of liver cancer has become a hot research topic.GPC3 not only has a unique value in the diagnosis of liver cancer,but also plays an important role in the treatment of liver cancer.This article also introduces the application of GPC3-derived tumor vaccines,GPC3 antibodies,GPC3 gene therapy,and targeted therapy and brings new ideas for the treatment of liver cancer.
REN Zhizhong, ZHANG Yuewei. （ Zunyi Medical University, Zunyi, Guizhou 563000, China）
liver neoplasms; glypicans; therapy; review
22-1108/R
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2017.07.037