ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks - Balmus, Gabriel; Pilger, Domenic; Coates, Julia; Demir, Mukerrem; Sczaniecka-Clift, Matylda; Barros, Ana C.; Woods, Michael; Fu, Beiyuan; Yang, Fengtang; Chen, Elisabeth; Ostermaier, Matthias; Stankovic, Tatjana; et al. (Nature communications, 2019)
Keywords: 13/100; 13/106; 14; 49; 631/208; 631/67; 631/80; 692/4028/67/1059/2326; 82/58; Adenosine diphosphate; Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Ataxia Telangiectasia Mutated Proteins - genetics; Ataxia Telangiectasia Mutated Proteins - metabolism; BRCA1 protein; BRCA1 Protein - metabolism; Breast cancer; Cell Line, Tumor; Cell Survival - genetics; Chemotherapy; CRISPR; CRISPR-Cas Systems - genetics; Damage; Deoxyribonucleic acid; Disruption; DNA; DNA biosynthesis; DNA Breaks, Double-Stranded - drug effects; DNA damage; DNA End-Joining Repair - genetics; DNA Ligase ATP - metabolism; DNA Replication - drug effects; DNA Replication - genetics; DNA topoisomerase; Drug Resistance, Neoplasm - genetics; Female; Genetic suppression; Genomes; Homologous recombination; Homology; Humanities and Social Sciences; Humans; Hypersensitivity; Inhibitors; LIG4 protein; Mice; Mice, Inbred NOD; Mice, Knockout; Mouse Embryonic Stem Cells; multidisciplinary; Mutation; Neoplasms, Experimental - drug therapy; Neoplasms, Experimental - genetics; Neoplasms, Experimental - pathology; Non-homologous end joining; Phthalazines - pharmacology; Phthalazines - therapeutic use; Piperazines - pharmacology; Piperazines - therapeutic use; Poly(ADP-ribose) polymerase; Replication; Replication forks; Ribose; Science; Science (multidisciplinary); Screens; Topotecan; Topotecan - pharmacology; Topotecan - therapeutic use; Toxicity; Tumor suppressor genes