ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms, we performed genome-wide CRISPR-Cas9 screens in cells treated with the DNA topoisomerase I inhibitor topotecan. Thus, we here establish that inactivat...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 10; no. 1; pp. 87 - 18
Main Authors Balmus, Gabriel, Pilger, Domenic, Coates, Julia, Demir, Mukerrem, Sczaniecka-Clift, Matylda, Barros, Ana C., Woods, Michael, Fu, Beiyuan, Yang, Fengtang, Chen, Elisabeth, Ostermaier, Matthias, Stankovic, Tatjana, Ponstingl, Hannes, Herzog, Mareike, Yusa, Kosuke, Martinez, Francisco Munoz, Durant, Stephen T., Galanty, Yaron, Beli, Petra, Adams, David J., Bradley, Allan, Metzakopian, Emmanouil, Forment, Josep V., Jackson, Stephen P.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 08.01.2019
Nature Publishing Group
Nature Portfolio
Subjects
13/100
13/106
14
49
631/208
631/67
631/80
692/4028/67/1059/2326
82/58
Adenosine diphosphate
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Ataxia Telangiectasia Mutated Proteins - genetics
Ataxia Telangiectasia Mutated Proteins - metabolism
BRCA1 protein
BRCA1 Protein - metabolism
Breast cancer
Cell Line, Tumor
Cell Survival - genetics
Chemotherapy
CRISPR
CRISPR-Cas Systems - genetics
Damage
Deoxyribonucleic acid
Disruption
DNA
DNA biosynthesis
DNA Breaks, Double-Stranded - drug effects
DNA damage
DNA End-Joining Repair - genetics
DNA Ligase ATP - metabolism
DNA Replication - drug effects
DNA Replication - genetics
DNA topoisomerase
Drug Resistance, Neoplasm - genetics
Female
Genetic suppression
Genomes
Homologous recombination
Homology
Humanities and Social Sciences
Humans
Hypersensitivity
Inhibitors
LIG4 protein
Mice
Mice, Inbred NOD
Mice, Knockout
Mouse Embryonic Stem Cells
multidisciplinary
Mutation
Neoplasms, Experimental - drug therapy
Neoplasms, Experimental - genetics
Neoplasms, Experimental - pathology
Non-homologous end joining
Phthalazines - pharmacology
Phthalazines - therapeutic use
Piperazines - pharmacology
Piperazines - therapeutic use
Poly(ADP-ribose) polymerase
Replication
Replication forks
Ribose
Science
Science (multidisciplinary)
Screens
Topotecan
Topotecan - pharmacology
Topotecan - therapeutic use
Toxicity
Tumor suppressor genes
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/s41467-018-07729-2

Cover

Abstract Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms, we performed genome-wide CRISPR-Cas9 screens in cells treated with the DNA topoisomerase I inhibitor topotecan. Thus, we here establish that inactivating terminal components of the non-homologous end-joining (NHEJ) machinery or of the BRCA1-A complex specifically confer topotecan resistance to ATM-deficient cells. We show that hypersensitivity of ATM -mutant cells to topotecan or the poly-(ADP-ribose) polymerase (PARP) inhibitor olaparib reflects delayed engagement of homologous recombination at DNA-replication-fork associated single-ended double-strand breaks (DSBs), allowing some to be subject to toxic NHEJ. Preventing DSB ligation by NHEJ, or enhancing homologous recombination by BRCA1-A complex disruption, suppresses this toxicity, highlighting a crucial role for ATM in preventing toxic LIG4-mediated chromosome fusions. Notably, suppressor mutations in ATM -mutant backgrounds are different to those in BRCA1 -mutant scenarios, suggesting new opportunities for patient stratification and additional therapeutic vulnerabilities for clinical exploitation. Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. Here, the authors provide evidence that these hypersensitivities reflect a crucial role for ATM at damaged replication forks being to prevent toxic DNA end-joining leading to chromosome fusions and cell death.
AbstractList Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms, we performed genome-wide CRISPR-Cas9 screens in cells treated with the DNA topoisomerase I inhibitor topotecan. Thus, we here establish that inactivating terminal components of the non-homologous end-joining (NHEJ) machinery or of the BRCA1-A complex specifically confer topotecan resistance to ATM-deficient cells. We show that hypersensitivity of ATM -mutant cells to topotecan or the poly-(ADP-ribose) polymerase (PARP) inhibitor olaparib reflects delayed engagement of homologous recombination at DNA-replication-fork associated single-ended double-strand breaks (DSBs), allowing some to be subject to toxic NHEJ. Preventing DSB ligation by NHEJ, or enhancing homologous recombination by BRCA1-A complex disruption, suppresses this toxicity, highlighting a crucial role for ATM in preventing toxic LIG4-mediated chromosome fusions. Notably, suppressor mutations in ATM -mutant backgrounds are different to those in BRCA1 -mutant scenarios, suggesting new opportunities for patient stratification and additional therapeutic vulnerabilities for clinical exploitation. Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. Here, the authors provide evidence that these hypersensitivities reflect a crucial role for ATM at damaged replication forks being to prevent toxic DNA end-joining leading to chromosome fusions and cell death.
Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms, we performed genome-wide CRISPR-Cas9 screens in cells treated with the DNA topoisomerase I inhibitor topotecan. Thus, we here establish that inactivating terminal components of the non-homologous end-joining (NHEJ) machinery or of the BRCA1-A complex specifically confer topotecan resistance to ATM-deficient cells. We show that hypersensitivity of ATM-mutant cells to topotecan or the poly-(ADP-ribose) polymerase (PARP) inhibitor olaparib reflects delayed engagement of homologous recombination at DNA-replication-fork associated single-ended double-strand breaks (DSBs), allowing some to be subject to toxic NHEJ. Preventing DSB ligation by NHEJ, or enhancing homologous recombination by BRCA1-A complex disruption, suppresses this toxicity, highlighting a crucial role for ATM in preventing toxic LIG4-mediated chromosome fusions. Notably, suppressor mutations in ATM-mutant backgrounds are different to those in BRCA1-mutant scenarios, suggesting new opportunities for patient stratification and additional therapeutic vulnerabilities for clinical exploitation.Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms, we performed genome-wide CRISPR-Cas9 screens in cells treated with the DNA topoisomerase I inhibitor topotecan. Thus, we here establish that inactivating terminal components of the non-homologous end-joining (NHEJ) machinery or of the BRCA1-A complex specifically confer topotecan resistance to ATM-deficient cells. We show that hypersensitivity of ATM-mutant cells to topotecan or the poly-(ADP-ribose) polymerase (PARP) inhibitor olaparib reflects delayed engagement of homologous recombination at DNA-replication-fork associated single-ended double-strand breaks (DSBs), allowing some to be subject to toxic NHEJ. Preventing DSB ligation by NHEJ, or enhancing homologous recombination by BRCA1-A complex disruption, suppresses this toxicity, highlighting a crucial role for ATM in preventing toxic LIG4-mediated chromosome fusions. Notably, suppressor mutations in ATM-mutant backgrounds are different to those in BRCA1-mutant scenarios, suggesting new opportunities for patient stratification and additional therapeutic vulnerabilities for clinical exploitation.
Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. Here, the authors provide evidence that these hypersensitivities reflect a crucial role for ATM at damaged replication forks being to prevent toxic DNA end-joining leading to chromosome fusions and cell death.
Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms, we performed genome-wide CRISPR-Cas9 screens in cells treated with the DNA topoisomerase I inhibitor topotecan. Thus, we here establish that inactivating terminal components of the non-homologous end-joining (NHEJ) machinery or of the BRCA1-A complex specifically confer topotecan resistance to ATM-deficient cells. We show that hypersensitivity of ATM-mutant cells to topotecan or the poly-(ADP-ribose) polymerase (PARP) inhibitor olaparib reflects delayed engagement of homologous recombination at DNA-replication-fork associated single-ended double-strand breaks (DSBs), allowing some to be subject to toxic NHEJ. Preventing DSB ligation by NHEJ, or enhancing homologous recombination by BRCA1-A complex disruption, suppresses this toxicity, highlighting a crucial role for ATM in preventing toxic LIG4-mediated chromosome fusions. Notably, suppressor mutations in ATM-mutant backgrounds are different to those in BRCA1-mutant scenarios, suggesting new opportunities for patient stratification and additional therapeutic vulnerabilities for clinical exploitation.
Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms, we performed genome-wide CRISPR-Cas9 screens in cells treated with the DNA topoisomerase I inhibitor topotecan. Thus, we here establish that inactivating terminal components of the non-homologous end-joining (NHEJ) machinery or of the BRCA1-A complex specifically confer topotecan resistance to ATM-deficient cells. We show that hypersensitivity of ATM-mutant cells to topotecan or the poly-(ADP-ribose) polymerase (PARP) inhibitor olaparib reflects delayed engagement of homologous recombination at DNA-replication-fork associated single-ended double-strand breaks (DSBs), allowing some to be subject to toxic NHEJ. Preventing DSB ligation by NHEJ, or enhancing homologous recombination by BRCA1-A complex disruption, suppresses this toxicity, highlighting a crucial role for ATM in preventing toxic LIG4-mediated chromosome fusions. Notably, suppressor mutations in ATM-mutant backgrounds are different to those in BRCA1-mutant scenarios, suggesting new opportunities for patient stratification and additional therapeutic vulnerabilities for clinical exploitation. Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. Here, the authors provide evidence that these hypersensitivities reflect a crucial role for ATM at damaged replication forks being to prevent toxic DNA end-joining leading to chromosome fusions and cell death.
Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms, we performed genome-wide CRISPR-Cas9 screens in cells treated with the DNA topoisomerase I inhibitor topotecan. Thus, we here establish that inactivating terminal components of the non-homologous end-joining (NHEJ) machinery or of the BRCA1-A complex specifically confer topotecan resistance to ATM-deficient cells. We show that hypersensitivity of ATM -mutant cells to topotecan or the poly-(ADP-ribose) polymerase (PARP) inhibitor olaparib reflects delayed engagement of homologous recombination at DNA-replication-fork associated single-ended double-strand breaks (DSBs), allowing some to be subject to toxic NHEJ. Preventing DSB ligation by NHEJ, or enhancing homologous recombination by BRCA1-A complex disruption, suppresses this toxicity, highlighting a crucial role for ATM in preventing toxic LIG4-mediated chromosome fusions. Notably, suppressor mutations in ATM -mutant backgrounds are different to those in BRCA1 -mutant scenarios, suggesting new opportunities for patient stratification and additional therapeutic vulnerabilities for clinical exploitation.
ArticleNumber 87
Author Adams, David J.
Yusa, Kosuke
Coates, Julia
Stankovic, Tatjana
Bradley, Allan
Chen, Elisabeth
Durant, Stephen T.
Woods, Michael
Martinez, Francisco Munoz
Forment, Josep V.
Demir, Mukerrem
Sczaniecka-Clift, Matylda
Pilger, Domenic
Jackson, Stephen P.
Barros, Ana C.
Galanty, Yaron
Beli, Petra
Metzakopian, Emmanouil
Yang, Fengtang
Balmus, Gabriel
Ponstingl, Hannes
Herzog, Mareike
Ostermaier, Matthias
Fu, Beiyuan
Author_xml – sequence: 1
  givenname: Gabriel
  orcidid: 0000-0003-2872-4468
  surname: Balmus
  fullname: Balmus, Gabriel
  organization: The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Wellcome Trust Sanger Institute, UK Dementia Research Institute and Department of Clinical Neurosciences, University of Cambridge
– sequence: 2
  givenname: Domenic
  orcidid: 0000-0001-7339-0685
  surname: Pilger
  fullname: Pilger, Domenic
  organization: The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge
– sequence: 3
  givenname: Julia
  surname: Coates
  fullname: Coates, Julia
  organization: The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge
– sequence: 4
  givenname: Mukerrem
  surname: Demir
  fullname: Demir, Mukerrem
  organization: The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge
– sequence: 5
  givenname: Matylda
  surname: Sczaniecka-Clift
  fullname: Sczaniecka-Clift, Matylda
  organization: The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge
– sequence: 6
  givenname: Ana C.
  surname: Barros
  fullname: Barros, Ana C.
  organization: Wellcome Trust Sanger Institute
– sequence: 7
  givenname: Michael
  surname: Woods
  fullname: Woods, Michael
  organization: Wellcome Trust Sanger Institute
– sequence: 8
  givenname: Beiyuan
  surname: Fu
  fullname: Fu, Beiyuan
  organization: Wellcome Trust Sanger Institute
– sequence: 9
  givenname: Fengtang
  orcidid: 0000-0002-3573-2354
  surname: Yang
  fullname: Yang, Fengtang
  organization: Wellcome Trust Sanger Institute
– sequence: 10
  givenname: Elisabeth
  orcidid: 0000-0003-2129-7985
  surname: Chen
  fullname: Chen, Elisabeth
  organization: Wellcome Trust Sanger Institute
– sequence: 11
  givenname: Matthias
  surname: Ostermaier
  fullname: Ostermaier, Matthias
  organization: Institute of Molecular Biology (IMB)
– sequence: 12
  givenname: Tatjana
  surname: Stankovic
  fullname: Stankovic, Tatjana
  organization: Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham
– sequence: 13
  givenname: Hannes
  orcidid: 0000-0001-7573-1703
  surname: Ponstingl
  fullname: Ponstingl, Hannes
  organization: Wellcome Trust Sanger Institute
– sequence: 14
  givenname: Mareike
  surname: Herzog
  fullname: Herzog, Mareike
  organization: The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Wellcome Trust Sanger Institute
– sequence: 15
  givenname: Kosuke
  surname: Yusa
  fullname: Yusa, Kosuke
  organization: Wellcome Trust Sanger Institute
– sequence: 16
  givenname: Francisco Munoz
  surname: Martinez
  fullname: Martinez, Francisco Munoz
  organization: The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge
– sequence: 17
  givenname: Stephen T.
  orcidid: 0000-0003-4209-7499
  surname: Durant
  fullname: Durant, Stephen T.
  organization: DNA Damage Response Biology, Bioscience Oncology IMED Biotech Unit, AstraZeneca
– sequence: 18
  givenname: Yaron
  orcidid: 0000-0001-7167-9004
  surname: Galanty
  fullname: Galanty, Yaron
  organization: The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge
– sequence: 19
  givenname: Petra
  orcidid: 0000-0001-9507-9820
  surname: Beli
  fullname: Beli, Petra
  organization: Institute of Molecular Biology (IMB)
– sequence: 20
  givenname: David J.
  surname: Adams
  fullname: Adams, David J.
  organization: Wellcome Trust Sanger Institute
– sequence: 21
  givenname: Allan
  surname: Bradley
  fullname: Bradley, Allan
  organization: Wellcome Trust Sanger Institute
– sequence: 22
  givenname: Emmanouil
  surname: Metzakopian
  fullname: Metzakopian, Emmanouil
  organization: Wellcome Trust Sanger Institute, UK Dementia Research Institute and Department of Clinical Neurosciences, University of Cambridge
– sequence: 23
  givenname: Josep V.
  orcidid: 0000-0002-7797-2583
  surname: Forment
  fullname: Forment, Josep V.
  email: josep.forment@astrazeneca.com
  organization: The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, DNA Damage Response Biology, Bioscience Oncology IMED Biotech Unit, AstraZeneca
– sequence: 24
  givenname: Stephen P.
  orcidid: 0000-0001-9317-7937
  surname: Jackson
  fullname: Jackson, Stephen P.
  email: s.jackson@gurdon.cam.ac.uk
  organization: The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30622252$$D View this record in MEDLINE/PubMed
BookMark eNqNUktv1DAYjFARLaV_gAOKxIVLwK_Y3gvSqrwqFbiUs_XF-ZL1NmsHOyn03-PuLqXtocI-2LJnRuMZPy8OfPBYFC8peUsJ1--SoEKqilBdEaXYomJPiiNGBK2oYvzgzv6wOElpTfLgC6qFeFYcciIZYzU7KsblxdcyRLvCNEWYMJXTCssP35ZVCxvosYyYxuATllMobZj9hDFvfztbZkPVKmzCEPowpxJ9W62D8873JUxlE8Ml-kwfB2dhcsGXXYiX6UXxtIMh4cl-PS5-fPp4cfqlOv_--ex0eV5ZSeRUdZrrljRSSpLfYTkQbAiouumgkbZlYDttVYOacSZBtNKqmi-UorJZgELLj4uznW4bYG3G6DYQr00AZ7YHIfYG4uTsgMYKwttGNky0Wiw6DqC4RaWUVkRbAVmL77RmP8L1LxiGW0FKzE0dZleHyXWYbR2GZdb7HWucmw22Fn1OeLhn5f6NdyvThysjOasp1VngzV4ghp9zLshsXLI4DOAxJ24YlXWeWooMff0Aug5z9DngLYpoUvMbR6_uOrq18vc7ZIDeAWwMKUXsjHXTtrxs0A2Pv5Y9oP5XRPtgUwb7HuM_24-w_gCEnesa
CitedBy_id crossref_primary_10_3390_biomedicines10092074
crossref_primary_10_1007_s42764_021_00056_9
crossref_primary_10_1016_j_drudis_2023_103662
crossref_primary_10_1016_j_cels_2023_04_007
crossref_primary_10_1016_j_molmed_2019_04_004
crossref_primary_10_1016_j_ctrv_2024_102808
crossref_primary_10_1038_s41571_024_00966_z
crossref_primary_10_1038_s41416_020_1016_2
crossref_primary_10_1002_adfm_202417439
crossref_primary_10_1016_j_celrep_2020_01_052
crossref_primary_10_3390_genes12071071
crossref_primary_10_1016_j_celrep_2021_109819
crossref_primary_10_3390_ijms231911790
crossref_primary_10_1002_ctd2_106
crossref_primary_10_1038_s41467_019_12836_9
crossref_primary_10_1038_s41580_019_0152_0
crossref_primary_10_1126_scitranslmed_abj4772
crossref_primary_10_1038_s41586_023_07009_0
crossref_primary_10_1038_s41580_022_00571_x
crossref_primary_10_1016_j_eururo_2020_11_018
crossref_primary_10_1016_j_molcel_2022_08_028
crossref_primary_10_1186_s40164_019_0154_9
crossref_primary_10_1083_jcb_202111050
crossref_primary_10_1093_hmg_ddz206
crossref_primary_10_1038_s41467_023_43680_7
crossref_primary_10_3389_fonc_2023_1162644
crossref_primary_10_1093_nar_gkab628
crossref_primary_10_1016_j_molcel_2020_12_025
crossref_primary_10_1590_1678_4685_gmb_2019_0070
crossref_primary_10_1016_j_celrep_2022_111909
crossref_primary_10_1038_s41568_022_00535_5
crossref_primary_10_1016_j_isci_2022_104892
crossref_primary_10_1093_nar_gkae105
crossref_primary_10_1096_fj_202402472R
crossref_primary_10_1016_j_dnarep_2022_103380
crossref_primary_10_1038_s41588_020_00739_1
crossref_primary_10_1016_j_molcel_2022_07_011
crossref_primary_10_1016_j_gde_2021_06_011
crossref_primary_10_1016_j_dnarep_2020_103023
crossref_primary_10_1016_j_tibs_2023_11_001
crossref_primary_10_3390_ijms21186684
crossref_primary_10_1146_annurev_biochem_080320_110356
crossref_primary_10_1021_acs_chemrestox_0c00052
crossref_primary_10_1038_s41580_021_00394_2
crossref_primary_10_18632_oncotarget_28454
crossref_primary_10_1038_s41598_021_82551_3
crossref_primary_10_1038_s41388_022_02384_w
crossref_primary_10_3390_cancers14112804
crossref_primary_10_1007_s10330_021_0534_4
crossref_primary_10_3389_fonc_2021_675972
crossref_primary_10_1016_j_semradonc_2021_09_008
crossref_primary_10_1038_s41596_019_0169_z
crossref_primary_10_3389_fonc_2021_754524
crossref_primary_10_1016_j_neuron_2021_11_019
crossref_primary_10_3390_genes12091370
crossref_primary_10_1042_EBC20200002
crossref_primary_10_1038_s41580_022_00452_3
crossref_primary_10_1016_j_semcdb_2020_09_003
crossref_primary_10_1038_s41467_021_26240_9
crossref_primary_10_1016_j_tig_2019_03_008
crossref_primary_10_1073_pnas_2021963118
crossref_primary_10_1158_2767_9764_CRC_22_0119
crossref_primary_10_1016_j_dnarep_2024_103710
crossref_primary_10_1016_j_dnarep_2020_102900
crossref_primary_10_2139_ssrn_4069036
crossref_primary_10_1007_s12551_025_01294_x
crossref_primary_10_3389_fonc_2022_989483
crossref_primary_10_1038_s41416_025_02963_0
crossref_primary_10_1038_s41467_023_40071_w
crossref_primary_10_1016_j_tig_2021_06_010
crossref_primary_10_1016_j_molcel_2023_02_008
crossref_primary_10_1038_s41388_020_1328_y
crossref_primary_10_1093_nar_gkaa640
crossref_primary_10_3390_ijms23105770
crossref_primary_10_1007_s42764_020_00017_8
crossref_primary_10_1158_0008_5472_CAN_20_2960
crossref_primary_10_1093_hmg_ddaa023
crossref_primary_10_1093_nar_gkaa723
crossref_primary_10_1158_1078_0432_CCR_23_3720
crossref_primary_10_1016_j_isci_2023_107045
crossref_primary_10_1016_j_tranon_2021_101012
crossref_primary_10_1016_j_dnarep_2022_103445
crossref_primary_10_1093_nar_gkac104
crossref_primary_10_1186_s12885_023_10772_y
crossref_primary_10_1158_1535_7163_MCT_22_0217
crossref_primary_10_1007_s00439_023_02589_3
crossref_primary_10_1186_s13059_024_03278_8
crossref_primary_10_1186_s13287_021_02405_7
crossref_primary_10_1016_j_xcrm_2023_101376
crossref_primary_10_1007_s00018_022_04204_6
crossref_primary_10_1093_nar_gkac472
crossref_primary_10_15252_embj_2022113190
crossref_primary_10_1016_j_celrep_2024_114538
crossref_primary_10_1016_j_mrrev_2021_108388
crossref_primary_10_1093_nar_gkab785
crossref_primary_10_1016_j_dnarep_2020_102925
crossref_primary_10_1038_s41568_022_00518_6
crossref_primary_10_1371_journal_pone_0305273
crossref_primary_10_1097_PAP_0000000000000422
crossref_primary_10_1126_sciadv_adg2263
crossref_primary_10_1186_s12885_020_07432_w
crossref_primary_10_1093_nar_gkad1184
crossref_primary_10_1038_s41416_022_01899_z
crossref_primary_10_1080_23723556_2019_1575692
crossref_primary_10_1073_pnas_1908003117
crossref_primary_10_1038_s41598_020_59163_4
crossref_primary_10_1093_nar_gkab151
crossref_primary_10_1038_s41388_021_02021_y
crossref_primary_10_1007_s00432_022_03928_z
crossref_primary_10_3390_cancers13050946
crossref_primary_10_1371_journal_pbio_3000666
crossref_primary_10_1016_j_critrevonc_2023_104058
crossref_primary_10_1016_j_ygyno_2020_08_035
crossref_primary_10_3390_ijms23042246
crossref_primary_10_1124_jpet_122_001558
crossref_primary_10_1016_j_gde_2021_05_006
crossref_primary_10_3390_cancers12030687
crossref_primary_10_1016_j_trecan_2022_01_015
crossref_primary_10_3390_cancers16010083
crossref_primary_10_1016_j_molmet_2021_101354
crossref_primary_10_3390_cancers13225678
crossref_primary_10_1038_s41467_023_42622_7
crossref_primary_10_1016_j_neuron_2021_09_040
crossref_primary_10_1038_s41467_021_24665_w
crossref_primary_10_1016_j_str_2020_04_010
crossref_primary_10_1002_advs_202201210
crossref_primary_10_1016_j_nbd_2020_105021
crossref_primary_10_1016_j_molcel_2023_01_012
crossref_primary_10_1016_j_tice_2025_102811
crossref_primary_10_1038_s41467_021_25415_8
crossref_primary_10_1101_gad_348667_121
crossref_primary_10_1038_s41467_022_33642_w
crossref_primary_10_1038_s41467_023_44108_y
Cites_doi 10.1186/2045-3701-2-6
10.1101/gad.1770609
10.1016/j.celrep.2016.09.026
10.1101/gad.2011011
10.1038/nsb725
10.1016/S0092-8674(00)80086-0
10.1038/nmeth1019
10.1158/1535-7163.MCT-15-0945
10.1038/nbt.2800
10.1007/978-1-4939-6955-5_16
10.1038/nature08467
10.1038/nprot.2007.261
10.1038/nrc.2016.72
10.1101/cshperspect.a016600
10.1038/nrm.2016.111
10.1074/jbc.M112.445825
10.1038/s41556-018-0152-x
10.1016/j.cels.2015.12.004
10.1038/nrc3599
10.1093/nar/gks879
10.1038/nsmb.1710
10.1186/s13059-014-0554-4
10.1038/ncb3452
10.1016/j.molcel.2010.09.019
10.1016/j.mrfmmm.2003.08.013
10.1101/gad.290510.116
10.1038/nrc.2015.21
10.1073/pnas.051632098
10.1126/science.273.5278.1109
10.1083/jcb.201203128
10.1016/j.tcb.2015.07.009
10.1016/j.cell.2010.03.012
10.1126/science.1140321
10.1016/0092-8674(93)90057-W
10.1016/j.stem.2011.10.012
10.1038/sj.bjc.6605642
10.1016/j.cell.2011.02.013
10.1038/s41556-018-0140-1
10.1038/nature10424
10.1371/journal.pgen.1003277
10.1038/ncomms12889
10.1038/ng.3934
10.1038/nature06337
10.1016/j.molcel.2012.07.029
10.1074/mcp.M111.011015
10.1126/science.1192277
10.1016/j.celrep.2016.08.069
10.1038/ncb3028
10.1074/mcp.M200025-MCP200
10.1038/nsmb.1831
10.1038/nbt.4017
10.1038/nbt.1511
10.1016/j.molcel.2014.07.007
10.1016/j.molcel.2017.05.015
10.1083/jcb.201303073
10.1038/nrm3546
10.4049/jimmunol.174.10.6477
10.1016/j.tibs.2012.06.007
10.1016/j.molonc.2011.07.001
10.1016/j.tcb.2013.09.003
10.1038/nm.4292
10.1158/0008-5472.CAN-04-2727
10.1016/j.molcel.2010.06.026
10.1038/nrc1977
10.1038/nrm3719
10.1126/scisignal.2000758
10.1038/bjc.2012.451
10.1073/pnas.1706392114
10.1038/nature10448
10.1038/nmeth1060
10.1007/s10577-007-1154-x
10.1093/nar/gks1094
10.4103/0976-500X.72351
10.1038/srep24356
10.1038/ncomms13816
10.1101/gad.1739609
10.1038/nature12912
10.1101/gad.1770309
10.1038/ncb3260
10.1074/jbc.M110.213728
10.1073/pnas.1611882113
10.1073/pnas.1216824110
10.1038/nature24027
10.1101/151472
ContentType Journal Article
Copyright The Author(s) 2019
This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2019
– notice: This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
ADTOC
UNPAY
DOA
DOI 10.1038/s41467-018-07729-2
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection (subscription)
ProQuest Central
Technology collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
Unpaywall for CDI: Periodical Content
Unpaywall
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic

MEDLINE

CrossRef
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 18
ExternalDocumentID oai_doaj_org_article_c403db6b24d849f3aa73ce7778708c4a
10.1038/s41467-018-07729-2
PMC6325118
30622252
10_1038_s41467_018_07729_2
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Cancer Research UK
  grantid: 18796
– fundername: Wellcome Trust
– fundername: Cancer Research UK
  grantid: 11224
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
PUEGO
CGR
CUY
CVF
ECM
EIF
NPM
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AARCD
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
SOI
7X8
5PM
4.4
ADTOC
BAPOH
CAG
COF
EJD
LGEZI
LOTEE
NADUK
NXXTH
UNPAY
ID FETCH-LOGICAL-c606t-f838d0b6660041c3a0eb0a75bfab6cd2acf8c7be82326a4d6c75397716b9a7ec3
IEDL.DBID M48
ISSN 2041-1723
IngestDate Wed Aug 27 01:26:16 EDT 2025
Wed Oct 01 16:43:02 EDT 2025
Tue Sep 30 16:55:29 EDT 2025
Thu Sep 04 17:05:27 EDT 2025
Wed Aug 13 07:17:23 EDT 2025
Mon Jul 21 05:35:50 EDT 2025
Wed Oct 01 03:02:33 EDT 2025
Thu Apr 24 22:50:28 EDT 2025
Fri Feb 21 02:40:15 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
cc-by
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c606t-f838d0b6660041c3a0eb0a75bfab6cd2acf8c7be82326a4d6c75397716b9a7ec3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0001-7339-0685
0000-0002-3573-2354
0000-0001-9317-7937
0000-0001-9507-9820
0000-0002-7797-2583
0000-0003-4209-7499
0000-0003-2872-4468
0000-0001-7573-1703
0000-0003-2129-7985
0000-0001-7167-9004
OpenAccessLink https://doaj.org/article/c403db6b24d849f3aa73ce7778708c4a
PMID 30622252
PQID 2165080532
PQPubID 546298
PageCount 18
ParticipantIDs doaj_primary_oai_doaj_org_article_c403db6b24d849f3aa73ce7778708c4a
unpaywall_primary_10_1038_s41467_018_07729_2
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6325118
proquest_miscellaneous_2165656864
proquest_journals_2165080532
pubmed_primary_30622252
crossref_citationtrail_10_1038_s41467_018_07729_2
crossref_primary_10_1038_s41467_018_07729_2
springer_journals_10_1038_s41467_018_07729_2
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2019-01-08
PublicationDateYYYYMMDD 2019-01-08
PublicationDate_xml – month: 01
  year: 2019
  text: 2019-01-08
  day: 08
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2019
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Helleday (CR15) 2011; 5
Li, Greenberg (CR22) 2012; 37
Blackford, Jackson (CR4) 2017; 66
Ciccia, Elledge (CR2) 2010; 40
Matsuoka (CR52) 2007; 316
Borisova, Wagner, Beli (CR80) 2017; 1599
Greenberg (CR58) 2018; 20
Prakash, Zhang, Feng, Jasin (CR13) 2015; 7
Pawlik (CR29) 1998; 4
Britton, Coates, Jackson (CR32) 2013; 202
Zamboni (CR66) 1998; 4
Abkevich (CR60) 2012; 107
Jackson, Bartek (CR3) 2009; 461
Ong (CR81) 2002; 1
Sibanda (CR26) 2001; 8
Yusa (CR71) 2011; 478
Rappsilber, Mann, Ishihama (CR82) 2007; 2
Workman (CR67) 2010; 102
Cottarel (CR28) 2013; 200
Hu (CR45) 2011; 25
White, Choi, Bakkenist (CR51) 2010; 3
Davies (CR61) 2017; 23
Helleday (CR14) 2003; 532
Kilkenny, Browne, Cuthill, Emerson, Altman (CR65) 2010; 1
House, Yang, Walsh, Moy, Freudenreich (CR21) 2014; 55
Pommier, Sun, Huang, Nitiss (CR38) 2016; 17
Shiloh, Ziv (CR49) 2013; 14
Shao (CR24) 2009; 23
Zimmermann, de Lange (CR59) 2014; 24
Leeb, Wutz (CR70) 2011; 479
Adamo (CR54) 2010; 39
Holohan, Van Schaeybroeck, Longley, Johnston (CR50) 2013; 13
Nielsen, van Overeem Hansen, Sørensen (CR6) 2016; 16
Lawrence (CR48) 2014; 505
Hustedt, Durocher (CR10) 2017; 19
Franceschini (CR87) 2013; 41
Bayani, Squire (CR77) 2005; 65
Bouwman (CR40) 2010; 17
Barlow (CR17) 1996; 86
Bin, Hurov, Hofmann, Elledge (CR25) 2009; 23
Liu, Shao, Jiang, Lee, Zha (CR37) 2017; 8
Hanahan, Weinberg (CR1) 2011; 144
Balmus (CR36) 2016; 30
Shultz (CR68) 2005; 174
Michalski (CR83) 2011; 10
Olsen (CR84) 2007; 4
Gottlieb, Jackson (CR30) 1993; 72
Dev (CR64) 2018; 20
Koike-Yusa, Li, Tan, Del Castillo Velasco-Herrera, Yusa (CR19) 2014; 32
Lescale (CR33) 2016; 16
Reynolds (CR53) 2012; 40
Polak (CR62) 2017; 49
Cox, Mann (CR85) 2008; 26
CR56
Kumar-Sinha, Chinnaiyan (CR63) 2018; 36
Kumar, Alt, Frock (CR34) 2016; 113
Hickson (CR27) 2004; 64
Nishi (CR79) 2014; 16
Li (CR73) 2014; 15
Bunting (CR39) 2010; 141
Coleman, Greenberg (CR46) 2011; 286
Chiang, le Sage, Larrieu, Demir, Jackson (CR75) 2016; 6
Huertas (CR5) 2010; 17
Panier, Boulton (CR12) 2014; 15
Sartori (CR43) 2007; 450
Elling (CR69) 2011; 9
Elling (CR78) 2017; 550
Elias, Gygi (CR86) 2007; 4
Wang (CR47) 2013; 9
Schmidt (CR44) 2015; 17
Pommier (CR20) 2006; 6
Sekiguchi (CR31) 2001; 98
Kass (CR42) 2013; 110
Rass, Chandramouly, Zha, Alt, Xie (CR41) 2013; 288
Chapman, Taylor, Boulton (CR8) 2012; 47
Ceccaldi, Rondinelli, D’Andrea (CR9) 2016; 26
Feng, Huang, Chen (CR23) 2009; 23
Tadi (CR35) 2016; 17
Chanut, Britton, Coates, Jackson, Calsou (CR11) 2016; 7
Pace (CR55) 2010; 329
Choi, Kipps, Kurzrock (CR18) 2016; 15
Liberzon (CR74) 2015; 1
Balmus (CR76) 2007; 15
Swann (CR72) 1996; 273
Chen (CR57) 2017; 114
Lord, Ashworth (CR16) 2016; 16
Wang (CR7) 2012; 2
M Leeb (7729_CR70) 2011; 479
V Abkevich (7729_CR60) 2012; 107
TM Gottlieb (7729_CR30) 1993; 72
EM Kass (7729_CR42) 2013; 110
A Ciccia (7729_CR2) 2010; 40
SP Jackson (7729_CR3) 2009; 461
L Feng (7729_CR23) 2009; 23
CA Pawlik (7729_CR29) 1998; 4
TWW Chiang (7729_CR75) 2016; 6
FC Nielsen (7729_CR6) 2016; 16
T Helleday (7729_CR15) 2011; 5
C Holohan (7729_CR50) 2013; 13
H Dev (7729_CR64) 2018; 20
R Prakash (7729_CR13) 2015; 7
J Cottarel (7729_CR28) 2013; 200
J Sekiguchi (7729_CR31) 2001; 98
C Kumar-Sinha (7729_CR63) 2018; 36
MS Lawrence (7729_CR48) 2014; 505
ML Li (7729_CR22) 2012; 37
JV Olsen (7729_CR84) 2007; 4
D Hanahan (7729_CR1) 2011; 144
CK Schmidt (7729_CR44) 2015; 17
SK Tadi (7729_CR35) 2016; 17
J Cox (7729_CR85) 2008; 26
G Shao (7729_CR24) 2009; 23
A Adamo (7729_CR54) 2010; 39
G Balmus (7729_CR36) 2016; 30
P Reynolds (7729_CR53) 2012; 40
P Polak (7729_CR62) 2017; 49
WC Zamboni (7729_CR66) 1998; 4
H Wang (7729_CR47) 2013; 9
SF Bunting (7729_CR39) 2010; 141
Y Pommier (7729_CR20) 2006; 6
Y Shiloh (7729_CR49) 2013; 14
T Helleday (7729_CR14) 2003; 532
P Pace (7729_CR55) 2010; 329
JE Elias (7729_CR86) 2007; 4
P Huertas (7729_CR5) 2010; 17
HR Davies (7729_CR61) 2017; 23
Roger A Greenberg (7729_CR58) 2018; 20
A Michalski (7729_CR83) 2011; 10
A Franceschini (7729_CR87) 2013; 41
CC Chen (7729_CR57) 2017; 114
C Kilkenny (7729_CR65) 2010; 1
7729_CR56
LD Shultz (7729_CR68) 2005; 174
JR Chapman (7729_CR8) 2012; 47
N Hustedt (7729_CR10) 2017; 19
B Wang (7729_CR7) 2012; 2
I Hickson (7729_CR27) 2004; 64
U Elling (7729_CR69) 2011; 9
SE Ong (7729_CR81) 2002; 1
Y Pommier (7729_CR38) 2016; 17
X Liu (7729_CR37) 2017; 8
E Rass (7729_CR41) 2013; 288
NCM House (7729_CR21) 2014; 55
K Yusa (7729_CR71) 2011; 478
V Kumar (7729_CR34) 2016; 113
C Lescale (7729_CR33) 2016; 16
A Liberzon (7729_CR74) 2015; 1
J Rappsilber (7729_CR82) 2007; 2
P Chanut (7729_CR11) 2016; 7
U Elling (7729_CR78) 2017; 550
BL Sibanda (7729_CR26) 2001; 8
R Nishi (7729_CR79) 2014; 16
W Li (7729_CR73) 2014; 15
AN Blackford (7729_CR4) 2017; 66
PF Swann (7729_CR72) 1996; 273
G Balmus (7729_CR76) 2007; 15
CJ Lord (7729_CR16) 2016; 16
M Zimmermann (7729_CR59) 2014; 24
ME Borisova (7729_CR80) 2017; 1599
KA Coleman (7729_CR46) 2011; 286
M Choi (7729_CR18) 2016; 15
H Koike-Yusa (7729_CR19) 2014; 32
S Britton (7729_CR32) 2013; 202
R Ceccaldi (7729_CR9) 2016; 26
P Bouwman (7729_CR40) 2010; 17
P Workman (7729_CR67) 2010; 102
S Matsuoka (7729_CR52) 2007; 316
J Bayani (7729_CR77) 2005; 65
S Panier (7729_CR12) 2014; 15
Y Hu (7729_CR45) 2011; 25
JS White (7729_CR51) 2010; 3
C Barlow (7729_CR17) 1996; 86
AA Sartori (7729_CR43) 2007; 450
W Bin (7729_CR25) 2009; 23
References_xml – volume: 2
  start-page: 6
  year: 2012
  ident: CR7
  article-title: BRCA1 tumor suppressor network: focusing on its tail
  publication-title: Cell Biosci.
  doi: 10.1186/2045-3701-2-6
– volume: 23
  start-page: 719
  year: 2009
  end-page: 728
  ident: CR23
  article-title: MERIT40 facilitates BRCA1 localization and DNA damage repair
  publication-title: Genes Dev.
  doi: 10.1101/gad.1770609
– volume: 17
  start-page: 541
  year: 2016
  end-page: 555
  ident: CR35
  article-title: PAXX is an accessory c-NHEJ factor that associates with Ku70 and has overlapping functions with XLF
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.09.026
– volume: 25
  start-page: 685
  year: 2011
  end-page: 700
  ident: CR45
  article-title: RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci
  publication-title: Genes Dev.
  doi: 10.1101/gad.2011011
– volume: 8
  start-page: 1015
  year: 2001
  end-page: 1019
  ident: CR26
  article-title: Crystal structure of an Xrcc4-DNA ligase IV complex
  publication-title: Nat. Struct. Biol.
  doi: 10.1038/nsb725
– volume: 86
  start-page: 159
  year: 1996
  end-page: 171
  ident: CR17
  article-title: Atm-deficient mice: a paradigm of ataxia telangiectasia
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80086-0
– volume: 4
  start-page: 207
  year: 2007
  end-page: 214
  ident: CR86
  article-title: Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
  publication-title: Nat. Methods
  doi: 10.1038/nmeth1019
– volume: 15
  start-page: 1781
  year: 2016
  end-page: 1791
  ident: CR18
  article-title: ATM mutations in cancer: therapeutic implications
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-15-0945
– volume: 32
  start-page: 267
  year: 2014
  end-page: 273
  ident: CR19
  article-title: Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2800
– volume: 1599
  start-page: 215
  year: 2017
  end-page: 227
  ident: CR80
  article-title: Mass spectrometry-based proteomics for quantifying DNA damage-induced phosphorylation
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-6955-5_16
– volume: 461
  start-page: 1071
  year: 2009
  end-page: 1078
  ident: CR3
  article-title: The DNA-damage response in human biology and disease
  publication-title: Nature
  doi: 10.1038/nature08467
– volume: 2
  start-page: 1896
  year: 2007
  end-page: 1906
  ident: CR82
  article-title: Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2007.261
– volume: 16
  start-page: 599
  year: 2016
  end-page: 612
  ident: CR6
  article-title: Hereditary breast and ovarian cancer: new genes in confined pathways
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2016.72
– volume: 7
  start-page: a016600
  year: 2015
  ident: CR13
  article-title: Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a016600
– volume: 17
  start-page: 703
  year: 2016
  end-page: 721
  ident: CR38
  article-title: Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
  publication-title: Nat. Rev. Mol. Cell. Biol.
  doi: 10.1038/nrm.2016.111
– volume: 288
  start-page: 7086
  year: 2013
  end-page: 7095
  ident: CR41
  article-title: Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.445825
– volume: 20
  start-page: 862
  issue: 8
  year: 2018
  end-page: 863
  ident: CR58
  article-title: Assembling a protective shield
  publication-title: Nature Cell Biology
  doi: 10.1038/s41556-018-0152-x
– volume: 1
  start-page: 417
  year: 2015
  end-page: 425
  ident: CR74
  article-title: The Molecular Signatures Database (MSigDB) hallmark gene set collection
  publication-title: Cell Syst.
  doi: 10.1016/j.cels.2015.12.004
– volume: 13
  start-page: 714
  year: 2013
  end-page: 726
  ident: CR50
  article-title: Cancer drug resistance: an evolving paradigm
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3599
– volume: 40
  start-page: 10821
  year: 2012
  end-page: 10831
  ident: CR53
  article-title: The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks879
– volume: 17
  start-page: 11
  year: 2010
  end-page: 16
  ident: CR5
  article-title: DNA resection in eukaryotes: deciding how to fix the break
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1710
– volume: 15
  year: 2014
  ident: CR73
  article-title: MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0554-4
– volume: 19
  start-page: 1
  year: 2017
  end-page: 9
  ident: CR10
  article-title: The control of DNA repair by the cell cycle
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3452
– volume: 40
  start-page: 179
  year: 2010
  end-page: 204
  ident: CR2
  article-title: The DNA damage response: making it safe to play with knives
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.09.019
– volume: 532
  start-page: 103
  year: 2003
  end-page: 115
  ident: CR14
  article-title: Pathways for mitotic homologous recombination in mammalian cells
  publication-title: Mutat. Res. Fundam. Mol. Mech. Mutagen.
  doi: 10.1016/j.mrfmmm.2003.08.013
– volume: 30
  start-page: 2152
  year: 2016
  end-page: 2157
  ident: CR36
  article-title: Synthetic lethality between PAXX and XLF in mammalian development
  publication-title: Genes Dev.
  doi: 10.1101/gad.290510.116
– volume: 16
  start-page: 110
  year: 2016
  end-page: 120
  ident: CR16
  article-title: BRCAness revisited
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2015.21
– volume: 98
  start-page: 3243
  year: 2001
  end-page: 3248
  ident: CR31
  article-title: Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.051632098
– volume: 273
  start-page: 1109
  year: 1996
  end-page: 1111
  ident: CR72
  article-title: Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine
  publication-title: Science
  doi: 10.1126/science.273.5278.1109
– volume: 200
  start-page: 173
  year: 2013
  end-page: 186
  ident: CR28
  article-title: A noncatalytic function of the ligation complex during nonhomologous end joining
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201203128
– volume: 26
  start-page: 52
  year: 2016
  end-page: 64
  ident: CR9
  article-title: Repair pathway choices and consequences at the double-strand break
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2015.07.009
– volume: 141
  start-page: 243
  year: 2010
  end-page: 254
  ident: CR39
  article-title: 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
  publication-title: Cell
  doi: 10.1016/j.cell.2010.03.012
– volume: 316
  start-page: 1160
  year: 2007
  end-page: 1166
  ident: CR52
  article-title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
  publication-title: Science
  doi: 10.1126/science.1140321
– volume: 72
  start-page: 131
  year: 1993
  end-page: 142
  ident: CR30
  article-title: The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
  publication-title: Cell
  doi: 10.1016/0092-8674(93)90057-W
– volume: 9
  start-page: 563
  year: 2011
  end-page: 574
  ident: CR69
  article-title: Forward and reverse genetics through derivation of haploid mouse embryonic stem cells
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2011.10.012
– volume: 102
  start-page: 1555
  year: 2010
  end-page: 1577
  ident: CR67
  article-title: Guidelines for the welfare and use of animals in cancer research
  publication-title: Br. J. Cancer
  doi: 10.1038/sj.bjc.6605642
– volume: 144
  start-page: 646
  year: 2011
  end-page: 674
  ident: CR1
  article-title: Hallmarks of cancer: the next generation
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
– volume: 20
  start-page: 954
  year: 2018
  end-page: 965
  ident: CR64
  article-title: Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-018-0140-1
– volume: 478
  start-page: 391
  year: 2011
  end-page: 394
  ident: CR71
  article-title: Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells
  publication-title: Nature
  doi: 10.1038/nature10424
– volume: 9
  start-page: e1003277
  year: 2013
  ident: CR47
  article-title: The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1003277
– volume: 65
  start-page: 22.7.1
  year: 2005
  end-page: 22.7.4
  ident: CR77
  article-title: Sister chromatid exchange
  publication-title: Curr. Protoc. Cell Biol.
– volume: 7
  year: 2016
  ident: CR11
  article-title: Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms12889
– volume: 49
  start-page: 1476
  year: 2017
  end-page: 1486
  ident: CR62
  article-title: A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3934
– volume: 450
  start-page: 509
  year: 2007
  end-page: 514
  ident: CR43
  article-title: Human CtIP promotes DNA end resection
  publication-title: Nature
  doi: 10.1038/nature06337
– volume: 47
  start-page: 497
  year: 2012
  end-page: 510
  ident: CR8
  article-title: Playing the end game: DNA Double-strand break repair pathway choice
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2012.07.029
– volume: 10
  start-page: M111.011015
  year: 2011
  ident: CR83
  article-title: Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole Orbitrap mass spectrometer
  publication-title: Mol. Cell. Proteom.
  doi: 10.1074/mcp.M111.011015
– volume: 329
  start-page: 219
  year: 2010
  end-page: 223
  ident: CR55
  article-title: Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway
  publication-title: Science
  doi: 10.1126/science.1192277
– volume: 16
  start-page: 2967
  year: 2016
  end-page: 2979
  ident: CR33
  article-title: Specific roles of XRCC4 paralogs PAXX and XLF during V(D)J eecombination
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.08.069
– volume: 16
  start-page: 1016
  year: 2014
  end-page: 1026
  ident: CR79
  article-title: Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3028
– volume: 1
  start-page: 376
  year: 2002
  end-page: 386
  ident: CR81
  article-title: Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
  publication-title: Mol. Cell. Proteom.
  doi: 10.1074/mcp.M200025-MCP200
– volume: 17
  start-page: 688
  year: 2010
  end-page: 695
  ident: CR40
  article-title: 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1831
– volume: 36
  start-page: 46
  year: 2018
  end-page: 60
  ident: CR63
  article-title: Precision oncology in the age of integrative genomics
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4017
– volume: 26
  start-page: 1367
  year: 2008
  end-page: 1372
  ident: CR85
  article-title: MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1511
– volume: 4
  start-page: 743
  year: 1998
  end-page: 753
  ident: CR66
  article-title: Studies of the efficacy and pharmacology of irinotecan against human colon tumor xenograft models
  publication-title: Clin. Cancer Res.
– volume: 55
  start-page: 818
  year: 2014
  end-page: 828
  ident: CR21
  article-title: NuA4 initiates dynamic histone H4 acetylation to promote high-fidelity sister chromatid recombination at postreplication gaps
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2014.07.007
– volume: 66
  start-page: 801
  year: 2017
  end-page: 817
  ident: CR4
  article-title: ATM, ATR, and DNA-PK: the trinity at the heart of the DNA damage response
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2017.05.015
– volume: 202
  start-page: 579
  year: 2013
  end-page: 595
  ident: CR32
  article-title: A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201303073
– volume: 14
  start-page: 197
  year: 2013
  end-page: 210
  ident: CR49
  article-title: The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
  publication-title: Nat. Rev. Mol. Cell. Biol.
  doi: 10.1038/nrm3546
– volume: 174
  start-page: 6477
  year: 2005
  end-page: 6489
  ident: CR68
  article-title: Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.174.10.6477
– volume: 37
  start-page: 418
  year: 2012
  end-page: 424
  ident: CR22
  article-title: Links between genome integrity and BRCA1 tumor suppression
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2012.06.007
– volume: 4
  start-page: 1995
  year: 1998
  end-page: 2002
  ident: CR29
  article-title: Effective schedules of exposure of medulloblastoma and rhabdomyosarcoma xenografts to topotecan correlate with in vitro assays
  publication-title: Clin. Cancer Res
– volume: 5
  start-page: 387
  year: 2011
  end-page: 393
  ident: CR15
  article-title: The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings
  publication-title: Mol. Oncol.
  doi: 10.1016/j.molonc.2011.07.001
– ident: CR56
– volume: 24
  start-page: 108
  year: 2014
  end-page: 117
  ident: CR59
  article-title: 53BP1: pro choice in DNA repair
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2013.09.003
– volume: 23
  start-page: 517
  year: 2017
  end-page: 525
  ident: CR61
  article-title: HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures
  publication-title: Nat. Med.
  doi: 10.1038/nm.4292
– volume: 64
  start-page: 9152
  year: 2004
  end-page: 9159
  ident: CR27
  article-title: Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-04-2727
– volume: 39
  start-page: 25
  year: 2010
  end-page: 35
  ident: CR54
  article-title: Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.06.026
– volume: 6
  start-page: 789
  year: 2006
  end-page: 802
  ident: CR20
  article-title: Topoisomerase I inhibitors: camptothecins and beyond
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1977
– volume: 15
  start-page: 7
  year: 2014
  end-page: 18
  ident: CR12
  article-title: Double-strand break repair: 53BP1 comes into focus
  publication-title: Nat. Rev. Mol. Cell. Biol.
  doi: 10.1038/nrm3719
– volume: 3
  start-page: ra44
  year: 2010
  end-page: ra44
  ident: CR51
  article-title: Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.2000758
– volume: 107
  start-page: 1776
  year: 2012
  end-page: 1782
  ident: CR60
  article-title: Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.2012.451
– volume: 114
  start-page: 7665
  year: 2017
  end-page: 7670
  ident: CR57
  article-title: ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1706392114
– volume: 479
  start-page: 131
  year: 2011
  end-page: 134
  ident: CR70
  article-title: Derivation of haploid embryonic stem cells from mouse embryos
  publication-title: Nature
  doi: 10.1038/nature10448
– volume: 4
  start-page: 709
  year: 2007
  end-page: 712
  ident: CR84
  article-title: Higher-energy C-trap dissociation for peptide modification analysis
  publication-title: Nat. Methods
  doi: 10.1038/nmeth1060
– volume: 15
  start-page: 499
  year: 2007
  end-page: 514
  ident: CR76
  article-title: Cross-species chromosome painting among camel, cattle, pig and human: further insights into the putative Cetartiodactyla ancestral karyotype
  publication-title: Chromosome Res.
  doi: 10.1007/s10577-007-1154-x
– volume: 41
  start-page: D808
  year: 2013
  end-page: D815
  ident: CR87
  article-title: STRING v9.1: protein–protein interaction networks, with increased coverage and integration
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks1094
– volume: 1
  start-page: 94
  year: 2010
  end-page: 99
  ident: CR65
  article-title: Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research
  publication-title: J. Pharmacol. Pharmacother.
  doi: 10.4103/0976-500X.72351
– volume: 6
  year: 2016
  ident: CR75
  article-title: CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing
  publication-title: Sci. Rep.
  doi: 10.1038/srep24356
– volume: 8
  year: 2017
  ident: CR37
  article-title: PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms13816
– volume: 23
  start-page: 740
  year: 2009
  end-page: 754
  ident: CR24
  article-title: MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks
  publication-title: Genes Dev.
  doi: 10.1101/gad.1739609
– volume: 505
  start-page: 495
  year: 2014
  end-page: 501
  ident: CR48
  article-title: Discovery and saturation analysis of cancer genes across 21 tumour types
  publication-title: Nature
  doi: 10.1038/nature12912
– volume: 23
  start-page: 729
  year: 2009
  end-page: 739
  ident: CR25
  article-title: NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control
  publication-title: Genes Dev.
  doi: 10.1101/gad.1770309
– volume: 17
  start-page: 1458
  year: 2015
  end-page: 1470
  ident: CR44
  article-title: Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3260
– volume: 286
  start-page: 13669
  year: 2011
  end-page: 13680
  ident: CR46
  article-title: The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.213728
– volume: 113
  start-page: 10619
  year: 2016
  end-page: 10624
  ident: CR34
  article-title: PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1611882113
– volume: 110
  start-page: 5564
  year: 2013
  end-page: 5569
  ident: CR42
  article-title: Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1216824110
– volume: 550
  start-page: 114
  year: 2017
  ident: CR78
  article-title: A reversible haploid mouse embryonic stem cell biobank resource for functional genomics
  publication-title: Nature
  doi: 10.1038/nature24027
– volume: 288
  start-page: 7086
  year: 2013
  ident: 7729_CR41
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.445825
– volume: 114
  start-page: 7665
  year: 2017
  ident: 7729_CR57
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1706392114
– volume: 19
  start-page: 1
  year: 2017
  ident: 7729_CR10
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3452
– volume: 113
  start-page: 10619
  year: 2016
  ident: 7729_CR34
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1611882113
– volume: 4
  start-page: 743
  year: 1998
  ident: 7729_CR66
  publication-title: Clin. Cancer Res.
– volume: 4
  start-page: 709
  year: 2007
  ident: 7729_CR84
  publication-title: Nat. Methods
  doi: 10.1038/nmeth1060
– volume: 23
  start-page: 729
  year: 2009
  ident: 7729_CR25
  publication-title: Genes Dev.
  doi: 10.1101/gad.1770309
– volume: 14
  start-page: 197
  year: 2013
  ident: 7729_CR49
  publication-title: Nat. Rev. Mol. Cell. Biol.
  doi: 10.1038/nrm3546
– volume: 20
  start-page: 954
  year: 2018
  ident: 7729_CR64
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-018-0140-1
– volume: 10
  start-page: M111.011015
  year: 2011
  ident: 7729_CR83
  publication-title: Mol. Cell. Proteom.
  doi: 10.1074/mcp.M111.011015
– volume: 141
  start-page: 243
  year: 2010
  ident: 7729_CR39
  publication-title: Cell
  doi: 10.1016/j.cell.2010.03.012
– volume: 2
  start-page: 6
  year: 2012
  ident: 7729_CR7
  publication-title: Cell Biosci.
  doi: 10.1186/2045-3701-2-6
– volume: 47
  start-page: 497
  year: 2012
  ident: 7729_CR8
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2012.07.029
– volume: 532
  start-page: 103
  year: 2003
  ident: 7729_CR14
  publication-title: Mutat. Res. Fundam. Mol. Mech. Mutagen.
  doi: 10.1016/j.mrfmmm.2003.08.013
– volume: 86
  start-page: 159
  year: 1996
  ident: 7729_CR17
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80086-0
– volume: 40
  start-page: 10821
  year: 2012
  ident: 7729_CR53
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks879
– volume: 8
  start-page: 1015
  year: 2001
  ident: 7729_CR26
  publication-title: Nat. Struct. Biol.
  doi: 10.1038/nsb725
– volume: 1
  start-page: 376
  year: 2002
  ident: 7729_CR81
  publication-title: Mol. Cell. Proteom.
  doi: 10.1074/mcp.M200025-MCP200
– volume: 110
  start-page: 5564
  year: 2013
  ident: 7729_CR42
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1216824110
– volume: 13
  start-page: 714
  year: 2013
  ident: 7729_CR50
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3599
– volume: 36
  start-page: 46
  year: 2018
  ident: 7729_CR63
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4017
– volume: 461
  start-page: 1071
  year: 2009
  ident: 7729_CR3
  publication-title: Nature
  doi: 10.1038/nature08467
– volume: 7
  year: 2016
  ident: 7729_CR11
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms12889
– volume: 23
  start-page: 740
  year: 2009
  ident: 7729_CR24
  publication-title: Genes Dev.
  doi: 10.1101/gad.1739609
– volume: 17
  start-page: 1458
  year: 2015
  ident: 7729_CR44
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3260
– volume: 4
  start-page: 207
  year: 2007
  ident: 7729_CR86
  publication-title: Nat. Methods
  doi: 10.1038/nmeth1019
– volume: 23
  start-page: 517
  year: 2017
  ident: 7729_CR61
  publication-title: Nat. Med.
  doi: 10.1038/nm.4292
– volume: 174
  start-page: 6477
  year: 2005
  ident: 7729_CR68
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.174.10.6477
– volume: 273
  start-page: 1109
  year: 1996
  ident: 7729_CR72
  publication-title: Science
  doi: 10.1126/science.273.5278.1109
– volume: 4
  start-page: 1995
  year: 1998
  ident: 7729_CR29
  publication-title: Clin. Cancer Res
– volume: 200
  start-page: 173
  year: 2013
  ident: 7729_CR28
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201203128
– volume: 16
  start-page: 2967
  year: 2016
  ident: 7729_CR33
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.08.069
– volume: 17
  start-page: 11
  year: 2010
  ident: 7729_CR5
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1710
– volume: 505
  start-page: 495
  year: 2014
  ident: 7729_CR48
  publication-title: Nature
  doi: 10.1038/nature12912
– ident: 7729_CR56
  doi: 10.1101/151472
– volume: 1
  start-page: 417
  year: 2015
  ident: 7729_CR74
  publication-title: Cell Syst.
  doi: 10.1016/j.cels.2015.12.004
– volume: 49
  start-page: 1476
  year: 2017
  ident: 7729_CR62
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3934
– volume: 72
  start-page: 131
  year: 1993
  ident: 7729_CR30
  publication-title: Cell
  doi: 10.1016/0092-8674(93)90057-W
– volume: 16
  start-page: 110
  year: 2016
  ident: 7729_CR16
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2015.21
– volume: 5
  start-page: 387
  year: 2011
  ident: 7729_CR15
  publication-title: Mol. Oncol.
  doi: 10.1016/j.molonc.2011.07.001
– volume: 102
  start-page: 1555
  year: 2010
  ident: 7729_CR67
  publication-title: Br. J. Cancer
  doi: 10.1038/sj.bjc.6605642
– volume: 9
  start-page: 563
  year: 2011
  ident: 7729_CR69
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2011.10.012
– volume: 15
  start-page: 1781
  year: 2016
  ident: 7729_CR18
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-15-0945
– volume: 7
  start-page: a016600
  year: 2015
  ident: 7729_CR13
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a016600
– volume: 65
  start-page: 22.7.1
  year: 2005
  ident: 7729_CR77
  publication-title: Curr. Protoc. Cell Biol.
– volume: 202
  start-page: 579
  year: 2013
  ident: 7729_CR32
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201303073
– volume: 55
  start-page: 818
  year: 2014
  ident: 7729_CR21
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2014.07.007
– volume: 1
  start-page: 94
  year: 2010
  ident: 7729_CR65
  publication-title: J. Pharmacol. Pharmacother.
  doi: 10.4103/0976-500X.72351
– volume: 478
  start-page: 391
  year: 2011
  ident: 7729_CR71
  publication-title: Nature
  doi: 10.1038/nature10424
– volume: 316
  start-page: 1160
  year: 2007
  ident: 7729_CR52
  publication-title: Science
  doi: 10.1126/science.1140321
– volume: 17
  start-page: 541
  year: 2016
  ident: 7729_CR35
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.09.026
– volume: 15
  start-page: 499
  year: 2007
  ident: 7729_CR76
  publication-title: Chromosome Res.
  doi: 10.1007/s10577-007-1154-x
– volume: 15
  start-page: 7
  year: 2014
  ident: 7729_CR12
  publication-title: Nat. Rev. Mol. Cell. Biol.
  doi: 10.1038/nrm3719
– volume: 32
  start-page: 267
  year: 2014
  ident: 7729_CR19
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2800
– volume: 6
  year: 2016
  ident: 7729_CR75
  publication-title: Sci. Rep.
  doi: 10.1038/srep24356
– volume: 25
  start-page: 685
  year: 2011
  ident: 7729_CR45
  publication-title: Genes Dev.
  doi: 10.1101/gad.2011011
– volume: 23
  start-page: 719
  year: 2009
  ident: 7729_CR23
  publication-title: Genes Dev.
  doi: 10.1101/gad.1770609
– volume: 66
  start-page: 801
  year: 2017
  ident: 7729_CR4
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2017.05.015
– volume: 107
  start-page: 1776
  year: 2012
  ident: 7729_CR60
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.2012.451
– volume: 26
  start-page: 1367
  year: 2008
  ident: 7729_CR85
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1511
– volume: 24
  start-page: 108
  year: 2014
  ident: 7729_CR59
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2013.09.003
– volume: 64
  start-page: 9152
  year: 2004
  ident: 7729_CR27
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-04-2727
– volume: 26
  start-page: 52
  year: 2016
  ident: 7729_CR9
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2015.07.009
– volume: 37
  start-page: 418
  year: 2012
  ident: 7729_CR22
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2012.06.007
– volume: 17
  start-page: 703
  year: 2016
  ident: 7729_CR38
  publication-title: Nat. Rev. Mol. Cell. Biol.
  doi: 10.1038/nrm.2016.111
– volume: 15
  year: 2014
  ident: 7729_CR73
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0554-4
– volume: 8
  year: 2017
  ident: 7729_CR37
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms13816
– volume: 3
  start-page: ra44
  year: 2010
  ident: 7729_CR51
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.2000758
– volume: 329
  start-page: 219
  year: 2010
  ident: 7729_CR55
  publication-title: Science
  doi: 10.1126/science.1192277
– volume: 98
  start-page: 3243
  year: 2001
  ident: 7729_CR31
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.051632098
– volume: 286
  start-page: 13669
  year: 2011
  ident: 7729_CR46
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.213728
– volume: 17
  start-page: 688
  year: 2010
  ident: 7729_CR40
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1831
– volume: 16
  start-page: 1016
  year: 2014
  ident: 7729_CR79
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3028
– volume: 16
  start-page: 599
  year: 2016
  ident: 7729_CR6
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2016.72
– volume: 20
  start-page: 862
  issue: 8
  year: 2018
  ident: 7729_CR58
  publication-title: Nature Cell Biology
  doi: 10.1038/s41556-018-0152-x
– volume: 30
  start-page: 2152
  year: 2016
  ident: 7729_CR36
  publication-title: Genes Dev.
  doi: 10.1101/gad.290510.116
– volume: 479
  start-page: 131
  year: 2011
  ident: 7729_CR70
  publication-title: Nature
  doi: 10.1038/nature10448
– volume: 6
  start-page: 789
  year: 2006
  ident: 7729_CR20
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1977
– volume: 550
  start-page: 114
  year: 2017
  ident: 7729_CR78
  publication-title: Nature
  doi: 10.1038/nature24027
– volume: 39
  start-page: 25
  year: 2010
  ident: 7729_CR54
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.06.026
– volume: 144
  start-page: 646
  year: 2011
  ident: 7729_CR1
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
– volume: 40
  start-page: 179
  year: 2010
  ident: 7729_CR2
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.09.019
– volume: 2
  start-page: 1896
  year: 2007
  ident: 7729_CR82
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2007.261
– volume: 450
  start-page: 509
  year: 2007
  ident: 7729_CR43
  publication-title: Nature
  doi: 10.1038/nature06337
– volume: 1599
  start-page: 215
  year: 2017
  ident: 7729_CR80
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-6955-5_16
– volume: 9
  start-page: e1003277
  year: 2013
  ident: 7729_CR47
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1003277
– volume: 41
  start-page: D808
  year: 2013
  ident: 7729_CR87
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks1094
SSID ssj0000391844
Score 2.6001616
Snippet Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms, we...
Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms, we...
Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. Here, the authors provide evidence that these...
SourceID doaj
unpaywall
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 87
SubjectTerms 13/100
13/106
14
49
631/208
631/67
631/80
692/4028/67/1059/2326
82/58
Adenosine diphosphate
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Ataxia Telangiectasia Mutated Proteins - genetics
Ataxia Telangiectasia Mutated Proteins - metabolism
BRCA1 protein
BRCA1 Protein - metabolism
Breast cancer
Cell Line, Tumor
Cell Survival - genetics
Chemotherapy
CRISPR
CRISPR-Cas Systems - genetics
Damage
Deoxyribonucleic acid
Disruption
DNA
DNA biosynthesis
DNA Breaks, Double-Stranded - drug effects
DNA damage
DNA End-Joining Repair - genetics
DNA Ligase ATP - metabolism
DNA Replication - drug effects
DNA Replication - genetics
DNA topoisomerase
Drug Resistance, Neoplasm - genetics
Female
Genetic suppression
Genomes
Homologous recombination
Homology
Humanities and Social Sciences
Humans
Hypersensitivity
Inhibitors
LIG4 protein
Mice
Mice, Inbred NOD
Mice, Knockout
Mouse Embryonic Stem Cells
multidisciplinary
Mutation
Neoplasms, Experimental - drug therapy
Neoplasms, Experimental - genetics
Neoplasms, Experimental - pathology
Non-homologous end joining
Phthalazines - pharmacology
Phthalazines - therapeutic use
Piperazines - pharmacology
Piperazines - therapeutic use
Poly(ADP-ribose) polymerase
Replication
Replication forks
Ribose
Science
Science (multidisciplinary)
Screens
Topotecan
Topotecan - pharmacology
Topotecan - therapeutic use
Toxicity
Tumor suppressor genes
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQJQQcEG9SCjISN2o1sR3bOS6PqkJqT63Um-VX1NJtskp2Bf33HTvZsCtQ4YByiWI7msx8tr-xnRmEPiglgoeZnFiWe8J5xYiipiSFq-rSUwsUP653HJ-IozP-7bw830j1Fc-EDeGBB8UdOJ4zb4Wl3Cte1cwYyVyQMgJNOZ6oEUxjG85UGoNZBa4LH_-SyZk66HkaE_JCkTwySkK3ZqIUsP9PLPP3w5LTjukj9GDVLMzNDzOfb0xKh0_Q45FN4tnwFU_RvdA8Q_eH_JI3z9FidnqM2y7lxIohIXoMdA9_OZkRb65hIMHdcEI24GWLU9aI0MHtz0uHm7YhF-11fFG76nFoPPnepmQS2Cyx7dqr0EDzafcbA_m96l-gs8Ovp5-PyJhigTjwXJakVkz53IIPEwNvOWbyYHMjS1sbK5ynxtXKSRsUEC9huBcO3BugjIWwlZHBsZdoBwQKrxEOVaiZymkQtecyWFPK2lJZcOmck5RlqFirW7sx_nhMgzHXaR-cKT2YSIOJdDKRphn6OLVZDNE37qz9KVpxqhkjZ6cHgCc94kn_DU8Z2ltjQI_dude0iEQ2JtHI0PupGDpi3F0xTQBDpDpwKcEz9GqAzCQJ-GXRr4bWcgtMW6JulzSXFynYt2DJCczQ_hp2v8S6SxX7EzT_QXO7_0Nzb9BDYJNVWp9Se2hn2a3CW2BsS_sudc5bXC07Rw
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELagCAEHxJtAQUbiRq0mtmM7J7Q8lgqpPbVSb5FfoaXbZEmygv57xk42ZQVaob1EGztyPOPxNzPOfAi9VUp4Bzs5MSx1hPOCEUV1TjJbVLmjBiB-iHccHomDE_71ND8dA27deKxybROjoXaNDTHyfZoFLBF4DN4vf5DAGhWyqyOFxk10K6OgSeFL8fmXKcYSqp8rzsdvZVKm9jseLUOaKZIGXEnoxn4Uy_b_C2v-fWRyypveQ3dW9VJf_dSLxR9b0_wBuj9iSjwblOAhuuHrR-j2wDJ59RgtZ8eHuGkjM1YoDNFhAH3409GMOH0J5gS3wzlZj_sGR-4I38Llr3OL66YmZ81leFCz6rCvHfneREoJrHts2ubC19B9yoFjgMAX3RN0Mv98_PGAjEQLxIL_0pNKMeVSA55MKL9lmU69SbXMTaWNsI5qWykrjVcAv4TmTlhwcgA4ZsIUWnrLnqIdGJB_jrAvfMVUSr2oHJfe6FxWhsqMS2utpCxB2Xq6SztWIQ9kGIsyZsOZKgcRlSCiMoqopAl6N_VZDjU4trb-EKQ4tQz1s-MfTfutHJdjaXnKnBGGcqd4UTGtJbNeymC-lOU6QbtrHSjHRd2V1yqYoDfTbViOIceiaw-CiG3gpwRP0LNBZaaRgHcWvGvoLTeUaWOom3fq87NY8luw6AomaG-tdtfD2jYVe5Nq_sfMvdj-0i_RXUCLRYw_qV2007cr_woQWW9ex2X3GydhMow
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELaqIgQcEG8CBRmJG7VIbMd2jstCVSG1p1bqLfIrtHSbrJKsoP-esfOAFVUFyiWK7WjkGdvf2ONvEHqvlPAOVnJiWOoI5wUjiuqcZLaockcNQPyw33F0LA5P-dez_GwH0ekuTAzaj5SWcZqeosM-djwO6TRTJA2AkMC0e0dJloUwvqVYzvsqgfFccT7ej0mZuqHp1hoUqfpvwpd_h0nOZ6UP0L1NvdbXP_Rq9cdydPAIPRxxJF4Mkj9GO75-gu4OmSWvn6L14uQIN23MhhXIIDoMQA9_Pl4Qp69gCsHtEBvrcd_gmC_Ct_D688LiuqnJeXMVftRsOuxrR743MY0E1j02bXPpa2g-n3tjgL2X3TN0evDlZHlIxuQKxILP0pNKMeVSA95LoNyyTKfepFrmptJGWEe1rZSVxiuAXEJzJyw4NgAWM2EKLb1lz9EuCORfIuwLXzGVUi8qx6U3OpeVoTLj0lorKUtQNnV3aUfm8ZAAY1XGE3CmykFFJaiojCoqaYI-zG3WA-_GrbU_BS3ONQNndvzQtN_K0YZKy1PmjDCUO8WLimktmfVShilLWa4TtDfZQDkO5K6kWYCwIX1Ggt7NxTAEw7mKrj0oItaBRwmeoBeDycySgEcWPGpoLbeMaUvU7ZL64jzSfAsW3b8E7U9m91us27pifzbNf-i5V__399foPiDGIu5BqT2027cb_wZQWW_exmH4C1COMHU
  priority: 102
  providerName: Springer Nature
Title ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
URI https://link.springer.com/article/10.1038/s41467-018-07729-2
https://www.ncbi.nlm.nih.gov/pubmed/30622252
https://www.proquest.com/docview/2165080532
https://www.proquest.com/docview/2165656864
https://pubmed.ncbi.nlm.nih.gov/PMC6325118
https://www.nature.com/articles/s41467-018-07729-2.pdf
https://doaj.org/article/c403db6b24d849f3aa73ce7778708c4a
UnpaywallVersion publishedVersion
Volume 10
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: KQ8
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: DOA
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVEBS
  databaseName: Inspec with Full Text
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: ADMLS
  dateStart: 20121101
  isFulltext: true
  titleUrlDefault: https://www.ebsco.com/products/research-databases/inspec-full-text
  providerName: EBSCOhost
– providerCode: PRVBFR
  databaseName: Free Medical Journals
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: DIK
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: http://www.freemedicaljournals.com
  providerName: Flying Publisher
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: M~E
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVAQN
  databaseName: PubMed Central
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: RPM
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
– providerCode: PRVAQT
  databaseName: Springer Nature - nature.com Journals - Fully Open Access
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: NAO
  dateStart: 20101201
  isFulltext: true
  titleUrlDefault: https://www.nature.com/siteindex/index.html
  providerName: Nature Publishing
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: 7X7
  dateStart: 20190101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: BENPR
  dateStart: 20190101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Technology Collection
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: 8FG
  dateStart: 20100401
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/technologycollection1
  providerName: ProQuest
– providerCode: PRVFZP
  databaseName: Scholars Portal Journals: Open Access
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 20250131
  omitProxy: true
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: M48
  dateStart: 20101001
  isFulltext: true
  titleUrlDefault: http://journals.scholarsportal.info
  providerName: Scholars Portal
– providerCode: PRVAVX
  databaseName: Springer Nature HAS Fully OA
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: AAJSJ
  dateStart: 20101201
  isFulltext: true
  titleUrlDefault: https://www.springernature.com
  providerName: Springer Nature
– providerCode: PRVAVX
  databaseName: Springer Nature OA Free Journals
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: C6C
  dateStart: 20101201
  isFulltext: true
  titleUrlDefault: http://www.springeropen.com/
  providerName: Springer Nature
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELfGJgQ8IL4JjMpIvDGzJHZj5wGhrqxMlVohWKW9Rf4KG-uSkrZi_e85O2mgoppAkZIosS3rPny_8yV3CL0RIrEGLDlRNDSEsZQSEcsuiXSad02sAOK7_Y7RODmZsOFZ92wHrcsdNQScb3XtXD2pSTV9d_1j9QEU_n39y7g4nDOv7mEkSOjAIoEleQ8sU-ykfNTAfb8y0xQcGhdojkMWEbDdtPmPZvswG7bKp_TfhkP__pyyjaneQ3eWxUyufsrp9A-zNXiA7jd4E_dqAXmIdmzxCN2uK1CuHqNZ73SEy8pXzXJJI-YYACH-OO4RI69gqcFV_Q2txYsS-7oStoLb6wuNi7Ig5-WVG6hczrEtDPle-nITWC6wqspLW0D3Nj6OAR5fzp-gyeD4tH9CmiIMRINvsyC5oMKECrwcl5pLUxlaFUreVblUiTax1LnQXFkB0CyRzCQaHCAAlVGiUsmtpk_RLkzIPkfYpjanIoxtkhvGrZJdnquYR4xrrYEXAYrW5M50k6HcFcqYZj5STkVWsygDFmWeRVkcoLdtn1mdn-PG1keOi21Ll1vbPyirb1mjqplmITUqUTEzgqU5lZJTbTl3S5vQTAZofy0D2VpeszhyUNeV2QjQ6_Y1qKqLv8jCAiN8GzhEwgL0rBaZdibguTnPG3rzDWHamOrmm-Li3KcDT6h3EwN0sBa739O6iRQHrWj-A-Ve_BedX6K7ACxTv1Ul9tHuolraVwDeFqqDbvEzDmcx-NRBe73e8OsQrkfH489f4Gk_6Xf8tkjHa-4v0AxCQg
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLbGEBo8IO4EBhgJnpi1JHZj5wGhwpg6tvapk_oWfAsb65KSthr9U_xGjp3LqEATL1Neovgix-f4-LOPfT6E3giRWAMzOVE0NISxlBIRyx6JdJr3TKwA4rv9juEoGRyzL5PeZAP9au_CuGOVrU30htqU2u2R78aRwxKOx-DD7AdxrFHOu9pSaNRqcWhXF7Bkm78_2AP5vo3j_c_jTwPSsAoQDWB9QXJBhQkVwHYXa0pTGVoVSt5TuVSJNrHUudBcWQFYI5HMJBoQPaCkKFGp5FZTqPcGusloyFysfj7h3Z6Oi7YuGGvu5oRU7M6Zt0RhJEjocCyJ1-Y_TxPwL2z79xHNzk97B20ti5lcXcjp9I-pcP8euttgWNyvle4-2rDFA3SrZrVcPUSz_niIy8ozcblAFHMMIBPvjfrEyHMwX7iqz-VavCix56qwFbz-PNW4KAtyUp67isrlHNvCkO-lp7DAcoFVVZ7ZAop3PncMkPts_ggdX4sIHqNNaJB9irBNbU5FGNskN4xbJXs8VzGPGNda85gGKGq7O9NN1HNHvjHNvPediqwWUQYiyryIsjhA77oyszrmx5W5PzopdjldvG7_oay-Zc3wzzQLqVGJipkRLM2plJxqy7kzl0IzGaDtVgeyxojMs0uVD9DrLhmGv_PpyMKCIHweeETCAvSkVpmuJbAadKt5KM3XlGmtqespxemJDzGeUL_0DNBOq3aXzbqqK3Y61fyPnnt29U-_QluD8fAoOzoYHT5HtwGppn7vS2yjzUW1tC8ADS7USz8EMfp63WP-N2SJcEI
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKEa8D4k2ggJHgRK1NbG_sHBBaWKqW0hWHVtpbsB2Hlm6TZbOrsn-NX8fYeZQVaMWlyiWK7cjxjMefPZP5EHolZWwzWMmJZmFGOE8YkVT1SWSSvJ9RDRDfnXccjOLdI_5p3B9voF_tvzAurLK1id5QZ6VxZ-Q9Gjks4XgMenkTFvFluPNu-oM4BinnaW3pNGoV2bfLc9i-VW_3hiDr15TufDz8sEsahgFiALjPSS6ZzEINEN7lnTJMhVaHSvR1rnRsMqpMLo3QVgLuiBXPYgPoHhBTFOtECWsYvPcKuioYZy6cTIxFd77jMq9Lzpv_dEImexX3VimMJAkdpiV0ZS30lAH_wrl_h2t2Pttb6MaimKrluZpM_lgWd-6g2w2exYNaAe-iDVvcQ9dqhsvlfTQdHB7gcuZZuVxSigoD4MTD0YBk6gxMGZ7VMboWz0vseSvsDG5_nhhclAU5Ls_ci8pFhW2Rke-lp7PAao71rDy1BTTv_O8Y4Pdp9QAdXYoIHqJN6JB9jLBNbM5kSG2cZ1xYrfoi11REXBhjBGUBitrhTk2TAd0RcUxS74lnMq1FlIKIUi-ilAboTddmWuf_WFv7vZNiV9Pl7vYPytm3tDEFqeEhy3SsKc8kT3KmlGDGCuFMpzRcBWir1YG0MShVeqH-AXrZFYMpcP4dVVgQhK8Dl4x5gB7VKtP1BHaGbmcPrcWKMq10dbWkODn26cZj5rehAdpu1e6iW-uGYrtTzf8YuSfrP_oFug6zPf28N9p_im4CaE38MZjcQpvz2cI-A2A418_9DMTo62VP-d_DAnR9
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=ATM+orchestrates+the+DNA-damage+response+to+counter+toxic+non-homologous+end-joining+at+broken+replication+forks&rft.jtitle=Nature+communications&rft.au=Balmus%2C+Gabriel&rft.au=Pilger%2C+Domenic&rft.au=Coates%2C+Julia&rft.au=Demir%2C+Mukerrem&rft.date=2019-01-08&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=10&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-018-07729-2&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41467_018_07729_2
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon