Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19

SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying host factors and markers for disease severity, e.g. requiring intensive care unit (ICU) treatment, remain poorly defined. To...

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Published inScientific reports Vol. 10; no. 1; pp. 20533 - 12
Main Authors Haljasmägi, Liis, Salumets, Ahto, Rumm, Anna Pauliina, Jürgenson, Meeri, Krassohhina, Ekaterina, Remm, Anu, Sein, Hanna, Kareinen, Lauri, Vapalahti, Olli, Sironen, Tarja, Peterson, Hedi, Milani, Lili, Tamm, Anu, Hayday, Adrian, Kisand, Kai, Peterson, Pärt
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 25.11.2020
Nature Publishing Group
Nature Portfolio
Subjects
631/250/127
631/250/255/2514
631/250/98
692/4017
Adult
Aged
Aged, 80 and over
Antibodies
Apoptosis
Biomarkers - blood
Caspase 8 - blood
Chemokines - blood
Coronaviruses
COVID-19
COVID-19 - blood
COVID-19 - diagnosis
COVID-19 - virology
COVID-19 Testing - methods
CXCL10 protein
CXCL11 protein
Female
Hospitalization
Humanities and Social Sciences
Humans
Hypertension
Inflammation
Inflammation - blood
Intensive Care Units
Interleukin 10
Interleukin 6
Longitudinal Studies
Male
Middle Aged
Monocyte chemoattractant protein 1
Monocytes
multidisciplinary
Neutralization
Plasma proteins
Proteins
Proteome
Proteomics - methods
Risk Factors
SARS-CoV-2 - genetics
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Transforming growth factor-b1
Up-Regulation
Young Adult
γ-Interferon
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-020-77525-w

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Abstract SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying host factors and markers for disease severity, e.g. requiring intensive care unit (ICU) treatment, remain poorly defined. To this end, we longitudinally profiled blood inflammation markers, antibodies, and 101 plasma proteins of hospitalized COVID-19 patients who did or did not require ICU admission. While essentially all patients displayed SARS-CoV-2-specific antibodies and virus-neutralization capacity within 12–15 days, a rapid, mostly transient upregulation of selective inflammatory markers including IL-6, CXCL10, CXCL11, IFNγ, IL-10, and monocyte-attracting CCL2, CCL7 and CCL8, was particularly evident in ICU patients. In addition, there was consistent and sustained upregulation of apoptosis-associated proteins CASP8, TNFSF14, HGF, and TGFB1, with HGF discriminating between ICU and non-ICU cohorts. Thus, COVID-19 is associated with a selective inflammatory milieu within which the apoptotic pathway is a cardinal feature with potential to aid risk-based patient stratification.
AbstractList SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying host factors and markers for disease severity, e.g. requiring intensive care unit (ICU) treatment, remain poorly defined. To this end, we longitudinally profiled blood inflammation markers, antibodies, and 101 plasma proteins of hospitalized COVID-19 patients who did or did not require ICU admission. While essentially all patients displayed SARS-CoV-2-specific antibodies and virus-neutralization capacity within 12–15 days, a rapid, mostly transient upregulation of selective inflammatory markers including IL-6, CXCL10, CXCL11, IFNγ, IL-10, and monocyte-attracting CCL2, CCL7 and CCL8, was particularly evident in ICU patients. In addition, there was consistent and sustained upregulation of apoptosis-associated proteins CASP8, TNFSF14, HGF, and TGFB1, with HGF discriminating between ICU and non-ICU cohorts. Thus, COVID-19 is associated with a selective inflammatory milieu within which the apoptotic pathway is a cardinal feature with potential to aid risk-based patient stratification.
SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying host factors and markers for disease severity, e.g. requiring intensive care unit (ICU) treatment, remain poorly defined. To this end, we longitudinally profiled blood inflammation markers, antibodies, and 101 plasma proteins of hospitalized COVID-19 patients who did or did not require ICU admission. While essentially all patients displayed SARS-CoV-2-specific antibodies and virus-neutralization capacity within 12–15 days, a rapid, mostly transient upregulation of selective inflammatory markers including IL-6, CXCL10, CXCL11, IFNγ, IL-10, and monocyte-attracting CCL2, CCL7 and CCL8, was particularly evident in ICU patients. In addition, there was consistent and sustained upregulation of apoptosis-associated proteins CASP8, TNFSF14, HGF, and TGFB1, with HGF discriminating between ICU and non-ICU cohorts. Thus, COVID-19 is associated with a selective inflammatory milieu within which the apoptotic pathway is a cardinal feature with potential to aid risk-based patient stratification.
Abstract SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying host factors and markers for disease severity, e.g. requiring intensive care unit (ICU) treatment, remain poorly defined. To this end, we longitudinally profiled blood inflammation markers, antibodies, and 101 plasma proteins of hospitalized COVID-19 patients who did or did not require ICU admission. While essentially all patients displayed SARS-CoV-2-specific antibodies and virus-neutralization capacity within 12–15 days, a rapid, mostly transient upregulation of selective inflammatory markers including IL-6, CXCL10, CXCL11, IFNγ, IL-10, and monocyte-attracting CCL2, CCL7 and CCL8, was particularly evident in ICU patients. In addition, there was consistent and sustained upregulation of apoptosis-associated proteins CASP8, TNFSF14, HGF, and TGFB1, with HGF discriminating between ICU and non-ICU cohorts. Thus, COVID-19 is associated with a selective inflammatory milieu within which the apoptotic pathway is a cardinal feature with potential to aid risk-based patient stratification.
SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying host factors and markers for disease severity, e.g. requiring intensive care unit (ICU) treatment, remain poorly defined. To this end, we longitudinally profiled blood inflammation markers, antibodies, and 101 plasma proteins of hospitalized COVID-19 patients who did or did not require ICU admission. While essentially all patients displayed SARS-CoV-2-specific antibodies and virus-neutralization capacity within 12-15 days, a rapid, mostly transient upregulation of selective inflammatory markers including IL-6, CXCL10, CXCL11, IFNγ, IL-10, and monocyte-attracting CCL2, CCL7 and CCL8, was particularly evident in ICU patients. In addition, there was consistent and sustained upregulation of apoptosis-associated proteins CASP8, TNFSF14, HGF, and TGFB1, with HGF discriminating between ICU and non-ICU cohorts. Thus, COVID-19 is associated with a selective inflammatory milieu within which the apoptotic pathway is a cardinal feature with potential to aid risk-based patient stratification.SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying host factors and markers for disease severity, e.g. requiring intensive care unit (ICU) treatment, remain poorly defined. To this end, we longitudinally profiled blood inflammation markers, antibodies, and 101 plasma proteins of hospitalized COVID-19 patients who did or did not require ICU admission. While essentially all patients displayed SARS-CoV-2-specific antibodies and virus-neutralization capacity within 12-15 days, a rapid, mostly transient upregulation of selective inflammatory markers including IL-6, CXCL10, CXCL11, IFNγ, IL-10, and monocyte-attracting CCL2, CCL7 and CCL8, was particularly evident in ICU patients. In addition, there was consistent and sustained upregulation of apoptosis-associated proteins CASP8, TNFSF14, HGF, and TGFB1, with HGF discriminating between ICU and non-ICU cohorts. Thus, COVID-19 is associated with a selective inflammatory milieu within which the apoptotic pathway is a cardinal feature with potential to aid risk-based patient stratification.
ArticleNumber 20533
Author Kisand, Kai
Remm, Anu
Rumm, Anna Pauliina
Vapalahti, Olli
Peterson, Hedi
Krassohhina, Ekaterina
Kareinen, Lauri
Milani, Lili
Hayday, Adrian
Jürgenson, Meeri
Peterson, Pärt
Tamm, Anu
Sironen, Tarja
Salumets, Ahto
Sein, Hanna
Haljasmägi, Liis
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33239683$$D View this record in MEDLINE/PubMed
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Snippet SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk...
Abstract SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are...
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Antibodies
Apoptosis
Biomarkers - blood
Caspase 8 - blood
Chemokines - blood
Coronaviruses
COVID-19
COVID-19 - blood
COVID-19 - diagnosis
COVID-19 - virology
COVID-19 Testing - methods
CXCL10 protein
CXCL11 protein
Female
Hospitalization
Humanities and Social Sciences
Humans
Hypertension
Inflammation
Inflammation - blood
Intensive Care Units
Interleukin 10
Interleukin 6
Longitudinal Studies
Male
Middle Aged
Monocyte chemoattractant protein 1
Monocytes
multidisciplinary
Neutralization
Plasma proteins
Proteins
Proteome
Proteomics - methods
Risk Factors
SARS-CoV-2 - genetics
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Transforming growth factor-b1
Up-Regulation
Young Adult
γ-Interferon
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Title Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19
URI https://link.springer.com/article/10.1038/s41598-020-77525-w
https://www.ncbi.nlm.nih.gov/pubmed/33239683
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https://www.proquest.com/docview/2464607512
https://pubmed.ncbi.nlm.nih.gov/PMC7689507
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