RET rearrangements are actionable alterations in breast cancer - Paratala, Bhavna S.; Chung, Jon H.; Williams, Casey B.; Yilmazel, Bahar; Petrosky, Whitney; Williams, Kirstin; Schrock, Alexa B.; Gay, Laurie M.; Lee, Ellen; Dolfi, Sonia C.; Pham, Kien; Lin, Stephanie; et al. (Nature communications, 2018)
Keywords: 1-Phosphatidylinositol 3-kinase; 13/1; 13/106; 13/51; 13/56; 13/95; 38/22; 38/90; 42/109; 42/44; 45; 45/23; 45/70; 45/71; 45/77; 45/88; 45/91; 631/67/1059; 631/67/1347; 631/67/1857; 631/67/69; 631/67/70; 64/60; 82/29; 96/63; Amplification; Anilides - pharmacology; Animals; Antineoplastic Agents - pharmacology; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; Cell Line, Tumor; Cell Transformation, Neoplastic - drug effects; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; ErbB-2 protein; Female; Gene Expression Regulation, Neoplastic; Genetic transformation; Humanities and Social Sciences; Humans; Lung cancer; Lungs; MAP kinase; MCF-7 Cells; Metastases; Mice; Mice, Nude; Missense mutation; Mitogen-Activated Protein Kinases - genetics; Mitogen-Activated Protein Kinases - metabolism; multidisciplinary; Mutation; NIH 3T3 Cells; Nuclear Receptor Coactivators - genetics; Nuclear Receptor Coactivators - metabolism; Oncogene Proteins, Fusion - antagonists & inhibitors; Oncogene Proteins, Fusion - genetics; Oncogene Proteins, Fusion - metabolism; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Piperidines - pharmacology; Proto-Oncogene Proteins c-ret - antagonists & inhibitors; Proto-Oncogene Proteins c-ret - genetics; Proto-Oncogene Proteins c-ret - metabolism; Pyridines - pharmacology; Quinazolines - pharmacology; ras Guanine Nucleotide Exchange Factors - genetics; ras Guanine Nucleotide Exchange Factors - metabolism; Receptor, ErbB-2 - genetics; Receptor, ErbB-2 - metabolism; Ret protein; Science; Science (multidisciplinary); Signal Transduction; Therapeutic applications; Thyroid; Tyrosine kinase inhibitors; Xenograft Model Antitumor Assays; Xenografts; Xenotransplantation