Adaptive mutations of neuraminidase stalk truncation and deglycosylation confer enhanced pathogenicity of influenza A viruses - Park, Sehee; Il Kim, Jin; Lee, Ilseob; Bae, Joon-Yong; Yoo, Kirim; Nam, Misun; Kim, Juwon; Sook Park, Mee; Song, Ki-Joon; Song, Jin-Won; Kee, Sun-Ho; Park, Man-Seong (Scientific reports, 2017)
Keywords: 45/70; 45/77; 631/181/735; 631/326/596/1578; 82/1; 82/80; Adaptation; Amino acids; Animals; Aquatic birds; Avian flu; Deglycosylation; Disease Models, Animal; Disseminated infection; Ecological adaptation; Exo-a-sialidase; Ferrets; Genetic transformation; Genetics; Glycosylation; Humanities and Social Sciences; Influenza; Influenza A; Influenza A Virus, H1N1 Subtype - genetics; Influenza A Virus, H1N1 Subtype - pathogenicity; Influenza A Virus, H7N9 Subtype - genetics; Influenza A Virus, H7N9 Subtype - pathogenicity; Lung - pathology; Mice; Mice, Inbred BALB C; multidisciplinary; Mutation; Neuraminidase - genetics; Neuraminidase - metabolism; Orthomyxoviridae Infections - pathology; Orthomyxoviridae Infections - virology; Pandemics; Pathogenicity; Pathogens; Respiratory organs; Reverse Genetics; Science; Science (multidisciplinary); Sequence Deletion; Survival Analysis; Viral Proteins - genetics; Viral Proteins - metabolism; Virulence Factors - genetics; Virulence Factors - metabolism; Viruses