Women and other risk factors for chronic kidney disease of unknown etiology in Thailand: National Health Examination V Survey

• Published in: Scientific reports Vol. 11; no. 1; pp. 21366 - 11
• Main Authors: Aekplakorn, Wichai, Chariyalertsak, Suwat, Kessomboon, Pattapong, Assanangkornchai, Sawitri, Taneepanichskul, Surasak, Neelapaichit, Nareemarn, Chittamma, Anchalee, Kitiyakara, Chagriya
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308/174; 692/4022; 692/4022/1585/104; Adult; Age Factors; Aged; Aged, 80 and over; Cross-Sectional Studies; Diabetes mellitus; Epidermal growth factor receptors; Etiology; Female; Glomerular Filtration Rate; Gout; Humanities and Social Sciences; Humans; Hypertension; Kidney - physiopathology; Kidney diseases; Kidneys; Male; Middle Aged; multidisciplinary; Prevalence; Proteinuria; Renal Insufficiency, Chronic - etiology; Renal Insufficiency, Chronic - physiopathology; Risk Factors; Rural areas; Rural Population; Science; Science (multidisciplinary); Sex Factors; Thailand - epidemiology; Thailand
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-00694-9

There are limited data on chronic kidney disease of unknown etiology (CKDu) from Southeast Asia. Initially described in working age men, a common approach to detect CKDu that includes all adults has recently been proposed. We determined the prevalence, and risk factors for CKDu using data from a cross-sectional, nationally representative survey of the adult population of Thailand. We used a proxy for CKDu as age < 70 with impaired kidney function (eGFR < 60) in the absence of diabetes and hypertension (CKDu1) and heavy proteinuria (CKDu2). Prevalence estimates were probability-weighted for the Thai population. The associations between risk factors and CKDu or elderly subjects with eGFR < 60 without traditional causes were assessed by multivariable logistic regression. Of 17,329 subjects, the prevalence were: eGFR < 60, 5.3%; CKDu1 0.78%; CKDu2, 0.75%. CKDu differed by 4.3-folds between regions. Women, farmers/laborers, older age, gout, painkillers, rural area, and stones were independent risk factors for CKDu. Women, age, rural, gout, painkillers were significant risk factors for both CKDu and elderly subjects. These data collected using standardized methodology showed that the prevalence of CKDu in Thailand was low overall, although some regions had higher risk. Unlike other countries, Thai women had a two-fold higher risk of CKDu.