AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice - Han, Ya-chun; Tang, Shi-qi; Liu, Yu-ting; Li, Ai-mei; Zhan, Ming; Yang, Ming; Song, Na; Zhang, Wei; Wu, Xue-qin; Peng, Can-hui; Zhang, Hao; Yang, Shikun (Cell death & disease, 2021)
Keywords: 13/89; 14/1; 14/19; 14/28; 14/34; 64/60; 692/308/1426; 692/699/1585/104/1586; 692/699/2743/137/138; 8-Hydroxy-2'-Deoxyguanosine - metabolism; Agonists; AMP-Activated Protein Kinases - metabolism; Animals; Antibodies; Biochemistry; Biomedical and Life Sciences; Blood Glucose - metabolism; Blood Urea Nitrogen; Cell Biology; Cell Culture; Cell Line; Collagen Type I - metabolism; Creatinine; Creatinine - blood; Cytoplasm; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - pathology; Diabetic nephropathy; Diet, High-Fat; Drinking water; Fibronectins - metabolism; Fibrosis; High fat diet; Humans; Immunology; Interleukin-1beta - metabolism; Kidney - pathology; Kidney - ultrastructure; Kidneys; Life Sciences; Metformin; Metformin - pharmacology; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondria - metabolism; Mitochondria - ultrastructure; Mitophagy; Mitophagy - drug effects; Molecular modelling; Nephropathy; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Overexpression; Oxidation; Oxidative stress; Oxidative Stress - drug effects; Parkin protein; Phosphorylation - drug effects; Protein Kinases - metabolism; PTEN-induced putative kinase; Reactive Oxygen Species - metabolism; siRNA; Streptozocin; Ubiquitin-Protein Ligases - metabolism