PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis - Mzoughi, Slim; Fong, Jia Yi; Papadopoli, David; Koh, Cheryl M.; Hulea, Laura; Pigini, Paolo; Di Tullio, Federico; Andreacchio, Giuseppe; Hoppe, Michal Marek; Wollmann, Heike; Low, Diana; Caldez, Matias J.; et al. (Nature communications, 2020)
Keywords: 1-Phosphatidylinositol 3-kinase; 38; 38/15; 38/91; 631/337/2019; 631/67/1990/291/1621/1915; 64/60; 96/106; 96/95; AKT protein; Animals; Apoptosis - genetics; Apoptosis - physiology; B-cell lymphoma; Blotting, Western; Cancer; Cell death; Cell Survival - genetics; Cell Survival - physiology; Chromatin Immunoprecipitation; Computational Biology; Depletion; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Female; Flow Cytometry; Gene Expression Regulation - genetics; Gene Expression Regulation - physiology; Glycolysis; Homeostasis; Homology; Humanities and Social Sciences; Humans; Lymphocytes B; Lymphoma; Lymphoma - genetics; Lymphoma - metabolism; Metabolism; Mice; Mice, SCID; multidisciplinary; Oncology; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Random Allocation; Regulators; Science; Science (multidisciplinary); Stem cells; TOR protein; Transcription; Transcription Factors - genetics; Transcription Factors - metabolism; Transcriptome - genetics