Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish

Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network support essential developmental processes and their disruption lead to neurodevelopmental disorders and neurodegeneration. We report that de novo missense variants in ARF3 , encoding a small GTPase regulating Golgi...

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Published inNature communications Vol. 13; no. 1; pp. 6841 - 29
Main Authors Fasano, Giulia, Muto, Valentina, Radio, Francesca Clementina, Venditti, Martina, Mosaddeghzadeh, Niloufar, Coppola, Simona, Paradisi, Graziamaria, Zara, Erika, Bazgir, Farhad, Ziegler, Alban, Chillemi, Giovanni, Bertuccini, Lucia, Tinari, Antonella, Vetro, Annalisa, Pantaleoni, Francesca, Pizzi, Simone, Conti, Libenzio Adrian, Petrini, Stefania, Bruselles, Alessandro, Prandi, Ingrid Guarnetti, Mancini, Cecilia, Chandramouli, Balasubramanian, Barth, Magalie, Bris, Céline, Milani, Donatella, Selicorni, Angelo, Macchiaiolo, Marina, Gonfiantini, Michaela V., Bartuli, Andrea, Mariani, Riccardo, Curry, Cynthia J., Guerrini, Renzo, Slavotinek, Anne, Iascone, Maria, Dallapiccola, Bruno, Ahmadian, Mohammad Reza, Lauri, Antonella, Tartaglia, Marco
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 11.11.2022
Nature Publishing Group
Nature Portfolio
Subjects
13/109
13/2
13/51
14
14/19
14/28
14/63
42
45/23
59
631/136/1425
631/208/2489/144
631/80/642/1525
64/116
692/699/375/366
ADP-Ribosylation Factors - metabolism
Animals
Binding
Biosynthesis
Cell division
Danio rerio
Disease
Endoplasmic reticulum
Endoplasmic Reticulum - metabolism
Evolution
Functional analysis
Golgi apparatus
Golgi Apparatus - metabolism
Humanities and Social Sciences
Humans
Membranes
Microcephaly
Microencephaly
Morphology
multidisciplinary
Mutation
Nervous system
Neural stem cells
Neurodegeneration
Neurodevelopmental disorders
Neurodevelopmental Disorders - genetics
Neurodevelopmental Disorders - metabolism
Neurological diseases
Nucleotides
Pediatrics
Proteins
Science
Science (multidisciplinary)
Stability analysis
Zebrafish
Zebrafish - genetics
Zebrafish - metabolism
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/s41467-022-34354-x

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Abstract Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network support essential developmental processes and their disruption lead to neurodevelopmental disorders and neurodegeneration. We report that de novo missense variants in ARF3 , encoding a small GTPase regulating Golgi dynamics, cause a developmental disease in humans impairing nervous system and skeletal formation. Microcephaly-associated ARF3 variants affect residues within the guanine nucleotide binding pocket and variably perturb protein stability and GTP/GDP binding. Functional analysis demonstrates variably disruptive consequences of ARF3 variants on Golgi morphology, vesicles assembly and trafficking. Disease modeling in zebrafish validates further the dominant behavior of the mutants and their differential impact on brain and body plan formation, recapitulating the variable disease expression. In-depth in vivo analyses traces back impaired neural precursors’ proliferation and planar cell polarity-dependent cell movements as the earliest detectable effects. Our findings document a key role of ARF3 in Golgi function and demonstrate its pleiotropic impact on development. Disruptions to the ER-Golgi network can lead to neurodevelopmental disorders, though our understanding of these Golgipathies remains incomplete. Here Lauri, Tartaglia and colleagues show that ARF3 mutations cause a rare pediatric neurological disorder and perform detailed molecular characterization in fish.
AbstractList Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network support essential developmental processes and their disruption lead to neurodevelopmental disorders and neurodegeneration. We report that de novo missense variants in ARF3 , encoding a small GTPase regulating Golgi dynamics, cause a developmental disease in humans impairing nervous system and skeletal formation. Microcephaly-associated ARF3 variants affect residues within the guanine nucleotide binding pocket and variably perturb protein stability and GTP/GDP binding. Functional analysis demonstrates variably disruptive consequences of ARF3 variants on Golgi morphology, vesicles assembly and trafficking. Disease modeling in zebrafish validates further the dominant behavior of the mutants and their differential impact on brain and body plan formation, recapitulating the variable disease expression. In-depth in vivo analyses traces back impaired neural precursors’ proliferation and planar cell polarity-dependent cell movements as the earliest detectable effects. Our findings document a key role of ARF3 in Golgi function and demonstrate its pleiotropic impact on development. Disruptions to the ER-Golgi network can lead to neurodevelopmental disorders, though our understanding of these Golgipathies remains incomplete. Here Lauri, Tartaglia and colleagues show that ARF3 mutations cause a rare pediatric neurological disorder and perform detailed molecular characterization in fish.
Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network support essential developmental processes and their disruption lead to neurodevelopmental disorders and neurodegeneration. We report that de novo missense variants in ARF3, encoding a small GTPase regulating Golgi dynamics, cause a developmental disease in humans impairing nervous system and skeletal formation. Microcephaly-associated ARF3 variants affect residues within the guanine nucleotide binding pocket and variably perturb protein stability and GTP/GDP binding. Functional analysis demonstrates variably disruptive consequences of ARF3 variants on Golgi morphology, vesicles assembly and trafficking. Disease modeling in zebrafish validates further the dominant behavior of the mutants and their differential impact on brain and body plan formation, recapitulating the variable disease expression. In-depth in vivo analyses traces back impaired neural precursors’ proliferation and planar cell polarity-dependent cell movements as the earliest detectable effects. Our findings document a key role of ARF3 in Golgi function and demonstrate its pleiotropic impact on development. Disruptions to the ER-Golgi network can lead to neurodevelopmental disorders, though our understanding of these Golgipathies remains incomplete. Here Lauri, Tartaglia and colleagues show that ARF3 mutations cause a rare pediatric neurological disorder and perform detailed molecular characterization in fish.
Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network support essential developmental processes and their disruption lead to neurodevelopmental disorders and neurodegeneration. We report that de novo missense variants in ARF3, encoding a small GTPase regulating Golgi dynamics, cause a developmental disease in humans impairing nervous system and skeletal formation. Microcephaly-associated ARF3 variants affect residues within the guanine nucleotide binding pocket and variably perturb protein stability and GTP/GDP binding. Functional analysis demonstrates variably disruptive consequences of ARF3 variants on Golgi morphology, vesicles assembly and trafficking. Disease modeling in zebrafish validates further the dominant behavior of the mutants and their differential impact on brain and body plan formation, recapitulating the variable disease expression. In-depth in vivo analyses traces back impaired neural precursors' proliferation and planar cell polarity-dependent cell movements as the earliest detectable effects. Our findings document a key role of ARF3 in Golgi function and demonstrate its pleiotropic impact on development.Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network support essential developmental processes and their disruption lead to neurodevelopmental disorders and neurodegeneration. We report that de novo missense variants in ARF3, encoding a small GTPase regulating Golgi dynamics, cause a developmental disease in humans impairing nervous system and skeletal formation. Microcephaly-associated ARF3 variants affect residues within the guanine nucleotide binding pocket and variably perturb protein stability and GTP/GDP binding. Functional analysis demonstrates variably disruptive consequences of ARF3 variants on Golgi morphology, vesicles assembly and trafficking. Disease modeling in zebrafish validates further the dominant behavior of the mutants and their differential impact on brain and body plan formation, recapitulating the variable disease expression. In-depth in vivo analyses traces back impaired neural precursors' proliferation and planar cell polarity-dependent cell movements as the earliest detectable effects. Our findings document a key role of ARF3 in Golgi function and demonstrate its pleiotropic impact on development.
Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network support essential developmental processes and their disruption lead to neurodevelopmental disorders and neurodegeneration. We report that de novo missense variants in ARF3 , encoding a small GTPase regulating Golgi dynamics, cause a developmental disease in humans impairing nervous system and skeletal formation. Microcephaly-associated ARF3 variants affect residues within the guanine nucleotide binding pocket and variably perturb protein stability and GTP/GDP binding. Functional analysis demonstrates variably disruptive consequences of ARF3 variants on Golgi morphology, vesicles assembly and trafficking. Disease modeling in zebrafish validates further the dominant behavior of the mutants and their differential impact on brain and body plan formation, recapitulating the variable disease expression. In-depth in vivo analyses traces back impaired neural precursors’ proliferation and planar cell polarity-dependent cell movements as the earliest detectable effects. Our findings document a key role of ARF3 in Golgi function and demonstrate its pleiotropic impact on development.
Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network support essential developmental processes and their disruption lead to neurodevelopmental disorders and neurodegeneration. We report that de novo missense variants in ARF3, encoding a small GTPase regulating Golgi dynamics, cause a developmental disease in humans impairing nervous system and skeletal formation. Microcephaly-associated ARF3 variants affect residues within the guanine nucleotide binding pocket and variably perturb protein stability and GTP/GDP binding. Functional analysis demonstrates variably disruptive consequences of ARF3 variants on Golgi morphology, vesicles assembly and trafficking. Disease modeling in zebrafish validates further the dominant behavior of the mutants and their differential impact on brain and body plan formation, recapitulating the variable disease expression. In-depth in vivo analyses traces back impaired neural precursors’ proliferation and planar cell polarity-dependent cell movements as the earliest detectable effects. Our findings document a key role of ARF3 in Golgi function and demonstrate its pleiotropic impact on development.Disruptions to the ER-Golgi network can lead to neurodevelopmental disorders, though our understanding of these Golgipathies remains incomplete. Here Lauri, Tartaglia and colleagues show that ARF3 mutations cause a rare pediatric neurological disorder and perform detailed molecular characterization in fish.
Disruptions to the ER-Golgi network can lead to neurodevelopmental disorders, though our understanding of these Golgipathies remains incomplete. Here Lauri, Tartaglia and colleagues show that ARF3 mutations cause a rare pediatric neurological disorder and perform detailed molecular characterization in fish.
Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network support essential developmental processes and their disruption lead to neurodevelopmental disorders and neurodegeneration. We report that de novo missense variants in ARF3, encoding a small GTPase regulating Golgi dynamics, cause a developmental disease in humans impairing nervous system and skeletal formation. Microcephaly-associated ARF3 variants affect residues within the guanine nucleotide binding pocket and variably perturb protein stability and GTP/GDP binding. Functional analysis demonstrates variably disruptive consequences of ARF3 variants on Golgi morphology, vesicles assembly and trafficking. Disease modeling in zebrafish validates further the dominant behavior of the mutants and their differential impact on brain and body plan formation, recapitulating the variable disease expression. In-depth in vivo analyses traces back impaired neural precursors' proliferation and planar cell polarity-dependent cell movements as the earliest detectable effects. Our findings document a key role of ARF3 in Golgi function and demonstrate its pleiotropic impact on development.
ArticleNumber 6841
Author Venditti, Martina
Pizzi, Simone
Mancini, Cecilia
Tartaglia, Marco
Curry, Cynthia J.
Ahmadian, Mohammad Reza
Bazgir, Farhad
Gonfiantini, Michaela V.
Chandramouli, Balasubramanian
Milani, Donatella
Mosaddeghzadeh, Niloufar
Barth, Magalie
Fasano, Giulia
Petrini, Stefania
Iascone, Maria
Slavotinek, Anne
Coppola, Simona
Conti, Libenzio Adrian
Paradisi, Graziamaria
Zara, Erika
Macchiaiolo, Marina
Tinari, Antonella
Bris, Céline
Vetro, Annalisa
Bruselles, Alessandro
Selicorni, Angelo
Mariani, Riccardo
Radio, Francesca Clementina
Lauri, Antonella
Chillemi, Giovanni
Bertuccini, Lucia
Ziegler, Alban
Guerrini, Renzo
Pantaleoni, Francesca
Bartuli, Andrea
Muto, Valentina
Prandi, Ingrid Guarnetti
Dallapiccola, Bruno
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36369169$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/S0955-0674(99)80067-2
10.1038/360350a0
10.1101/cshperspect.a022392
10.4161/cl.21627
10.1136/jmedgenet-2018-105503
10.3389/fcell.2021.784700
10.1074/jbc.M111.267971
10.3389/fnins.2019.01381
10.1242/dev.082362
10.1086/504394
10.1063/1.464397
10.1101/cshperspect.a005256
10.3389/fcell.2021.642235
10.1136/jmg.2007.055772
10.1038/ncb2508
10.1056/NEJMra0910494
10.1093/hmg/ddu148
10.1186/1471-2202-10-27
10.1038/onc.2011.100
10.1016/j.cell.2008.04.037
10.1074/jbc.M611716200
10.1083/jcb.20111048
10.1038/npjgenmed.2016.36
10.1038/360352a0
10.1091/mbc.E20-02-0129
10.1136/jmg.2007.050450
10.1093/embo-reports/kvf221
10.1038/s41467-019-13484-9
10.1038/nrm3117
10.1002/humu.22844
10.1038/gim.0b013e31822dd91f
10.1096/fasebj.10.12.8903506
10.1038/ncomms4885
10.1016/j.ajhg.2019.04.013
10.1091/mbc.e06-09-0798
10.1172/JCI0215420
10.1101/gad.348866.121
10.1038/ng1276
10.1111/j.1749-6632.2010.05790.x
10.1091/mbc.e04-12-1042
10.1111/cge.13603
10.1038/372704a0
10.1016/j.ceb.2017.03.008
10.1136/jmg.2006.046300
10.3389/fcell.2019.00112
10.1016/j.semcdb.2009.09.004
10.15252/embj.2020106118
10.1016/j.ajhg.2016.06.011
10.1091/mbc.02-01-0007
10.1002/humu.20616
10.3389/fnhum.2014.00497
10.1242/jcs.03066
10.1242/bio.20122659
10.1016/j.ydbio.2010.03.008
10.1038/nrm3332
10.1074/jbc.272.7.4141
10.1074/jbc.M106660200
10.7554/eLife.51221
10.1002/ajmg.a.40635
10.1002/1873-3468.12931
10.1038/ng1748
10.1038/ncb828
10.1016/j.ajhg.2019.04.014
10.1038/s41580-018-0053-7
10.1186/1750-1172-8-178
10.1016/j.ajhg.2020.11.015
10.1093/hmg/ddab224
10.1073/pnas.95.11.6187
10.1002/aja.1002030302
10.1091/mbc.e07-08-0847
10.1038/372055a0
10.1093/nar/gky1015
10.1002/dvdy.21354
10.1002/1873-3468.13567
10.1080/21541248.2017.1304854
10.1111/tra.12390
10.1091/mbc.e10-01-0016
10.1242/jcs.114.24.4543
10.1002/bies.201700063
10.1073/pnas.1320192111
10.1091/mbc.E17-11-0622
10.1016/j.neuron.2005.11.005
10.1073/pnas.2234055100
10.1371/journal.pone.0010367
10.1083/jcb.124.3.289
10.1002/jcc.23354
10.1016/j.devcel.2018.02.025
10.1016/j.cell.2012.01.015
10.1016/j.ajhg.2019.04.002
10.4161/cc.10.11.15797
10.1093/hmg/ddv038
10.1186/s13229-017-0168-2
10.1091/mbc.e03-12-0872
10.1093/nar/gkx1153
10.1093/nar/gky427
10.1002/humu.20431
10.1042/BST20180323
10.1016/S0092-8674(00)81754-7
10.1074/jbc.M111.261800
10.1038/nrm1315
10.1063/1.2408420
10.1074/jbc.272.49.30848
10.1093/hmg/ddz108
10.1016/S0959-440X(02)00344-5
10.1089/zeb.2016.1321
10.1073/pnas.1905095116
10.1038/ncomms7751
10.1016/j.cell.2005.06.043
10.1002/jcc.20084
10.1038/nrm1910
10.1016/S0021-9258(17)42277-0
10.1016/j.tig.2022.02.012
10.1038/nmeth.2019
10.1074/jbc.M009771200
10.1083/jcb.202106100
10.1016/S0021-9258(18)98387-0
10.1016/j.ceb.2019.10.003
10.1093/jb/mvv088
10.1101/cshperspect.a016774
10.1098/rsob.130065
10.1159/000497035
10.3109/10409238.2015.1085827
10.1016/j.devcel.2005.08.011
10.1152/ajpcell.00462.2010
10.1038/nprot.2007.514
10.1042/bj3240413
10.1247/csf.12015
10.1038/sj.emboj.7601634
10.1038/jid.2015.55
10.1063/5.0018516
10.1073/pnas.170290597
10.1016/S1534-5807(02)00197-1
10.1091/mbc.e15-08-0558
10.1021/jp003020w
10.1126/science.8290961
10.1038/s41467-021-27705-7
10.1016/j.devcel.2004.07.020
10.1016/j.ajhg.2021.01.015
10.1007/s00439-015-1632-8
10.1016/0263-7855(96)00018-5
10.1146/annurev-cellbio-100913-013012
10.1126/science.273.5276.797
10.1146/annurev.cellbio.23.090506.123209
10.1073/pnas.1000219107
10.3389/fcell.2022.925228
10.1073/pnas.1432391100
10.1016/j.cell.2015.06.014
10.3389/fnmol.2022.855786
10.1093/brain/awab052
10.3791/62642
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References Ratcliffe, Sahgal, Parachoniak, Ivaska, Park (CR60) 2016; 17
Denayer (CR102) 2008; 29
Cockcroft (CR2) 1994; 263
Coutinho (CR128) 2004; 7
Ménétrey (CR58) 2007; 26
Gebhardt (CR82) 2019; 10
Shamseldin, Bennett, Alfadhel, Gupta, Alkuraya (CR11) 2016; 135
Mark, Nilsson (CR141) 2001; 105
Johnson, Chen, Murchison, Green, Enns (CR75) 2007; 18
De Matteis, Luini (CR9) 2011; 365
Northup, Jian, Randazzo (CR111) 2012; 2
Randazzo (CR33) 1997; 324
Rothman (CR35) 1994; 372
Pettersen (CR137) 2004; 25
CR153
Chen (CR87) 2014; 5
Kulkarni-Gosavi, Makhoul, Gleeson (CR39) 2019; 593
Nakayama (CR45) 2016; 51
Petko (CR48) 2009; 10
Jessen (CR120) 2002; 4
Gripp, Lin (CR108) 2012; 14
Lu, Tai, Hong (CR62) 2004; 15
Makhoul, Gosavi, Gleeson (CR5) 2018; 46
Zaqout, Kaindl (CR79) 2022; 9
Kodani, Sütterlin (CR88) 2008; 19
Burd, Cullen (CR113) 2014; 6
Liu (CR118) 2021; 68
Cole (CR146) 1996; 273
Lauri, Fasano, Venditti, Dallapiccola, Tartaglia (CR123) 2021; 9
Lee (CR52) 2019; 116
Tang, Yuan, Vielemeyer, Perez, Wang (CR154) 2012; 1
Hanai (CR44) 2016; 159
Wallingford, Fraser, Harland (CR122) 2002; 2
Horton (CR129) 2005; 48
Volpicelli-Daley, Li, Zhang, Kahn (CR20) 2005; 16
Carvajal-Gonzalez (CR47) 2015; 6
Takahashi (CR71) 2012; 125
Tartaglia, Gelb (CR97) 2010; 1214
Joshi, Chi, Huang, Wang (CR64) 2014; 111
Kimmel, Ballard, Kimmel, Ullmann, Schilling (CR76) 1995; 203
Pasqualato, Renault, Cherfils (CR53) 2002; 3
Rodrigues, Harris (CR46) 2019; 10
Boulay (CR119) 2011; 30
Phan, Holland (CR80) 2021; 35
Schindelin (CR151) 2012; 9
Carta (CR54) 2006; 79
Humphrey, Dalke, Schulten (CR135) 1996; 14
Munro (CR38) 2011; 3
Dunbrack (CR138) 2002; 12
Izumi (CR14) 2016; 99
Zaghloul (CR77) 2010; 107
Barkovich, Dobyns, Guerrini (CR86) 2015; 5
Kim (CR117) 2017; 8
CR134
Gillingham, Munro (CR25) 2007; 23
Manolea (CR65) 2010; 21
Dascher, Balch (CR41) 1994; 269
Helms, Rothman (CR27) 1992; 360
Merithew (CR109) 2001; 276
Prigozhina, Waterman-Storer (CR124) 2006; 119
Ito, Tanaka, Okamoto, Ohshima (CR83) 2010; 342
Bagwell (CR94) 2020; 9
Villefranc, Amigo, Lawson (CR144) 2007; 236
CR150
Phan (CR85) 2021; 40
Sheen (CR16) 2004; 36
Gosavi, Gleeson (CR6) 2017; 39
García-Cazorla, Oyarzábal, Saudubray, Martinelli, Dionisi-Vici (CR115) 2022; 38
Ayala, Colanzi (CR116) 2022; 10
Tate (CR96) 2019; 47
Lim (CR103) 2015; 135
Denayer, de Ravel, Legius (CR110) 2008; 45
Novorol (CR93) 2013; 3
Waterhouse (CR136) 2018; 46
Halperin (CR15) 2019; 56
D’Souza-Schorey, Chavrier (CR1) 2006; 7
Lin (CR133) 2021; 108
Kondo (CR40) 2012; 37
Kjeldgaard, Nyborg, Clark (CR32) 1996; 10
Nava (CR107) 2007; 44
Khan, Ménétrey (CR24) 2013; 21
Dupuis (CR13) 2015; 24
Landrum (CR106) 2018; 46
Hsu, Bai, Li (CR66) 2012; 13
Zenker (CR105) 2007; 44
Rasika, Passemard, Verloes, Gressens, El Ghouzzi (CR12) 2018; 40
Reinhard, Schweikert, Wieland, Nickel (CR34) 2003; 100
Amor (CR57) 2001; 276
Schubbert (CR104) 2006; 38
Donaldson, Jackson (CR22) 2011; 12
Darden, York, Pedersen (CR143) 1993; 98
Xiang, Seemann, Bisel, Punthambaker, Wang (CR61) 2007; 282
Makhoul, Gosavi, Gleeson (CR4) 2019; 7
Pennauer, Buczak, Prescianotto-Baschong, Spiess (CR112) 2022; 221
Thisse, Thisse (CR155) 2008; 3
Seifert (CR10) 2011; 286
Maxfield, McGraw (CR72) 2004; 5
Pezzani (CR130) 2018; 176
Peri, Nüsslein-Volhard (CR148) 2008; 133
Niihori (CR100) 2019; 104
Robineau, Chabre, Antonny (CR42) 2000; 97
Mani (CR68) 2016; 27
Carpentieri (CR114) 2022; 13
Gammella (CR74) 2021; 32
Flex (CR99) 2014; 23
Tran (CR149) 2012; 139
Capri (CR101) 2019; 104
Sheff, Pelletier, O’Connell, Warren, Mellman (CR67) 2002; 156
Chavrier, Goud (CR21) 1999; 11
Rink, Ghigo, Kalaidzidis, Zerial (CR69) 2005; 122
CR84
Popoff (CR36) 2011; 286
CR81
Guo, Sirkis, Schekman (CR3) 2014; 30
Ebanks, Lewis, Bandopadhyay (CR18) 2019; 13
Bussi, Donadio, Parrinello (CR142) 2007; 126
Randazzo, Yang, Rulka, Kahn (CR28) 1993; 268
Ravichandran, Goud, Manneville (CR95) 2020; 62
Xie, Hur, Zhao, Abrams, Bankaitis (CR8) 2018; 44
Zhang (CR23) 1994; 124
Liang, Kornfeld (CR19) 1997; 272
Páll (CR139) 2020; 153
Zhang (CR90) 2011; 10
Amor, Harrison, Kahn, Ringe (CR31) 1994; 372
Lu, Horstmann, Ng, Hong (CR63) 2001; 114
Choudhury (CR147) 2002; 109
Cullen, Steinberg (CR73) 2018; 19
Farag (CR92) 2013; 8
Goldberg (CR30) 1998; 95
Sakamoto (CR50) 2021; 31
Zampino (CR55) 2007; 28
Altan-Bonnet, Phair, Polishchuk, Weigert, Lippincott-Schwartz (CR43) 2003; 100
Ulrich (CR126) 2005; 9
Radio (CR132) 2021; 108
Huang, MacKerell (CR140) 2013; 34
Wei, Seemann (CR7) 2017; 47
Suárez, Gobius, Richards (CR78) 2014; 8
Sarmah (CR127) 2010; 5
Ge (CR49) 2016; 1
Ren (CR70) 1998; 95
Wei, Zhang, Wynn, Seemann (CR89) 2015; 162
Yu, Breitman, Goldberg (CR59) 2012; 148
Motta (CR98) 2020; 29
Dunn, Kamocka, McDonald (CR152) 2011; 300
Gilbert, Sztul, Machamer (CR37) 2018; 29
Donaldson, Finazzi, Klausner (CR26) 1992; 360
Sobreira, Schiettecatte, Valle, Hamosh (CR51) 2015; 36
Winter (CR125) 2012; 14
Ansar (CR91) 2019; 104
Antonny, Huber, Paris, Chabre, Cassel (CR29) 1997; 272
Don (CR145) 2017; 14
Ziegler (CR131) 2019; 96
Roszko, Sawada, Solnica-Krezel (CR121) 2009; 20
Click, Stearns, Botstein (CR56) 2002; 13
Cui, Yang, Teasdale (CR17) 2018; 592
JR Jessen (34354_CR120) 2002; 4
C Dascher (34354_CR41) 1994; 269
CDH Ratcliffe (34354_CR60) 2016; 17
T Darden (34354_CR143) 1993; 98
LA Volpicelli-Daley (34354_CR20) 2005; 16
CE Gilbert (34354_CR37) 2018; 29
JA Petko (34354_CR48) 2009; 10
EF Pettersen (34354_CR137) 2004; 25
C Makhoul (34354_CR5) 2018; 46
E Denayer (34354_CR102) 2008; 29
C Thisse (34354_CR155) 2008; 3
L Lu (34354_CR62) 2004; 15
S Rasika (34354_CR12) 2018; 40
CB Kimmel (34354_CR76) 1995; 203
Y-C Lin (34354_CR133) 2021; 108
Y Cui (34354_CR17) 2018; 592
J Bagwell (34354_CR94) 2020; 9
C Nava (34354_CR107) 2007; 44
J Huang (34354_CR140) 2013; 34
L Lu (34354_CR63) 2001; 114
C Gebhardt (34354_CR82) 2019; 10
RL Dunbrack (34354_CR138) 2002; 12
CJ Zhang (34354_CR23) 1994; 124
C Novorol (34354_CR93) 2013; 3
M Pennauer (34354_CR112) 2022; 221
M Ansar (34354_CR91) 2019; 104
K Ebanks (34354_CR18) 2019; 13
34354_CR81
P-L Boulay (34354_CR119) 2011; 30
A Choudhury (34354_CR147) 2002; 109
PA Randazzo (34354_CR33) 1997; 324
MA De Matteis (34354_CR9) 2011; 365
34354_CR84
D Halperin (34354_CR15) 2019; 56
D Tang (34354_CR154) 2012; 1
M Kjeldgaard (34354_CR32) 1996; 10
M Ren (34354_CR70) 1998; 95
T Niihori (34354_CR100) 2019; 104
JK Northup (34354_CR111) 2012; 2
D Sheff (34354_CR67) 2002; 156
A Hanai (34354_CR44) 2016; 159
A Kodani (34354_CR88) 2008; 19
Y Xiang (34354_CR61) 2007; 282
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HE Shamseldin (34354_CR11) 2016; 135
N Sobreira (34354_CR51) 2015; 36
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MB Johnson (34354_CR75) 2007; 18
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JB Helms (34354_CR27) 1992; 360
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AK Gillingham (34354_CR25) 2007; 23
M Zenker (34354_CR105) 2007; 44
S Zaqout (34354_CR79) 2022; 9
A Waterhouse (34354_CR136) 2018; 46
PJ Cullen (34354_CR73) 2018; 19
Y Guo (34354_CR3) 2014; 30
B Antonny (34354_CR29) 1997; 272
K Nakayama (34354_CR45) 2016; 51
YH Lim (34354_CR103) 2015; 135
S Páll (34354_CR139) 2020; 153
P Mark (34354_CR141) 2001; 105
A Ziegler (34354_CR131) 2019; 96
HG Farag (34354_CR92) 2013; 8
F Ulrich (34354_CR126) 2005; 9
34354_CR150
PA Randazzo (34354_CR28) 1993; 268
VW Hsu (34354_CR66) 2012; 13
Y Capri (34354_CR101) 2019; 104
P Gosavi (34354_CR6) 2017; 39
Y Lee (34354_CR52) 2019; 116
C Carta (34354_CR54) 2006; 79
J Ménétrey (34354_CR58) 2007; 26
JG Donaldson (34354_CR22) 2011; 12
R Suárez (34354_CR78) 2014; 8
S Munro (34354_CR38) 2011; 3
G Bussi (34354_CR142) 2007; 126
NB Cole (34354_CR146) 1996; 273
X Yu (34354_CR59) 2012; 148
C-H Zhang (34354_CR90) 2011; 10
I Ayala (34354_CR116) 2022; 10
C Burd (34354_CR113) 2014; 6
ES Click (34354_CR56) 2002; 13
X Ge (34354_CR49) 2016; 1
FC Radio (34354_CR132) 2021; 108
O-H Kim (34354_CR117) 2017; 8
JC Amor (34354_CR31) 1994; 372
M Tartaglia (34354_CR97) 2010; 1214
NL Prigozhina (34354_CR124) 2006; 119
A García-Cazorla (34354_CR115) 2022; 38
G Joshi (34354_CR64) 2014; 111
34354_CR134
KW Gripp (34354_CR108) 2012; 14
J Schindelin (34354_CR151) 2012; 9
NA Zaghloul (34354_CR77) 2010; 107
E Merithew (34354_CR109) 2001; 276
M Sakamoto (34354_CR50) 2021; 31
EK Don (34354_CR145) 2017; 14
Z Xie (34354_CR8) 2018; 44
J Goldberg (34354_CR30) 1998; 95
TP Phan (34354_CR80) 2021; 35
S Pasqualato (34354_CR53) 2002; 3
J Liu (34354_CR118) 2021; 68
E Flex (34354_CR99) 2014; 23
S Takahashi (34354_CR71) 2012; 125
JG Tate (34354_CR96) 2019; 47
W Humphrey (34354_CR135) 1996; 14
FR Maxfield (34354_CR72) 2004; 5
AC Horton (34354_CR129) 2005; 48
JG Donaldson (34354_CR26) 1992; 360
Y Kondo (34354_CR40) 2012; 37
C D’Souza-Schorey (34354_CR1) 2006; 7
P Coutinho (34354_CR128) 2004; 7
J Rink (34354_CR69) 2005; 122
TP Phan (34354_CR85) 2021; 40
P Chavrier (34354_CR21) 1999; 11
J-F Chen (34354_CR87) 2014; 5
F Manolea (34354_CR65) 2010; 21
S Cockcroft (34354_CR2) 1994; 263
JM Carvajal-Gonzalez (34354_CR47) 2015; 6
L Pezzani (34354_CR130) 2018; 176
JC Amor (34354_CR57) 2001; 276
N Dupuis (34354_CR13) 2015; 24
JA Villefranc (34354_CR144) 2007; 236
M Mani (34354_CR68) 2016; 27
P Kulkarni-Gosavi (34354_CR39) 2019; 593
C Makhoul (34354_CR4) 2019; 7
F Peri (34354_CR148) 2008; 133
VL Sheen (34354_CR16) 2004; 36
K Izumi (34354_CR14) 2016; 99
S Robineau (34354_CR42) 2000; 97
JE Rothman (34354_CR35) 1994; 372
C Reinhard (34354_CR34) 2003; 100
FF Rodrigues (34354_CR46) 2019; 10
J-H Wei (34354_CR89) 2015; 162
N Altan-Bonnet (34354_CR43) 2003; 100
AJ Barkovich (34354_CR86) 2015; 5
M Motta (34354_CR98) 2020; 29
JB Wallingford (34354_CR122) 2002; 2
I Roszko (34354_CR121) 2009; 20
Y Ravichandran (34354_CR95) 2020; 62
KW Dunn (34354_CR152) 2011; 300
E Gammella (34354_CR74) 2021; 32
G Zampino (34354_CR55) 2007; 28
JF Winter (34354_CR125) 2012; 14
References_xml – ident: CR150
– volume: 11
  start-page: 466
  year: 1999
  end-page: 475
  ident: CR21
  article-title: The role of ARF and Rab GTPases in membrane transport
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/S0955-0674(99)80067-2
– volume: 360
  start-page: 350
  year: 1992
  end-page: 352
  ident: CR26
  article-title: Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein
  publication-title: Nature
  doi: 10.1038/360350a0
– volume: 5
  start-page: a022392
  year: 2015
  ident: CR86
  article-title: Malformations of cortical development and epilepsy
  publication-title: Cold Spring Harb. Perspect. Med.
  doi: 10.1101/cshperspect.a022392
– volume: 2
  start-page: 140
  year: 2012
  end-page: 146
  ident: CR111
  article-title: Nucleotide exchange factors
  publication-title: Cell. Logist.
  doi: 10.4161/cl.21627
– volume: 56
  start-page: 139
  year: 2019
  end-page: 148
  ident: CR15
  article-title: SEC31A mutation affects ER homeostasis, causing a neurological syndrome
  publication-title: J. Med. Genet.
  doi: 10.1136/jmedgenet-2018-105503
– volume: 9
  start-page: 784700
  year: 2022
  ident: CR79
  article-title: Autosomal Recessive Primary Microcephaly: Not Just a Small Brain
  publication-title: Front. Cell Dev. Biol
  doi: 10.3389/fcell.2021.784700
– volume: 286
  start-page: 37665
  year: 2011
  end-page: 37675
  ident: CR10
  article-title: Cohen syndrome-associated protein, COH1, is a novel, giant Golgi matrix protein required for Golgi integrity
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.267971
– volume: 13
  start-page: 1381
  year: 2019
  ident: CR18
  article-title: Vesicular dysfunction and the pathogenesis of Parkinson’s disease: clues from genetic studies
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2019.01381
– volume: 139
  start-page: 3644
  year: 2012
  end-page: 3652
  ident: CR149
  article-title: Dynamic microtubules at the vegetal cortex predict the embryonic axis in zebrafish
  publication-title: Development
  doi: 10.1242/dev.082362
– volume: 79
  start-page: 129
  year: 2006
  end-page: 135
  ident: CR54
  article-title: Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/504394
– volume: 98
  start-page: 10089
  year: 1993
  end-page: 10092
  ident: CR143
  article-title: Particle mesh Ewald: an ⋅log( ) method for Ewald sums in large systems
  publication-title: J. Chem. Phys.
  doi: 10.1063/1.464397
– volume: 21
  start-page: 1284
  year: 2013
  end-page: 1297
  ident: CR24
  article-title: Structural biology of Arf and Rab GTPases’ effector recruitment and specificity
  publication-title: Struct. Lond. Engl. 1993
– volume: 3
  start-page: a005256
  year: 2011
  ident: CR38
  article-title: The golgin coiled-coil proteins of the Golgi apparatus
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a005256
– volume: 9
  start-page: 642235
  year: 2021
  ident: CR123
  article-title: In vivo functional genomics for undiagnosed patients: the impact of small GTPases signaling dysregulation at pan-embryo developmental scale
  publication-title: Front. Cell Dev. Biol
  doi: 10.3389/fcell.2021.642235
– volume: 45
  start-page: 695
  year: 2008
  end-page: 703
  ident: CR110
  article-title: Clinical and molecular aspects of RAS related disorders
  publication-title: J. Med. Genet.
  doi: 10.1136/jmg.2007.055772
– volume: 14
  start-page: 666
  year: 2012
  end-page: 676
  ident: CR125
  article-title: screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2508
– volume: 365
  start-page: 927
  year: 2011
  end-page: 938
  ident: CR9
  article-title: Mendelian disorders of membrane trafficking
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra0910494
– volume: 23
  start-page: 4315
  year: 2014
  end-page: 4327
  ident: CR99
  article-title: Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddu148
– volume: 10
  year: 2009
  ident: CR48
  article-title: Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish
  publication-title: BMC Neurosci.
  doi: 10.1186/1471-2202-10-27
– volume: 30
  start-page: 3846
  year: 2011
  end-page: 3861
  ident: CR119
  article-title: ARF1 controls proliferation of breast cancer cells by regulating the retinoblastoma protein
  publication-title: Oncogene
  doi: 10.1038/onc.2011.100
– volume: 133
  start-page: 916
  year: 2008
  end-page: 927
  ident: CR148
  article-title: Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivo
  publication-title: Cell
  doi: 10.1016/j.cell.2008.04.037
– volume: 282
  start-page: 21829
  year: 2007
  end-page: 21837
  ident: CR61
  article-title: Active ADP-ribosylation factor-1 (ARF1) is required for mitotic Golgi fragmentation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M611716200
– volume: 156
  start-page: 797
  year: 2002
  end-page: 804
  ident: CR67
  article-title: Transferrin receptor recycling in the absence of perinuclear recycling endosomes
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.20111048
– volume: 1
  start-page: 16036
  year: 2016
  ident: CR49
  article-title: Missense-depleted regions in population exomes implicate ras superfamily nucleotide-binding protein alteration in patients with brain malformation
  publication-title: NPJ Genom. Med
  doi: 10.1038/npjgenmed.2016.36
– volume: 360
  start-page: 352
  year: 1992
  end-page: 354
  ident: CR27
  article-title: Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF
  publication-title: Nature
  doi: 10.1038/360352a0
– volume: 32
  start-page: 98
  year: 2021
  end-page: 108
  ident: CR74
  article-title: Unconventional endocytosis and trafficking of transferrin receptor induced by iron
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.E20-02-0129
– volume: 44
  start-page: 763
  year: 2007
  end-page: 771
  ident: CR107
  article-title: Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome
  publication-title: J. Med. Genet.
  doi: 10.1136/jmg.2007.050450
– volume: 3
  start-page: 1035
  year: 2002
  end-page: 1041
  ident: CR53
  article-title: Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for ‘front-back’ communication
  publication-title: EMBO Rep.
  doi: 10.1093/embo-reports/kvf221
– volume: 10
  year: 2019
  ident: CR82
  article-title: An interhemispheric neural circuit allowing binocular integration in the optic tectum
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-13484-9
– ident: CR153
– volume: 12
  start-page: 362
  year: 2011
  end-page: 375
  ident: CR22
  article-title: ARF family G proteins and their regulators: roles in membrane transport, development and disease
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3117
– volume: 36
  start-page: 928
  year: 2015
  end-page: 930
  ident: CR51
  article-title: GeneMatcher: a matching tool for connecting investigators with an interest in the same gene
  publication-title: Hum. Mutat.
  doi: 10.1002/humu.22844
– volume: 14
  start-page: 285
  year: 2012
  end-page: 292
  ident: CR108
  article-title: Costello syndrome: a Ras/mitogen activated protein kinase pathway syndrome (rasopathy) resulting from HRAS germline mutations
  publication-title: Genet. Med.
  doi: 10.1038/gim.0b013e31822dd91f
– volume: 10
  start-page: 1347
  year: 1996
  end-page: 1368
  ident: CR32
  article-title: The GTP binding motif: variations on a theme
  publication-title: FASEB J.
  doi: 10.1096/fasebj.10.12.8903506
– volume: 5
  year: 2014
  ident: CR87
  article-title: Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms4885
– volume: 104
  start-page: 1223
  year: 2019
  end-page: 1232
  ident: CR101
  article-title: Activating mutations of RRAS2 are a rare cause of Noonan syndrome
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2019.04.013
– volume: 18
  start-page: 743
  year: 2007
  end-page: 754
  ident: CR75
  article-title: Transferrin receptor 2: evidence for ligand-induced stabilization and redirection to a recycling pathway
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e06-09-0798
– volume: 109
  start-page: 1541
  year: 2002
  end-page: 1550
  ident: CR147
  article-title: Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann–Pick C cells
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI0215420
– volume: 35
  start-page: 1551
  year: 2021
  end-page: 1578
  ident: CR80
  article-title: Time is of the essence: the molecular mechanisms of primary microcephaly
  publication-title: Genes Dev.
  doi: 10.1101/gad.348866.121
– volume: 36
  start-page: 69
  year: 2004
  end-page: 76
  ident: CR16
  article-title: Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex
  publication-title: Nat. Genet.
  doi: 10.1038/ng1276
– volume: 1214
  start-page: 99
  year: 2010
  end-page: 121
  ident: CR97
  article-title: Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanisms
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.2010.05790.x
– volume: 16
  start-page: 4495
  year: 2005
  end-page: 4508
  ident: CR20
  article-title: Isoform-selective effects of the depletion of ADP-ribosylation factors 1–5 on membrane traffic
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e04-12-1042
– volume: 96
  start-page: 354
  year: 2019
  end-page: 358
  ident: CR131
  article-title: Confirmation that variants in TTI2 are responsible for autosomal recessive intellectual disability
  publication-title: Clin. Genet.
  doi: 10.1111/cge.13603
– volume: 372
  start-page: 704
  year: 1994
  end-page: 708
  ident: CR31
  article-title: Structure of the human ADP-ribosylation factor 1 complexed with GDP
  publication-title: Nature
  doi: 10.1038/372704a0
– volume: 47
  start-page: 43
  year: 2017
  end-page: 51
  ident: CR7
  article-title: Golgi ribbon disassembly during mitosis, differentiation and disease progression
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2017.03.008
– volume: 44
  start-page: 131
  year: 2007
  end-page: 135
  ident: CR105
  article-title: Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations
  publication-title: J. Med. Genet.
  doi: 10.1136/jmg.2006.046300
– volume: 7
  start-page: 112
  year: 2019
  ident: CR4
  article-title: Golgi dynamics: the morphology of the mammalian Golgi apparatus in health and disease
  publication-title: Front. Cell Dev. Biol.
  doi: 10.3389/fcell.2019.00112
– volume: 20
  start-page: 986
  year: 2009
  end-page: 997
  ident: CR121
  article-title: Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway
  publication-title: Semin. Cell Dev. Biol.
  doi: 10.1016/j.semcdb.2009.09.004
– volume: 40
  start-page: e106118
  year: 2021
  ident: CR85
  article-title: Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway
  publication-title: EMBO J.
  doi: 10.15252/embj.2020106118
– volume: 99
  start-page: 451
  year: 2016
  end-page: 459
  ident: CR14
  article-title: ARCN1 mutations cause a recognizable craniofacial syndrome due to COPI-mediated transport defects
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2016.06.011
– volume: 13
  start-page: 1652
  year: 2002
  end-page: 1664
  ident: CR56
  article-title: Systematic structure-function analysis of the small GTPase Arf1 in yeast
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.02-01-0007
– volume: 29
  start-page: 232
  year: 2008
  end-page: 239
  ident: CR102
  article-title: Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation
  publication-title: Hum. Mutat.
  doi: 10.1002/humu.20616
– volume: 8
  start-page: 497
  year: 2014
  ident: CR78
  article-title: Evolution and development of interhemispheric connections in the vertebrate forebrain
  publication-title: Front. Hum. Neurosci.
  doi: 10.3389/fnhum.2014.00497
– volume: 119
  start-page: 3571
  year: 2006
  end-page: 3582
  ident: CR124
  article-title: Decreased polarity and increased random motility in PtK1 epithelial cells correlate with inhibition of endosomal recycling
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.03066
– volume: 1
  start-page: 1204
  year: 2012
  end-page: 1214
  ident: CR154
  article-title: Sequential phosphorylation of GRASP65 during mitotic Golgi disassembly
  publication-title: Biol. Open
  doi: 10.1242/bio.20122659
– volume: 342
  start-page: 26
  year: 2010
  end-page: 38
  ident: CR83
  article-title: Characterization of neural stem cells and their progeny in the adult zebrafish optic tectum
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2010.03.008
– volume: 13
  start-page: 323
  year: 2012
  end-page: 328
  ident: CR66
  article-title: Getting active: protein sorting in endocytic recycling
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3332
– volume: 272
  start-page: 4141
  year: 1997
  end-page: 4148
  ident: CR19
  article-title: Comparative activity of ADP-ribosylation factor family members in the early steps of coated vesicle formation on rat liver Golgi membranes
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.272.7.4141
– volume: 276
  start-page: 42477
  year: 2001
  end-page: 42484
  ident: CR57
  article-title: Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M106660200
– volume: 9
  start-page: e51221
  year: 2020
  ident: CR94
  article-title: Notochord vacuoles absorb compressive bone growth during zebrafish spine formation
  publication-title: eLife
  doi: 10.7554/eLife.51221
– volume: 176
  start-page: 2867
  year: 2018
  end-page: 2871
  ident: CR130
  article-title: Atypical presentation of pediatric BRAF RASopathy with acute encephalopathy
  publication-title: Am. J. Med. Genet. A
  doi: 10.1002/ajmg.a.40635
– volume: 592
  start-page: 1096
  year: 2018
  end-page: 1112
  ident: CR17
  article-title: The functional roles of retromer in Parkinson’s disease
  publication-title: FEBS Lett.
  doi: 10.1002/1873-3468.12931
– volume: 38
  start-page: 331
  year: 2006
  end-page: 336
  ident: CR104
  article-title: Germline KRAS mutations cause Noonan syndrome
  publication-title: Nat. Genet.
  doi: 10.1038/ng1748
– volume: 4
  start-page: 610
  year: 2002
  end-page: 615
  ident: CR120
  article-title: Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb828
– volume: 104
  start-page: 1233
  year: 2019
  end-page: 1240
  ident: CR100
  article-title: Germline-Activating RRAS2 Mutations Cause Noonan Syndrome
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2019.04.014
– volume: 19
  start-page: 679
  year: 2018
  end-page: 696
  ident: CR73
  article-title: To degrade or not to degrade: mechanisms and significance of endocytic recycling
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-018-0053-7
– volume: 8
  year: 2013
  ident: CR92
  article-title: Abnormal centrosome and spindle morphology in a patient with autosomal recessive primary microcephaly type 2 due to compound heterozygous WDR62 gene mutation
  publication-title: Orphanet J. Rare Dis.
  doi: 10.1186/1750-1172-8-178
– volume: 108
  start-page: 115
  year: 2021
  end-page: 133
  ident: CR133
  article-title: SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2020.11.015
– ident: CR134
– volume: 31
  start-page: 69
  year: 2021
  end-page: 81
  ident: CR50
  article-title: De novo ARF3 variants cause neurodevelopmental disorder with brain abnormality
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddab224
– volume: 95
  start-page: 6187
  year: 1998
  end-page: 6192
  ident: CR70
  article-title: Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.95.11.6187
– volume: 203
  start-page: 253
  year: 1995
  end-page: 310
  ident: CR76
  article-title: Stages of embryonic development of the zebrafish
  publication-title: Dev. Dyn.
  doi: 10.1002/aja.1002030302
– volume: 19
  start-page: 745
  year: 2008
  end-page: 753
  ident: CR88
  article-title: The Golgi protein GM130 regulates centrosome morphology and function
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e07-08-0847
– volume: 372
  start-page: 55
  year: 1994
  end-page: 63
  ident: CR35
  article-title: Mechanisms of intracellular protein transport
  publication-title: Nature
  doi: 10.1038/372055a0
– volume: 47
  start-page: D941
  year: 2019
  end-page: D947
  ident: CR96
  article-title: COSMIC: the Catalogue Of Somatic Mutations In Cancer
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky1015
– volume: 236
  start-page: 3077
  year: 2007
  end-page: 3087
  ident: CR144
  article-title: Gateway compatible vectors for analysis of gene function in the zebrafish
  publication-title: Dev. Dyn.
  doi: 10.1002/dvdy.21354
– volume: 593
  start-page: 2289
  year: 2019
  end-page: 2305
  ident: CR39
  article-title: Form and function of the Golgi apparatus: scaffolds, cytoskeleton and signalling
  publication-title: FEBS Lett.
  doi: 10.1002/1873-3468.13567
– volume: 10
  start-page: 403
  year: 2019
  end-page: 410
  ident: CR46
  article-title: Key roles of Arf small G proteins and biosynthetic trafficking for animal development
  publication-title: Small GTPases
  doi: 10.1080/21541248.2017.1304854
– volume: 17
  start-page: 670
  year: 2016
  end-page: 688
  ident: CR60
  article-title: Regulation of cell migration and β1 integrin trafficking by the endosomal adaptor GGA3
  publication-title: Traffic Cph. Den.
  doi: 10.1111/tra.12390
– volume: 21
  start-page: 1836
  year: 2010
  end-page: 1849
  ident: CR65
  article-title: Arf3 is activated uniquely at the trans-Golgi network by brefeldin A-inhibited guanine nucleotide exchange factors
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e10-01-0016
– volume: 114
  start-page: 4543
  year: 2001
  end-page: 4555
  ident: CR63
  article-title: Regulation of Golgi structure and function by ARF-like protein 1 (Arl1)
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.114.24.4543
– volume: 39
  start-page: 1700063
  year: 2017
  ident: CR6
  article-title: The function of the Golgi ribbon structure—an enduring mystery unfolds!
  publication-title: BioEssays
  doi: 10.1002/bies.201700063
– volume: 111
  start-page: E1230
  year: 2014
  end-page: E1239
  ident: CR64
  article-title: Aβ-induced Golgi fragmentation in Alzheimer’s disease enhances Aβ production
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1320192111
– volume: 29
  start-page: 937
  year: 2018
  end-page: 947
  ident: CR37
  article-title: Commonly used trafficking blocks disrupt ARF1 activation and the localization and function of specific Golgi proteins
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.E17-11-0622
– volume: 48
  start-page: 757
  year: 2005
  end-page: 771
  ident: CR129
  article-title: Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis
  publication-title: Neuron
  doi: 10.1016/j.neuron.2005.11.005
– volume: 100
  start-page: 13314
  year: 2003
  end-page: 13319
  ident: CR43
  article-title: A role for Arf1 in mitotic Golgi disassembly, chromosome segregation, and cytokinesis
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.2234055100
– volume: 5
  start-page: e10367
  year: 2010
  ident: CR127
  article-title: Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0010367
– volume: 124
  start-page: 289
  year: 1994
  end-page: 300
  ident: CR23
  article-title: Expression of a dominant allele of human ARF1 inhibits membrane traffic in vivo
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.124.3.289
– volume: 34
  start-page: 2135
  year: 2013
  end-page: 2145
  ident: CR140
  article-title: CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data
  publication-title: J. Comput. Chem.
  doi: 10.1002/jcc.23354
– volume: 44
  start-page: 725
  year: 2018
  end-page: 740.e4
  ident: CR8
  article-title: A Golgi lipid signaling pathway controls apical Golgi distribution and cell polarity during neurogenesis
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2018.02.025
– volume: 148
  start-page: 530
  year: 2012
  end-page: 542
  ident: CR59
  article-title: A structure-based mechanism for Arf1-dependent recruitment of coatomer to membranes
  publication-title: Cell
  doi: 10.1016/j.cell.2012.01.015
– volume: 104
  start-page: 1073
  year: 2019
  end-page: 1087
  ident: CR91
  article-title: Bi-allelic variants in DYNC1I2 cause syndromic microcephaly with intellectual disability, cerebral malformations, and dysmorphic facial features
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2019.04.002
– volume: 10
  start-page: 1861
  year: 2011
  end-page: 1870
  ident: CR90
  article-title: GM130, a cis-Golgi protein, regulates meiotic spindle assembly and asymmetric division in mouse oocyte
  publication-title: Cell Cycle Georget. Tex.
  doi: 10.4161/cc.10.11.15797
– volume: 24
  start-page: 2771
  year: 2015
  end-page: 2783
  ident: CR13
  article-title: Dymeclin deficiency causes postnatal microcephaly, hypomyelination and reticulum-to-Golgi trafficking defects in mice and humans
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddv038
– volume: 8
  year: 2017
  ident: CR117
  article-title: Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism
  publication-title: Mol. Autism
  doi: 10.1186/s13229-017-0168-2
– volume: 15
  start-page: 4426
  year: 2004
  end-page: 4443
  ident: CR62
  article-title: Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-Golgi network
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e03-12-0872
– volume: 46
  start-page: D1062
  year: 2018
  end-page: D1067
  ident: CR106
  article-title: ClinVar: improving access to variant interpretations and supporting evidence
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkx1153
– volume: 46
  start-page: W296
  year: 2018
  end-page: W303
  ident: CR136
  article-title: SWISS-MODEL: homology modelling of protein structures and complexes
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky427
– volume: 28
  start-page: 265
  year: 2007
  end-page: 272
  ident: CR55
  article-title: Diversity, parental germline origin, and phenotypic spectrum of de novo HRAS missense changes in Costello syndrome
  publication-title: Hum. Mutat.
  doi: 10.1002/humu.20431
– volume: 46
  start-page: 1063
  year: 2018
  end-page: 1072
  ident: CR5
  article-title: The Golgi architecture and cell sensing
  publication-title: Biochem. Soc. Trans.
  doi: 10.1042/BST20180323
– volume: 95
  start-page: 237
  year: 1998
  end-page: 248
  ident: CR30
  article-title: Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81754-7
– volume: 286
  start-page: 35634
  year: 2011
  end-page: 35642
  ident: CR36
  article-title: Several ADP-ribosylation factor (Arf) isoforms support COPI vesicle formation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.261800
– ident: CR84
– volume: 125
  start-page: 4049
  year: 2012
  end-page: 4057
  ident: CR71
  article-title: Rab11 regulates exocytosis of recycling vesicles at the plasma membrane
  publication-title: J. Cell Sci.
– volume: 5
  start-page: 121
  year: 2004
  end-page: 132
  ident: CR72
  article-title: Endocytic recycling
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm1315
– volume: 126
  start-page: 014101
  year: 2007
  ident: CR142
  article-title: Canonical sampling through velocity rescaling
  publication-title: J. Chem. Phys.
  doi: 10.1063/1.2408420
– volume: 272
  start-page: 30848
  year: 1997
  end-page: 30851
  ident: CR29
  article-title: Activation of ADP-ribosylation factor 1 GTPase-activating protein by phosphatidylcholine-derived diacylglycerols
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.272.49.30848
– volume: 29
  start-page: 1772
  year: 2020
  end-page: 1783
  ident: CR98
  article-title: Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddz108
– volume: 12
  start-page: 431
  year: 2002
  end-page: 440
  ident: CR138
  article-title: Rotamer libraries in the 21st century
  publication-title: Curr. Opin. Struct. Biol.
  doi: 10.1016/S0959-440X(02)00344-5
– volume: 14
  start-page: 69
  year: 2017
  end-page: 72
  ident: CR145
  article-title: A Tol2 gateway-compatible toolbox for the study of the nervous system and neurodegenerative disease
  publication-title: Zebrafish
  doi: 10.1089/zeb.2016.1321
– volume: 116
  start-page: 18031
  year: 2019
  end-page: 18040
  ident: CR52
  article-title: Makes caterpillars floppy-like effector-containing MARTX toxins require host ADP-ribosylation factor (ARF) proteins for systemic pathogenicity
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1905095116
– volume: 6
  year: 2015
  ident: CR47
  article-title: The clathrin adaptor AP-1 complex and Arf1 regulate planar cell polarity in vivo
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms7751
– volume: 122
  start-page: 735
  year: 2005
  end-page: 749
  ident: CR69
  article-title: Rab conversion as a mechanism of progression from early to late endosomes
  publication-title: Cell
  doi: 10.1016/j.cell.2005.06.043
– volume: 25
  start-page: 1605
  year: 2004
  end-page: 1612
  ident: CR137
  article-title: UCSF Chimera—a visualization system for exploratory research and analysis
  publication-title: J. Comput. Chem.
  doi: 10.1002/jcc.20084
– volume: 7
  start-page: 347
  year: 2006
  end-page: 358
  ident: CR1
  article-title: ARF proteins: roles in membrane traffic and beyond
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm1910
– volume: 269
  start-page: 1437
  year: 1994
  end-page: 1448
  ident: CR41
  article-title: Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(17)42277-0
– volume: 38
  start-page: 724
  year: 2022
  end-page: 751
  ident: CR115
  article-title: Genetic disorders of cellular trafficking
  publication-title: Trends Genet.
  doi: 10.1016/j.tig.2022.02.012
– volume: 9
  start-page: 676
  year: 2012
  end-page: 682
  ident: CR151
  article-title: Fiji: an open-source platform for biological-image analysis
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2019
– volume: 276
  start-page: 13982
  year: 2001
  end-page: 13988
  ident: CR109
  article-title: Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition*
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M009771200
– volume: 221
  start-page: e202106100
  year: 2022
  ident: CR112
  article-title: Shared and specific functions of Arfs 1–5 at the Golgi revealed by systematic knockouts
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.202106100
– volume: 268
  start-page: 9555
  year: 1993
  end-page: 9563
  ident: CR28
  article-title: Activation of ADP-ribosylation factor by Golgi membranes. Evidence for a brefeldin A- and protease-sensitive activating factor on Golgi membranes
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)98387-0
– ident: CR81
– volume: 62
  start-page: 104
  year: 2020
  end-page: 113
  ident: CR95
  article-title: The Golgi apparatus and cell polarity: roles of the cytoskeleton, the Golgi matrix, and Golgi membranes
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2019.10.003
– volume: 159
  start-page: 201
  year: 2016
  end-page: 208
  ident: CR44
  article-title: Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis
  publication-title: J. Biochem.
  doi: 10.1093/jb/mvv088
– volume: 6
  start-page: a016774
  year: 2014
  ident: CR113
  article-title: Retromer: a master conductor of endosome sorting
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a016774
– volume: 3
  start-page: 130065
  year: 2013
  ident: CR93
  article-title: Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression
  publication-title: Open Biol.
  doi: 10.1098/rsob.130065
– volume: 40
  start-page: 396
  year: 2018
  end-page: 416
  ident: CR12
  article-title: Golgipathies in neurodevelopment: a new view of old defects
  publication-title: Dev. Neurosci.
  doi: 10.1159/000497035
– volume: 51
  start-page: 1
  year: 2016
  end-page: 6
  ident: CR45
  article-title: Regulation of cytokinesis by membrane trafficking involving small GTPases and the ESCRT machinery
  publication-title: Crit. Rev. Biochem. Mol. Biol.
  doi: 10.3109/10409238.2015.1085827
– volume: 9
  start-page: 555
  year: 2005
  end-page: 564
  ident: CR126
  article-title: Wnt11 functions in gastrulation by controlling cell cohesion through Rab5c and E-cadherin
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2005.08.011
– volume: 300
  start-page: C723
  year: 2011
  end-page: C742
  ident: CR152
  article-title: A practical guide to evaluating colocalization in biological microscopy
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00462.2010
– volume: 3
  start-page: 59
  year: 2008
  end-page: 69
  ident: CR155
  article-title: High-resolution in situ hybridization to whole-mount zebrafish embryos
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2007.514
– volume: 324
  start-page: 413
  year: 1997
  end-page: 419
  ident: CR33
  article-title: Resolution of two ADP-ribosylation factor 1 GTPase-activating proteins from rat liver
  publication-title: Biochem. J.
  doi: 10.1042/bj3240413
– volume: 37
  start-page: 141
  year: 2012
  end-page: 154
  ident: CR40
  article-title: ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway
  publication-title: Cell Struct. Funct.
  doi: 10.1247/csf.12015
– volume: 26
  start-page: 1953
  year: 2007
  end-page: 1962
  ident: CR58
  article-title: Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7601634
– volume: 135
  start-page: 1698
  year: 2015
  end-page: 1700
  ident: CR103
  article-title: Somatic activating RAS mutations cause vascular tumors including pyogenic granuloma
  publication-title: J. Investig. Dermatol.
  doi: 10.1038/jid.2015.55
– volume: 153
  start-page: 134110
  year: 2020
  ident: CR139
  article-title: Heterogeneous parallelization and acceleration of molecular dynamics simulations in GROMACS
  publication-title: J. Chem. Phys.
  doi: 10.1063/5.0018516
– volume: 68
  start-page: 223
  year: 2021
  end-page: 229
  ident: CR118
  article-title: ARF3 inhibits proliferation and promotes apoptosis in gastric cancer by regulating AKT and ERK pathway
  publication-title: Acta. Biochim. Pol.
– volume: 97
  start-page: 9913
  year: 2000
  end-page: 9918
  ident: CR42
  article-title: Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.170290597
– volume: 2
  start-page: 695
  year: 2002
  end-page: 706
  ident: CR122
  article-title: Convergent extension: the molecular control of polarized cell movement during embryonic development
  publication-title: Dev. Cell
  doi: 10.1016/S1534-5807(02)00197-1
– volume: 27
  start-page: 334
  year: 2016
  end-page: 348
  ident: CR68
  article-title: Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e15-08-0558
– volume: 105
  start-page: 9954
  year: 2001
  end-page: 9960
  ident: CR141
  article-title: Structure and dynamics of the TIP3P, SPC, and SPC/E water models at 298 K
  publication-title: J. Phys. Chem. A
  doi: 10.1021/jp003020w
– volume: 263
  start-page: 523
  year: 1994
  end-page: 526
  ident: CR2
  article-title: Phospholipase D: a downstream effector of ARF in granulocytes
  publication-title: Science
  doi: 10.1126/science.8290961
– volume: 13
  year: 2022
  ident: CR114
  article-title: Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-27705-7
– volume: 7
  start-page: 547
  year: 2004
  end-page: 558
  ident: CR128
  article-title: Differential requirements for COPI transport during vertebrate early development
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2004.07.020
– volume: 108
  start-page: 502
  year: 2021
  end-page: 516
  ident: CR132
  article-title: SPEN haploinsufficiency causes a neurodevelopmental disorder overlapping proximal 1p36 deletion syndrome with an episignature of X chromosomes in females
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2021.01.015
– volume: 135
  start-page: 245
  year: 2016
  end-page: 251
  ident: CR11
  article-title: GOLGA2, encoding a master regulator of Golgi apparatus, is mutated in a patient with a neuromuscular disorder
  publication-title: Hum. Genet.
  doi: 10.1007/s00439-015-1632-8
– volume: 14
  start-page: 27
  year: 1996
  end-page: 28
  ident: CR135
  article-title: VMD: visual molecular dynamics
  publication-title: J. Mol. Graph.
  doi: 10.1016/0263-7855(96)00018-5
– volume: 30
  start-page: 169
  year: 2014
  end-page: 206
  ident: CR3
  article-title: Protein sorting at the trans-Golgi network
  publication-title: Annu. Rev. Cell Dev. Biol.
  doi: 10.1146/annurev-cellbio-100913-013012
– volume: 273
  start-page: 797
  year: 1996
  end-page: 801
  ident: CR146
  article-title: Diffusional mobility of Golgi proteins in membranes of living cells
  publication-title: Science
  doi: 10.1126/science.273.5276.797
– volume: 23
  start-page: 579
  year: 2007
  end-page: 611
  ident: CR25
  article-title: The small G proteins of the Arf family and their regulators
  publication-title: Annu. Rev. Cell Dev. Biol.
  doi: 10.1146/annurev.cellbio.23.090506.123209
– volume: 107
  start-page: 10602
  year: 2010
  end-page: 10607
  ident: CR77
  article-title: Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet–Biedl syndrome
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1000219107
– volume: 10
  start-page: 925228
  year: 2022
  ident: CR116
  article-title: Structural organization and function of the Golgi ribbon during cell division
  publication-title: Front. Cell Dev. Biol.
  doi: 10.3389/fcell.2022.925228
– volume: 100
  start-page: 8253
  year: 2003
  end-page: 8257
  ident: CR34
  article-title: Functional reconstitution of COPI coat assembly and disassembly using chemically defined components
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1432391100
– volume: 162
  start-page: 287
  year: 2015
  end-page: 299
  ident: CR89
  article-title: GM130 regulates golgi-derived spindle assembly by activating TPX2 and capturing microtubules
  publication-title: Cell
  doi: 10.1016/j.cell.2015.06.014
– volume: 16
  start-page: 4495
  year: 2005
  ident: 34354_CR20
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e04-12-1042
– volume: 1
  start-page: 16036
  year: 2016
  ident: 34354_CR49
  publication-title: NPJ Genom. Med
  doi: 10.1038/npjgenmed.2016.36
– volume: 21
  start-page: 1836
  year: 2010
  ident: 34354_CR65
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e10-01-0016
– volume: 9
  start-page: 784700
  year: 2022
  ident: 34354_CR79
  publication-title: Front. Cell Dev. Biol
  doi: 10.3389/fcell.2021.784700
– volume: 24
  start-page: 2771
  year: 2015
  ident: 34354_CR13
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddv038
– volume: 276
  start-page: 13982
  year: 2001
  ident: 34354_CR109
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M009771200
– volume: 5
  start-page: 121
  year: 2004
  ident: 34354_CR72
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm1315
– volume: 79
  start-page: 129
  year: 2006
  ident: 34354_CR54
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/504394
– volume: 272
  start-page: 30848
  year: 1997
  ident: 34354_CR29
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.272.49.30848
– volume: 148
  start-page: 530
  year: 2012
  ident: 34354_CR59
  publication-title: Cell
  doi: 10.1016/j.cell.2012.01.015
– volume: 62
  start-page: 104
  year: 2020
  ident: 34354_CR95
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2019.10.003
– volume: 203
  start-page: 253
  year: 1995
  ident: 34354_CR76
  publication-title: Dev. Dyn.
  doi: 10.1002/aja.1002030302
– volume: 263
  start-page: 523
  year: 1994
  ident: 34354_CR2
  publication-title: Science
  doi: 10.1126/science.8290961
– volume: 46
  start-page: 1063
  year: 2018
  ident: 34354_CR5
  publication-title: Biochem. Soc. Trans.
  doi: 10.1042/BST20180323
– volume: 37
  start-page: 141
  year: 2012
  ident: 34354_CR40
  publication-title: Cell Struct. Funct.
  doi: 10.1247/csf.12015
– volume: 44
  start-page: 725
  year: 2018
  ident: 34354_CR8
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2018.02.025
– volume: 36
  start-page: 928
  year: 2015
  ident: 34354_CR51
  publication-title: Hum. Mutat.
  doi: 10.1002/humu.22844
– volume: 9
  start-page: 676
  year: 2012
  ident: 34354_CR151
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2019
– volume: 97
  start-page: 9913
  year: 2000
  ident: 34354_CR42
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.170290597
– volume: 276
  start-page: 42477
  year: 2001
  ident: 34354_CR57
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M106660200
– volume: 126
  start-page: 014101
  year: 2007
  ident: 34354_CR142
  publication-title: J. Chem. Phys.
  doi: 10.1063/1.2408420
– volume: 300
  start-page: C723
  year: 2011
  ident: 34354_CR152
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00462.2010
– volume: 23
  start-page: 579
  year: 2007
  ident: 34354_CR25
  publication-title: Annu. Rev. Cell Dev. Biol.
  doi: 10.1146/annurev.cellbio.23.090506.123209
– volume: 14
  start-page: 27
  year: 1996
  ident: 34354_CR135
  publication-title: J. Mol. Graph.
  doi: 10.1016/0263-7855(96)00018-5
– volume: 221
  start-page: e202106100
  year: 2022
  ident: 34354_CR112
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.202106100
– volume: 360
  start-page: 350
  year: 1992
  ident: 34354_CR26
  publication-title: Nature
  doi: 10.1038/360350a0
– volume: 593
  start-page: 2289
  year: 2019
  ident: 34354_CR39
  publication-title: FEBS Lett.
  doi: 10.1002/1873-3468.13567
– volume: 7
  start-page: 347
  year: 2006
  ident: 34354_CR1
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm1910
– volume: 36
  start-page: 69
  year: 2004
  ident: 34354_CR16
  publication-title: Nat. Genet.
  doi: 10.1038/ng1276
– volume: 2
  start-page: 695
  year: 2002
  ident: 34354_CR122
  publication-title: Dev. Cell
  doi: 10.1016/S1534-5807(02)00197-1
– volume: 273
  start-page: 797
  year: 1996
  ident: 34354_CR146
  publication-title: Science
  doi: 10.1126/science.273.5276.797
– volume: 46
  start-page: D1062
  year: 2018
  ident: 34354_CR106
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkx1153
– volume: 12
  start-page: 362
  year: 2011
  ident: 34354_CR22
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3117
– volume: 39
  start-page: 1700063
  year: 2017
  ident: 34354_CR6
  publication-title: BioEssays
  doi: 10.1002/bies.201700063
– volume: 25
  start-page: 1605
  year: 2004
  ident: 34354_CR137
  publication-title: J. Comput. Chem.
  doi: 10.1002/jcc.20084
– volume: 135
  start-page: 1698
  year: 2015
  ident: 34354_CR103
  publication-title: J. Investig. Dermatol.
  doi: 10.1038/jid.2015.55
– volume: 1214
  start-page: 99
  year: 2010
  ident: 34354_CR97
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.2010.05790.x
– volume: 139
  start-page: 3644
  year: 2012
  ident: 34354_CR149
  publication-title: Development
  doi: 10.1242/dev.082362
– volume: 13
  year: 2022
  ident: 34354_CR114
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-27705-7
– volume: 372
  start-page: 55
  year: 1994
  ident: 34354_CR35
  publication-title: Nature
  doi: 10.1038/372055a0
– volume: 38
  start-page: 724
  year: 2022
  ident: 34354_CR115
  publication-title: Trends Genet.
  doi: 10.1016/j.tig.2022.02.012
– volume: 100
  start-page: 8253
  year: 2003
  ident: 34354_CR34
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1432391100
– volume: 34
  start-page: 2135
  year: 2013
  ident: 34354_CR140
  publication-title: J. Comput. Chem.
  doi: 10.1002/jcc.23354
– volume: 268
  start-page: 9555
  year: 1993
  ident: 34354_CR28
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)98387-0
– volume: 95
  start-page: 237
  year: 1998
  ident: 34354_CR30
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81754-7
– ident: 34354_CR81
  doi: 10.3389/fnmol.2022.855786
– volume: 104
  start-page: 1223
  year: 2019
  ident: 34354_CR101
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2019.04.013
– volume: 109
  start-page: 1541
  year: 2002
  ident: 34354_CR147
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI0215420
– volume: 6
  start-page: a016774
  year: 2014
  ident: 34354_CR113
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a016774
– volume: 27
  start-page: 334
  year: 2016
  ident: 34354_CR68
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e15-08-0558
– volume: 10
  start-page: 1347
  year: 1996
  ident: 34354_CR32
  publication-title: FASEB J.
  doi: 10.1096/fasebj.10.12.8903506
– volume: 13
  start-page: 1652
  year: 2002
  ident: 34354_CR56
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.02-01-0007
– volume: 5
  year: 2014
  ident: 34354_CR87
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms4885
– volume: 133
  start-page: 916
  year: 2008
  ident: 34354_CR148
  publication-title: Cell
  doi: 10.1016/j.cell.2008.04.037
– volume: 122
  start-page: 735
  year: 2005
  ident: 34354_CR69
  publication-title: Cell
  doi: 10.1016/j.cell.2005.06.043
– volume: 269
  start-page: 1437
  year: 1994
  ident: 34354_CR41
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(17)42277-0
– volume: 119
  start-page: 3571
  year: 2006
  ident: 34354_CR124
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.03066
– volume: 153
  start-page: 134110
  year: 2020
  ident: 34354_CR139
  publication-title: J. Chem. Phys.
  doi: 10.1063/5.0018516
– volume: 21
  start-page: 1284
  year: 2013
  ident: 34354_CR24
  publication-title: Struct. Lond. Engl. 1993
– volume: 32
  start-page: 98
  year: 2021
  ident: 34354_CR74
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.E20-02-0129
– volume: 3
  start-page: a005256
  year: 2011
  ident: 34354_CR38
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a005256
– volume: 17
  start-page: 670
  year: 2016
  ident: 34354_CR60
  publication-title: Traffic Cph. Den.
  doi: 10.1111/tra.12390
– volume: 10
  year: 2019
  ident: 34354_CR82
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-13484-9
– volume: 29
  start-page: 232
  year: 2008
  ident: 34354_CR102
  publication-title: Hum. Mutat.
  doi: 10.1002/humu.20616
– volume: 30
  start-page: 169
  year: 2014
  ident: 34354_CR3
  publication-title: Annu. Rev. Cell Dev. Biol.
  doi: 10.1146/annurev-cellbio-100913-013012
– volume: 29
  start-page: 1772
  year: 2020
  ident: 34354_CR98
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddz108
– volume: 47
  start-page: 43
  year: 2017
  ident: 34354_CR7
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2017.03.008
– volume: 3
  start-page: 130065
  year: 2013
  ident: 34354_CR93
  publication-title: Open Biol.
  doi: 10.1098/rsob.130065
– volume: 14
  start-page: 285
  year: 2012
  ident: 34354_CR108
  publication-title: Genet. Med.
  doi: 10.1038/gim.0b013e31822dd91f
– volume: 7
  start-page: 112
  year: 2019
  ident: 34354_CR4
  publication-title: Front. Cell Dev. Biol.
  doi: 10.3389/fcell.2019.00112
– volume: 105
  start-page: 9954
  year: 2001
  ident: 34354_CR141
  publication-title: J. Phys. Chem. A
  doi: 10.1021/jp003020w
– volume: 360
  start-page: 352
  year: 1992
  ident: 34354_CR27
  publication-title: Nature
  doi: 10.1038/360352a0
– volume: 95
  start-page: 6187
  year: 1998
  ident: 34354_CR70
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.95.11.6187
– volume: 176
  start-page: 2867
  year: 2018
  ident: 34354_CR130
  publication-title: Am. J. Med. Genet. A
  doi: 10.1002/ajmg.a.40635
– volume: 124
  start-page: 289
  year: 1994
  ident: 34354_CR23
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.124.3.289
– ident: 34354_CR134
  doi: 10.1093/brain/awab052
– volume: 372
  start-page: 704
  year: 1994
  ident: 34354_CR31
  publication-title: Nature
  doi: 10.1038/372704a0
– volume: 8
  year: 2017
  ident: 34354_CR117
  publication-title: Mol. Autism
  doi: 10.1186/s13229-017-0168-2
– volume: 116
  start-page: 18031
  year: 2019
  ident: 34354_CR52
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1905095116
– volume: 13
  start-page: 1381
  year: 2019
  ident: 34354_CR18
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2019.01381
– volume: 9
  start-page: 555
  year: 2005
  ident: 34354_CR126
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2005.08.011
– volume: 99
  start-page: 451
  year: 2016
  ident: 34354_CR14
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2016.06.011
– volume: 272
  start-page: 4141
  year: 1997
  ident: 34354_CR19
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.272.7.4141
– volume: 114
  start-page: 4543
  year: 2001
  ident: 34354_CR63
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.114.24.4543
– volume: 29
  start-page: 937
  year: 2018
  ident: 34354_CR37
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.E17-11-0622
– volume: 125
  start-page: 4049
  year: 2012
  ident: 34354_CR71
  publication-title: J. Cell Sci.
– volume: 28
  start-page: 265
  year: 2007
  ident: 34354_CR55
  publication-title: Hum. Mutat.
  doi: 10.1002/humu.20431
– volume: 44
  start-page: 763
  year: 2007
  ident: 34354_CR107
  publication-title: J. Med. Genet.
  doi: 10.1136/jmg.2007.050450
– volume: 8
  year: 2013
  ident: 34354_CR92
  publication-title: Orphanet J. Rare Dis.
  doi: 10.1186/1750-1172-8-178
– volume: 365
  start-page: 927
  year: 2011
  ident: 34354_CR9
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra0910494
– volume: 342
  start-page: 26
  year: 2010
  ident: 34354_CR83
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2010.03.008
– volume: 162
  start-page: 287
  year: 2015
  ident: 34354_CR89
  publication-title: Cell
  doi: 10.1016/j.cell.2015.06.014
– volume: 5
  start-page: e10367
  year: 2010
  ident: 34354_CR127
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0010367
– volume: 35
  start-page: 1551
  year: 2021
  ident: 34354_CR80
  publication-title: Genes Dev.
  doi: 10.1101/gad.348866.121
– volume: 10
  start-page: 925228
  year: 2022
  ident: 34354_CR116
  publication-title: Front. Cell Dev. Biol.
  doi: 10.3389/fcell.2022.925228
– volume: 2
  start-page: 140
  year: 2012
  ident: 34354_CR111
  publication-title: Cell. Logist.
  doi: 10.4161/cl.21627
– volume: 108
  start-page: 502
  year: 2021
  ident: 34354_CR132
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2021.01.015
– volume: 18
  start-page: 743
  year: 2007
  ident: 34354_CR75
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e06-09-0798
– volume: 10
  start-page: 1861
  year: 2011
  ident: 34354_CR90
  publication-title: Cell Cycle Georget. Tex.
  doi: 10.4161/cc.10.11.15797
– volume: 108
  start-page: 115
  year: 2021
  ident: 34354_CR133
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2020.11.015
– volume: 104
  start-page: 1073
  year: 2019
  ident: 34354_CR91
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2019.04.002
– volume: 11
  start-page: 466
  year: 1999
  ident: 34354_CR21
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/S0955-0674(99)80067-2
– volume: 40
  start-page: 396
  year: 2018
  ident: 34354_CR12
  publication-title: Dev. Neurosci.
  doi: 10.1159/000497035
– volume: 68
  start-page: 223
  year: 2021
  ident: 34354_CR118
  publication-title: Acta. Biochim. Pol.
– volume: 100
  start-page: 13314
  year: 2003
  ident: 34354_CR43
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.2234055100
– ident: 34354_CR84
  doi: 10.3791/62642
– volume: 286
  start-page: 35634
  year: 2011
  ident: 34354_CR36
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.261800
– volume: 592
  start-page: 1096
  year: 2018
  ident: 34354_CR17
  publication-title: FEBS Lett.
  doi: 10.1002/1873-3468.12931
– volume: 38
  start-page: 331
  year: 2006
  ident: 34354_CR104
  publication-title: Nat. Genet.
  doi: 10.1038/ng1748
– volume: 56
  start-page: 139
  year: 2019
  ident: 34354_CR15
  publication-title: J. Med. Genet.
  doi: 10.1136/jmedgenet-2018-105503
– volume: 12
  start-page: 431
  year: 2002
  ident: 34354_CR138
  publication-title: Curr. Opin. Struct. Biol.
  doi: 10.1016/S0959-440X(02)00344-5
– volume: 26
  start-page: 1953
  year: 2007
  ident: 34354_CR58
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7601634
– volume: 98
  start-page: 10089
  year: 1993
  ident: 34354_CR143
  publication-title: J. Chem. Phys.
  doi: 10.1063/1.464397
– volume: 30
  start-page: 3846
  year: 2011
  ident: 34354_CR119
  publication-title: Oncogene
  doi: 10.1038/onc.2011.100
– volume: 48
  start-page: 757
  year: 2005
  ident: 34354_CR129
  publication-title: Neuron
  doi: 10.1016/j.neuron.2005.11.005
– volume: 156
  start-page: 797
  year: 2002
  ident: 34354_CR67
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.20111048
– volume: 107
  start-page: 10602
  year: 2010
  ident: 34354_CR77
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1000219107
– ident: 34354_CR150
– volume: 40
  start-page: e106118
  year: 2021
  ident: 34354_CR85
  publication-title: EMBO J.
  doi: 10.15252/embj.2020106118
– volume: 13
  start-page: 323
  year: 2012
  ident: 34354_CR66
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3332
– volume: 159
  start-page: 201
  year: 2016
  ident: 34354_CR44
  publication-title: J. Biochem.
  doi: 10.1093/jb/mvv088
– volume: 19
  start-page: 679
  year: 2018
  ident: 34354_CR73
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-018-0053-7
– volume: 14
  start-page: 666
  year: 2012
  ident: 34354_CR125
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2508
– volume: 236
  start-page: 3077
  year: 2007
  ident: 34354_CR144
  publication-title: Dev. Dyn.
  doi: 10.1002/dvdy.21354
– volume: 31
  start-page: 69
  year: 2021
  ident: 34354_CR50
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddab224
– volume: 324
  start-page: 413
  year: 1997
  ident: 34354_CR33
  publication-title: Biochem. J.
  doi: 10.1042/bj3240413
– volume: 286
  start-page: 37665
  year: 2011
  ident: 34354_CR10
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.267971
– volume: 19
  start-page: 745
  year: 2008
  ident: 34354_CR88
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e07-08-0847
– volume: 14
  start-page: 69
  year: 2017
  ident: 34354_CR145
  publication-title: Zebrafish
  doi: 10.1089/zeb.2016.1321
– volume: 44
  start-page: 131
  year: 2007
  ident: 34354_CR105
  publication-title: J. Med. Genet.
  doi: 10.1136/jmg.2006.046300
– volume: 51
  start-page: 1
  year: 2016
  ident: 34354_CR45
  publication-title: Crit. Rev. Biochem. Mol. Biol.
  doi: 10.3109/10409238.2015.1085827
– volume: 282
  start-page: 21829
  year: 2007
  ident: 34354_CR61
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M611716200
– volume: 47
  start-page: D941
  year: 2019
  ident: 34354_CR96
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky1015
– volume: 7
  start-page: 547
  year: 2004
  ident: 34354_CR128
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2004.07.020
– ident: 34354_CR153
– volume: 1
  start-page: 1204
  year: 2012
  ident: 34354_CR154
  publication-title: Biol. Open
  doi: 10.1242/bio.20122659
– volume: 96
  start-page: 354
  year: 2019
  ident: 34354_CR131
  publication-title: Clin. Genet.
  doi: 10.1111/cge.13603
– volume: 6
  year: 2015
  ident: 34354_CR47
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms7751
– volume: 104
  start-page: 1233
  year: 2019
  ident: 34354_CR100
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2019.04.014
– volume: 5
  start-page: a022392
  year: 2015
  ident: 34354_CR86
  publication-title: Cold Spring Harb. Perspect. Med.
  doi: 10.1101/cshperspect.a022392
– volume: 8
  start-page: 497
  year: 2014
  ident: 34354_CR78
  publication-title: Front. Hum. Neurosci.
  doi: 10.3389/fnhum.2014.00497
– volume: 10
  start-page: 403
  year: 2019
  ident: 34354_CR46
  publication-title: Small GTPases
  doi: 10.1080/21541248.2017.1304854
– volume: 111
  start-page: E1230
  year: 2014
  ident: 34354_CR64
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1320192111
– volume: 4
  start-page: 610
  year: 2002
  ident: 34354_CR120
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb828
– volume: 20
  start-page: 986
  year: 2009
  ident: 34354_CR121
  publication-title: Semin. Cell Dev. Biol.
  doi: 10.1016/j.semcdb.2009.09.004
– volume: 10
  year: 2009
  ident: 34354_CR48
  publication-title: BMC Neurosci.
  doi: 10.1186/1471-2202-10-27
– volume: 15
  start-page: 4426
  year: 2004
  ident: 34354_CR62
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e03-12-0872
– volume: 46
  start-page: W296
  year: 2018
  ident: 34354_CR136
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky427
– volume: 3
  start-page: 1035
  year: 2002
  ident: 34354_CR53
  publication-title: EMBO Rep.
  doi: 10.1093/embo-reports/kvf221
– volume: 9
  start-page: e51221
  year: 2020
  ident: 34354_CR94
  publication-title: eLife
  doi: 10.7554/eLife.51221
– volume: 135
  start-page: 245
  year: 2016
  ident: 34354_CR11
  publication-title: Hum. Genet.
  doi: 10.1007/s00439-015-1632-8
– volume: 45
  start-page: 695
  year: 2008
  ident: 34354_CR110
  publication-title: J. Med. Genet.
  doi: 10.1136/jmg.2007.055772
– volume: 23
  start-page: 4315
  year: 2014
  ident: 34354_CR99
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddu148
– volume: 9
  start-page: 642235
  year: 2021
  ident: 34354_CR123
  publication-title: Front. Cell Dev. Biol
  doi: 10.3389/fcell.2021.642235
– volume: 3
  start-page: 59
  year: 2008
  ident: 34354_CR155
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2007.514
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Snippet Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network support essential developmental processes and their disruption lead to...
Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network support essential developmental processes and their disruption lead to...
Disruptions to the ER-Golgi network can lead to neurodevelopmental disorders, though our understanding of these Golgipathies remains incomplete. Here Lauri,...
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ADP-Ribosylation Factors - metabolism
Animals
Binding
Biosynthesis
Cell division
Danio rerio
Disease
Endoplasmic reticulum
Endoplasmic Reticulum - metabolism
Evolution
Functional analysis
Golgi apparatus
Golgi Apparatus - metabolism
Humanities and Social Sciences
Humans
Membranes
Microcephaly
Microencephaly
Morphology
multidisciplinary
Mutation
Nervous system
Neural stem cells
Neurodegeneration
Neurodevelopmental disorders
Neurodevelopmental Disorders - genetics
Neurodevelopmental Disorders - metabolism
Neurological diseases
Nucleotides
Pediatrics
Proteins
Science
Science (multidisciplinary)
Stability analysis
Zebrafish
Zebrafish - genetics
Zebrafish - metabolism
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Title Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish
URI https://link.springer.com/article/10.1038/s41467-022-34354-x
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