A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer’s disease - Nygaard, Haakon B; Wagner, Allison F; Bowen, Garrett S; Good, Susan P; MacAvoy, Martha G; Strittmatter, Kurt A; Kaufman, Adam C; Rosenberg, Brian J; Sekine-Konno, Tomoko; Varma, Pradeep; Chen, Kewei; Koleske, Anthony J; et al. (Alzheimer's research & therapy, 2015)
Keywords: Activities of daily living; Advertising executives; Alzheimer's disease; Analysis; Biomedical and Life Sciences; Biomedicine; Care and treatment; Central nervous system; Clinical trials; Dextrose; Genetic engineering; Geriatric Psychiatry; Geriatrics/Gerontology; Glucose; Glucose metabolism; Health aspects; Medical research; Medicine, Experimental; Neurology; Neurosciences; PET imaging; Prions; Protein binding; Clinical Efficacy Measure; Clinical Efficacy Assessment; Oral AZD0530; Regional Cerebral Glucose Metabolism; Multiple Ascend Dose Study