Vascular and hepatic enhancements at MR imaging: comparison of Gd-EOB-DTPA and Gd-DTPA in the same subjects

• Published in: Clinical imaging Vol. 38; no. 3; pp. 287 - 291
• Main Authors: Lin, Yen-Heng, Hwang, Ruey-Ming, Chen, Bang-Bin, Hsu, Chao-Yu, Yu, Chih-Wei, Kao, Jia-Horng, Lee, Hsuan-Shu, Liang, Po-Chin, Wei, Shwu-Yuan, Shih, Tiffany Ting-Fang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2014; Elsevier Limited
• Subjects: Abdomen; Adult; Contrast agents; Contrast Media; Coronary vessels; DCE-MRI; Female; Gadolinium DTPA; Gd-DTPA; Gd-EOB-DTPA; Hepatic Artery; Hepatic Veins; Humans; Image Enhancement - methods; Liver - blood supply; Liver - cytology; Magnetic Resonance Angiography; Magnetic Resonance Imaging - methods; Male; Middle Aged; NMR; Nuclear magnetic resonance; Patients; Perfusion imaging; Portal Vein; Radiology; Review boards; Veins & arteries; Gd-DTPA; Gd-EOB-DTPA; DCE-MRI; Perfusion imaging
• ISSN: 0899-7071; 1873-4499; 1873-4499
• DOI: 10.1016/j.clinimag.2014.01.001

The objective was to compare vascular and hepatic enhancement differences at magnetic resonance imaging (MRI) between Gd-EOB-DTPA and Gd-DTPA in the same subjects. Ten healthy subjects received dynamic contrast-enhanced MRI (DCE-MRI) with Gd-EOB-DTPA and then Gd-DTPA to obtain quantitative parameters at 60 and 100 s, respectively. At 60 s, no difference was noted in DCE-MRI parameters between the two contrast agents. At 100 s, mean transit time (MTT) was higher in Gd-EOB-DTPA than in Gd-DTPA (P=.008). Gd-EOB-DTPA showed vascular and hepatic enhancement similar to Gd-DTPA within the initial 60 s during the dynamic phase, but showed increased MTT due to hepatocytes uptake at 100 s.