Optimal cutoff points for HOMA-IR and QUICKI in the diagnosis of metabolic syndrome and non-alcoholic fatty liver disease: A population based study

• Published in: Journal of diabetes and its complications Vol. 30; no. 2; pp. 269 - 274
• Main Authors: Motamed, Nima, Miresmail, Seyed Javad Haji, Rabiee, Behnam, Keyvani, Hossein, Farahani, Behzad, Maadi, Mansooreh, Zamani, Farhad
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2016; Elsevier Limited
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Child; Cohort Studies; Diagnostic index; Diagnostic Techniques, Endocrine - standards; Endocrinology & Metabolism; Female; Homeostatic model assessment index; Humans; Insulin; Insulin Resistance; Liver; Male; Metabolic syndrome; Metabolic Syndrome - diagnosis; Metabolic Syndrome - metabolism; Middle Aged; Non-alcoholic fatty liver disease; Non-alcoholic Fatty Liver Disease - diagnosis; Non-alcoholic Fatty Liver Disease - metabolism; Quantitative insulin sensitivity check index; Reference Values; ROC Curve; Sensitivity and Specificity; Studies; Young Adult; Homeostatic model assessment index; Metabolic syndrome; Non-alcoholic fatty liver disease; Diagnostic index; Quantitative insulin sensitivity check index
• ISSN: 1056-8727; 1873-460X; 1873-460X
• DOI: 10.1016/j.jdiacomp.2015.11.019

The present study was carried out to determine the optimal cutoff points for homeostatic model assessment (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) in the diagnosis of metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD). The baseline data of 5511 subjects aged ≥18years of a cohort study in northern Iran were utilized to analyze. Receiver operating characteristic (ROC) analysis was conducted to determine the discriminatory capability of HOMA-IR and QUICKI in the diagnosis of MetS and NAFLD. Youden index was utilized to determine the optimal cutoff points of HOMA-IR and QUICKI in the diagnosis of MetS and NAFLD. The optimal cutoff points for HOMA-IR in the diagnosis of MetS and NAFLD were 2.0 [sensitivity=64.4%, specificity=66.8%] and 1.79 [sensitivity=66.2%, specificity=62.2%] in men and were 2.5 [sensitivity=57.6%, specificity=67.9%] and 1.95 [sensitivity=65.1%, specificity=54.7%] in women respectively. Furthermore, the optimal cutoff points for QUICKI in the diagnosis of MetS and NAFLD were 0.343 [sensitivity=63.7%, specificity=67.8%] and 0.347 [sensitivity=62.9%, specificity=65.0%] in men and were 0.331 [sensitivity=55.7%, specificity=70.7%] and 0.333 [sensitivity=53.2%, specificity=67.7%] in women respectively. Not only the optimal cutoff points of HOMA-IR and QUICKI were different for MetS and NAFLD, but also different cutoff points were obtained for men and women for each of these two conditions.