The lysosomal protein cathepsin L is a progranulin protease - Lee, Chris W.; Stankowski, Jeannette N.; Chew, Jeannie; Cook, Casey N.; Lam, Ying-Wai; Almeida, Sandra; Carlomagno, Yari; Lau, Kwok-Fai; Prudencio, Mercedes; Gao, Fen-Biao; Bogyo, Matthew; Dickson, Dennis W.; et al. (Molecular neurodegeneration, 2017)
Keywords: Age; Binding sites; Biomedical and Life Sciences; Biomedicine; Cathepsin L; Cathepsin L - metabolism; Cathepsins; Cells, Cultured; Cloning; Cysteine; Cysteine proteinase; Dementia; Dementia disorders; Development and progression; Frontotemporal dementia; Frontotemporal lobar degeneration; Frontotemporal Lobar Degeneration - metabolism; Genetic aspects; Granulin; Haploinsufficiency; Humans; Intercellular Signaling Peptides and Proteins - metabolism; Intracellular; Lysosomal protein; Lysosome; Lysosomes; Lysosomes - metabolism; Molecular Medicine; Neurodegeneration; Neurology; Neuronal ceroid lipofuscinosis; Neurons - metabolism; Neurosciences; Neutrophil elastase; Neutrophils; Peptides; Physiological aspects; Progranulin; Progranulins; Proteins; Proteins - metabolism; Proteolysis; Short Report; United States; Frontotemporal lobar degeneration; Cathepsin L; Neutrophil elastase; Progranulin; Neuronal ceroid lipofuscinosis; Lysosome