Regulatory mechanisms of B cell responses and the implication in B cell-related diseases

Terminally differentiated B cell, the plasma cell, is the sole cell type capable of producing antibodies in our body. Over the past 30 years, the identification of many key molecules controlling B cell activation and differentiation has elucidated the molecular pathways for generating antibody-produ...

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Published inJournal of biomedical science Vol. 26; no. 1; pp. 64 - 13
Main Authors Tsai, Dong-Yan, Hung, Kuo-Hsuan, Chang, Chia-Wei, Lin, Kuo-I
Format Journal Article
LanguageEnglish
Published London BioMed Central 01.09.2019
BioMed Central Ltd
BMC
Subjects
Animals
Antibodies
Antibody
Antigens
Apoptosis
Autoimmune diseases
B cell
B-Lymphocytes - metabolism
Biomedical and Life Sciences
Biomedicine
Bone marrow
Cell activation
Cell cycle
Cell differentiation
Cell growth
Diagnosis
Disease control
Epigenesis, Genetic
Epigenetic regulation
Epigenetics
Gene Expression Regulation
Gene regulation
Hematopoietic stem cells
Humans
Immunological memory
Leukocyte Disorders - genetics
Leukocyte Disorders - physiopathology
Lymphocytes
Lymphocytes B
Lymphocytes T
MicroRNA
MicroRNAs
Plasma
Plasma cell
Plasma cells
Post-transcription
Proteins
Regulatory mechanisms (biology)
Review
Risk factors
Transcription factor
Transcription factors
Translating innovative biomedical research in disease treatments
B cell
B cell malignancy
Antibody
Plasma cell
microRNA
Autoimmune disease
Epigenetic regulation
Transcription factor
Online AccessGet full text
ISSN1423-0127
1021-7770
1423-0127
DOI10.1186/s12929-019-0558-1

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Abstract Terminally differentiated B cell, the plasma cell, is the sole cell type capable of producing antibodies in our body. Over the past 30 years, the identification of many key molecules controlling B cell activation and differentiation has elucidated the molecular pathways for generating antibody-producing plasma cells. Several types of regulation modulating the functions of the important key molecules in B cell activation and differentiation add other layers of complexity in shaping B cell responses following antigen exposure in the absence or presence of T cell help. Further understanding of the mechanisms contributing to the proper activation and differentiation of B cells into antibody-secreting plasma cells may enable us to develop new strategies for managing antibody humoral responses during health and disease. Herein, we reviewed the effect of different types of regulation, including transcriptional regulation, post-transcriptional regulation and epigenetic regulation, on B cell activation, and on mounting memory B cell and antibody responses. We also discussed the link between the dysregulation of the abovementioned regulatory mechanisms and B cell-related disorders.
AbstractList Terminally differentiated B cell, the plasma cell, is the sole cell type capable of producing antibodies in our body. Over the past 30 years, the identification of many key molecules controlling B cell activation and differentiation has elucidated the molecular pathways for generating antibody-producing plasma cells. Several types of regulation modulating the functions of the important key molecules in B cell activation and differentiation add other layers of complexity in shaping B cell responses following antigen exposure in the absence or presence of T cell help. Further understanding of the mechanisms contributing to the proper activation and differentiation of B cells into antibody-secreting plasma cells may enable us to develop new strategies for managing antibody humoral responses during health and disease. Herein, we reviewed the effect of different types of regulation, including transcriptional regulation, post-transcriptional regulation and epigenetic regulation, on B cell activation, and on mounting memory B cell and antibody responses. We also discussed the link between the dysregulation of the abovementioned regulatory mechanisms and B cell-related disorders.
Terminally differentiated B cell, the plasma cell, is the sole cell type capable of producing antibodies in our body. Over the past 30 years, the identification of many key molecules controlling B cell activation and differentiation has elucidated the molecular pathways for generating antibody-producing plasma cells. Several types of regulation modulating the functions of the important key molecules in B cell activation and differentiation add other layers of complexity in shaping B cell responses following antigen exposure in the absence or presence of T cell help. Further understanding of the mechanisms contributing to the proper activation and differentiation of B cells into antibody-secreting plasma cells may enable us to develop new strategies for managing antibody humoral responses during health and disease. Herein, we reviewed the effect of different types of regulation, including transcriptional regulation, post-transcriptional regulation and epigenetic regulation, on B cell activation, and on mounting memory B cell and antibody responses. We also discussed the link between the dysregulation of the abovementioned regulatory mechanisms and B cell-related disorders.Terminally differentiated B cell, the plasma cell, is the sole cell type capable of producing antibodies in our body. Over the past 30 years, the identification of many key molecules controlling B cell activation and differentiation has elucidated the molecular pathways for generating antibody-producing plasma cells. Several types of regulation modulating the functions of the important key molecules in B cell activation and differentiation add other layers of complexity in shaping B cell responses following antigen exposure in the absence or presence of T cell help. Further understanding of the mechanisms contributing to the proper activation and differentiation of B cells into antibody-secreting plasma cells may enable us to develop new strategies for managing antibody humoral responses during health and disease. Herein, we reviewed the effect of different types of regulation, including transcriptional regulation, post-transcriptional regulation and epigenetic regulation, on B cell activation, and on mounting memory B cell and antibody responses. We also discussed the link between the dysregulation of the abovementioned regulatory mechanisms and B cell-related disorders.
Abstract Terminally differentiated B cell, the plasma cell, is the sole cell type capable of producing antibodies in our body. Over the past 30 years, the identification of many key molecules controlling B cell activation and differentiation has elucidated the molecular pathways for generating antibody-producing plasma cells. Several types of regulation modulating the functions of the important key molecules in B cell activation and differentiation add other layers of complexity in shaping B cell responses following antigen exposure in the absence or presence of T cell help. Further understanding of the mechanisms contributing to the proper activation and differentiation of B cells into antibody-secreting plasma cells may enable us to develop new strategies for managing antibody humoral responses during health and disease. Herein, we reviewed the effect of different types of regulation, including transcriptional regulation, post-transcriptional regulation and epigenetic regulation, on B cell activation, and on mounting memory B cell and antibody responses. We also discussed the link between the dysregulation of the abovementioned regulatory mechanisms and B cell-related disorders.
ArticleNumber 64
Audience Academic
Author Lin, Kuo-I
Hung, Kuo-Hsuan
Chang, Chia-Wei
Tsai, Dong-Yan
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  fullname: Hung, Kuo-Hsuan
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  organization: Genomics Research Center, Academia Sinica, Graduate Institute of Immunology, College of Medicine, National Taiwan University
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  orcidid: 0000-0003-4477-0798
  surname: Lin
  fullname: Lin, Kuo-I
  email: kuoilin@gate.sinica.edu.tw
  organization: Genomics Research Center, Academia Sinica, Graduate Institute of Immunology, College of Medicine, National Taiwan University
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1021-7770
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Issue 1
Keywords B cell
B cell malignancy
Antibody
Plasma cell
microRNA
Autoimmune disease
Epigenetic regulation
Transcription factor
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Snippet Terminally differentiated B cell, the plasma cell, is the sole cell type capable of producing antibodies in our body. Over the past 30 years, the...
Abstract Terminally differentiated B cell, the plasma cell, is the sole cell type capable of producing antibodies in our body. Over the past 30 years, the...
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pubmed
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StartPage 64
SubjectTerms Animals
Antibodies
Antibody
Antigens
Apoptosis
Autoimmune diseases
B cell
B-Lymphocytes - metabolism
Biomedical and Life Sciences
Biomedicine
Bone marrow
Cell activation
Cell cycle
Cell differentiation
Cell growth
Diagnosis
Disease control
Epigenesis, Genetic
Epigenetic regulation
Epigenetics
Gene Expression Regulation
Gene regulation
Hematopoietic stem cells
Humans
Immunological memory
Leukocyte Disorders - genetics
Leukocyte Disorders - physiopathology
Lymphocytes
Lymphocytes B
Lymphocytes T
MicroRNA
MicroRNAs
Plasma
Plasma cell
Plasma cells
Post-transcription
Proteins
Regulatory mechanisms (biology)
Review
Risk factors
Transcription factor
Transcription factors
Translating innovative biomedical research in disease treatments
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Title Regulatory mechanisms of B cell responses and the implication in B cell-related diseases
URI https://link.springer.com/article/10.1186/s12929-019-0558-1
https://www.ncbi.nlm.nih.gov/pubmed/31472685
https://www.proquest.com/docview/2292847474
https://www.proquest.com/docview/2283293179
https://pubmed.ncbi.nlm.nih.gov/PMC6717636
https://doaj.org/article/a206491393354751b3064786a1f85d3b
Volume 26
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