Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin-2 levels
Background Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier function and the associati...
Saved in:
| Published in | Critical care (London, England) Vol. 23; no. 1; pp. 117 - 10 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
11.04.2019
BioMed Central Ltd Springer Nature B.V BMC |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1364-8535 1466-609X 1364-8535 1466-609X 1366-609X |
| DOI | 10.1186/s13054-019-2418-5 |
Cover
| Abstract | Background
Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier function and the association with microcirculatory perfusion and angiopoietin-2 levels in patients after CPB.
Methods
Clinical data, sublingual microcirculatory data, and plasma samples were collected from patients undergoing coronary artery bypass graft surgery with CPB (
n
= 17) before and at several time points up to 72 h after CPB. Renal and pulmonary microvascular endothelial cells were incubated with patient plasma, and in vitro endothelial barrier function was assessed using electric cell–substrate impedance sensing. Plasma levels of angiopoietin-1,-2, and soluble Tie2 were measured, and the association with in vitro endothelial barrier function and in vivo microcirculatory perfusion was determined.
Results
A plasma-induced reduction of renal and pulmonary endothelial barrier function was observed in all samples taken within the first three postoperative days (
P
< 0.001 for all time points vs. pre-CPB). Angiopoietin-2 and soluble Tie2 levels increased within 72 h after CPB (5.7 ± 4.4 vs. 1.7 ± 0.4 ng/ml,
P
< 0.0001; 16.3 ± 4.7 vs. 11.9 ± 1.9 ng/ml,
P
= 0.018, vs. pre-CPB), whereas angiopoietin-1 remained stable. Interestingly, reduced in vitro renal and pulmonary endothelial barrier moderately correlated with reduced in vivo microcirculatory perfusion after CPB (
r
= 0.47,
P
= 0.005;
r
= 0.79,
P
< 0.001). In addition, increased angiopoietin-2 levels moderately correlated with reduced in vitro renal and pulmonary endothelial barrier (
r
= − 0.46,
P
< 0.001;
r
= − 0.40,
P
= 0.005) and reduced in vivo microcirculatory perfusion (
r
= − 0.43,
P
= 0.01;
r
= − 0.41,
P
= 0.03).
Conclusions
CPB is associated with an impairment of in vitro endothelial barrier function that continues in the first postoperative days and correlates with reduced postoperative microcirculatory perfusion and increased circulating angiopoietin-2 levels. These results suggest that angiopoietin-2 is a biomarker for postoperative endothelial hyperpermeability, which may contribute to delayed recovery of microcirculatory perfusion after CPB.
Trial registration
NTR4212
. |
|---|---|
| AbstractList | Background
Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier function and the association with microcirculatory perfusion and angiopoietin-2 levels in patients after CPB.
Methods
Clinical data, sublingual microcirculatory data, and plasma samples were collected from patients undergoing coronary artery bypass graft surgery with CPB (
n
= 17) before and at several time points up to 72 h after CPB. Renal and pulmonary microvascular endothelial cells were incubated with patient plasma, and in vitro endothelial barrier function was assessed using electric cell–substrate impedance sensing. Plasma levels of angiopoietin-1,-2, and soluble Tie2 were measured, and the association with in vitro endothelial barrier function and in vivo microcirculatory perfusion was determined.
Results
A plasma-induced reduction of renal and pulmonary endothelial barrier function was observed in all samples taken within the first three postoperative days (
P
< 0.001 for all time points vs. pre-CPB). Angiopoietin-2 and soluble Tie2 levels increased within 72 h after CPB (5.7 ± 4.4 vs. 1.7 ± 0.4 ng/ml,
P
< 0.0001; 16.3 ± 4.7 vs. 11.9 ± 1.9 ng/ml,
P
= 0.018, vs. pre-CPB), whereas angiopoietin-1 remained stable. Interestingly, reduced in vitro renal and pulmonary endothelial barrier moderately correlated with reduced in vivo microcirculatory perfusion after CPB (
r
= 0.47,
P
= 0.005;
r
= 0.79,
P
< 0.001). In addition, increased angiopoietin-2 levels moderately correlated with reduced in vitro renal and pulmonary endothelial barrier (
r
= − 0.46,
P
< 0.001;
r
= − 0.40,
P
= 0.005) and reduced in vivo microcirculatory perfusion (
r
= − 0.43,
P
= 0.01;
r
= − 0.41,
P
= 0.03).
Conclusions
CPB is associated with an impairment of in vitro endothelial barrier function that continues in the first postoperative days and correlates with reduced postoperative microcirculatory perfusion and increased circulating angiopoietin-2 levels. These results suggest that angiopoietin-2 is a biomarker for postoperative endothelial hyperpermeability, which may contribute to delayed recovery of microcirculatory perfusion after CPB.
Trial registration
NTR4212
. Background Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier function and the association with microcirculatory perfusion and angiopoietin-2 levels in patients after CPB. Methods Clinical data, sublingual microcirculatory data, and plasma samples were collected from patients undergoing coronary artery bypass graft surgery with CPB (n = 17) before and at several time points up to 72 h after CPB. Renal and pulmonary microvascular endothelial cells were incubated with patient plasma, and in vitro endothelial barrier function was assessed using electric cell–substrate impedance sensing. Plasma levels of angiopoietin-1,-2, and soluble Tie2 were measured, and the association with in vitro endothelial barrier function and in vivo microcirculatory perfusion was determined. Results A plasma-induced reduction of renal and pulmonary endothelial barrier function was observed in all samples taken within the first three postoperative days (P < 0.001 for all time points vs. pre-CPB). Angiopoietin-2 and soluble Tie2 levels increased within 72 h after CPB (5.7 ± 4.4 vs. 1.7 ± 0.4 ng/ml, P < 0.0001; 16.3 ± 4.7 vs. 11.9 ± 1.9 ng/ml, P = 0.018, vs. pre-CPB), whereas angiopoietin-1 remained stable. Interestingly, reduced in vitro renal and pulmonary endothelial barrier moderately correlated with reduced in vivo microcirculatory perfusion after CPB (r = 0.47, P = 0.005; r = 0.79, P < 0.001). In addition, increased angiopoietin-2 levels moderately correlated with reduced in vitro renal and pulmonary endothelial barrier (r = − 0.46, P < 0.001; r = − 0.40, P = 0.005) and reduced in vivo microcirculatory perfusion (r = − 0.43, P = 0.01; r = − 0.41, P = 0.03). Conclusions CPB is associated with an impairment of in vitro endothelial barrier function that continues in the first postoperative days and correlates with reduced postoperative microcirculatory perfusion and increased circulating angiopoietin-2 levels. These results suggest that angiopoietin-2 is a biomarker for postoperative endothelial hyperpermeability, which may contribute to delayed recovery of microcirculatory perfusion after CPB. Trial registration NTR4212. Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier function and the association with microcirculatory perfusion and angiopoietin-2 levels in patients after CPB.BACKGROUNDEndothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier function and the association with microcirculatory perfusion and angiopoietin-2 levels in patients after CPB.Clinical data, sublingual microcirculatory data, and plasma samples were collected from patients undergoing coronary artery bypass graft surgery with CPB (n = 17) before and at several time points up to 72 h after CPB. Renal and pulmonary microvascular endothelial cells were incubated with patient plasma, and in vitro endothelial barrier function was assessed using electric cell-substrate impedance sensing. Plasma levels of angiopoietin-1,-2, and soluble Tie2 were measured, and the association with in vitro endothelial barrier function and in vivo microcirculatory perfusion was determined.METHODSClinical data, sublingual microcirculatory data, and plasma samples were collected from patients undergoing coronary artery bypass graft surgery with CPB (n = 17) before and at several time points up to 72 h after CPB. Renal and pulmonary microvascular endothelial cells were incubated with patient plasma, and in vitro endothelial barrier function was assessed using electric cell-substrate impedance sensing. Plasma levels of angiopoietin-1,-2, and soluble Tie2 were measured, and the association with in vitro endothelial barrier function and in vivo microcirculatory perfusion was determined.A plasma-induced reduction of renal and pulmonary endothelial barrier function was observed in all samples taken within the first three postoperative days (P < 0.001 for all time points vs. pre-CPB). Angiopoietin-2 and soluble Tie2 levels increased within 72 h after CPB (5.7 ± 4.4 vs. 1.7 ± 0.4 ng/ml, P < 0.0001; 16.3 ± 4.7 vs. 11.9 ± 1.9 ng/ml, P = 0.018, vs. pre-CPB), whereas angiopoietin-1 remained stable. Interestingly, reduced in vitro renal and pulmonary endothelial barrier moderately correlated with reduced in vivo microcirculatory perfusion after CPB (r = 0.47, P = 0.005; r = 0.79, P < 0.001). In addition, increased angiopoietin-2 levels moderately correlated with reduced in vitro renal and pulmonary endothelial barrier (r = - 0.46, P < 0.001; r = - 0.40, P = 0.005) and reduced in vivo microcirculatory perfusion (r = - 0.43, P = 0.01; r = - 0.41, P = 0.03).RESULTSA plasma-induced reduction of renal and pulmonary endothelial barrier function was observed in all samples taken within the first three postoperative days (P < 0.001 for all time points vs. pre-CPB). Angiopoietin-2 and soluble Tie2 levels increased within 72 h after CPB (5.7 ± 4.4 vs. 1.7 ± 0.4 ng/ml, P < 0.0001; 16.3 ± 4.7 vs. 11.9 ± 1.9 ng/ml, P = 0.018, vs. pre-CPB), whereas angiopoietin-1 remained stable. Interestingly, reduced in vitro renal and pulmonary endothelial barrier moderately correlated with reduced in vivo microcirculatory perfusion after CPB (r = 0.47, P = 0.005; r = 0.79, P < 0.001). In addition, increased angiopoietin-2 levels moderately correlated with reduced in vitro renal and pulmonary endothelial barrier (r = - 0.46, P < 0.001; r = - 0.40, P = 0.005) and reduced in vivo microcirculatory perfusion (r = - 0.43, P = 0.01; r = - 0.41, P = 0.03).CPB is associated with an impairment of in vitro endothelial barrier function that continues in the first postoperative days and correlates with reduced postoperative microcirculatory perfusion and increased circulating angiopoietin-2 levels. These results suggest that angiopoietin-2 is a biomarker for postoperative endothelial hyperpermeability, which may contribute to delayed recovery of microcirculatory perfusion after CPB.CONCLUSIONSCPB is associated with an impairment of in vitro endothelial barrier function that continues in the first postoperative days and correlates with reduced postoperative microcirculatory perfusion and increased circulating angiopoietin-2 levels. These results suggest that angiopoietin-2 is a biomarker for postoperative endothelial hyperpermeability, which may contribute to delayed recovery of microcirculatory perfusion after CPB.NTR4212 .TRIAL REGISTRATIONNTR4212 . Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier function and the association with microcirculatory perfusion and angiopoietin-2 levels in patients after CPB. Clinical data, sublingual microcirculatory data, and plasma samples were collected from patients undergoing coronary artery bypass graft surgery with CPB (n = 17) before and at several time points up to 72 h after CPB. Renal and pulmonary microvascular endothelial cells were incubated with patient plasma, and in vitro endothelial barrier function was assessed using electric cell-substrate impedance sensing. Plasma levels of angiopoietin-1,-2, and soluble Tie2 were measured, and the association with in vitro endothelial barrier function and in vivo microcirculatory perfusion was determined. A plasma-induced reduction of renal and pulmonary endothelial barrier function was observed in all samples taken within the first three postoperative days (P < 0.001 for all time points vs. pre-CPB). Angiopoietin-2 and soluble Tie2 levels increased within 72 h after CPB (5.7 ± 4.4 vs. 1.7 ± 0.4 ng/ml, P < 0.0001; 16.3 ± 4.7 vs. 11.9 ± 1.9 ng/ml, P = 0.018, vs. pre-CPB), whereas angiopoietin-1 remained stable. Interestingly, reduced in vitro renal and pulmonary endothelial barrier moderately correlated with reduced in vivo microcirculatory perfusion after CPB (r = 0.47, P = 0.005; r = 0.79, P < 0.001). In addition, increased angiopoietin-2 levels moderately correlated with reduced in vitro renal and pulmonary endothelial barrier (r = - 0.46, P < 0.001; r = - 0.40, P = 0.005) and reduced in vivo microcirculatory perfusion (r = - 0.43, P = 0.01; r = - 0.41, P = 0.03). CPB is associated with an impairment of in vitro endothelial barrier function that continues in the first postoperative days and correlates with reduced postoperative microcirculatory perfusion and increased circulating angiopoietin-2 levels. These results suggest that angiopoietin-2 is a biomarker for postoperative endothelial hyperpermeability, which may contribute to delayed recovery of microcirculatory perfusion after CPB. NTR4212 . Background Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier function and the association with microcirculatory perfusion and angiopoietin-2 levels in patients after CPB. Methods Clinical data, sublingual microcirculatory data, and plasma samples were collected from patients undergoing coronary artery bypass graft surgery with CPB (n = 17) before and at several time points up to 72 h after CPB. Renal and pulmonary microvascular endothelial cells were incubated with patient plasma, and in vitro endothelial barrier function was assessed using electric cell-substrate impedance sensing. Plasma levels of angiopoietin-1,-2, and soluble Tie2 were measured, and the association with in vitro endothelial barrier function and in vivo microcirculatory perfusion was determined. Results A plasma-induced reduction of renal and pulmonary endothelial barrier function was observed in all samples taken within the first three postoperative days (P < 0.001 for all time points vs. pre-CPB). Angiopoietin-2 and soluble Tie2 levels increased within 72 h after CPB (5.7 [+ or -] 4.4 vs. 1.7 [+ or -] 0.4 ng/ml, P < 0.0001; 16.3 [+ or -] 4.7 vs. 11.9 [+ or -] 1.9 ng/ml, P = 0.018, vs. pre-CPB), whereas angiopoietin-1 remained stable. Interestingly, reduced in vitro renal and pulmonary endothelial barrier moderately correlated with reduced in vivo microcirculatory perfusion after CPB (r = 0.47, P = 0.005; r = 0.79, P < 0.001). In addition, increased angiopoietin-2 levels moderately correlated with reduced in vitro renal and pulmonary endothelial barrier (r = - 0.46, P < 0.001; r = - 0.40, P = 0.005) and reduced in vivo microcirculatory perfusion (r = - 0.43, P = 0.01; r = - 0.41, P = 0.03). Conclusions CPB is associated with an impairment of in vitro endothelial barrier function that continues in the first postoperative days and correlates with reduced postoperative microcirculatory perfusion and increased circulating angiopoietin-2 levels. These results suggest that angiopoietin-2 is a biomarker for postoperative endothelial hyperpermeability, which may contribute to delayed recovery of microcirculatory perfusion after CPB. Trial registration NTR4212. Keywords: Cardiopulmonary bypass, Angiopoietin-2, Capillary permeability, Microcirculation, Endothelium Abstract Background Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier function and the association with microcirculatory perfusion and angiopoietin-2 levels in patients after CPB. Methods Clinical data, sublingual microcirculatory data, and plasma samples were collected from patients undergoing coronary artery bypass graft surgery with CPB (n = 17) before and at several time points up to 72 h after CPB. Renal and pulmonary microvascular endothelial cells were incubated with patient plasma, and in vitro endothelial barrier function was assessed using electric cell–substrate impedance sensing. Plasma levels of angiopoietin-1,-2, and soluble Tie2 were measured, and the association with in vitro endothelial barrier function and in vivo microcirculatory perfusion was determined. Results A plasma-induced reduction of renal and pulmonary endothelial barrier function was observed in all samples taken within the first three postoperative days (P < 0.001 for all time points vs. pre-CPB). Angiopoietin-2 and soluble Tie2 levels increased within 72 h after CPB (5.7 ± 4.4 vs. 1.7 ± 0.4 ng/ml, P < 0.0001; 16.3 ± 4.7 vs. 11.9 ± 1.9 ng/ml, P = 0.018, vs. pre-CPB), whereas angiopoietin-1 remained stable. Interestingly, reduced in vitro renal and pulmonary endothelial barrier moderately correlated with reduced in vivo microcirculatory perfusion after CPB (r = 0.47, P = 0.005; r = 0.79, P < 0.001). In addition, increased angiopoietin-2 levels moderately correlated with reduced in vitro renal and pulmonary endothelial barrier (r = − 0.46, P < 0.001; r = − 0.40, P = 0.005) and reduced in vivo microcirculatory perfusion (r = − 0.43, P = 0.01; r = − 0.41, P = 0.03). Conclusions CPB is associated with an impairment of in vitro endothelial barrier function that continues in the first postoperative days and correlates with reduced postoperative microcirculatory perfusion and increased circulating angiopoietin-2 levels. These results suggest that angiopoietin-2 is a biomarker for postoperative endothelial hyperpermeability, which may contribute to delayed recovery of microcirculatory perfusion after CPB. Trial registration NTR4212. Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier function and the association with microcirculatory perfusion and angiopoietin-2 levels in patients after CPB. Clinical data, sublingual microcirculatory data, and plasma samples were collected from patients undergoing coronary artery bypass graft surgery with CPB (n = 17) before and at several time points up to 72 h after CPB. Renal and pulmonary microvascular endothelial cells were incubated with patient plasma, and in vitro endothelial barrier function was assessed using electric cell-substrate impedance sensing. Plasma levels of angiopoietin-1,-2, and soluble Tie2 were measured, and the association with in vitro endothelial barrier function and in vivo microcirculatory perfusion was determined. A plasma-induced reduction of renal and pulmonary endothelial barrier function was observed in all samples taken within the first three postoperative days (P < 0.001 for all time points vs. pre-CPB). Angiopoietin-2 and soluble Tie2 levels increased within 72 h after CPB (5.7 [+ or -] 4.4 vs. 1.7 [+ or -] 0.4 ng/ml, P < 0.0001; 16.3 [+ or -] 4.7 vs. 11.9 [+ or -] 1.9 ng/ml, P = 0.018, vs. pre-CPB), whereas angiopoietin-1 remained stable. Interestingly, reduced in vitro renal and pulmonary endothelial barrier moderately correlated with reduced in vivo microcirculatory perfusion after CPB (r = 0.47, P = 0.005; r = 0.79, P < 0.001). In addition, increased angiopoietin-2 levels moderately correlated with reduced in vitro renal and pulmonary endothelial barrier (r = - 0.46, P < 0.001; r = - 0.40, P = 0.005) and reduced in vivo microcirculatory perfusion (r = - 0.43, P = 0.01; r = - 0.41, P = 0.03). CPB is associated with an impairment of in vitro endothelial barrier function that continues in the first postoperative days and correlates with reduced postoperative microcirculatory perfusion and increased circulating angiopoietin-2 levels. These results suggest that angiopoietin-2 is a biomarker for postoperative endothelial hyperpermeability, which may contribute to delayed recovery of microcirculatory perfusion after CPB. |
| ArticleNumber | 117 |
| Audience | Academic |
| Author | Szulcek, Robert Boer, Christa van Leeuwen, Anoek L. I. van Strien, Willem W. J. van den Brom, Charissa E. Vonk, Alexander B. A. Hordijk, Peter L. Dekker, Nicole A. M. Majolée, Jisca |
| Author_xml | – sequence: 1 givenname: Nicole A. M. orcidid: 0000-0002-0300-3026 surname: Dekker fullname: Dekker, Nicole A. M. email: n.dekker@vumc.nl organization: Amsterdam UMC, Vrije Universiteit Amsterdam, Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Physiology, Experimental Laboratory for Vital Signs, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Cardiothoracic Surgery, Amsterdam Cardiovascular Sciences – sequence: 2 givenname: Anoek L. I. surname: van Leeuwen fullname: van Leeuwen, Anoek L. I. organization: Amsterdam UMC, Vrije Universiteit Amsterdam, Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Physiology, Experimental Laboratory for Vital Signs, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Cardiothoracic Surgery, Amsterdam Cardiovascular Sciences – sequence: 3 givenname: Willem W. J. surname: van Strien fullname: van Strien, Willem W. J. organization: Amsterdam UMC, Vrije Universiteit Amsterdam, Anesthesiology, Amsterdam Cardiovascular Sciences – sequence: 4 givenname: Jisca surname: Majolée fullname: Majolée, Jisca organization: Amsterdam UMC, Vrije Universiteit Amsterdam, Physiology, Experimental Laboratory for Vital Signs, Amsterdam Cardiovascular Sciences – sequence: 5 givenname: Robert surname: Szulcek fullname: Szulcek, Robert organization: Amsterdam UMC, Vrije Universiteit Amsterdam, Physiology, Experimental Laboratory for Vital Signs, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Pulmonology, Amsterdam Cardiovascular Sciences – sequence: 6 givenname: Alexander B. A. surname: Vonk fullname: Vonk, Alexander B. A. organization: Amsterdam UMC, Vrije Universiteit Amsterdam, Physiology, Experimental Laboratory for Vital Signs, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Cardiothoracic Surgery, Amsterdam Cardiovascular Sciences – sequence: 7 givenname: Peter L. surname: Hordijk fullname: Hordijk, Peter L. organization: Amsterdam UMC, Vrije Universiteit Amsterdam, Physiology, Experimental Laboratory for Vital Signs, Amsterdam Cardiovascular Sciences – sequence: 8 givenname: Christa surname: Boer fullname: Boer, Christa organization: Amsterdam UMC, Vrije Universiteit Amsterdam, Anesthesiology, Amsterdam Cardiovascular Sciences – sequence: 9 givenname: Charissa E. surname: van den Brom fullname: van den Brom, Charissa E. organization: Amsterdam UMC, Vrije Universiteit Amsterdam, Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Physiology, Experimental Laboratory for Vital Signs, Amsterdam Cardiovascular Sciences |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30975180$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNUk1v1DAQjRCIfsAP4IIiceGSYieO7b0gVRUflYq4wNmaOJNdV157sZ1W-9_4ccyypbQVIBQrtsbvvfHMm6PqcYgBq-oFZyeca_km8471omF80bSC66Z_VB3yTopG913_-M75oDrK-ZIxrrTsnlYHHVuonmt2WH3_5GyK1iU7eygxbesNpmnOLoZ6dLnMaYBgMddT9D5eu7CsLaTRga3znJZIhGtXVvtg3Mx-HQNQcNhuIOcaEta0UwIoOO6hLtRXrqRYYxhjWaF34OvVlvLSWiMMzruyrSGMBLUJIRMTwpLko8PiQtPWHq_Q52fVkwl8xuc3-3H19f27L2cfm4vPH87PTi8aK1lXGtBiQFz0VliccBBDDxJHqaXslO2QKYZ6QE1npSfstB70JNpWCM1R6l53x9X5XneMcGk2ya2pRBPBmZ-BmJYGUnHWo7G2HwemgHEpBe9QcyFUq1pUoMiOjrTavdYcNrC9Bu9vBTkzO1vN3lZDtpqdraYn0ts9aTMPaxwthpLA33vJ_ZvgVmYZr4wUkqlOkcDrG4EUv82Yi1m7bNF7CBjnbNqWLfqFXMgd9NUD6GWcU6D-EorzViqh76CWQFW7MEXKa3ei5pQ6xpWiP6FO_oCib8S1szTMk6P4PcLLu4XeVvhrYAmg9gCa2pwTTsa6AoXGlZSd_2cP-QPm__T9xqxM2EDT_rsXfyf9ADzvI08 |
| CitedBy_id | crossref_primary_10_1007_s12265_023_10407_4 crossref_primary_10_1186_s12964_020_00606_w crossref_primary_10_3233_CH_190642 crossref_primary_10_4103_IJCIIS_IJCIIS_197_20 crossref_primary_10_1080_0886022X_2024_2331062 crossref_primary_10_1186_s40635_021_00389_5 crossref_primary_10_3390_jcm10030469 crossref_primary_10_3390_ijms251910680 crossref_primary_10_1007_s10877_022_00936_9 crossref_primary_10_1016_j_mvr_2024_104694 crossref_primary_10_1053_j_jvca_2021_03_025 crossref_primary_10_1186_s13613_023_01165_2 crossref_primary_10_3390_cells12101432 crossref_primary_10_1177_02676591211052161 crossref_primary_10_1007_s44200_023_00036_2 crossref_primary_10_1111_micc_12891 crossref_primary_10_1186_s40635_022_00478_z crossref_primary_10_1186_s12967_020_02236_9 crossref_primary_10_1213_ANE_0000000000005023 crossref_primary_10_1186_s40635_021_00393_9 crossref_primary_10_3390_biomedicines9070803 crossref_primary_10_1080_1354750X_2020_1748716 crossref_primary_10_1186_s40635_024_00661_4 crossref_primary_10_18705_2311_4495_2020_7_5_17_28 crossref_primary_10_4103_aca_ACA_139_20 crossref_primary_10_1016_j_clim_2021_108849 |
| Cites_doi | 10.1016/j.bja.2017.11.095 10.1097/CCM.0b013e31825fdc31 10.1186/cc7153 10.1016/j.cyto.2012.04.002 10.1038/sj.onc.1202992 10.1097/CCM.0b013e318206d285 10.1172/JCI66549 10.1097/CCM.0000000000001853 10.1177/0267659109105079 10.1053/j.jvca.2014.03.004 10.1126/scitranslmed.aad9260 10.3892/mmr.2016.4831 10.1164/rccm.201506-1231OC 10.1242/jcs.017897 10.1111/anae.14577 10.1097/SHK.0b013e3181b2f978 10.1111/trf.12126 10.1093/bja/aev411 10.1371/journal.pone.0136205 10.1038/srep11030 10.1371/journal.pmed.0030046 10.1186/s13054-016-1238-0 10.1007/s00134-008-1174-9 10.4161/21688362.2014.957508 10.1097/SHK.0000000000000190 10.1186/cc6118 10.1016/j.bja.2018.05.049 10.1053/j.jvca.2005.01.029 10.1371/journal.pone.0070459 |
| ContentType | Journal Article |
| Copyright | The Author(s). 2019 COPYRIGHT 2019 BioMed Central Ltd. 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s). 2019 – notice: COPYRIGHT 2019 BioMed Central Ltd. – notice: 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM ADTOC UNPAY DOA |
| DOI | 10.1186/s13054-019-2418-5 |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Proquest Central ProQuest One ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: C6C name: SpringerOpen Free (Free internet resource, activated by CARLI) url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository – sequence: 6 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1364-8535 1466-609X 1366-609X |
| EndPage | 10 |
| ExternalDocumentID | oai_doaj_org_article_cc5db07a0166413e81447272e7a71363 10.1186/s13054-019-2418-5 PMC6460737 A583177583 30975180 10_1186_s13054_019_2418_5 |
| Genre | Journal Article |
| GeographicLocations | Netherlands United States--US |
| GeographicLocations_xml | – name: Netherlands – name: United States--US |
| GrantInformation_xml | – fundername: Netherlands Cardiovascular Research Initiative Grant grantid: Grant number 2012-08 – fundername: European Society of Intensive Care Medicine grantid: Levi-Montalcini Award 2017 – fundername: Hartstichting grantid: 2016T064 funderid: http://dx.doi.org/10.13039/501100002996 – fundername: Dutch Society of Anesthesiology grantid: Young Investigator Grant 2017 – fundername: European Society of Anaesthesiology grantid: Research Project Grant 2016 funderid: http://dx.doi.org/10.13039/501100011924 – fundername: Hartstichting grantid: 2016T064 – fundername: European Society of Anaesthesiology grantid: Research Project Grant 2016 – fundername: ; grantid: Young Investigator Grant 2017 – fundername: ; grantid: Levi-Montalcini Award 2017 – fundername: ; grantid: 2016T064 – fundername: ; grantid: Grant number 2012-08 – fundername: ; grantid: Research Project Grant 2016 |
| GroupedDBID | --- 0R~ 29F 2WC 4.4 53G 5GY 5VS 6J9 6PF 7X7 88E 8FI 8FJ AAFWJ AAJSJ AASML AAWTL ABUWG ACGFS ACJQM ADBBV ADUKV AEGXH AENEX AFKRA AFPKN AHBYD AHMBA AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIAM AOIJS BAPOH BAWUL BCNDV BENPR BFQNJ BMC BPHCQ BVXVI C6C CCPQU CS3 DIK E3Z EBD EBLON EBS EJD EMOBN F5P FYUFA GROUPED_DOAJ GX1 HMCUK HYE IAO IHR INH INR ITC KQ8 M1P OK1 PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO PUEGO RBZ ROL RPM RSV SJN SMD SOJ SV3 TR2 U2A UKHRP WOQ YOC AAYXX CITATION -5E -5G -BR 3V. ACRMQ ADINQ ALIPV C24 CGR CUY CVF ECM EIF NPM 7XB 8FK AZQEC DWQXO K9. PKEHL PQEST PQUKI PRINS 7X8 5PM ADTOC AHSBF C1A H13 O5R O5S UNPAY |
| ID | FETCH-LOGICAL-c603t-a84bee95c4cefeb4b5a6ed686637c3e070e8be87c378fe388b8f4224481e68583 |
| IEDL.DBID | DOA |
| ISSN | 1364-8535 1466-609X |
| IngestDate | Fri Oct 03 12:52:48 EDT 2025 Sun Oct 26 04:12:00 EDT 2025 Tue Sep 30 16:55:07 EDT 2025 Fri Sep 05 13:22:13 EDT 2025 Tue Oct 14 12:41:20 EDT 2025 Mon Oct 20 22:23:38 EDT 2025 Mon Oct 20 16:45:54 EDT 2025 Thu Jan 02 22:59:21 EST 2025 Thu Apr 24 22:51:41 EDT 2025 Wed Oct 01 04:34:03 EDT 2025 Sat Sep 06 07:25:17 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Cardiopulmonary bypass Capillary permeability Microcirculation Angiopoietin-2 Endothelium |
| Language | English |
| License | Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. cc-by |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c603t-a84bee95c4cefeb4b5a6ed686637c3e070e8be87c378fe388b8f4224481e68583 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-0300-3026 |
| OpenAccessLink | https://doaj.org/article/cc5db07a0166413e81447272e7a71363 |
| PMID | 30975180 |
| PQID | 2211267487 |
| PQPubID | 44362 |
| PageCount | 10 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_cc5db07a0166413e81447272e7a71363 unpaywall_primary_10_1186_s13054_019_2418_5 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6460737 proquest_miscellaneous_2209596967 proquest_journals_2211267487 gale_infotracmisc_A583177583 gale_infotracacademiconefile_A583177583 pubmed_primary_30975180 crossref_citationtrail_10_1186_s13054_019_2418_5 crossref_primary_10_1186_s13054_019_2418_5 springer_journals_10_1186_s13054_019_2418_5 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2019-04-11 |
| PublicationDateYYYYMMDD | 2019-04-11 |
| PublicationDate_xml | – month: 04 year: 2019 text: 2019-04-11 day: 11 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Critical care (London, England) |
| PublicationTitleAbbrev | Crit Care |
| PublicationTitleAlternate | Crit Care |
| PublicationYear | 2019 |
| Publisher | BioMed Central BioMed Central Ltd Springer Nature B.V BMC |
| Publisher_xml | – name: BioMed Central – name: BioMed Central Ltd – name: Springer Nature B.V – name: BMC |
| References | J Fisher (2418_CR14) 2016; 44 DR Ricciuto (2418_CR15) 2011; 39 SM Parikh (2418_CR31) 2017; 28 C Clajus (2418_CR10) 2012; 60 NJ Koning (2418_CR3) 2016; 116 CS Brudney (2418_CR7) 2005; 19 G Fachinger (2418_CR29) 2009; 18 NJ Koning (2418_CR4) 2018; 120 T Ushida (2418_CR23) 2014; 28 J Zhang (2418_CR22) 2016; 13 M Meurs van (2418_CR30) 2009; 13 RM Jongman (2418_CR16) 2015; 10 S Han (2418_CR25) 2016; 8 T Hilbert (2418_CR8) 2016; 20 KE Milam (2418_CR12) 2015; 3 N.A.M. Dekker (2418_CR5) 2018; 121 E Hirleman (2418_CR1) 2009; 23 JS Giuliano Jr (2418_CR9) 2008; 34 RM Jongman (2418_CR2) 2014; 42 AB Vonk (2418_CR17) 2013; 53 MG Sugiyama (2418_CR21) 2015; 5 M Heijden van der (2418_CR28) 2010; 33 SM Parikh (2418_CR13) 2006; 3 E Dejana (2418_CR27) 2008; 121 N. A. M. Dekker (2418_CR6) 2019; 74 R Szulcek (2418_CR18) 2016; 193 S David (2418_CR24) 2012; 40 AV Benest (2418_CR11) 2013; 8 R Szulcek (2418_CR19) 2014; 28 D Backer De (2418_CR20) 2007; 11 Tilman Ziegler (2418_CR26) 2013; 123 |
| References_xml | – volume: 120 start-page: 1165 issue: 6 year: 2018 ident: 2418_CR4 publication-title: Br J Anaesth doi: 10.1016/j.bja.2017.11.095 – volume: 40 start-page: 3034 issue: 11 year: 2012 ident: 2418_CR24 publication-title: Crit Care Med doi: 10.1097/CCM.0b013e31825fdc31 – volume: 13 start-page: 207 issue: 2 year: 2009 ident: 2418_CR30 publication-title: Crit Care doi: 10.1186/cc7153 – volume: 60 start-page: 352 year: 2012 ident: 2418_CR10 publication-title: Cytokine doi: 10.1016/j.cyto.2012.04.002 – volume: 18 start-page: 5948 year: 2009 ident: 2418_CR29 publication-title: Oncogene doi: 10.1038/sj.onc.1202992 – volume: 39 start-page: 702 issue: 4 year: 2011 ident: 2418_CR15 publication-title: Crit Care Med doi: 10.1097/CCM.0b013e318206d285 – volume: 123 start-page: 3436 issue: 8 year: 2013 ident: 2418_CR26 publication-title: Journal of Clinical Investigation doi: 10.1172/JCI66549 – volume: 44 start-page: 2018 issue: 11 year: 2016 ident: 2418_CR14 publication-title: Crit Care Med doi: 10.1097/CCM.0000000000001853 – volume: 23 start-page: 311 year: 2009 ident: 2418_CR1 publication-title: Perfusion doi: 10.1177/0267659109105079 – volume: 28 start-page: 1293 issue: 5 year: 2014 ident: 2418_CR23 publication-title: J Cardiothorac Vasc Anesth doi: 10.1053/j.jvca.2014.03.004 – volume: 8 start-page: 335ra55 issue: 335 year: 2016 ident: 2418_CR25 publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aad9260 – volume: 13 start-page: 2918 issue: 3 year: 2016 ident: 2418_CR22 publication-title: Mol Med Rep doi: 10.3892/mmr.2016.4831 – volume: 193 start-page: 1410 issue: 12 year: 2016 ident: 2418_CR18 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201506-1231OC – volume: 28 start-page: 197319 year: 2017 ident: 2418_CR31 publication-title: J Am Soc Nephrol – volume: 121 start-page: 2115 year: 2008 ident: 2418_CR27 publication-title: J Cell Science doi: 10.1242/jcs.017897 – volume: 74 start-page: 609 issue: 5 year: 2019 ident: 2418_CR6 publication-title: Anaesthesia doi: 10.1111/anae.14577 – volume: 33 start-page: 263 issue: 3 year: 2010 ident: 2418_CR28 publication-title: Shock doi: 10.1097/SHK.0b013e3181b2f978 – volume: 53 start-page: 2782 year: 2013 ident: 2418_CR17 publication-title: Transfusion doi: 10.1111/trf.12126 – volume: 116 start-page: 223 issue: 2 year: 2016 ident: 2418_CR3 publication-title: Br J Anaesth doi: 10.1093/bja/aev411 – volume: 10 start-page: e0136205 issue: 8 year: 2015 ident: 2418_CR16 publication-title: PLoS One doi: 10.1371/journal.pone.0136205 – volume: 5 start-page: 11030 year: 2015 ident: 2418_CR21 publication-title: Sci Rep doi: 10.1038/srep11030 – volume: 3 start-page: e46 year: 2006 ident: 2418_CR13 publication-title: PLoS Med doi: 10.1371/journal.pmed.0030046 – volume: 20 start-page: 51 year: 2016 ident: 2418_CR8 publication-title: Crit Care doi: 10.1186/s13054-016-1238-0 – volume: 34 start-page: 1851 year: 2008 ident: 2418_CR9 publication-title: Intensive Care Med doi: 10.1007/s00134-008-1174-9 – volume: 28 start-page: 85 year: 2014 ident: 2418_CR19 publication-title: J Vis Exp – volume: 3 start-page: e957508 issue: 1–2 year: 2015 ident: 2418_CR12 publication-title: Tissue Barriers doi: 10.4161/21688362.2014.957508 – volume: 42 start-page: 121 issue: 2 year: 2014 ident: 2418_CR2 publication-title: Shock doi: 10.1097/SHK.0000000000000190 – volume: 11 start-page: R101 issue: 5 year: 2007 ident: 2418_CR20 publication-title: Crit Care doi: 10.1186/cc6118 – volume: 121 start-page: 1041 issue: 5 year: 2018 ident: 2418_CR5 publication-title: British Journal of Anaesthesia doi: 10.1016/j.bja.2018.05.049 – volume: 19 start-page: 188 issue: 2 year: 2005 ident: 2418_CR7 publication-title: J Cardiothorac Vasc Anaesth doi: 10.1053/j.jvca.2005.01.029 – volume: 8 start-page: e70459 issue: 8 year: 2013 ident: 2418_CR11 publication-title: PLoS One doi: 10.1371/journal.pone.0070459 |
| SSID | ssj0017863 |
| Score | 2.42672 |
| Snippet | Background
Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative... Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications... Background Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative... Abstract Background Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and... |
| SourceID | doaj unpaywall pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 117 |
| SubjectTerms | Aged Analysis Angiopoietin-1 - analysis Angiopoietin-1 - blood Angiopoietin-2 Angiopoietin-2 - analysis Angiopoietin-2 - blood Biomarkers Biomarkers - analysis Biomarkers - blood Blood Blood platelets Capillary permeability Cardiac output Cardiac patients Cardiopulmonary bypass Cardiopulmonary Bypass - adverse effects Cardiopulmonary Bypass - methods Cell adhesion & migration Cell culture Coronary artery bypass Critical care Critical Care Medicine Emergency Medicine Endothelial Cells - metabolism Endothelial Cells - physiology Endothelium Female Heart surgery Hospital patients Humans Inflammation Intensive Kidney - blood supply Kidney - physiopathology Kidneys Kinases Lung - blood supply Lung - physiopathology Male Medicine Medicine & Public Health Microcirculation Microcirculation - physiology Middle Aged Permeability Postoperative complications Receptor, TIE-2 - analysis Receptor, TIE-2 - blood Sepsis Sufentanil Surgery |
| SummonAdditionalLinks | – databaseName: Proquest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1ba9swFBZdCrs8jN26ZeuGBoPBimls6-aHMdrRUgYJY6zQNyFLchvI7MxOVvLf9uN2jm-tN8ggD8E6si3r0zlHOjdC3nlmGAdVNJDWyYAxroJUpDyIXDoB6WyF8BjgPJ2Js3P25YJf7JBZFwuDbpUdT6wZtSssnpEfRhEGu0jQrz8tfwZYNQqtq10JDdOWVnAf6xRjd8huhJmxRmT3-GT29VtvV5Cqrq0WxoIFIKh4a-cMlTisgJtz9MhAi0OoAj6QVHVC_3_Z9i259bdPZW9YfUDurfOl2VybxeKW7Dp9RB62Sic9alDymOz4_Am5O23N6k_J7ym65dl5iU6paHWnS19mazxIow5wsC5TBEdFM0BNcQ3Po7ZGlqVVE1ZN8Ty3uYgVweBjGbiYbpagm1NTempaGHjXkM5z-mu-Kgvqc4dBYAtYB_QKNsUl_H74Jnv4hprcASlqthX0NPkl3L6YY5h2ENEFOjxVz8j56cn3z2dBW9YhsGISrwKjWOp9wi2zPvMpS7kR3gkFuo-0sQce5FXqFfyXKvOxUqnKGGgaTIUes-XHe2SUF7l_QWjMMy5cGKVWxkxym4B2yo1xXrgkk1kyJpNuCrVtc55j6Y2Frvc-Suhm1jXMusZZ13xMPvRdlk3Cj23Ex4iLnhBzddcXivJSt0tfW8sB-NKAci1AZfAK9rBo_vbSSABiPCbvEVUaOQq8nDVtYAQMEXNz6SMYcihhXweU-wNK4AR22NzhUrecqNI362ZM3vbN2BO963JfrJEGT4NFIoDmeQPjfkjxJEHL3GRM5ADggzEPW_L5VZ2nXDABAgTuedAthZvX2vJJD_rV8v8JeLl9yK_I_QgXNObmDPfJaFWu_WtQIlfpm5Yz_AGlQnFj priority: 102 providerName: ProQuest – databaseName: SpringerLink Journals (ICM) dbid: U2A link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlR1ri9QwMOgJPj6Ib1dPiSAIHuV227z6cRWPQ1g_uXDfQpJO7xZqu7S7Hvvf_HHOtN16VTkR-qEkk2yz88hM5hHG3oJwQqIqGumQ6UgIaSKvvIzizE9xdw5KASU4L76o06X4fCbP-jzuZh_tvndJtpK6ZWujjhuUtpIiJsgjMDORvMluSarmhUS8jOeD60AblfTuy78OG21AbZ3-P6Xxle3o91DJwV96j93Zlmu3u3RFcWVLOnnA7ve6JJ93yH_IbkD5iN1e9N7yx-zHgqLtwqqmWFNypvM11PmWzsd4hujd1p5w3vAciaG6xN_joSWYwJsuW5rTMW3XSBd9Ick6bPS7Narc3NXAXY9dyDrQVcm_rzZ1xaHMKLerQPLmF2jr1vh8g64o-I67MkNQUlgbHOnKc5y-WlH2dRTzguKYmidsefLp68fTqL-tIQpqmmwiZ4QHSGUQAXLwwkunIFMGVRodEkDRAsaDwXdtckiM8SYXqEAIMwMqgp88ZQdlVcJzxhOZS5XNYh90IrQMKSqd0rkMVJbmOk8nbLpHoQ19KXO6UaOwrUljlO2wbhHrlrBu5YS9H4asuzoe1wF_ILoYAKkEd9tQ1ee252gbgkR61g51ZoWaABg0TcmrDdqh4a-SCXtHVGVJUODHBdfnO-ASqeSWneOSZxrNNYQ8HEEig4dx954ubS9gGhvHlPul0dycsDdDN42koLkSqi3B0CGvShXCPOvIeFhSMk3J4TadMD0i8NGaxz3l6qItP66Ewn0B5zzas8Kvz7rmLz0auOXfCHjxX3O_ZHdj4m-qwDk7ZAebeguvUFXc-NetaPgJcXRllg priority: 102 providerName: Springer Nature – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1ba9swFBZdCrs87H7J1g0NBoMVp46tmx-z0VIGKXtYoHsykiy3oZ4d7Hgl-237cTvHdrK4Gx1jkAdjHYnIOjfpnPOJkDeOacbBFfWkTaTHGFeeEYZ7QWJ8sM5WCIcFztMTcTxjH0_56Q45XNfCWNuAEIy2i8-zRmPDg704WCRpK-hKHFSgfznmUGCMYKw8foPsCg4u-YDszk4-Tb60NVfMA5PE2yoj4Qk_Ou2im38co2efGhj_35X1lrW6mkm5CafeIbfqfKFXlzrLtizW0b02s6RqgA4xUeViVC_NyH6_AgP53x_jPrnb-bR00jLhA7Lj8ofk5rSL2j8iP6aY9WfnJea8YlCfLlyZ1nhORxNgs7o0yHsVTYEpi0uYGLUN41patVXbFI-L25d44RiIjoaXZrUA15_q0lHdcZlLWtJ5Tr_Nl2VBXZ5gjVkGYkbPYc9dwu-ra8HJV1TnCZCi41xBT52fwfDFHKvAvYBmmE9VPSazo8PPH4697tYIzwo_XHpaMeNcxC2zLnWGGa6FS4QC10ra0IGKc8o4Bc9SpS5UyqiUgSPD1NghGH_4hAzyInfPCA15ykUyDoyVIZPcRuD8cq0TJ5IolWk0JP6aV2LbQarjzR5Z3GytlIjbVYlhVWJclZgPybtNl0WLJ3Id8XtkwA0hQoE3L4ryLO40S2wtB7mSGnx3AR6JU7BFxui6k1oC94dD8hbZN0aFhWyju7oLmCJCf8UTmPJYwrYRKPd6lKBobL95LQBxp-iqOAiwBk3CtndIXm-asScm7-WuqJEGD5tFJIDmaSsvmymFfoSBP39IZE-SenPut-Tz8wYGXTAB9gnG3F_L3K-_dc0n3d-I5d8X4Pk_Ub8gtwOUP0QCHe-RwbKs3UtwWZfmVaeQfgIL3pGj priority: 102 providerName: Unpaywall |
| Title | Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin-2 levels |
| URI | https://link.springer.com/article/10.1186/s13054-019-2418-5 https://www.ncbi.nlm.nih.gov/pubmed/30975180 https://www.proquest.com/docview/2211267487 https://www.proquest.com/docview/2209596967 https://pubmed.ncbi.nlm.nih.gov/PMC6460737 https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-019-2418-5 https://doaj.org/article/cc5db07a0166413e81447272e7a71363 |
| UnpaywallVersion | publishedVersion |
| Volume | 23 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVADU databaseName: BioMed Central Open Access Free customDbUrl: eissn: 1364-8535 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017863 issn: 1466-609X databaseCode: RBZ dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1364-8535 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017863 issn: 1466-609X databaseCode: KQ8 dateStart: 19970101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1364-8535 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017863 issn: 1466-609X databaseCode: KQ8 dateStart: 19970801 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1364-8535 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017863 issn: 1466-609X databaseCode: KQ8 dateStart: 19980101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1364-8535 dateEnd: 20231231 omitProxy: true ssIdentifier: ssj0017863 issn: 1466-609X databaseCode: DOA dateStart: 19980101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1364-8535 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017863 issn: 1466-609X databaseCode: DIK dateStart: 19970101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1364-8535 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017863 issn: 1466-609X databaseCode: GX1 dateStart: 0 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 1364-8535 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017863 issn: 1466-609X databaseCode: RPM dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1364-8535 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017863 issn: 1466-609X databaseCode: 7X7 dateStart: 20150101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1364-8535 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017863 issn: 1466-609X databaseCode: BENPR dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVAVX databaseName: HAS SpringerNature Open Access 2022 customDbUrl: eissn: 1364-8535 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017863 issn: 1466-609X databaseCode: AAJSJ dateStart: 19970401 isFulltext: true titleUrlDefault: https://www.springernature.com providerName: Springer Nature – providerCode: PRVAVX databaseName: SpringerLink Journals (ICM) customDbUrl: eissn: 1364-8535 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017863 issn: 1466-609X databaseCode: U2A dateStart: 19970401 isFulltext: true titleUrlDefault: http://www.springerlink.com/journals/ providerName: Springer Nature – providerCode: PRVAVX databaseName: SpringerOpen Free (Free internet resource, activated by CARLI) customDbUrl: eissn: 1364-8535 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017863 issn: 1466-609X databaseCode: C6C dateStart: 19970104 isFulltext: true titleUrlDefault: http://www.springeropen.com/ providerName: Springer Nature |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3ra9swEBdbC3t8GHsvWxc0GAxWTP3Qyx-T0FIGCaUskO2LkGW5DWROsJOV_G_743ZnO168QftlEIwtnxzL99PpTnc6EfLRMcM4qKKetKn0GOPKS0TCvTBNfBidrRAOFziPJ-J8yr7M-Gxvqy-MCavTA9cf7sRaDtWkAdVEgMB1CiwAdB46acC-ElWeT1_FO2Oq8R9IJaLGhxkocVKCpOYYbYHehEB5vDMKVcn6_xXJe2PS3_GSrdP0MXm4yVdme2MWi71x6ewpedIolHRQN-QZuefy5-TBuHGZvyC_xhhyZ-cFBpyiR52uXJFtcJKMpsDjTZEg40uaASKWN_B_1FaosbSsl0xTnKutC3G3L8CtgcJkuwK9m5rCUdOw2KU16TynP-frYkldnuICrwVgnF6DwVvA74erM4NvqclTIEWttYSaJr-Cxy_nuATbC-kCg5nKl2R6dvp1dO41WzZ4VvjR2jOKJc7F3DLrMpewhBvhUqFAr5E2ciBfnEqcgnOpMhcplaiMgRbBVOAwE370ihzky9y9ITTiGRdpECZWRkxyG4PmyY1JnUjjTGZxj_g7Fmrb5DPHbTUWurJrlNA11zVwXSPXNe-Rz22VVZ3M4zbiIeKiJcQ83FUBoFM36NR3obNHPiGqNEoLeDlrmkUP0ETMu6UH0ORAgs0GlEcdSujltnt7h0vdSJlShyEuAJNgc_bIh_Y21sTIudwtN0iDM70iFkDzuoZx26TIj9Hr5veI7AC80-bunXx-XeUgF0zA4ADPPN51hT-vdcsnPW57y90MePs_GPCOPAqx22N2zuCIHKyLjXsPauQ66ZP7cib75HB4Orm4hKuRGPUrKQLHy-F3OE5DOD-cTi4G334DkPp3Dw |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR1da9NQ9DI3cPogfludegVFcIQ1yf3Kw5BNNza3FpEN9nZ3c3OzFWpSk9bS_yb-Ns9J0mxVqE-DPpTckzS35_ueL0LeOmYYB1PUkzaRHmNcebGIuRckcRe0sxXCYYFzry8OTtmXM362Qn7Pa2EwrXIuEytBneQWz8i3ggCLXSTY1x9HPzycGoXR1fkIDdOMVki2qxZjTWHHkZtNwYUrtw8_A77fBcH-3smnA6-ZMuBZ0Q3HnlEsdi7illmXupjF3AiXCAWqWNrQAUs4FTsF36VKXahUrFIGio8p32Hz9hCee4ussZBF4Pyt7e71v35r4xhSVbPc_FAwDxQjb-KqvhJbJWgPjhkgGOHwlccXNGM1QOBfNXFNT_6dw9kGcu-S9Uk2MrOpGQ6v6cr9--ReY-TSnZoqH5AVlz0kt3tNGP8R-dXDNEA7KDAJFqP8dOSKdIIHdzQBupsUMRJjSVOg0nwKv0dtRcmWlnUZN8Xz4_oiTiAD5Bi4GM9G4AtQUzhqGrJzSQ06yOjPwbjIqcsSLDobAt_RS3DCC_h8d3W38hk1WQKgaEmXcKfJLuDx-QDLwr2ADjHBqnxMTm8EwU_IapZn7hmhIU-5SPwgtjJkktsIrGFuTOJEEqUyjTqkO0ehtk2PdRz1MdSVr6WErrGuAesasa55h3xobxnVDUaWAe8iXbSA2Bu8upAXF7oRNdpaDowmDRjzAkwUp8BnxnC7k0YCIYYd8h6pSqMEg5ezpinEgC1iLzC9A1v2JfiRALmxAAmSxy4uz-lSN5Kv1Fd82iFv2mW8E7P5MpdPEAZPn0UkAOZpTcbtlsJuhJHAbofIBQJf2PPiSja4rPqiCyZAYcEzN-escPVaS_7SzZZb_o-A58u3_JqsH5z0jvXxYf_oBbkTIHNjX1B_g6yOi4l7CQbsOH7VSAlKzm9aMP0BV9eu1w |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlR3bbtMw1IIhDXhA3AaFAUZCQmKK1iS-5XEUpnHpxAOT9mY5zslWqSRV0jL13_g4zknSsAAaQspDZB-7cc_VPhcz9gqEExJN0UD7TAdCSBOkKpVBlKVj1M5eKaAE5-mxOjoRH0_laXfPab2Jdt-4JNucBqrSVCz3F1nesrhR-zVKXknRE-QdCE0gr7MbApUbXWEwUZPejaCNijtX5l-HDZRRU7P_T8l8STX9HjbZ-05vs5urYuHWF24-v6SeDu-yO51dyQ9aQrjHrkFxn21PO8_5A_ZjSpF3flZR3Ck51vkCqnxFZ2U8Q1SvqpTwX_McCaO8wN_jviEez-s2c5rTkW3bSJd-Ifk6bEzXCzS_uauAuw7TkLWgs4J_ny2rkkORUZ7XHEmdn-O-t8LnG7QFwtfcFRmCkvFa40hXnOH05YwysYOIzymmqX7ITg7ff50cBd3NDYFX43gZOCNSgER64SGHVKTSKciUQfNG-xhQzIBJweC7NjnExqQmF2hMCBMCFcSPd9hWURbwmPFY5lJlYZR6HQstfYIGqHQuA5Uluc6TERtvUGh9V9acbteY22Z7Y5RtsW4R65awbuWIvemHLNqaHlcBvyW66AGpHHfTUFZntuNu671E2tYO7WeFVgEY3KaShxu002Gs4hF7TVRlSWjgx3nX5T7gEqn8lj3AJYcat24IuTuARGb3w-4NXdpO2NQ2iigPTOPWc8Re9t00kgLoCihXBEMHvipRCPOoJeN-SfE4IefbeMT0gMAHax72FLPzphS5Egp1BM65t2GFX591xV-613PLvxHw5L_mfsG2v7w7tJ8_HH96ym5FxOpUmDPcZVvLagXP0IJcps8bKfETtftsqA |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1ba9swFBZdCrs87H7J1g0NBoMVp46tmx-z0VIGKXtYoHsykiy3oZ4d7Hgl-237cTvHdrK4Gx1jkAdjHYnIOjfpnPOJkDeOacbBFfWkTaTHGFeeEYZ7QWJ8sM5WCIcFztMTcTxjH0_56Q45XNfCWNuAEIy2i8-zRmPDg704WCRpK-hKHFSgfznmUGCMYKw8foPsCg4u-YDszk4-Tb60NVfMA5PE2yoj4Qk_Ou2im38co2efGhj_35X1lrW6mkm5CafeIbfqfKFXlzrLtizW0b02s6RqgA4xUeViVC_NyH6_AgP53x_jPrnb-bR00jLhA7Lj8ofk5rSL2j8iP6aY9WfnJea8YlCfLlyZ1nhORxNgs7o0yHsVTYEpi0uYGLUN41patVXbFI-L25d44RiIjoaXZrUA15_q0lHdcZlLWtJ5Tr_Nl2VBXZ5gjVkGYkbPYc9dwu-ra8HJV1TnCZCi41xBT52fwfDFHKvAvYBmmE9VPSazo8PPH4697tYIzwo_XHpaMeNcxC2zLnWGGa6FS4QC10ra0IGKc8o4Bc9SpS5UyqiUgSPD1NghGH_4hAzyInfPCA15ykUyDoyVIZPcRuD8cq0TJ5IolWk0JP6aV2LbQarjzR5Z3GytlIjbVYlhVWJclZgPybtNl0WLJ3Id8XtkwA0hQoE3L4ryLO40S2wtB7mSGnx3AR6JU7BFxui6k1oC94dD8hbZN0aFhWyju7oLmCJCf8UTmPJYwrYRKPd6lKBobL95LQBxp-iqOAiwBk3CtndIXm-asScm7-WuqJEGD5tFJIDmaSsvmymFfoSBP39IZE-SenPut-Tz8wYGXTAB9gnG3F_L3K-_dc0n3d-I5d8X4Pk_Ub8gtwOUP0QCHe-RwbKs3UtwWZfmVaeQfgIL3pGj |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Microcirculatory+perfusion+disturbances+following+cardiac+surgery+with+cardiopulmonary+bypass+are+associated+with+in+vitro+endothelial+hyperpermeability+and+increased+angiopoietin-2+levels&rft.jtitle=Critical+care+%28London%2C+England%29&rft.au=Dekker%2C+Nicole+A+M&rft.au=van+Leeuwen%2C+Anoek+L+I&rft.au=van+Strien%2C+Willem+W+J&rft.au=Majol%C3%A9e%2C+Jisca&rft.date=2019-04-11&rft.issn=1466-609X&rft.eissn=1466-609X&rft.volume=23&rft.issue=1&rft.spage=117&rft_id=info:doi/10.1186%2Fs13054-019-2418-5&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1364-8535&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1364-8535&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1364-8535&client=summon |