6-溴-4,4-二甲基二氢苯并噻喃的合成研究

O626.23; 提出了一种合成6-溴-4,4-二氢苯并噻喃的新路线,并对合成过程中的工艺条件进行了优化,得到了较优的反应条件.本工艺以溴苯为起始原料,经氯磺化、还原、硫醚化、环合4步反应得到6-溴-4,4-二氢苯并噻喃,最终收率为88.5％.除还原这一步需要较高温度外,其他3步反应均在50℃以下进行,既降低了能耗,又减少了副产物的生成.与已有工艺路线相比,本工艺路线具有成本低廉的优点,适合工业化生产....

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Published in浙江大学学报（理学版） Vol. 39; no. 2; pp. 187 - 189
Main Authors 袁继新, 廖祖态, 吕雪皓, 周少东, 钱超, 陈新志
Format Journal Article
LanguageChinese
Published 浙江大学化工系,浙江杭州,310027%江西仁明医药化工有限公司,江西彭泽,330012 2012
Subjects
合成
6-溴-4,4-二氢苯并噻喃
新路线
Online AccessGet full text
ISSN1008-9497
DOI10.3785/j.issn.1008-9497.2012.02.013

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Abstract O626.23; 提出了一种合成6-溴-4,4-二氢苯并噻喃的新路线,并对合成过程中的工艺条件进行了优化,得到了较优的反应条件.本工艺以溴苯为起始原料,经氯磺化、还原、硫醚化、环合4步反应得到6-溴-4,4-二氢苯并噻喃,最终收率为88.5％.除还原这一步需要较高温度外,其他3步反应均在50℃以下进行,既降低了能耗,又减少了副产物的生成.与已有工艺路线相比,本工艺路线具有成本低廉的优点,适合工业化生产.
AbstractList O626.23; 提出了一种合成6-溴-4,4-二氢苯并噻喃的新路线,并对合成过程中的工艺条件进行了优化,得到了较优的反应条件.本工艺以溴苯为起始原料,经氯磺化、还原、硫醚化、环合4步反应得到6-溴-4,4-二氢苯并噻喃,最终收率为88.5％.除还原这一步需要较高温度外,其他3步反应均在50℃以下进行,既降低了能耗,又减少了副产物的生成.与已有工艺路线相比,本工艺路线具有成本低廉的优点,适合工业化生产.
Author 吕雪皓
廖祖态
袁继新
周少东
钱超
陈新志
AuthorAffiliation 浙江大学化工系,浙江杭州,310027%江西仁明医药化工有限公司,江西彭泽,330012
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Author_FL QIAN Chao
CHEN Xin-zhi
YUAN Ji-xin
LIAO Zu-tai
L(U) Xue-hao
ZHOU Shao-dong
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6-溴-4,4-二氢苯并噻喃
新路线
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Snippet O626.23; 提出了一种合成6-溴-4,4-二氢苯并噻喃的新路线,并对合成过程中的工艺条件进行了优化,得到了较优的反应条件.本工艺以溴苯为起始原料,经氯磺化、还原、硫醚化、环合4...
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Title 6-溴-4,4-二甲基二氢苯并噻喃的合成研究
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