Factors that influence persistence or recurrence of high-grade squamous intraepithelial lesion with positive margins after the loop electrosurgical excision procedure: a retrospective study

Background In 5–20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision procedure (LEEP) is associated with persistence/recurrence, but the prognostic value of other clinico-pathological factors is less clear. Method...

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Published inBMC cancer Vol. 15; no. 1; p. 744
Main Authors Zhu, Menghan, He, Yuan, Baak, Jan PA, Zhou, Xianrong, Qu, Yuqing, Sui, Long, Feng, Weiwei, Wang, Qing
Format Journal Article
LanguageEnglish
Published London BioMed Central 20.10.2015
BioMed Central Ltd
Subjects
Adult
Aged
Biomedical and Life Sciences
Biomedicine
Biopsy
Cancer Research
Cellular biology
Cervical cancer
Electrosurgery - methods
Female
Follow-Up Studies
Gynecology
Health Promotion and Disease Prevention
Histology
Hospitals
Human papillomavirus
Humans
Hypotheses
Hysterectomy
Medicine/Public Health
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local
Obstetrics
Odds Ratio
Oncology
Patients
Research Article
Retrospective Studies
Risk Factors
Squamous Intraepithelial Lesions of the Cervix - epidemiology
Squamous Intraepithelial Lesions of the Cervix - pathology
Squamous Intraepithelial Lesions of the Cervix - surgery
Surgery
Surgical Oncology
Young Adult
Persistence
Recurrence
Positive margins
LEEP
HSIL
Follow-up
Online AccessGet full text
ISSN1471-2407
1471-2407
DOI10.1186/s12885-015-1748-1

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Abstract Background In 5–20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision procedure (LEEP) is associated with persistence/recurrence, but the prognostic value of other clinico-pathological factors is less clear. Methods Among 4336 patients with HSIL who underwent an initial LEEP, 275 (6 %) had HSIL-positive margins, 37 of whom were lost to follow-up. We evaluated the remaining 238 patients. Persistence/recurrence was defined as histopathological HSIL during follow-up. Results The age of the patients ranged from 21 to 69 years (median: 40). The median follow-up period was 25 months (range: 6–43). Of the 238 patients, 211 (88.7 %) patients remained free of persistence/recurrence, while 27 (11.3 %) experienced persistence/recurrence. According to a univariate analysis, age ( P  = 0.03) and maximum specimen diameter ( P  = 0.043) were associated with persistence/recurrence, but number/location of involved margin sections and the pathology of the endocervical curettage were not ( P  > 0.10). The relative risk of the subjects (greater than or equal to 35 years ages) was 4.6 times of the subject less than 35 years, the difference was statistically significant (14 % vs. 3 %, P  < 0.05). A multivariate analysis indicated that an age of 35 years or older was the only independent risk factor (OR 4.97, 95 % CI 1.14–21.62, P  = 0.03). Conclusion In patients with HSIL and HSIL-involved margins after an initial LEEP, age is a strong independent predictor of persistence/recurrence. Follow-up with screening cytology and/or biopsy may be considered in younger patients, whereas a secondary LEEP/hysterectomy may be considered in older patients.
AbstractList In 5-20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision procedure (LEEP) is associated with persistence/recurrence, but the prognostic value of other clinico-pathological factors is less clear. Among 4336 patients with HSIL who underwent an initial LEEP, 275 (6 %) had HSIL-positive margins, 37 of whom were lost to follow-up. We evaluated the remaining 238 patients. Persistence/recurrence was defined as histopathological HSIL during follow-up. The age of the patients ranged from 21 to 69 years (median: 40). The median follow-up period was 25 months (range: 6-43). Of the 238 patients, 211 (88.7 %) patients remained free of persistence/recurrence, while 27 (11.3 %) experienced persistence/recurrence. According to a univariate analysis, age (P = 0.03) and maximum specimen diameter (P = 0.043) were associated with persistence/recurrence, but number/location of involved margin sections and the pathology of the endocervical curettage were not (P > 0.10). The relative risk of the subjects (greater than or equal to 35 years ages) was 4.6 times of the subject less than 35 years, the difference was statistically significant (14 % vs. 3 %, P < 0.05). A multivariate analysis indicated that an age of 35 years or older was the only independent risk factor (OR 4.97, 95 % CI 1.14-21.62, P = 0.03). In patients with HSIL and HSIL-involved margins after an initial LEEP, age is a strong independent predictor of persistence/recurrence. Follow-up with screening cytology and/or biopsy may be considered in younger patients, whereas a secondary LEEP/hysterectomy may be considered in older patients.
Background In 5-20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision procedure (LEEP) is associated with persistence/recurrence, but the prognostic value of other clinico-pathological factors is less clear. Methods Among 4336 patients with HSIL who underwent an initial LEEP, 275 (6 %) had HSIL-positive margins, 37 of whom were lost to follow-up. We evaluated the remaining 238 patients. Persistence/recurrence was defined as histopathological HSIL during follow-up. Results The age of the patients ranged from 21 to 69 years (median: 40). The median follow-up period was 25 months (range: 6-43). Of the 238 patients, 211 (88.7 %) patients remained free of persistence/recurrence, while 27 (11.3 %) experienced persistence/recurrence. According to a univariate analysis, age (P = 0.03) and maximum specimen diameter (P = 0.043) were associated with persistence/recurrence, but number/location of involved margin sections and the pathology of the endocervical curettage were not (P > 0.10). The relative risk of the subjects (greater than or equal to 35 years ages) was 4.6 times of the subject less than 35 years, the difference was statistically significant (14 % vs. 3 %, P < 0.05). A multivariate analysis indicated that an age of 35 years or older was the only independent risk factor (OR 4.97, 95 % CI 1.14-21.62, P = 0.03). Conclusion In patients with HSIL and HSIL-involved margins after an initial LEEP, age is a strong independent predictor of persistence/recurrence. Follow-up with screening cytology and/or biopsy may be considered in younger patients, whereas a secondary LEEP/hysterectomy may be considered in older patients. Keywords: HSIL, LEEP, Positive margins, Recurrence, Persistence, Follow-up
In 5-20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision procedure (LEEP) is associated with persistence/recurrence, but the prognostic value of other clinico-pathological factors is less clear. Among 4336 patients with HSIL who underwent an initial LEEP, 275 (6 %) had HSIL-positive margins, 37 of whom were lost to follow-up. We evaluated the remaining 238 patients. Persistence/recurrence was defined as histopathological HSIL during follow-up. The age of the patients ranged from 21 to 69 years (median: 40). The median follow-up period was 25 months (range: 6-43). Of the 238 patients, 211 (88.7 %) patients remained free of persistence/recurrence, while 27 (11.3 %) experienced persistence/recurrence. According to a univariate analysis, age (P = 0.03) and maximum specimen diameter (P = 0.043) were associated with persistence/recurrence, but number/location of involved margin sections and the pathology of the endocervical curettage were not (P > 0.10). The relative risk of the subjects (greater than or equal to 35 years ages) was 4.6 times of the subject less than 35 years, the difference was statistically significant (14 % vs. 3 %, P < 0.05). A multivariate analysis indicated that an age of 35 years or older was the only independent risk factor (OR 4.97, 95 % CI 1.14-21.62, P = 0.03). In patients with HSIL and HSIL-involved margins after an initial LEEP, age is a strong independent predictor of persistence/recurrence. Follow-up with screening cytology and/or biopsy may be considered in younger patients, whereas a secondary LEEP/hysterectomy may be considered in older patients.
Background In 5-20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision procedure (LEEP) is associated with persistence/recurrence, but the prognostic value of other clinico-pathological factors is less clear. Methods Among 4336 patients with HSIL who underwent an initial LEEP, 275 (6 %) had HSIL-positive margins, 37 of whom were lost to follow-up. We evaluated the remaining 238 patients. Persistence/recurrence was defined as histopathological HSIL during follow-up. Results The age of the patients ranged from 21 to 69 years (median: 40). The median follow-up period was 25 months (range: 6-43). Of the 238 patients, 211 (88.7 %) patients remained free of persistence/recurrence, while 27 (11.3 %) experienced persistence/recurrence. According to a univariate analysis, age (P = 0.03) and maximum specimen diameter (P = 0.043) were associated with persistence/recurrence, but number/location of involved margin sections and the pathology of the endocervical curettage were not (P > 0.10). The relative risk of the subjects (greater than or equal to 35 years ages) was 4.6 times of the subject less than 35 years, the difference was statistically significant (14 % vs. 3 %, P < 0.05). A multivariate analysis indicated that an age of 35 years or older was the only independent risk factor (OR 4.97, 95 % CI 1.14-21.62, P = 0.03). Conclusion In patients with HSIL and HSIL-involved margins after an initial LEEP, age is a strong independent predictor of persistence/recurrence. Follow-up with screening cytology and/or biopsy may be considered in younger patients, whereas a secondary LEEP/hysterectomy may be considered in older patients.
In 5-20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision procedure (LEEP) is associated with persistence/recurrence, but the prognostic value of other clinico-pathological factors is less clear.BACKGROUNDIn 5-20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision procedure (LEEP) is associated with persistence/recurrence, but the prognostic value of other clinico-pathological factors is less clear.Among 4336 patients with HSIL who underwent an initial LEEP, 275 (6 %) had HSIL-positive margins, 37 of whom were lost to follow-up. We evaluated the remaining 238 patients. Persistence/recurrence was defined as histopathological HSIL during follow-up.METHODSAmong 4336 patients with HSIL who underwent an initial LEEP, 275 (6 %) had HSIL-positive margins, 37 of whom were lost to follow-up. We evaluated the remaining 238 patients. Persistence/recurrence was defined as histopathological HSIL during follow-up.The age of the patients ranged from 21 to 69 years (median: 40). The median follow-up period was 25 months (range: 6-43). Of the 238 patients, 211 (88.7 %) patients remained free of persistence/recurrence, while 27 (11.3 %) experienced persistence/recurrence. According to a univariate analysis, age (P = 0.03) and maximum specimen diameter (P = 0.043) were associated with persistence/recurrence, but number/location of involved margin sections and the pathology of the endocervical curettage were not (P > 0.10). The relative risk of the subjects (greater than or equal to 35 years ages) was 4.6 times of the subject less than 35 years, the difference was statistically significant (14 % vs. 3 %, P < 0.05). A multivariate analysis indicated that an age of 35 years or older was the only independent risk factor (OR 4.97, 95 % CI 1.14-21.62, P = 0.03).RESULTSThe age of the patients ranged from 21 to 69 years (median: 40). The median follow-up period was 25 months (range: 6-43). Of the 238 patients, 211 (88.7 %) patients remained free of persistence/recurrence, while 27 (11.3 %) experienced persistence/recurrence. According to a univariate analysis, age (P = 0.03) and maximum specimen diameter (P = 0.043) were associated with persistence/recurrence, but number/location of involved margin sections and the pathology of the endocervical curettage were not (P > 0.10). The relative risk of the subjects (greater than or equal to 35 years ages) was 4.6 times of the subject less than 35 years, the difference was statistically significant (14 % vs. 3 %, P < 0.05). A multivariate analysis indicated that an age of 35 years or older was the only independent risk factor (OR 4.97, 95 % CI 1.14-21.62, P = 0.03).In patients with HSIL and HSIL-involved margins after an initial LEEP, age is a strong independent predictor of persistence/recurrence. Follow-up with screening cytology and/or biopsy may be considered in younger patients, whereas a secondary LEEP/hysterectomy may be considered in older patients.CONCLUSIONIn patients with HSIL and HSIL-involved margins after an initial LEEP, age is a strong independent predictor of persistence/recurrence. Follow-up with screening cytology and/or biopsy may be considered in younger patients, whereas a secondary LEEP/hysterectomy may be considered in older patients.
Background In 5–20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision procedure (LEEP) is associated with persistence/recurrence, but the prognostic value of other clinico-pathological factors is less clear. Methods Among 4336 patients with HSIL who underwent an initial LEEP, 275 (6 %) had HSIL-positive margins, 37 of whom were lost to follow-up. We evaluated the remaining 238 patients. Persistence/recurrence was defined as histopathological HSIL during follow-up. Results The age of the patients ranged from 21 to 69 years (median: 40). The median follow-up period was 25 months (range: 6–43). Of the 238 patients, 211 (88.7 %) patients remained free of persistence/recurrence, while 27 (11.3 %) experienced persistence/recurrence. According to a univariate analysis, age ( P  = 0.03) and maximum specimen diameter ( P  = 0.043) were associated with persistence/recurrence, but number/location of involved margin sections and the pathology of the endocervical curettage were not ( P  > 0.10). The relative risk of the subjects (greater than or equal to 35 years ages) was 4.6 times of the subject less than 35 years, the difference was statistically significant (14 % vs. 3 %, P  < 0.05). A multivariate analysis indicated that an age of 35 years or older was the only independent risk factor (OR 4.97, 95 % CI 1.14–21.62, P  = 0.03). Conclusion In patients with HSIL and HSIL-involved margins after an initial LEEP, age is a strong independent predictor of persistence/recurrence. Follow-up with screening cytology and/or biopsy may be considered in younger patients, whereas a secondary LEEP/hysterectomy may be considered in older patients.
ArticleNumber 744
Audience Academic
Author Zhou, Xianrong
Sui, Long
Zhu, Menghan
He, Yuan
Qu, Yuqing
Baak, Jan PA
Feng, Weiwei
Wang, Qing
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  organization: Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University
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  organization: Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai Key Laboratory of Female Reproductive Endocrine-Related Disease, Fudan University
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  givenname: Xianrong
  surname: Zhou
  fullname: Zhou, Xianrong
  organization: Department of Pathology, Obstetrics and Gynecology Hospital, Fudan University
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  givenname: Yuqing
  surname: Qu
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  givenname: Weiwei
  surname: Feng
  fullname: Feng, Weiwei
  email: wfeng7347@aliyun.com
  organization: Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai Key Laboratory of Female Reproductive Endocrine-Related Disease, Fudan University
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  givenname: Qing
  surname: Wang
  fullname: Wang, Qing
  email: wqexcel@163.com
  organization: Shanghai Key Laboratory of Female Reproductive Endocrine-Related Disease, Fudan University, Department of Cervical Diseases, Obstetrics and Gynecology Hospital, Fudan University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26486312$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1007/s00404-009-1298-3
10.1016/j.ejogrb.2012.08.016
10.1016/j.bpobgyn.2005.02.008
10.1016/0090-8258(89)90551-9
10.1016/j.vaccine.2012.06.095
10.1136/jcp.2010.083626
10.1097/LGT.0b013e3181fee61d
10.3760/cma.j.issn.0366-6999.2009.04.002
10.1016/j.ygyno.2005.09.015
10.1016/j.ygyno.2006.04.016
10.1111/j.1471-0528.2006.01063.x
10.1016/j.ygyno.2007.05.014
10.1016/S0090-8258(03)00372-X
10.1111/j.1600-0463.2007.00769.x
10.1097/AOG.0b013e3181ab6dca
10.1016/j.ajog.2004.12.044
10.1016/j.jcv.2004.05.012
10.1016/j.ejso.2010.08.135
10.1111/j.1447-0756.2007.00628.x
10.1006/gyno.1997.4817
10.1016/j.ejogrb.2012.06.026
10.1097/00004347-199304000-00018
10.1111/j.1471-0528.1993.tb14292.x
10.1016/S1470-2045(07)70283-8
10.1111/j.1471-0528.2011.03068.x
10.1016/S0020-7292(01)00523-9
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Issue 1
Keywords Persistence
Recurrence
Positive margins
LEEP
HSIL
Follow-up
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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References VH Debarge (1748_CR2) 2003; 90
I Alonso (1748_CR4) 2006; 103
A Baloglu (1748_CR11) 2010; 282
K MohamedNoor (1748_CR20) 1997; 67
C Kietpeerakool (1748_CR9) 2007; 33
AG Ostor (1748_CR15) 1993; 12
BG Lindeque (1748_CR8) 2005; 19
P Leguevaque (1748_CR7) 2010; 36
JY Park (1748_CR10) 2009; 114
M Arbyn (1748_CR28) 2011; 118
CA Livasy (1748_CR22) 1999; 12
M Milojkovic (1748_CR5) 2002; 76
M Arbyn (1748_CR29) 2012; 30
S Ghaem-Maghami (1748_CR6) 2007; 8
J Verguts (1748_CR24) 2006; 113
R Malapati (1748_CR12) 2011; 15
AD Brockmeyer (1748_CR13) 2005; 192
N Husseinzadeh (1748_CR18) 1989; 33
TD Tillmanns (1748_CR3) 2006; 100
AC Munk (1748_CR16) 2007; 115
JY Park (1748_CR23) 2007; 107
D Kalogirou (1748_CR21) 1997; 18
1748_CR17
XG Sun (1748_CR25) 2009; 122
N Mahadevan (1748_CR1) 1993; 100
DE Townsend (1748_CR19) 1994; 84
LM Kliemann (1748_CR14) 2012; 165
L Sarian (1748_CR27) 2004; 31
IT Ovestad (1748_CR30) 2011; 64
M Serati (1748_CR26) 2012; 165
17582476 - Gynecol Oncol. 2007 Oct;107(1):39-44
8463044 - Int J Gynecol Pathol. 1993 Apr;12(2):186-92
16978225 - BJOG. 2006 Nov;113(11):1303-7
16321430 - Gynecol Oncol. 2006 Feb;100(2):379-84
21421698 - J Clin Pathol. 2011 Apr;64(4):303-7
21716049 - J Low Genit Tract Dis. 2011 Jul;15(3):177-9
9105859 - Eur J Gynaecol Oncol. 1997;18(2):113-6
7936537 - Obstet Gynecol. 1994 Nov;84(5):898
23199969 - Vaccine. 2012 Nov 20;30 Suppl 5:F88-99
19302737 - Chin Med J (Engl). 2009 Feb 20;122(4):367-72
10102607 - Mod Pathol. 1999 Mar;12(3):233-8
15902114 - Am J Obstet Gynecol. 2005 May;192(5):1379-81
16150393 - Best Pract Res Clin Obstet Gynaecol. 2005 Aug;19(4):545-61
19546763 - Obstet Gynecol. 2009 Jul;114(1):87-92
9345353 - Gynecol Oncol. 1997 Oct;67(1):34-8
11818094 - Int J Gynaecol Obstet. 2002 Jan;76(1):49-53
21834887 - BJOG. 2011 Sep;118(10):1274-5; author reply 1275-6
15494268 - J Clin Virol. 2004 Dec;31(4):270-4
8399031 - Br J Obstet Gynaecol. 1993 Aug;100(8):794-5
17845326 - J Obstet Gynaecol Res. 2007 Oct;33(5):660-4
19940997 - Arch Gynecol Obstet. 2010 Jul;282(1):69-73
22948133 - Eur J Obstet Gynecol Reprod Biol. 2012 Dec;165(2):342-6
22771223 - Eur J Obstet Gynecol Reprod Biol. 2012 Nov;165(1):86-90
17928267 - Lancet Oncol. 2007 Nov;8(11):985-93
2703181 - Gynecol Oncol. 1989 May;33(2):198-200
20870375 - Eur J Surg Oncol. 2010 Nov;36(11):1073-9
16780934 - Gynecol Oncol. 2006 Nov;103(2):631-6
13678729 - Gynecol Oncol. 2003 Sep;90(3):587-92
18184413 - APMIS. 2007 Dec;115(12):1409-14
References_xml – volume: 282
  start-page: 69
  year: 2010
  ident: 1748_CR11
  publication-title: Arch Gynecol Obstet
  doi: 10.1007/s00404-009-1298-3
– volume: 165
  start-page: 342
  year: 2012
  ident: 1748_CR14
  publication-title: Eur J Obstet Gynecol Reprod Biol
  doi: 10.1016/j.ejogrb.2012.08.016
– volume: 19
  start-page: 545
  year: 2005
  ident: 1748_CR8
  publication-title: Best Pract Res Clin Obstet Gynaecol
  doi: 10.1016/j.bpobgyn.2005.02.008
– volume: 33
  start-page: 198
  year: 1989
  ident: 1748_CR18
  publication-title: Gynecol Oncol
  doi: 10.1016/0090-8258(89)90551-9
– volume: 30
  start-page: F88
  issue: Suppl 5
  year: 2012
  ident: 1748_CR29
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2012.06.095
– volume: 64
  start-page: 303
  year: 2011
  ident: 1748_CR30
  publication-title: J Clin Pathol
  doi: 10.1136/jcp.2010.083626
– volume: 15
  start-page: 177
  year: 2011
  ident: 1748_CR12
  publication-title: J Low Genit Tract Dis
  doi: 10.1097/LGT.0b013e3181fee61d
– volume: 122
  start-page: 367
  year: 2009
  ident: 1748_CR25
  publication-title: Chin Med J (Engl)
  doi: 10.3760/cma.j.issn.0366-6999.2009.04.002
– volume: 100
  start-page: 379
  year: 2006
  ident: 1748_CR3
  publication-title: Gynecol Oncol
  doi: 10.1016/j.ygyno.2005.09.015
– volume: 103
  start-page: 631
  year: 2006
  ident: 1748_CR4
  publication-title: Gynecol Oncol
  doi: 10.1016/j.ygyno.2006.04.016
– volume: 113
  start-page: 1303
  year: 2006
  ident: 1748_CR24
  publication-title: BJOG
  doi: 10.1111/j.1471-0528.2006.01063.x
– volume: 107
  start-page: 39
  year: 2007
  ident: 1748_CR23
  publication-title: Gynecol Oncol
  doi: 10.1016/j.ygyno.2007.05.014
– volume: 90
  start-page: 587
  year: 2003
  ident: 1748_CR2
  publication-title: Gynecol Oncol
  doi: 10.1016/S0090-8258(03)00372-X
– volume: 115
  start-page: 1409
  year: 2007
  ident: 1748_CR16
  publication-title: APMIS
  doi: 10.1111/j.1600-0463.2007.00769.x
– volume: 18
  start-page: 113
  year: 1997
  ident: 1748_CR21
  publication-title: Eur J Gynaecol Oncol
– volume: 114
  start-page: 87
  year: 2009
  ident: 1748_CR10
  publication-title: Obstet Gynecol
  doi: 10.1097/AOG.0b013e3181ab6dca
– volume: 192
  start-page: 1379
  year: 2005
  ident: 1748_CR13
  publication-title: Am J Obstet Gynecol
  doi: 10.1016/j.ajog.2004.12.044
– volume: 31
  start-page: 270
  year: 2004
  ident: 1748_CR27
  publication-title: J Clin Virol
  doi: 10.1016/j.jcv.2004.05.012
– volume: 36
  start-page: 1073
  year: 2010
  ident: 1748_CR7
  publication-title: Eur J Surg Oncol
  doi: 10.1016/j.ejso.2010.08.135
– volume: 33
  start-page: 660
  year: 2007
  ident: 1748_CR9
  publication-title: J Obstet Gynaecol Res
  doi: 10.1111/j.1447-0756.2007.00628.x
– volume: 67
  start-page: 34
  year: 1997
  ident: 1748_CR20
  publication-title: Gynecol Oncol
  doi: 10.1006/gyno.1997.4817
– volume: 165
  start-page: 86
  year: 2012
  ident: 1748_CR26
  publication-title: Eur J Obstet Gynecol Reprod Biol
  doi: 10.1016/j.ejogrb.2012.06.026
– volume: 12
  start-page: 186
  year: 1993
  ident: 1748_CR15
  publication-title: Int J Gynecol Pathol
  doi: 10.1097/00004347-199304000-00018
– volume: 100
  start-page: 794
  year: 1993
  ident: 1748_CR1
  publication-title: Br J Obstet Gynaecol
  doi: 10.1111/j.1471-0528.1993.tb14292.x
– volume: 12
  start-page: 233
  issue: 3
  year: 1999
  ident: 1748_CR22
  publication-title: Mod Pathol
– volume: 8
  start-page: 985
  year: 2007
  ident: 1748_CR6
  publication-title: Lancet Oncol
  doi: 10.1016/S1470-2045(07)70283-8
– volume: 84
  start-page: 898
  year: 1994
  ident: 1748_CR19
  publication-title: Obstet Gynecol
– ident: 1748_CR17
– volume: 118
  start-page: 1274
  year: 2011
  ident: 1748_CR28
  publication-title: BJOG
  doi: 10.1111/j.1471-0528.2011.03068.x
– volume: 76
  start-page: 49
  year: 2002
  ident: 1748_CR5
  publication-title: Int J Gynaecol Obstet
  doi: 10.1016/S0020-7292(01)00523-9
– reference: 2703181 - Gynecol Oncol. 1989 May;33(2):198-200
– reference: 22948133 - Eur J Obstet Gynecol Reprod Biol. 2012 Dec;165(2):342-6
– reference: 16780934 - Gynecol Oncol. 2006 Nov;103(2):631-6
– reference: 13678729 - Gynecol Oncol. 2003 Sep;90(3):587-92
– reference: 11818094 - Int J Gynaecol Obstet. 2002 Jan;76(1):49-53
– reference: 17582476 - Gynecol Oncol. 2007 Oct;107(1):39-44
– reference: 17928267 - Lancet Oncol. 2007 Nov;8(11):985-93
– reference: 18184413 - APMIS. 2007 Dec;115(12):1409-14
– reference: 19302737 - Chin Med J (Engl). 2009 Feb 20;122(4):367-72
– reference: 21716049 - J Low Genit Tract Dis. 2011 Jul;15(3):177-9
– reference: 9345353 - Gynecol Oncol. 1997 Oct;67(1):34-8
– reference: 7936537 - Obstet Gynecol. 1994 Nov;84(5):898
– reference: 20870375 - Eur J Surg Oncol. 2010 Nov;36(11):1073-9
– reference: 23199969 - Vaccine. 2012 Nov 20;30 Suppl 5:F88-99
– reference: 19546763 - Obstet Gynecol. 2009 Jul;114(1):87-92
– reference: 22771223 - Eur J Obstet Gynecol Reprod Biol. 2012 Nov;165(1):86-90
– reference: 15902114 - Am J Obstet Gynecol. 2005 May;192(5):1379-81
– reference: 19940997 - Arch Gynecol Obstet. 2010 Jul;282(1):69-73
– reference: 21834887 - BJOG. 2011 Sep;118(10):1274-5; author reply 1275-6
– reference: 21421698 - J Clin Pathol. 2011 Apr;64(4):303-7
– reference: 10102607 - Mod Pathol. 1999 Mar;12(3):233-8
– reference: 16321430 - Gynecol Oncol. 2006 Feb;100(2):379-84
– reference: 15494268 - J Clin Virol. 2004 Dec;31(4):270-4
– reference: 8463044 - Int J Gynecol Pathol. 1993 Apr;12(2):186-92
– reference: 9105859 - Eur J Gynaecol Oncol. 1997;18(2):113-6
– reference: 16978225 - BJOG. 2006 Nov;113(11):1303-7
– reference: 17845326 - J Obstet Gynaecol Res. 2007 Oct;33(5):660-4
– reference: 16150393 - Best Pract Res Clin Obstet Gynaecol. 2005 Aug;19(4):545-61
– reference: 8399031 - Br J Obstet Gynaecol. 1993 Aug;100(8):794-5
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Snippet Background In 5–20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision...
In 5-20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision procedure...
Background In 5-20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision...
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SubjectTerms Adult
Aged
Biomedical and Life Sciences
Biomedicine
Biopsy
Cancer Research
Cellular biology
Cervical cancer
Electrosurgery - methods
Female
Follow-Up Studies
Gynecology
Health Promotion and Disease Prevention
Histology
Hospitals
Human papillomavirus
Humans
Hypotheses
Hysterectomy
Medicine/Public Health
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local
Obstetrics
Odds Ratio
Oncology
Patients
Research Article
Retrospective Studies
Risk Factors
Squamous Intraepithelial Lesions of the Cervix - epidemiology
Squamous Intraepithelial Lesions of the Cervix - pathology
Squamous Intraepithelial Lesions of the Cervix - surgery
Surgery
Surgical Oncology
Young Adult
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Title Factors that influence persistence or recurrence of high-grade squamous intraepithelial lesion with positive margins after the loop electrosurgical excision procedure: a retrospective study
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