女性正畸患者月经周期中最佳加力时机的初步研究
目的：通过在女性月经周期中的不同时期对正畸牙加力，研究龈沟液内雌激素（E2）、骨钙素（OCN）、核因子κB受体活化因子配体（RANKL）、骨保护素（OPG）的时效性表达，从而为临床选择最佳加力时机提供理论依据。方法选取18~28周岁双侧对称拔除第一恒前磨牙青年女性恒牙患者12人。随机选取其中6人为月经期加力组，6人为排卵期加力组，于右侧尖牙单侧使用镍钛拉簧施加1.5N正畸力使之远中移动，对侧尖牙不做处理。使用牙周滤纸分别于加力前，加力后15、30、45d取右侧尖牙远中（压力侧）龈沟液样本。使用化学发光法测定龈沟液中E2、OCN的活性水平。使用酶联免疫法检测龈沟液中RANKL及OPG的活性水平。...
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| Published in | 华西口腔医学杂志 Vol. 32; no. 3; pp. 252 - 255 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
重庆医科大学附属口腔医院正畸科
2014
口腔疾病与生物医学重庆市重点实验室，重庆 401147 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-1182 |
| DOI | 10.7518/hxkq.2014.03.010 |
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| Abstract | 目的：通过在女性月经周期中的不同时期对正畸牙加力，研究龈沟液内雌激素（E2）、骨钙素（OCN）、核因子κB受体活化因子配体（RANKL）、骨保护素（OPG）的时效性表达，从而为临床选择最佳加力时机提供理论依据。方法选取18~28周岁双侧对称拔除第一恒前磨牙青年女性恒牙患者12人。随机选取其中6人为月经期加力组，6人为排卵期加力组，于右侧尖牙单侧使用镍钛拉簧施加1.5N正畸力使之远中移动，对侧尖牙不做处理。使用牙周滤纸分别于加力前，加力后15、30、45d取右侧尖牙远中（压力侧）龈沟液样本。使用化学发光法测定龈沟液中E2、OCN的活性水平。使用酶联免疫法检测龈沟液中RANKL及OPG的活性水平。结果排卵期加力组龈沟液E2和OCN水平高于月经期加力组（P〈0.05）。月经期加力组与排卵期加力组中RANKL水平与OPG水平及RANKL/OPG比值均未见明显差异（P〉0.05）。结论女性正畸拔牙患者于雌激素水平较高的排卵期施加正畸力，骨保护因子E2、OCN表达增强，不利于牙槽骨改建。而于月经期加力，上述因子表达减弱，可能有助于牙齿快速移动。 |
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| AbstractList | R783.5; 目的：通过在女性月经周期中的不同时期对正畸牙加力，研究龈沟液内雌激素（E2）、骨钙素（OCN）、核因子κB受体活化因子配体（RANKL）、骨保护素（OPG）的时效性表达，从而为临床选择最佳加力时机提供理论依据。方法选取18~28周岁双侧对称拔除第一恒前磨牙青年女性恒牙患者12人。随机选取其中6人为月经期加力组，6人为排卵期加力组，于右侧尖牙单侧使用镍钛拉簧施加1.5N正畸力使之远中移动，对侧尖牙不做处理。使用牙周滤纸分别于加力前，加力后15、30、45d取右侧尖牙远中（压力侧）龈沟液样本。使用化学发光法测定龈沟液中E2、OCN的活性水平。使用酶联免疫法检测龈沟液中RANKL及OPG的活性水平。结果排卵期加力组龈沟液E2和OCN水平高于月经期加力组（P<0.05）。月经期加力组与排卵期加力组中RANKL水平与OPG水平及RANKL/OPG比值均未见明显差异（P>0.05）。结论女性正畸拔牙患者于雌激素水平较高的排卵期施加正畸力，骨保护因子E2、OCN表达增强，不利于牙槽骨改建。而于月经期加力，上述因子表达减弱，可能有助于牙齿快速移动。 目的：通过在女性月经周期中的不同时期对正畸牙加力，研究龈沟液内雌激素（E2）、骨钙素（OCN）、核因子κB受体活化因子配体（RANKL）、骨保护素（OPG）的时效性表达，从而为临床选择最佳加力时机提供理论依据。方法选取18~28周岁双侧对称拔除第一恒前磨牙青年女性恒牙患者12人。随机选取其中6人为月经期加力组，6人为排卵期加力组，于右侧尖牙单侧使用镍钛拉簧施加1.5N正畸力使之远中移动，对侧尖牙不做处理。使用牙周滤纸分别于加力前，加力后15、30、45d取右侧尖牙远中（压力侧）龈沟液样本。使用化学发光法测定龈沟液中E2、OCN的活性水平。使用酶联免疫法检测龈沟液中RANKL及OPG的活性水平。结果排卵期加力组龈沟液E2和OCN水平高于月经期加力组（P〈0.05）。月经期加力组与排卵期加力组中RANKL水平与OPG水平及RANKL/OPG比值均未见明显差异（P〉0.05）。结论女性正畸拔牙患者于雌激素水平较高的排卵期施加正畸力，骨保护因子E2、OCN表达增强，不利于牙槽骨改建。而于月经期加力，上述因子表达减弱，可能有助于牙齿快速移动。 |
| Abstract_FL | Objective To investigate the exerted force in different phases of the female menstrual cycle, as well as the changes in estrogen (E2), osteocalcin (OCN), receptor activator of nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG) levels in the gingival crevicular fluid (GCF) during orthodontic tooth movement, to provide a theoretical basis for the selection of the best opportunity for efficient tooth movement. Methods Twelve women (aged 18 years to 28 years) with extracted first premolars had been selected. Six women in the group were randomly selected as the menstrual period group, whereas the remaining six were assigned to the ovulation period group. Right canines were retracted with 1.5 N NiTi close coil spring. GCF samples were collected prior to the force exertion experiments at 0 (T0), 15 (T1), 30 (T2), and 45 d (T3). The levels of E2, OCN, OPG and RANKL in GCF were measured by chemiluminescence and enzymelinked immunosorbent assay. Results The E2 and OCN levels were significantly higher in the ovulation period group than in the menstrual period group (P<0.05). No significant differences were found in RANKL and OPG levels between the two groups (P>0.05). Finally, no significant difference was found in RANKL/OPG ratio between the two groups (P>0.05). Conclusion Exerted force on teeth during the menstrual period may promote rapid tooth movement. |
| Author | 杨曦 戴红卫 王斌 黄兰 |
| AuthorAffiliation | 重庆医科大学附属口腔医院正畸科、口腔疾病与生物医学重庆市重点实验室,重庆401147 |
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| Author_FL | Wang Bin Huang Lan Dai Hongwei Yang Xi |
| Author_FL_xml | – sequence: 1 fullname: Yang Xi – sequence: 2 fullname: Dai Hongwei – sequence: 3 fullname: Wang Bin – sequence: 4 fullname: Huang Lan |
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| DocumentTitleAlternate | Preliminary study on the best-exerted force chance in the female menstrual cycle |
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| Keywords | estrogen 骨保护素 正畸力 雌激素 gingival crevicular fluid osteoprotegerin 龈沟液 orthodontic force |
| Language | Chinese |
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| Notes | 51-1169/R Yang Xi, Dai Hongwei, Wang Bin, Huang Lan （Dept. of Orthodontics, The Affiliated Hospital of Stomatology, Chongqing Medical University; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing 401147, China） gingival crevicular fluid;estrogen;orthodontic force;osteoprotegerin Objective To investigate the exerted force in different phases of the female menstrual cycle, as well as the changes in estrogen （E2）, osteocalcin （OCN）, receptor activator of nuclear factor-κB ligand （RANKL）, and osteoprotegerin （OPG） levels in the gingival crevicular fluid （GCF） during orthodontic tooth movement, to provide a theoretical basis for the selection of the best opportunity for efficient tooth movement. Methods Twelve women （aged 18 years to 28 years） with extracted first premolars had been selected. Six women in the group were randomly selected as the menstrual period group, whereas the remaining six were assigned to the ovulation period group. Right canines were retracted with 1.5 N NiTi close c |
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| Publisher | 重庆医科大学附属口腔医院正畸科 口腔疾病与生物医学重庆市重点实验室，重庆 401147 |
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| Snippet | 目的：通过在女性月经周期中的不同时期对正畸牙加力，研究龈沟液内雌激素（E2）、骨钙素（OCN）、核因子κB受体活化因子配体（RANKL）、骨保护素（OPG）的时效性表达，从而为... R783.5; 目的：通过在女性月经周期中的不同时期对正畸牙加力，研究龈沟液内雌激素（E2）、骨钙素（OCN）、核因子κB受体活化因子配体（RANKL）、骨保护素（OPG）的时效性表... |
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| SubjectTerms | 正畸力 雌激素 骨保护素 龈沟液 |
| Title | 女性正畸患者月经周期中最佳加力时机的初步研究 |
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