Deep mutational scanning of the Neisseria meningitidis major pilin reveals the importance of pilus tip‐mediated adhesion - Kennouche, Paul; Charles‐Orszag, Arthur; Nishiguchi, Daiki; Goussard, Sylvie; Imhaus, Anne‐Flore; Dupré, Mathieu; Chamot‐Rooke, Julia; Duménil, Guillaume (The EMBO journal, 2019)
Keywords: Adhesion; Agglomeration; Bacteria; Bacterial Adhesion; Biochemistry, Molecular Biology; Cell adhesion; Cell adhesion & migration; Cell Aggregation; Cell surface; deep mutational scanning; Domains; Electropositivity; EMBO05; EMBO23; Filaments; Fimbriae Proteins - chemistry; Fimbriae Proteins - genetics; Fimbriae Proteins - metabolism; Fimbriae, Bacterial - physiology; Gene Expression Regulation, Bacterial; Gram-negative bacteria; Human Umbilical Vein Endothelial Cells; Humans; Life Sciences; meningitis; Mutagenesis, Site-Directed; Mutation; Neisseria meningitidis; Neisseria meningitidis - physiology; Pathogens; Pili; Pilin; Prokaryotes; Residues; Scanning; type IV pilus; Virulence; pilin; deep mutational scanning; type IV pilus; bacterial adhesion; meningitis; type IV pilus Subject Categories Cell Adhesion; Virology & Host Pathogen Interaction; Microbiology; Polarity & Cytoskeleton