药物性肝损伤发病机制的研究进展

近年来,随着用药种类和不合理用药的日益增多,药物性肝损伤（DILI）发病率及病死率日益增高。DILI发病机制复杂,可能涉及药物的直接肝毒性作用、免疫介导性的肝损伤、线粒体损伤、胆道损伤等方面。探讨及了解其发病机制对预防及治疗DILI尤为重要。综述了DILI发病机制的研究进展。...

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Published in临床肝胆病杂志 Vol. 32; no. 2; pp. 382 - 385
Main Author 许新 纪莉莎 芦琳琳 陈丽丽 辛永宁 宣世英
Format Journal Article
LanguageChinese
Published 青岛市消化疾病重点实验室,青岛266021 2016
青岛市市立医院内镜中心,青岛266021%青岛市市立医院内镜中心,青岛,266021%青岛市市立医院中心实验室,青岛,266021%青岛市市立医院消化内二科,青岛266021
大连医科大学,辽宁大连116044
青岛市消化疾病重点实验室,青岛266021%青岛市市立医院消化内二科,青岛266021
中国海洋大学医药学院,青岛266003
Subjects
综述
肝疾病
liver diseases
综述
肝疾病
review
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2016.02.041

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Summary:近年来,随着用药种类和不合理用药的日益增多,药物性肝损伤（DILI）发病率及病死率日益增高。DILI发病机制复杂,可能涉及药物的直接肝毒性作用、免疫介导性的肝损伤、线粒体损伤、胆道损伤等方面。探讨及了解其发病机制对预防及治疗DILI尤为重要。综述了DILI发病机制的研究进展。
Bibliography:XU Xin, JI Lisha, LU Linlin, et al. （ Dalian Medical University, Dalian, Liaoning 116044 , China）
In recent years, with an increasing number of drug types and unreasonable drug use, incidence and mortality of drug - in- duced liver injury （DILI） have been increasing. The pathogenesis of DILI is complex, and may involve liver injury caused by the direct effect of drugs, immune -mediated liver injury, mitochondrial injury, and bile duct injury, etc. This article mvesngates the pathogenesis and its important role in the prevention and treatment of DILI, and reviews the research advances in the pathogenesis of DILI.
liver diseases ; review
22-1108/R
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2016.02.041