127例药疹患者回顾性分析
目的：探讨药疹患者的临床特点、致敏药物、治疗及转归,为临床合理用药、减少药疹的发生提供参考。方法：收集上海市皮肤病医院住院部2014年12月至2016年12月127例住院药疹患者的临床资料进行回顾性分析。结果：主要致敏药物为抗菌药物（57例,占44.9%）、中药及中药制剂（22例,占17.32%）、解热镇痛类（20例,占15.8%）;主要药疹类型为荨麻疹型（63例,占49.61%）,其次为发疹型（29例,占22.83%）、多形红斑型（18例,占14.18%）。119例非重症药疹中,有血象异常者109例,肝、肾功能异常者42例。8例重症药疹中,血象异常者7例,肝、肾功能异常者5例。结论：荨麻疹型...
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| Published in | 药学服务与研究 Vol. 17; no. 4; pp. 310 - 313 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
上海市皮肤病医院药剂科 ,上海,200443
2017
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1671-2838 |
| DOI | 10.5428/pcar20170419 |
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| Abstract | 目的：探讨药疹患者的临床特点、致敏药物、治疗及转归,为临床合理用药、减少药疹的发生提供参考。方法：收集上海市皮肤病医院住院部2014年12月至2016年12月127例住院药疹患者的临床资料进行回顾性分析。结果：主要致敏药物为抗菌药物（57例,占44.9%）、中药及中药制剂（22例,占17.32%）、解热镇痛类（20例,占15.8%）;主要药疹类型为荨麻疹型（63例,占49.61%）,其次为发疹型（29例,占22.83%）、多形红斑型（18例,占14.18%）。119例非重症药疹中,有血象异常者109例,肝、肾功能异常者42例。8例重症药疹中,血象异常者7例,肝、肾功能异常者5例。结论：荨麻疹型和发疹型药疹最为常见,药疹的主要致敏药物是抗菌药物和中药及中药制剂。对易致药疹药物应加强药学监护,增强患者安全用药意识,尽量降低药疹发生率。 |
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| AbstractList | 目的：探讨药疹患者的临床特点、致敏药物、治疗及转归,为临床合理用药、减少药疹的发生提供参考。方法：收集上海市皮肤病医院住院部2014年12月至2016年12月127例住院药疹患者的临床资料进行回顾性分析。结果：主要致敏药物为抗菌药物（57例,占44.9%）、中药及中药制剂（22例,占17.32%）、解热镇痛类（20例,占15.8%）;主要药疹类型为荨麻疹型（63例,占49.61%）,其次为发疹型（29例,占22.83%）、多形红斑型（18例,占14.18%）。119例非重症药疹中,有血象异常者109例,肝、肾功能异常者42例。8例重症药疹中,血象异常者7例,肝、肾功能异常者5例。结论：荨麻疹型和发疹型药疹最为常见,药疹的主要致敏药物是抗菌药物和中药及中药制剂。对易致药疹药物应加强药学监护,增强患者安全用药意识,尽量降低药疹发生率。 R994.11%R969.3; 目的:探讨药疹患者的临床特点、致敏药物、治疗及转归,为临床合理用药、减少药疹的发生提供参考.方法 :收集上海市皮肤病医院住院部2014年12月至2016年12月127例住院药疹患者的临床资料进行回顾性分析.结果:主要致敏药物为抗菌药物(57例,占44.9％)、中药及中药制剂(22例,占17.32％)、解热镇痛类(20例,占15.8％);主要药疹类型为荨麻疹型(63例,占49.61％),其次为发疹型(29例,占22.83％)、多形红斑型(18例,占14.18％).119例非重症药疹中,有血象异常者109例,肝、肾功能异常者42例.8例重症药疹中,血象异常者7例,肝、肾功能异常者5例.结论 :荨麻疹型和发疹型药疹最为常见 ,药疹的主要致敏药物是抗菌药物和中药及中药制剂.对易致药疹药物应加强药学监护 ,增强患者安全用药意识 ,尽量降低药疹发生率. |
| Abstract_FL | Objective:To explore clinical features of the patients with drug eruptions ,causative drugs and therapy ,so as to provide reference for rational medication and reduction of drug eruptions .Methods :The clinical data of 127 patients with drug eruptions hospitalized in Shanghai Hospital of Skin Diseases from December 2014 to December 2016 were collected and a retrospective analysis was made for the study .Results:The drugs that induced drug eruptions were mainly antibacterials (57 cases ,44 .9％ ) ,traditional Chinese herbal medicine and their preparations (22 cases ,17 .32％ ) and antipyretic analgesics (20 cases ,15 .8％ ) ,respectiuely .Urticarial drug eruptions (63 cases ,49 .61％ ) was the most common type of drug eruptions ,fol-lowed by exanthesis (29 cases ,22 .83％ ) and erythema multiforme (18 cases ,14 .18％ ) .Of the 119 cases of non-severe drug eruptions ,there were 109 cases with hematological abnormality ,42 cases with liver or kidney dysfunctions .Of the 8 cases of severe drug eruptions ,there were 7 cases with hematological abnormality and 5 cases with liver or kidney dysfunctions .Conclu-sion:The most common types of drug eruptions were urticarial and exanthesis eruptions ,and the main causative drugs were an-tibacterials ,traditional Chinese herbal medicine and their preparations . Pharmaceutical monitoring of those allergic drugs should be strengthened and awareness of safe medication should be enhanced ,so as to minimize the incidence of drug eruptions . |
| Author | 信如娟 陈中建 李莹 沈敏 朱全刚 |
| AuthorAffiliation | 上海市皮肤病医院药剂科,上海200443 |
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| Author_FL | CHEN ZhongJian ZHU QuanGang XIN RuJuan SHEN Min LI Ying |
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| Snippet | 目的：探讨药疹患者的临床特点、致敏药物、治疗及转归,为临床合理用药、减少药疹的发生提供参考。方法：收集上海市皮肤病医院住院部2014年12月至2016年12月127例住院药疹患者... R994.11%R969.3; 目的:探讨药疹患者的临床特点、致敏药物、治疗及转归,为临床合理用药、减少药疹的发生提供参考.方法 :收集上海市皮肤病医院住院部2014年12月至2016年12月127... |
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| Title | 127例药疹患者回顾性分析 |
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