白藜芦醇对甲醛中毒小鼠免疫系统损伤的保护作用
目的探讨白藜芦醇(Res)对甲醛中毒小鼠免疫系统损伤的保护作用。 方法〓取50只健康小鼠(雌雄各半)随机分为阴性对照组(N组),阳性对照组(P组),Res低(L)、中(M)、高(H)剂量组(分别为L、M、H组),每组10只。通过灌胃建立甲醛中毒模型,除N组外,其余各组均给予37%甲醛溶液50 mg/kg灌胃每天1次,共5 d。第6天,N组和 P组给予0.9%氯化钠注射液,L、M、H组分别给予7.5、15.0、30.0 mg/kg的Res,均按0.1 mL/10 g腹腔注射,每天1次,连续7 d。检测各组小鼠巨噬细胞吞噬率、胸腺指数和脾脏指数。 结果与P组比较,N、L、M、H组小鼠细胞吞噬率、胸...
Saved in:
| Published in | 现代医药卫生 Vol. 33; no. 23; pp. 3537 - 3538 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
海南医学院国际护理学院,海南海口,571199%海南医学院药学院,海南海口,571199
2017
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1009-5519 |
| DOI | 10.3969/j.issn.1009-5519.2017.23.001 |
Cover
| Abstract | 目的探讨白藜芦醇(Res)对甲醛中毒小鼠免疫系统损伤的保护作用。 方法〓取50只健康小鼠(雌雄各半)随机分为阴性对照组(N组),阳性对照组(P组),Res低(L)、中(M)、高(H)剂量组(分别为L、M、H组),每组10只。通过灌胃建立甲醛中毒模型,除N组外,其余各组均给予37%甲醛溶液50 mg/kg灌胃每天1次,共5 d。第6天,N组和 P组给予0.9%氯化钠注射液,L、M、H组分别给予7.5、15.0、30.0 mg/kg的Res,均按0.1 mL/10 g腹腔注射,每天1次,连续7 d。检测各组小鼠巨噬细胞吞噬率、胸腺指数和脾脏指数。 结果与P组比较,N、L、M、H组小鼠细胞吞噬率、胸腺指数和脾脏指数均明显升高,差异均有统计学意义(P<0.05);与 L组比较,H组腹腔巨噬细胞吞噬率、胸腺指数和脾脏指数均明显升高,差异均有统计学意义(P<0.05);而H组小鼠胸腺指数和脾腺指数与N组比较,差异均无统计学意义(P>0.05)。 结论Res对甲醛中毒小鼠免疫系统具有保护作用,对健康小鼠没有显著影响。 |
|---|---|
| AbstractList | 目的 探讨白藜芦醇(Res)对甲醛中毒小鼠免疫系统损伤的保护作用.方法 取50只健康小鼠(雌雄各半)随机分为阴性对照组(N组),阳性对照组(P组),Res低(L)、中(M)、高(H)剂量组(分别为L、M、H组),每组10只.通过灌胃建立甲醛中毒模型,除N组外,其余各组均给予37%甲醛溶液50 mg/kg灌胃每天1次,共5 d.第6天,N组和P组给予0.9%氯化钠注射液,L、M、H组分别给予7.5、15.0、30.0 mg/kg的Res,均按0.1 mL/10 g腹腔注射,每天1次,连续7 d.检测各组小鼠巨噬细胞吞噬率、胸腺指数和脾脏指数.结果 与P组比较,N、L、M、H组小鼠细胞吞噬率、胸腺指数和脾脏指数均明显升高,差异均有统计学意义(P<0.05);与L组比较,H组腹腔巨噬细胞吞噬率、胸腺指数和脾脏指数均明显升高,差异均有统计学意义(P<0.05);而H组小鼠胸腺指数和脾腺指数与N组比较,差异均无统计学意义(P>0.05).结论 Res对甲醛中毒小鼠免疫系统具有保护作用,对健康小鼠没有显著影响. 目的探讨白藜芦醇(Res)对甲醛中毒小鼠免疫系统损伤的保护作用。 方法〓取50只健康小鼠(雌雄各半)随机分为阴性对照组(N组),阳性对照组(P组),Res低(L)、中(M)、高(H)剂量组(分别为L、M、H组),每组10只。通过灌胃建立甲醛中毒模型,除N组外,其余各组均给予37%甲醛溶液50 mg/kg灌胃每天1次,共5 d。第6天,N组和 P组给予0.9%氯化钠注射液,L、M、H组分别给予7.5、15.0、30.0 mg/kg的Res,均按0.1 mL/10 g腹腔注射,每天1次,连续7 d。检测各组小鼠巨噬细胞吞噬率、胸腺指数和脾脏指数。 结果与P组比较,N、L、M、H组小鼠细胞吞噬率、胸腺指数和脾脏指数均明显升高,差异均有统计学意义(P<0.05);与 L组比较,H组腹腔巨噬细胞吞噬率、胸腺指数和脾脏指数均明显升高,差异均有统计学意义(P<0.05);而H组小鼠胸腺指数和脾腺指数与N组比较,差异均无统计学意义(P>0.05)。 结论Res对甲醛中毒小鼠免疫系统具有保护作用,对健康小鼠没有显著影响。 |
| Author | 张希;薛亮;王小蒙;刘园园 |
| AuthorAffiliation | 海南医学院国际护理学院,海南海口571199;海南医学院药学院,海南海口571199 |
| AuthorAffiliation_xml | – name: 海南医学院国际护理学院,海南海口,571199%海南医学院药学院,海南海口,571199 |
| Author_FL | Zhang Xi Wang Xiaomeng Xue Liang Liu Yuanyuan |
| Author_FL_xml | – sequence: 1 fullname: Zhang Xi – sequence: 2 fullname: Xue Liang – sequence: 3 fullname: Liu Yuanyuan – sequence: 4 fullname: Wang Xiaomeng |
| Author_xml | – sequence: 1 fullname: 张希;薛亮;王小蒙;刘园园 |
| BookMark | eNo9kE1LAlEUhu_CIDN_RUGrmc6dO193WdIXCG3cD_fOnbGRupZDmPsyECQIKSrDFhJBhFGbQqU_Mzr6LxoxWh045-E9PO8SSsmy9BBaxaASatL1khqEoVQxAFUMA1NVA2ypGlEBcAql__eLKBuGAQcDE0vXLJxGm_HdcHLbnjSep_XLUe87bn1M6w_R19u4dz16v5oOnkYXzfjmNf7sx_3OuNmJBt34_jz6eRw3utGwHbdeltGCzw5DL_s3M6iwvVXI7Sr5_Z293EZecU3AimthZjOfeEBt7lnUN12dck-I5KpxnVAXC1fYrs51T2jCNBjYJvE55RYDzjnJoLV5bJVJn8miUyqfVmTy0DkTtVo1nClrJBFOyJU56R6UZfEkSNjjSnDEKjXHAoBZY5pBfgGliXUK |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3969/j.issn.1009-5519.2017.23.001 |
| DatabaseName | 维普_期刊 中文科技期刊数据库-CALIS站点 维普中文期刊数据库 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | Protective effects of resveratrol on immune system injury in mice with formaldehyde poisoning |
| DocumentTitle_FL | Protective effects of resveratrol on immune system injury in mice with formaldehyde poisoning |
| EndPage | 3538 |
| ExternalDocumentID | xdyyws201723001 7000396925 |
| GrantInformation_xml | – fundername: 国家级大学生创新创业训练计划项目 funderid: (201611810080) |
| GroupedDBID | -05 -0E -SE -S~ .5D 2B. 2C~ 2RA 5SA 5VR 92F 92I 92L 92M 93N 93R 9D9 9DE AAITT ABDBF ACGFS AFUIB ALMA_UNASSIGNED_HOLDINGS CAJEE CAJUS CCEZO CIEJG CQIGP CW7 CW9 EOJEC ESX FA0 J.9 JUIAU M~T M~X OBODZ PB1 PB7 Q-- Q-4 R-E RT5 S.. T8U TCJ TGQ U1F U1G U5E U5O W91 WFFXF ~WA 4A8 ABJNI ACUHS PSX |
| ID | FETCH-LOGICAL-c601-c71a8af3e098be79f6c49beddc602b439c1dcd8c4b4ed2d65a0863fb9b7a0bbb3 |
| ISSN | 1009-5519 |
| IngestDate | Thu May 29 03:59:49 EDT 2025 Wed Feb 14 10:03:44 EST 2024 |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 23 |
| Keywords | 甲醛/中毒 白藜芦醇 醇类 小鼠 免疫系统 免疫保护 藜芦生物碱类 |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c601-c71a8af3e098be79f6c49beddc602b439c1dcd8c4b4ed2d65a0863fb9b7a0bbb3 |
| Notes | Objective To study the protective effects of resveratrol渊Res冤on the immune system injury in mice with formaldehyde poisoning.Methods Fifty healthy mice渊half male and half female冤were randomly divided into the negative control group渊N冤袁positive control group渊P冤袁Res low渊L冤袁medium渊M冤and high渊H冤dose groups袁10cases in each group.The mouse formaldehyde poisoning model was established by gavage.Except for the group N袁the other groups were given37%formaldehyde solution50mg/kg by gavage for5d.On6d袁the group N and P were given0.9%sodium chloride injection袁and the group L袁Mand H were given7.5袁15.0袁30.0mg/kg of Res袁by intraperitoneal injection with0.1mL/10g袁once daily for continuous7d.The phagocytosis rate of peritoneal marcrophages袁thymus index and spleen index were detected.Results Compared with the group P袁the phagocytosis rate of peritoneal macrophages袁thymus index and spleen index in the group N袁L袁M and H were significantly increased袁the difference was statistically significant渊P<0.05冤曰compared with the group L袁t |
| PageCount | 2 |
| ParticipantIDs | wanfang_journals_xdyyws201723001 chongqing_primary_7000396925 |
| PublicationCentury | 2000 |
| PublicationDate | 2017 |
| PublicationDateYYYYMMDD | 2017-01-01 |
| PublicationDate_xml | – year: 2017 text: 2017 |
| PublicationDecade | 2010 |
| PublicationTitle | 现代医药卫生 |
| PublicationTitleAlternate | Modern Medicine Health |
| PublicationTitle_FL | Journal of Modern Medicine & Health |
| PublicationYear | 2017 |
| Publisher | 海南医学院国际护理学院,海南海口,571199%海南医学院药学院,海南海口,571199 |
| Publisher_xml | – name: 海南医学院国际护理学院,海南海口,571199%海南医学院药学院,海南海口,571199 |
| SSID | ssib051374271 ssj0002402475 |
| Score | 2.088912 |
| Snippet | 目的探讨白藜芦醇(Res)对甲醛中毒小鼠免疫系统损伤的保护作用。 方法〓取50只健康小鼠(雌雄各半)随机分为阴性对照组(N组),阳性对照组(P组),Res低(L)、中(M)、高(H)剂量组(分别为L、M、H组),每组10只。通过灌胃建立甲醛中毒模型,除N组外,其余各组均给予37%甲醛溶液50... 目的 探讨白藜芦醇(Res)对甲醛中毒小鼠免疫系统损伤的保护作用.方法 取50只健康小鼠(雌雄各半)随机分为阴性对照组(N组),阳性对照组(P组),Res低(L)、中(M)、高(H)剂量组(分别为L、M、H组),每组10只.通过灌胃建立甲醛中毒模型,除N组外,其余各组均给予37%甲醛溶液50... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 3537 |
| SubjectTerms | 免疫保护 免疫系统 小鼠 甲醛/中毒 白藜芦醇 藜芦生物碱类 醇类 |
| Title | 白藜芦醇对甲醛中毒小鼠免疫系统损伤的保护作用 |
| URI | http://lib.cqvip.com/qk/91143A/201723/7000396925.html https://d.wanfangdata.com.cn/periodical/xdyyws201723001 |
| Volume | 33 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR1Na9RQ8FFbEC-iqFit0kPfcdfkJXkfx7zdLEXQU4XeliSbtKet2i21PWuFQhGkKGqlHooIIhW9KG3xz-xu2ps_wZmXNM2hFBWWMJnMvJn3JnlvJnkzS8hUaPFUea6ocS5jCFBkWAsZEzUs3pbYsfRYiLnD9-7z6Qfu3VlvdmTkd2XX0lIvqserp-aV_I9VAQd2xSzZf7Bs2SggAAb7whEsDMe_sjENBFWK6iYNJFUANxCQPvU5DRSVnEKoH3jUb1GtDLFLNSsuKU0DOJXUB3aONIohsbaobCGNblDfQoyEX9OwA5lGQDtU54CmqoXsQICAa7hcQ-xT6RoMtGxEoGI5pmlUNfr4suofI1IGqAOSaeo7RoGGESdRCugZGH1yTaAFVW5ONuofaw09Az7H8Kmyu6BCYJBGjtSVHkscABhOxyAlnEoEgBFHqACqb0nydNBiSsfPP-AXquqcnxffKO5t5lRmcMfLi9AU3gCcytNWGkdxZVYalFEvZeBeQVFnWDXXPllhy32PwuRCc8W8c2SMCc7ZKBnzdVO3judAz3aEywoXHb0J_PrlmnrRpZDzZKrQ4M5Z8rFayPxCd-4R-EAmJa2bht25ivc0c4lcLMKeST-_hy-TkdX5K0Rnbw4OX28drn88Wns-2P2ZbX47WnvX__FluPty8PXF0f6HwbON7NXn7Ptetrc93Nju7-9kb5_2f70fru_0D7ayzU9XyUwrmGlM14r_9KjFEPrXYmGHMkydxFIySoRKeeyqKOl04CqLwDmO7Q5Wq3AjN-mwDvdCCLmdNFKRCK0oipxrZLS70E2uk0khrRgWEHAxFXhiqZJeaovQlqkbx1KIcJxMlN1vP8xLt7RPDDBOJosRaRdP9GL7SWdlZXkRhxACc8u-cXYLN8kFJM3fx02Q0d7jpeQWeKi96HZh1D_JUHPa |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E7%99%BD%E8%97%9C%E8%8A%A6%E9%86%87%E5%AF%B9%E7%94%B2%E9%86%9B%E4%B8%AD%E6%AF%92%E5%B0%8F%E9%BC%A0%E5%85%8D%E7%96%AB%E7%B3%BB%E7%BB%9F%E6%8D%9F%E4%BC%A4%E7%9A%84%E4%BF%9D%E6%8A%A4%E4%BD%9C%E7%94%A8&rft.jtitle=%E7%8E%B0%E4%BB%A3%E5%8C%BB%E8%8D%AF%E5%8D%AB%E7%94%9F&rft.au=%E5%BC%A0%E5%B8%8C%3B%E8%96%9B%E4%BA%AE%3B%E7%8E%8B%E5%B0%8F%E8%92%99%3B%E5%88%98%E5%9B%AD%E5%9B%AD&rft.date=2017&rft.issn=1009-5519&rft.volume=33&rft.issue=23&rft.spage=3537&rft.epage=3538&rft_id=info:doi/10.3969%2Fj.issn.1009-5519.2017.23.001&rft.externalDocID=7000396925 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F91143A%2F91143A.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fxdyyws%2Fxdyyws.jpg |