Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms and consequences - Leclercq, Isabelle A.; Da Silva Morais, Alain; Schroyen, Ben; Van Hul, Noémi; Geerts, Albert (Journal of hepatology, 2007)
Keywords: Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Gastroenterology and Hepatology; Hepatocytes - metabolism; Hepatocytes - pathology; Humans; Insulin Resistance; Liver - metabolism; Liver - pathology; Medical sciences; Metabolic diseases; Metabolic Syndrome - metabolism; Metabolic Syndrome - pathology; Miscellaneous; Other metabolic disorders; Stem Cells - metabolism; Stem Cells - pathology; FFA; JNK; GSK-3; IKKβ; IRS; PKD1; TNF; NF-κB; PI3K; PPAR; VLDL; KC; HSC; NAFLD/NASH; AGE; IL; PEPCK; PKB; IR; PKC; SOCS; RAGE; MAPK; SREBP-1c; ECM; MCD; SEC; ChREBP; ROS; AMPK; FAS; PIP3; GLUT4; LPC; ERK; sterol regulatory element-binding protein-1c; non-alcoholic fatty liver disease/non-alcoholic steatohepatitis; receptor of advanced glycation end-products; AMP-dependent kinase; hepatic stellate cells; phosphatidylinositol-3-kinase; nuclear factor-kappa B; Inhibitory kappa B kinase beta; fatty acid synthase; very low density lipoprotein; phosphoenol-pyruvate carboxy-kinase; tumor necrosis factor α; Kupffer cells; free fatty acids; advanced glycation end-products; mitogen-activated protein kinase; glycogen synthase kinase-3; reactive oxygen species; sinusoidal endothelial cells; insulin receptor substrate; peroxisome proliferator-activated receptor; interleukin; c-Jun-N-terminal kinase; protein kinase C; protein kinase B; Phosphatidylinositol (3,4,5) triphosphate; suppressor of cytokine signaling; carbohydrate regulatory element-binding protein; phosphoinositide-dependent protein kinase; liver progenitor cells; extracellular regulated kinase; methionine and choline-deficient; glucose transporter-4; insulin receptor; extracellular matrix; Endocrinopathy; Type 2 diabetes; Hyperinsulinemia; Oxidative stress; Hepatic sinusoid; Liver; Cardiovascular disease