Skp2在鼻型NK／T细胞淋巴瘤中的表达及临床意义
目的探讨Skp2与鼻型NK／T细胞淋巴瘤的预后及其他临床特点之间的关系。方法收集95例鼻型NK／T细胞淋巴瘤患者临床病理学资料，用免疫组化方法检测肿瘤石蜡包埋标本的EB病毒编码RNA（EBVencodedRNA，EBER）、Skp2及Ki-67的表达情况，将Skp2阳性细胞比率超过50％的病例计入高表达组，低于50％的计入低表达组，分析患者的预后、EBER表达状态与Skp2、Ki-67表达率之间的关系。结果在Skp2高表达组，中位生存期为20．54个月（95％CI：18．49—22．59），1年总体生存率为76％；在Skp2低表达组，中位生存期为17．54个月（95％CI：20．31-22．2...
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| Published in | 复旦学报（医学版） Vol. 41; no. 1; pp. 60 - 65 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
复旦大学附属眼耳鼻喉科医院病理科,上海,200031%复旦大学附属华山医院病理科,上海,200040
2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-8467 |
| DOI | 10.3969/j.issn.1672-8467.2014.01.010 |
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| Abstract | 目的探讨Skp2与鼻型NK／T细胞淋巴瘤的预后及其他临床特点之间的关系。方法收集95例鼻型NK／T细胞淋巴瘤患者临床病理学资料，用免疫组化方法检测肿瘤石蜡包埋标本的EB病毒编码RNA（EBVencodedRNA，EBER）、Skp2及Ki-67的表达情况，将Skp2阳性细胞比率超过50％的病例计入高表达组，低于50％的计入低表达组，分析患者的预后、EBER表达状态与Skp2、Ki-67表达率之间的关系。结果在Skp2高表达组，中位生存期为20．54个月（95％CI：18．49—22．59），1年总体生存率为76％；在Skp2低表达组，中位生存期为17．54个月（95％CI：20．31-22．24），1年总体生存率为71％；在Skp2阴性组，中位生存期为个21．71个月（95％CI：11．15—16．18），1年总体生存率为91％。生存分析显示，Skp2高表达组与Skp2阴性组间差异具有统计学意义（P=0．035）。结论Skp2的高表达可能是鼻腔NK／T细胞淋巴瘤预后的不良因素。 |
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| AbstractList | 目的探讨Skp2与鼻型NK／T细胞淋巴瘤的预后及其他临床特点之间的关系。方法收集95例鼻型NK／T细胞淋巴瘤患者临床病理学资料，用免疫组化方法检测肿瘤石蜡包埋标本的EB病毒编码RNA（EBVencodedRNA，EBER）、Skp2及Ki-67的表达情况，将Skp2阳性细胞比率超过50％的病例计入高表达组，低于50％的计入低表达组，分析患者的预后、EBER表达状态与Skp2、Ki-67表达率之间的关系。结果在Skp2高表达组，中位生存期为20．54个月（95％CI：18．49—22．59），1年总体生存率为76％；在Skp2低表达组，中位生存期为17．54个月（95％CI：20．31-22．24），1年总体生存率为71％；在Skp2阴性组，中位生存期为个21．71个月（95％CI：11．15—16．18），1年总体生存率为91％。生存分析显示，Skp2高表达组与Skp2阴性组间差异具有统计学意义（P=0．035）。结论Skp2的高表达可能是鼻腔NK／T细胞淋巴瘤预后的不良因素。 R73; 目的 探讨Skp2与鼻型NK/T细胞淋巴瘤的预后及其他临床特点之间的关系.方法 收集95例鼻型NK/T细胞淋巴瘤患者临床病理学资料,用免疫组化方法检测肿瘤石蜡包埋标本的EB病毒编码RNA (EBV encoded RNA,EBER)、Skp2及Ki-67的表达情况,将Skp2阳性细胞比率超过50%的病例计入高表达组,低于50%的计入低表达组,分析患者的预后、EBER表达状态与Skp2、Ki-67表达率之间的关系.结果 在Skp2高表达组,中位生存期为20.54个月(95%CI:18.49-22.59),1年总体生存率为76%;在Skp2低表达组,中位生存期为17.54个月(95%CI:20.31-22.24),1年总体生存率为71%;在Skp2阴性组,中位生存期为个21.71个月(95%CI:11.15-16.18),1年总体生存率为91%.生存分析显示,Skp2高表达组与Skp2阴性组间差异具有统计学意义(P=0.035).结论 Skp2的高表达可能是鼻腔NK/T细胞淋巴瘤预后的不良因素. |
| Author | 邢岳 王纾宜 许祖德 |
| AuthorAffiliation | 复旦大学附属眼耳鼻喉科医院病理科,上海200031 复旦大学附属华山医院病理科,上海200040 |
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| Author_FL | WANG Shu-Yi XU Zu-De XING Yue |
| Author_FL_xml | – sequence: 1 fullname: XING Yue – sequence: 2 fullname: WANG Shu-Yi – sequence: 3 fullname: XU Zu-De |
| Author_xml | – sequence: 1 fullname: 邢岳 王纾宜 许祖德 |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| DOI | 10.3969/j.issn.1672-8467.2014.01.010 |
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| DocumentTitleAlternate | The expression and clinical significance of Skp2 in nasal type NK/T-cell lymphoma |
| DocumentTitle_FL | The expression and clinical significance of Skp2 in nasal type NK/T-cell lymphoma |
| EndPage | 65 |
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| Keywords | Ki-67 EB病毒编码RNA EBER Skp2 鼻型NK/T细胞淋巴瘤 |
| Language | Chinese |
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| Notes | Objective To discuss the correlation between Skp2 and the prognosis and other clinicopathological features of nasal type NK/T-cell lymphoma. Methods We collected the clinicopathological data of 95 cases of nasal type NK/T-cell lymphoma,detected the expression of EBV encoded RNA （EBER）, Skp2 and Ki-67 of paraffin-embedded tissue of tumors using immunohistochemical method. The cases with the Skp2-positive rate of tumor cells above 50% were classified into high expression group, those with below 50 % were classified into low expression group. We analyzed the correlation between the expression of Skp2 and Ki-67, and the prognosis or EBER status. Results In the high expression group,the mean overall survival was 20.54 months （95%CI. 18.49 - 22.59）, the 1-year overall survival rate was 76%. In the low expression group, the mean overall survival was 17.54 months （95%CI.20.31 - 22.24） ,the 1-year overall survival rate was 71%.In the negative expression group, the mean overall survival was 21. 71 months （95% CI.-11. 1 |
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| PublicationTitle | 复旦学报（医学版） |
| PublicationTitleAlternate | Fudan University Journal of Medical Sciences |
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| PublicationYear | 2014 |
| Publisher | 复旦大学附属眼耳鼻喉科医院病理科,上海,200031%复旦大学附属华山医院病理科,上海,200040 |
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| Snippet | 目的探讨Skp2与鼻型NK／T细胞淋巴瘤的预后及其他临床特点之间的关系。方法收集95例鼻型NK／T细胞淋巴瘤患者临床病理学资料，用免疫组化方法检测肿瘤石蜡包埋标本的EB病毒编... R73; 目的 探讨Skp2与鼻型NK/T细胞淋巴瘤的预后及其他临床特点之间的关系.方法 收集95例鼻型NK/T细胞淋巴瘤患者临床病理学资料,用免疫组化方法检测肿瘤石蜡包埋标本的EB病... |
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| SubjectTerms | EB病毒编码RNA（EBER） Ki-67 Skp2 T细胞淋巴瘤 鼻型NK |
| Title | Skp2在鼻型NK／T细胞淋巴瘤中的表达及临床意义 |
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