Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation - Wu, Jianqiang; Keng, Vincent W.; Patmore, Deanna M.; Kendall, Jed J.; Patel, Ami V.; Jousma, Edwin; Jessen, Walter J.; Choi, Kwangmin; Tschida, Barbara R.; Silverstein, Kevin A.T.; Fan, Danhua; Schwartz, Eric B.; et al. (Cell reports (Cambridge), 2016)
Keywords: Animals; beta Catenin - genetics; beta Catenin - metabolism; Carcinogenesis - genetics; Carcinogenesis - metabolism; Carcinogenesis - pathology; Disease Models, Animal; DNA Helicases - genetics; DNA Helicases - metabolism; DNA-Binding Proteins - antagonists & inhibitors; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Female; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta - antagonists & inhibitors; Glycogen Synthase Kinase 3 beta - genetics; Glycogen Synthase Kinase 3 beta - metabolism; Histones - genetics; Histones - metabolism; Humans; Mice; Mice, Nude; Mutagenesis, Insertional; N-Terminal Acetyltransferase A - antagonists & inhibitors; N-Terminal Acetyltransferase A - genetics; N-Terminal Acetyltransferase A - metabolism; Neoplasm Transplantation; Neural Stem Cells - metabolism; Neural Stem Cells - pathology; Neurofibromatosis 1 - genetics; Neurofibromatosis 1 - metabolism; Neurofibromatosis 1 - pathology; Neurofibromin 1 - genetics; Neurofibromin 1 - metabolism; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Peripheral Nervous System Neoplasms - genetics; Peripheral Nervous System Neoplasms - metabolism; Peripheral Nervous System Neoplasms - pathology; Phosphorylation; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; Schwann Cells - metabolism; Schwann Cells - pathology; Signal Transduction; STAT3 Transcription Factor - antagonists & inhibitors; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism