A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells
Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard chemoradiation. Identification of the cell-intrinsic mechanisms governing this clinically important cell state may lead to the discovery of therapeutic s...
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| Published in | Cell reports (Cambridge) Vol. 11; no. 11; pp. 1809 - 1821 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
23.06.2015
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2211-1247 2211-1247 |
| DOI | 10.1016/j.celrep.2015.05.027 |
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| Abstract | Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard chemoradiation. Identification of the cell-intrinsic mechanisms governing this clinically important cell state may lead to the discovery of therapeutic strategies for this challenging malignancy. Here, we demonstrate that the mitotic E3 ubiquitin ligase CDC20-anaphase-promoting complex (CDC20-APC) drives invasiveness and self-renewal in patient tumor-derived GSCs. Moreover, CDC20 knockdown inhibited and CDC20 overexpression increased the ability of human GSCs to generate brain tumors in an orthotopic xenograft model in vivo. CDC20-APC control of GSC invasion and self-renewal operates through pluripotency-related transcription factor SOX2. Our results identify a CDC20-APC/SOX2 signaling axis that controls key biological properties of GSCs, with implications for CDC20-APC-targeted strategies in the treatment of glioblastoma.
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•CDC20-APC drives the invasiveness and self-renewal of glioblastoma stem-like cells•CDC20 is essential for the in vivo tumorigenicity of glioblastoma stem-like cells•CDC20-APC operates through SOX2 to control glioblastoma stem-like cell function•CDC20 is prognostic of overall survival in Proneural subtype glioblastoma patients
Mao et al. report that E3 ubiquitin ligase CDC20-APC is required for invasiveness, self-renewal, and in vivo tumorigenicity of human glioblastoma stem-like cells (GSCs). CDC20-APC interacts with and regulates SOX2 protein to promote SOX2-dependent transcription and drive GSC invasiveness and self-renewal. Using the Cancer Genome Atlas dataset, the authors find that high CDC20 expression in proneural glioblastomas is associated with shorter overall survival. |
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| AbstractList | Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard chemoradiation. Identification of the cell-intrinsic mechanisms governing this clinically important cell state may lead to the discovery of therapeutic strategies for this challenging malignancy. Here, we demonstrate that the mitotic E3 ubiquitin ligase CDC20-anaphase-promoting complex (CDC20-APC) drives invasiveness and self-renewal in patient tumor-derived GSCs. Moreover, CDC20 knockdown inhibited and CDC20 overexpression increased the ability of human GSCs to generate brain tumors in an orthotopic xenograft model in vivo. CDC20-APC control of GSC invasion and self-renewal operates through pluripotency-related transcription factor SOX2. Our results identify a CDC20-APC/SOX2 signaling axis that controls key biological properties of GSCs, with implications for CDC20-APC-targeted strategies in the treatment of glioblastoma.Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard chemoradiation. Identification of the cell-intrinsic mechanisms governing this clinically important cell state may lead to the discovery of therapeutic strategies for this challenging malignancy. Here, we demonstrate that the mitotic E3 ubiquitin ligase CDC20-anaphase-promoting complex (CDC20-APC) drives invasiveness and self-renewal in patient tumor-derived GSCs. Moreover, CDC20 knockdown inhibited and CDC20 overexpression increased the ability of human GSCs to generate brain tumors in an orthotopic xenograft model in vivo. CDC20-APC control of GSC invasion and self-renewal operates through pluripotency-related transcription factor SOX2. Our results identify a CDC20-APC/SOX2 signaling axis that controls key biological properties of GSCs, with implications for CDC20-APC-targeted strategies in the treatment of glioblastoma. Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard chemoradiation. Identification of the cell-intrinsic mechanisms governing this clinically important cell state may lead to the discovery of novel therapeutic strategies for this challenging malignancy. Here, we demonstrate that the mitotic E3 ubiquitin ligase CDC20-Anaphase-Promoting Complex (CDC20-APC) drives invasiveness and self-renewal in patient tumor-derived GSCs. Moreover, CDC20 knockdown inhibited and CDC20 overexpression increased the ability of human GSCs to generate brain tumors in an orthotopic xenograft model in vivo . CDC20-APC control of GSC invasion and self-renewal operates through pluripotency-related transcription factor SOX2 . Our results identify a CDC20-APC/SOX2 signaling axis that controls key biological properties of GSCs, with implications for CDC20-APC-targeted strategies in the treatment of glioblastoma. Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard chemoradiation. Identification of the cell-intrinsic mechanisms governing this clinically important cell state may lead to the discovery of therapeutic strategies for this challenging malignancy. Here, we demonstrate that the mitotic E3 ubiquitin ligase CDC20-anaphase-promoting complex (CDC20-APC) drives invasiveness and self-renewal in patient tumor-derived GSCs. Moreover, CDC20 knockdown inhibited and CDC20 overexpression increased the ability of human GSCs to generate brain tumors in an orthotopic xenograft model in vivo. CDC20-APC control of GSC invasion and self-renewal operates through pluripotency-related transcription factor SOX2. Our results identify a CDC20-APC/SOX2 signaling axis that controls key biological properties of GSCs, with implications for CDC20-APC-targeted strategies in the treatment of glioblastoma. Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard chemoradiation. Identification of the cell-intrinsic mechanisms governing this clinically important cell state may lead to the discovery of therapeutic strategies for this challenging malignancy. Here, we demonstrate that the mitotic E3 ubiquitin ligase CDC20-anaphase-promoting complex (CDC20-APC) drives invasiveness and self-renewal in patient tumor-derived GSCs. Moreover, CDC20 knockdown inhibited and CDC20 overexpression increased the ability of human GSCs to generate brain tumors in an orthotopic xenograft model in vivo. CDC20-APC control of GSC invasion and self-renewal operates through pluripotency-related transcription factor SOX2. Our results identify a CDC20-APC/SOX2 signaling axis that controls key biological properties of GSCs, with implications for CDC20-APC-targeted strategies in the treatment of glioblastoma. [Display omitted] •CDC20-APC drives the invasiveness and self-renewal of glioblastoma stem-like cells•CDC20 is essential for the in vivo tumorigenicity of glioblastoma stem-like cells•CDC20-APC operates through SOX2 to control glioblastoma stem-like cell function•CDC20 is prognostic of overall survival in Proneural subtype glioblastoma patients Mao et al. report that E3 ubiquitin ligase CDC20-APC is required for invasiveness, self-renewal, and in vivo tumorigenicity of human glioblastoma stem-like cells (GSCs). CDC20-APC interacts with and regulates SOX2 protein to promote SOX2-dependent transcription and drive GSC invasiveness and self-renewal. Using the Cancer Genome Atlas dataset, the authors find that high CDC20 expression in proneural glioblastomas is associated with shorter overall survival. Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard chemoradiation. Identification of the cell-intrinsic mechanisms governing this clinically important cell state may lead to the discovery of therapeutic strategies for this challenging malignancy. Here, we demonstrate that the mitotic E3 ubiquitin ligase CDC20-anaphase-promoting complex (CDC20-APC) drives invasiveness and self-renewal in patient tumor-derived GSCs. Moreover, CDC20 knockdown inhibited and CDC20 overexpression increased the ability of human GSCs to generate brain tumors in an orthotopic xenograft model in vivo. CDC20-APC control of GSC invasion and self-renewal operates through pluripotency-related transcription factor SOX2. Our results identify a CDC20-APC/SOX2 signaling axis that controls key biological properties of GSCs, with implications for CDC20-APC-targeted strategies in the treatment of glioblastoma. |
| Author | Chen, Ishita Turski, Alice Pan, Yanchun Kim, Albert H. Achilefu, Samuel Yano, Hiroko Leuthardt, Eric C. Zipfel, Gregory J. Dowling, Joshua L. Mahlokozera, Tatenda Rich, Keith M. Mao, Diane D. Thompson, Elizabeth A. Tran, David D. Luo, Jingqin Dunn, Gavin P. Chicoine, Michael R. Brost, Taylor Dacey, Ralph G. Gujar, Amit D. |
| AuthorAffiliation | 12 Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110 USA 5 Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110 USA 8 Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110 USA 7 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 USA 2 Program in Neuroscience, Washington University School of Medicine, St. Louis, MO 63110 USA 9 Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110 USA 6 Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110 USA 11 Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110 USA 10 Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110 USA 1 Department of Neurological Surgery, Washington Univer |
| AuthorAffiliation_xml | – name: 9 Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110 USA – name: 2 Program in Neuroscience, Washington University School of Medicine, St. Louis, MO 63110 USA – name: 7 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 USA – name: 5 Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110 USA – name: 3 Division of Biostatistics, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110 USA – name: 6 Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110 USA – name: 8 Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110 USA – name: 1 Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110 USA – name: 10 Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110 USA – name: 11 Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110 USA – name: 12 Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110 USA – name: 4 Program in Molecular Cell Biology, Washington University School of Medicine, St. Louis, MO 63110 USA |
| Author_xml | – sequence: 1 givenname: Diane D. surname: Mao fullname: Mao, Diane D. organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 2 givenname: Amit D. surname: Gujar fullname: Gujar, Amit D. organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 3 givenname: Tatenda surname: Mahlokozera fullname: Mahlokozera, Tatenda organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 4 givenname: Ishita surname: Chen fullname: Chen, Ishita organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 5 givenname: Yanchun surname: Pan fullname: Pan, Yanchun organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 6 givenname: Jingqin surname: Luo fullname: Luo, Jingqin organization: Division of Biostatistics, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 7 givenname: Taylor surname: Brost fullname: Brost, Taylor organization: Program in Molecular Cell Biology, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 8 givenname: Elizabeth A. surname: Thompson fullname: Thompson, Elizabeth A. organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 9 givenname: Alice surname: Turski fullname: Turski, Alice organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 10 givenname: Eric C. surname: Leuthardt fullname: Leuthardt, Eric C. organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 11 givenname: Gavin P. surname: Dunn fullname: Dunn, Gavin P. organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 12 givenname: Michael R. surname: Chicoine fullname: Chicoine, Michael R. organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 13 givenname: Keith M. surname: Rich fullname: Rich, Keith M. organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 14 givenname: Joshua L. surname: Dowling fullname: Dowling, Joshua L. organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 15 givenname: Gregory J. surname: Zipfel fullname: Zipfel, Gregory J. organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 16 givenname: Ralph G. surname: Dacey fullname: Dacey, Ralph G. organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 17 givenname: Samuel surname: Achilefu fullname: Achilefu, Samuel organization: Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 18 givenname: David D. surname: Tran fullname: Tran, David D. organization: Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 19 givenname: Hiroko surname: Yano fullname: Yano, Hiroko organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 20 givenname: Albert H. surname: Kim fullname: Kim, Albert H. email: kima@wudosis.wustl.edu organization: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26074073$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/nature04151 10.1016/j.ymeth.2005.08.001 10.1016/j.copbio.2007.09.007 10.1016/j.febslet.2014.05.002 10.1016/j.molcel.2014.06.018 10.1016/j.ccr.2006.03.030 10.1016/j.ccr.2010.10.028 10.1002/stem.168 10.1371/journal.pone.0025631 10.1016/j.devcel.2014.04.022 10.1056/NEJMoa0808710 10.1146/annurev.cellbio.042308.113248 10.1016/j.biocel.2009.08.018 10.1371/journal.pone.0026740 10.1038/nrm1988 10.1056/NEJMra0708126 10.1016/j.celrep.2013.07.031 10.1016/j.jim.2009.06.008 10.1002/stem.540 10.1371/journal.pone.0041335 10.1016/j.ccr.2009.12.020 10.1016/j.bbrc.2011.02.123 10.1126/science.1164382 10.1083/jcb.141.6.1393 10.1038/nature03128 10.1634/stemcells.2008-0493 10.1016/j.neo.2014.03.006 10.1038/nn.2857 10.1038/nature05236 10.1016/j.ccr.2010.08.010 10.1007/s12032-014-0922-7 10.1038/nature11287 10.1007/s00401-010-0781-z 10.1126/science.1177087 10.1002/jnr.21635 10.1016/j.ccr.2013.08.001 10.1016/j.molcel.2008.02.027 10.1016/j.cell.2008.11.050 10.1016/j.pharmthera.2015.04.002 10.1089/omi.2013.0058 10.1038/labinvest.2011.188 10.1007/s00428-008-0685-7 10.1016/j.stem.2009.03.014 10.1016/j.cell.2014.02.030 |
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| References | Turnell, Stewart, Grand, Rookes, Martin, Yamano, Elledge, Gallimore (bib34) 2005; 438 Suvà, Rheinbay, Gillespie, Patel, Wakimoto, Rabkin, Riggi, Chi, Cahill, Nahed (bib33) 2014; 157 Yan, Parsons, Jin, McLendon, Rasheed, Yuan, Kos, Batinic-Haberle, Jones, Riggins (bib42) 2009; 360 Baltus, Kowalski, Zhai, Tutter, Quinn, Wall, Kadam (bib2) 2009; 27 Wan, Tan, Yang, Inuzuka, Dai, Wu, Liu, Shaik, Chen, Deng (bib37) 2014; 29 Zeng, Sigoillot, Gaur, Choi, Pfaff, Oh, Hathaway, Dimova, Cuny, King (bib44) 2010; 18 Cheng, Wu, Guryanova, Huang, Huang, Rich, Bao (bib8) 2011; 406 Jeong, Cho, Kim, Kim, Cho, Lee, Jeon, Lee, Yao, Keum (bib18) 2010; 28 Puram, Kim, Ikeuchi, Wilson-Grady, Merdes, Gygi, Bonni (bib30) 2011; 14 Bie, Zhao, Cheng, Rondeau, Porwollik, Ju, Xia, McClelland (bib6) 2011; 6 Hu, Smyth (bib17) 2009; 347 Wang, Zhang, Wan, Zhou, Wang, Wei (bib38) 2015 Fukushima, Ogura, Wan, Lu, Li, Gao, Liu, Lau, Wu, Kirschner (bib11) 2013; 4 Kim, Puram, Bilimoria, Ikeuchi, Keough, Wong, Rowitch, Bonni (bib20) 2009; 136 Bao, Wu, McLendon, Hao, Shi, Hjelmeland, Dewhirst, Bigner, Rich (bib3) 2006; 444 Pevny, Nicolis (bib28) 2010; 42 Forghanifard, Ardalan Khales, Javdani-Mallak, Rad, Farshchian, Abbaszadegan (bib10) 2014; 31 Wen, Kesari (bib39) 2008; 359 Lewitzky, Yamanaka (bib22) 2007; 18 Hartmann, Hentschel, Wick, Capper, Felsberg, Simon, Westphal, Schackert, Meyermann, Pietsch (bib15) 2010; 120 Kallio, Weinstein, Daum, Burke, Gorbsky (bib19) 1998; 141 Bhat, Balasubramaniyan, Vaillant, Ezhilarasan, Hummelink, Hollingsworth, Wani, Heathcock, James, Goodman (bib5) 2013; 24 Valster, Tran, Nakada, Berens, Chan, Symons (bib35) 2005; 37 Singh, Hawkins, Clarke, Squire, Bayani, Hide, Henkelman, Cusimano, Dirks (bib32) 2004; 432 Chen, Li, Yu, McKay, Burns, Kernie, Parada (bib7) 2012; 488 Peters (bib27) 2006; 7 Wolthuis, Clay-Farrace, van Zon, Yekezare, Koop, Ogink, Medema, Pines (bib40) 2008; 30 Lou, Han, Jin, Tian, Yu, Ding, Cheng, Huang, Jiang, Lin (bib23) 2013; 17 Parsons, Jones, Zhang, Lin, Leary, Angenendt, Mankoo, Carter, Siu, Gallia (bib26) 2008; 321 Gangemi, Griffero, Marubbi, Perera, Capra, Malatesta, Ravetti, Zona, Daga, Corte (bib12) 2009; 27 Pollard, Yoshikawa, Clarke, Danovi, Stricker, Russell, Bayani, Head, Lee, Bernstein (bib29) 2009; 4 Sikorska, Sandhu, Deb-Rinker, Jezierski, Leblanc, Charlebois, Ribecco-Lutkiewicz, Bani-Yaghoub, Walker (bib31) 2008; 86 Han, Fang, Lou, Hua, Ding, Foltz, Hood, Yuan, Lin (bib14) 2012; 7 Verhaak, Hoadley, Purdom, Wang, Qi, Wilkerson, Miller, Ding, Golub, Mesirov (bib36) 2010; 17 Fang, Zhang, Wei, Jin, Wang, Tong, Li, Du, Wong (bib9) 2014; 55 Girouard, Laga, Mihm, Scolyer, Thompson, Zhan, Widlund, Lee, Murphy (bib13) 2012; 92 Manchado, Guillamot, de Cárcer, Eguren, Trickey, García-Higuera, Moreno, Yamano, Cañamero, Malumbres (bib24) 2010; 18 Xia, Wu, Liu, Wang, Chen (bib41) 2014; 588 Alonso, Diez-Valle, Manterola, Rubio, Liu, Cortes-Santiago, Urquiza, Jauregi, Lopez de Munain, Sampron (bib1) 2011; 6 Marucci, Morandi, Magrini, Farnedi, Franceschi, Miglio, Calò, Pession, Foschini, Eusebi (bib25) 2008; 453 Yang, Kim, Yamada, Wu, Bilimoria, Ikeuchi, de la Iglesia, Shen, Bonni (bib43) 2009; 326 Berezovsky, Poisson, Cherba, Webb, Transou, Lemke, Hong, Hasselbach, Irtenkauf, Mikkelsen, deCarvalho (bib4) 2014; 16 Lee, Kotliarova, Kotliarov, Li, Su, Donin, Pastorino, Purow, Christopher, Zhang (bib21) 2006; 9 He, Nakada, Morrison (bib16) 2009; 25 Wan (10.1016/j.celrep.2015.05.027_bib37) 2014; 29 Pollard (10.1016/j.celrep.2015.05.027_bib29) 2009; 4 Bao (10.1016/j.celrep.2015.05.027_bib3) 2006; 444 Lou (10.1016/j.celrep.2015.05.027_bib23) 2013; 17 Alonso (10.1016/j.celrep.2015.05.027_bib1) 2011; 6 Lewitzky (10.1016/j.celrep.2015.05.027_bib22) 2007; 18 Sikorska (10.1016/j.celrep.2015.05.027_bib31) 2008; 86 Manchado (10.1016/j.celrep.2015.05.027_bib24) 2010; 18 Pevny (10.1016/j.celrep.2015.05.027_bib28) 2010; 42 Xia (10.1016/j.celrep.2015.05.027_bib41) 2014; 588 Han (10.1016/j.celrep.2015.05.027_bib14) 2012; 7 Gangemi (10.1016/j.celrep.2015.05.027_bib12) 2009; 27 Kim (10.1016/j.celrep.2015.05.027_bib20) 2009; 136 Suvà (10.1016/j.celrep.2015.05.027_bib33) 2014; 157 Kallio (10.1016/j.celrep.2015.05.027_bib19) 1998; 141 Turnell (10.1016/j.celrep.2015.05.027_bib34) 2005; 438 Girouard (10.1016/j.celrep.2015.05.027_bib13) 2012; 92 Puram (10.1016/j.celrep.2015.05.027_bib30) 2011; 14 Yan (10.1016/j.celrep.2015.05.027_bib42) 2009; 360 Bie (10.1016/j.celrep.2015.05.027_bib6) 2011; 6 Singh (10.1016/j.celrep.2015.05.027_bib32) 2004; 432 Yang (10.1016/j.celrep.2015.05.027_bib43) 2009; 326 Berezovsky (10.1016/j.celrep.2015.05.027_bib4) 2014; 16 Chen (10.1016/j.celrep.2015.05.027_bib7) 2012; 488 Fukushima (10.1016/j.celrep.2015.05.027_bib11) 2013; 4 Jeong (10.1016/j.celrep.2015.05.027_bib18) 2010; 28 Peters (10.1016/j.celrep.2015.05.027_bib27) 2006; 7 Wang (10.1016/j.celrep.2015.05.027_bib38) 2015 Forghanifard (10.1016/j.celrep.2015.05.027_bib10) 2014; 31 Hartmann (10.1016/j.celrep.2015.05.027_bib15) 2010; 120 Lee (10.1016/j.celrep.2015.05.027_bib21) 2006; 9 Fang (10.1016/j.celrep.2015.05.027_bib9) 2014; 55 Verhaak (10.1016/j.celrep.2015.05.027_bib36) 2010; 17 Wolthuis (10.1016/j.celrep.2015.05.027_bib40) 2008; 30 Cheng (10.1016/j.celrep.2015.05.027_bib8) 2011; 406 Valster (10.1016/j.celrep.2015.05.027_bib35) 2005; 37 Bhat (10.1016/j.celrep.2015.05.027_bib5) 2013; 24 Parsons (10.1016/j.celrep.2015.05.027_bib26) 2008; 321 Baltus (10.1016/j.celrep.2015.05.027_bib2) 2009; 27 Hu (10.1016/j.celrep.2015.05.027_bib17) 2009; 347 Zeng (10.1016/j.celrep.2015.05.027_bib44) 2010; 18 He (10.1016/j.celrep.2015.05.027_bib16) 2009; 25 Marucci (10.1016/j.celrep.2015.05.027_bib25) 2008; 453 Wen (10.1016/j.celrep.2015.05.027_bib39) 2008; 359 19733254 - Int J Biochem Cell Biol. 2010 Mar;42(3):421-4 19591226 - Stem Cells. 2009 Sep;27(9):2175-84 22912670 - PLoS One. 2012;7(8):e41335 21088844 - Acta Neuropathol. 2010 Dec;120(6):707-18 16697959 - Cancer Cell. 2006 May;9(5):391-403 18024106 - Curr Opin Biotechnol. 2007 Oct;18(5):467-73 24659265 - Med Oncol. 2014 Apr;31(4):922 20945330 - Stem Cells. 2010 Dec;28(12):2141-50 18772396 - Science. 2008 Sep 26;321(5897):1807-12 9628895 - J Cell Biol. 1998 Jun 15;141(6):1393-406 19497285 - Cell Stem Cell. 2009 Jun 5;4(6):568-80 23895273 - OMICS. 2013 Oct;17(10):510-8 24726434 - Cell. 2014 Apr 24;157(3):580-94 20129251 - Cancer Cell. 2010 Jan 19;17(1):98-110 19167333 - Cell. 2009 Jan 23;136(2):322-36 16288884 - Methods. 2005 Oct;37(2):208-15 22022424 - PLoS One. 2011;6(10):e25631 18293417 - J Neurosci Res. 2008 Jun;86(8):1680-93 24871945 - Dev Cell. 2014 May 27;29(4):377-91 16896351 - Nat Rev Mol Cell Biol. 2006 Sep;7(9):644-56 25850036 - Pharmacol Ther. 2015 Jul;151:141-51 22184093 - Lab Invest. 2012 Mar;92(3):362-70 18471975 - Mol Cell. 2008 May 9;30(3):290-302 18948646 - Stem Cells. 2009 Jan;27(1):40-8 23972993 - Cell Rep. 2013 Aug 29;4(4):803-16 19228619 - N Engl J Med. 2009 Feb 19;360(8):765-73 24842609 - FEBS Lett. 2014 Jun 27;588(14):2238-45 21156286 - Cancer Cell. 2010 Dec 14;18(6):641-54 23993863 - Cancer Cell. 2013 Sep 9;24(3):331-46 21371437 - Biochem Biophys Res Commun. 2011 Mar 25;406(4):643-8 15549107 - Nature. 2004 Nov 18;432(7015):396-401 19900895 - Science. 2009 Oct 23;326(5952):575-8 19575646 - Annu Rev Cell Dev Biol. 2009;25:377-406 24726753 - Neoplasia. 2014 Mar;16(3):193-206, 206.e19-25 19567251 - J Immunol Methods. 2009 Aug 15;347(1-2):70-8 21725312 - Nat Neurosci. 2011 Aug;14(8):973-83 20951947 - Cancer Cell. 2010 Oct 19;18(4):382-95 25042802 - Mol Cell. 2014 Aug 21;55(4):537-51 17051156 - Nature. 2006 Dec 7;444(7120):756-60 22069467 - PLoS One. 2011;6(11):e26740 18953566 - Virchows Arch. 2008 Dec;453(6):599-609 16319895 - Nature. 2005 Dec 1;438(7068):690-5 18669428 - N Engl J Med. 2008 Jul 31;359(5):492-507 22854781 - Nature. 2012 Aug 23;488(7412):522-6 |
| References_xml | – volume: 37 start-page: 208 year: 2005 end-page: 215 ident: bib35 article-title: Cell migration and invasion assays publication-title: Methods – volume: 55 start-page: 537 year: 2014 end-page: 551 ident: bib9 article-title: A methylation-phosphorylation switch determines Sox2 stability and function in ESC maintenance or differentiation publication-title: Mol. Cell – volume: 25 start-page: 377 year: 2009 end-page: 406 ident: bib16 article-title: Mechanisms of stem cell self-renewal publication-title: Annu. Rev. Cell Dev. Biol. – volume: 9 start-page: 391 year: 2006 end-page: 403 ident: bib21 article-title: Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines publication-title: Cancer Cell – volume: 86 start-page: 1680 year: 2008 end-page: 1693 ident: bib31 article-title: Epigenetic modifications of SOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiation publication-title: J. Neurosci. Res. – volume: 120 start-page: 707 year: 2010 end-page: 718 ident: bib15 article-title: Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas publication-title: Acta Neuropathol. – volume: 136 start-page: 322 year: 2009 end-page: 336 ident: bib20 article-title: A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons publication-title: Cell – volume: 347 start-page: 70 year: 2009 end-page: 78 ident: bib17 article-title: ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays publication-title: J. Immunol. Methods – volume: 17 start-page: 98 year: 2010 end-page: 110 ident: bib36 article-title: Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1 publication-title: Cancer Cell – volume: 28 start-page: 2141 year: 2010 end-page: 2150 ident: bib18 article-title: Phosphorylation of Sox2 cooperates in reprogramming to pluripotent stem cells publication-title: Stem Cells – volume: 29 start-page: 377 year: 2014 end-page: 391 ident: bib37 article-title: APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction publication-title: Dev. Cell – volume: 30 start-page: 290 year: 2008 end-page: 302 ident: bib40 article-title: Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A publication-title: Mol. Cell – volume: 7 start-page: 644 year: 2006 end-page: 656 ident: bib27 article-title: The anaphase promoting complex/cyclosome: a machine designed to destroy publication-title: Nat. Rev. Mol. Cell Biol. – volume: 588 start-page: 2238 year: 2014 end-page: 2245 ident: bib41 article-title: Downregulation of miR-638 promotes invasion and proliferation by regulating SOX2 and induces EMT in NSCLC publication-title: FEBS Lett. – volume: 16 start-page: 193 year: 2014 end-page: 206.e19–e25 ident: bib4 article-title: Sox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiation publication-title: Neoplasia – volume: 18 start-page: 467 year: 2007 end-page: 473 ident: bib22 article-title: Reprogramming somatic cells towards pluripotency by defined factors publication-title: Curr. Opin. Biotechnol. – volume: 14 start-page: 973 year: 2011 end-page: 983 ident: bib30 article-title: A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain publication-title: Nat. Neurosci. – volume: 406 start-page: 643 year: 2011 end-page: 648 ident: bib8 article-title: Elevated invasive potential of glioblastoma stem cells publication-title: Biochem. Biophys. Res. Commun. – volume: 17 start-page: 510 year: 2013 end-page: 518 ident: bib23 article-title: SOX2 targets fibronectin 1 to promote cell migration and invasion in ovarian cancer: new molecular leads for therapeutic intervention publication-title: OMICS – volume: 4 start-page: 568 year: 2009 end-page: 580 ident: bib29 article-title: Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens publication-title: Cell Stem Cell – volume: 321 start-page: 1807 year: 2008 end-page: 1812 ident: bib26 article-title: An integrated genomic analysis of human glioblastoma multiforme publication-title: Science – volume: 27 start-page: 40 year: 2009 end-page: 48 ident: bib12 article-title: SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity publication-title: Stem Cells – volume: 141 start-page: 1393 year: 1998 end-page: 1406 ident: bib19 article-title: Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events publication-title: J. Cell Biol. – volume: 453 start-page: 599 year: 2008 end-page: 609 ident: bib25 article-title: Gene expression profiling in glioblastoma and immunohistochemical evaluation of IGFBP-2 and CDC20 publication-title: Virchows Arch. – volume: 6 start-page: e26740 year: 2011 ident: bib1 article-title: Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas publication-title: PLoS ONE – volume: 27 start-page: 2175 year: 2009 end-page: 2184 ident: bib2 article-title: Acetylation of sox2 induces its nuclear export in embryonic stem cells publication-title: Stem Cells – volume: 6 start-page: e25631 year: 2011 ident: bib6 article-title: The accuracy of survival time prediction for patients with glioma is improved by measuring mitotic spindle checkpoint gene expression publication-title: PLoS ONE – volume: 438 start-page: 690 year: 2005 end-page: 695 ident: bib34 article-title: The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression publication-title: Nature – year: 2015 ident: bib38 article-title: Targeting Cdc20 as a novel cancer therapeutic strategy publication-title: Pharmacol. Ther. – volume: 444 start-page: 756 year: 2006 end-page: 760 ident: bib3 article-title: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response publication-title: Nature – volume: 42 start-page: 421 year: 2010 end-page: 424 ident: bib28 article-title: Sox2 roles in neural stem cells publication-title: Int. J. Biochem. Cell Biol. – volume: 7 start-page: e41335 year: 2012 ident: bib14 article-title: Silencing SOX2 induced mesenchymal-epithelial transition and its expression predicts liver and lymph node metastasis of CRC patients publication-title: PLoS ONE – volume: 24 start-page: 331 year: 2013 end-page: 346 ident: bib5 article-title: Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma publication-title: Cancer Cell – volume: 31 start-page: 922 year: 2014 ident: bib10 article-title: Stemness state regulators SALL4 and SOX2 are involved in progression and invasiveness of esophageal squamous cell carcinoma publication-title: Med. Oncol. – volume: 360 start-page: 765 year: 2009 end-page: 773 ident: bib42 article-title: IDH1 and IDH2 mutations in gliomas publication-title: N. Engl. J. Med. – volume: 157 start-page: 580 year: 2014 end-page: 594 ident: bib33 article-title: Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells publication-title: Cell – volume: 432 start-page: 396 year: 2004 end-page: 401 ident: bib32 article-title: Identification of human brain tumour initiating cells publication-title: Nature – volume: 92 start-page: 362 year: 2012 end-page: 370 ident: bib13 article-title: SOX2 contributes to melanoma cell invasion publication-title: Lab. Invest. – volume: 359 start-page: 492 year: 2008 end-page: 507 ident: bib39 article-title: Malignant gliomas in adults publication-title: N. Engl. J. Med. – volume: 4 start-page: 803 year: 2013 end-page: 816 ident: bib11 article-title: SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression publication-title: Cell Rep. – volume: 326 start-page: 575 year: 2009 end-page: 578 ident: bib43 article-title: A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation publication-title: Science – volume: 18 start-page: 382 year: 2010 end-page: 395 ident: bib44 article-title: Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage publication-title: Cancer Cell – volume: 488 start-page: 522 year: 2012 end-page: 526 ident: bib7 article-title: A restricted cell population propagates glioblastoma growth after chemotherapy publication-title: Nature – volume: 18 start-page: 641 year: 2010 end-page: 654 ident: bib24 article-title: Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase publication-title: Cancer Cell – volume: 438 start-page: 690 year: 2005 ident: 10.1016/j.celrep.2015.05.027_bib34 article-title: The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression publication-title: Nature doi: 10.1038/nature04151 – volume: 37 start-page: 208 year: 2005 ident: 10.1016/j.celrep.2015.05.027_bib35 article-title: Cell migration and invasion assays publication-title: Methods doi: 10.1016/j.ymeth.2005.08.001 – volume: 18 start-page: 467 year: 2007 ident: 10.1016/j.celrep.2015.05.027_bib22 article-title: Reprogramming somatic cells towards pluripotency by defined factors publication-title: Curr. Opin. Biotechnol. doi: 10.1016/j.copbio.2007.09.007 – volume: 588 start-page: 2238 year: 2014 ident: 10.1016/j.celrep.2015.05.027_bib41 article-title: Downregulation of miR-638 promotes invasion and proliferation by regulating SOX2 and induces EMT in NSCLC publication-title: FEBS Lett. doi: 10.1016/j.febslet.2014.05.002 – volume: 55 start-page: 537 year: 2014 ident: 10.1016/j.celrep.2015.05.027_bib9 article-title: A methylation-phosphorylation switch determines Sox2 stability and function in ESC maintenance or differentiation publication-title: Mol. Cell doi: 10.1016/j.molcel.2014.06.018 – volume: 9 start-page: 391 year: 2006 ident: 10.1016/j.celrep.2015.05.027_bib21 article-title: Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines publication-title: Cancer Cell doi: 10.1016/j.ccr.2006.03.030 – volume: 18 start-page: 641 year: 2010 ident: 10.1016/j.celrep.2015.05.027_bib24 article-title: Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase publication-title: Cancer Cell doi: 10.1016/j.ccr.2010.10.028 – volume: 27 start-page: 2175 year: 2009 ident: 10.1016/j.celrep.2015.05.027_bib2 article-title: Acetylation of sox2 induces its nuclear export in embryonic stem cells publication-title: Stem Cells doi: 10.1002/stem.168 – volume: 6 start-page: e25631 year: 2011 ident: 10.1016/j.celrep.2015.05.027_bib6 article-title: The accuracy of survival time prediction for patients with glioma is improved by measuring mitotic spindle checkpoint gene expression publication-title: PLoS ONE doi: 10.1371/journal.pone.0025631 – volume: 29 start-page: 377 year: 2014 ident: 10.1016/j.celrep.2015.05.027_bib37 article-title: APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction publication-title: Dev. Cell doi: 10.1016/j.devcel.2014.04.022 – volume: 360 start-page: 765 year: 2009 ident: 10.1016/j.celrep.2015.05.027_bib42 article-title: IDH1 and IDH2 mutations in gliomas publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0808710 – volume: 25 start-page: 377 year: 2009 ident: 10.1016/j.celrep.2015.05.027_bib16 article-title: Mechanisms of stem cell self-renewal publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev.cellbio.042308.113248 – volume: 42 start-page: 421 year: 2010 ident: 10.1016/j.celrep.2015.05.027_bib28 article-title: Sox2 roles in neural stem cells publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2009.08.018 – volume: 6 start-page: e26740 year: 2011 ident: 10.1016/j.celrep.2015.05.027_bib1 article-title: Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas publication-title: PLoS ONE doi: 10.1371/journal.pone.0026740 – volume: 7 start-page: 644 year: 2006 ident: 10.1016/j.celrep.2015.05.027_bib27 article-title: The anaphase promoting complex/cyclosome: a machine designed to destroy publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1988 – volume: 359 start-page: 492 year: 2008 ident: 10.1016/j.celrep.2015.05.027_bib39 article-title: Malignant gliomas in adults publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra0708126 – volume: 4 start-page: 803 year: 2013 ident: 10.1016/j.celrep.2015.05.027_bib11 article-title: SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression publication-title: Cell Rep. doi: 10.1016/j.celrep.2013.07.031 – volume: 347 start-page: 70 year: 2009 ident: 10.1016/j.celrep.2015.05.027_bib17 article-title: ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays publication-title: J. Immunol. Methods doi: 10.1016/j.jim.2009.06.008 – volume: 28 start-page: 2141 year: 2010 ident: 10.1016/j.celrep.2015.05.027_bib18 article-title: Phosphorylation of Sox2 cooperates in reprogramming to pluripotent stem cells publication-title: Stem Cells doi: 10.1002/stem.540 – volume: 7 start-page: e41335 year: 2012 ident: 10.1016/j.celrep.2015.05.027_bib14 article-title: Silencing SOX2 induced mesenchymal-epithelial transition and its expression predicts liver and lymph node metastasis of CRC patients publication-title: PLoS ONE doi: 10.1371/journal.pone.0041335 – volume: 17 start-page: 98 year: 2010 ident: 10.1016/j.celrep.2015.05.027_bib36 article-title: Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1 publication-title: Cancer Cell doi: 10.1016/j.ccr.2009.12.020 – volume: 406 start-page: 643 year: 2011 ident: 10.1016/j.celrep.2015.05.027_bib8 article-title: Elevated invasive potential of glioblastoma stem cells publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2011.02.123 – volume: 321 start-page: 1807 year: 2008 ident: 10.1016/j.celrep.2015.05.027_bib26 article-title: An integrated genomic analysis of human glioblastoma multiforme publication-title: Science doi: 10.1126/science.1164382 – volume: 141 start-page: 1393 year: 1998 ident: 10.1016/j.celrep.2015.05.027_bib19 article-title: Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events publication-title: J. Cell Biol. doi: 10.1083/jcb.141.6.1393 – volume: 432 start-page: 396 year: 2004 ident: 10.1016/j.celrep.2015.05.027_bib32 article-title: Identification of human brain tumour initiating cells publication-title: Nature doi: 10.1038/nature03128 – volume: 27 start-page: 40 year: 2009 ident: 10.1016/j.celrep.2015.05.027_bib12 article-title: SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity publication-title: Stem Cells doi: 10.1634/stemcells.2008-0493 – volume: 16 start-page: 193 year: 2014 ident: 10.1016/j.celrep.2015.05.027_bib4 article-title: Sox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiation publication-title: Neoplasia doi: 10.1016/j.neo.2014.03.006 – volume: 14 start-page: 973 year: 2011 ident: 10.1016/j.celrep.2015.05.027_bib30 article-title: A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain publication-title: Nat. Neurosci. doi: 10.1038/nn.2857 – volume: 444 start-page: 756 year: 2006 ident: 10.1016/j.celrep.2015.05.027_bib3 article-title: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response publication-title: Nature doi: 10.1038/nature05236 – volume: 18 start-page: 382 year: 2010 ident: 10.1016/j.celrep.2015.05.027_bib44 article-title: Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage publication-title: Cancer Cell doi: 10.1016/j.ccr.2010.08.010 – volume: 31 start-page: 922 year: 2014 ident: 10.1016/j.celrep.2015.05.027_bib10 article-title: Stemness state regulators SALL4 and SOX2 are involved in progression and invasiveness of esophageal squamous cell carcinoma publication-title: Med. Oncol. doi: 10.1007/s12032-014-0922-7 – volume: 488 start-page: 522 year: 2012 ident: 10.1016/j.celrep.2015.05.027_bib7 article-title: A restricted cell population propagates glioblastoma growth after chemotherapy publication-title: Nature doi: 10.1038/nature11287 – volume: 120 start-page: 707 year: 2010 ident: 10.1016/j.celrep.2015.05.027_bib15 article-title: Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas publication-title: Acta Neuropathol. doi: 10.1007/s00401-010-0781-z – volume: 326 start-page: 575 year: 2009 ident: 10.1016/j.celrep.2015.05.027_bib43 article-title: A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation publication-title: Science doi: 10.1126/science.1177087 – volume: 86 start-page: 1680 year: 2008 ident: 10.1016/j.celrep.2015.05.027_bib31 article-title: Epigenetic modifications of SOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiation publication-title: J. Neurosci. Res. doi: 10.1002/jnr.21635 – volume: 24 start-page: 331 year: 2013 ident: 10.1016/j.celrep.2015.05.027_bib5 article-title: Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma publication-title: Cancer Cell doi: 10.1016/j.ccr.2013.08.001 – volume: 30 start-page: 290 year: 2008 ident: 10.1016/j.celrep.2015.05.027_bib40 article-title: Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A publication-title: Mol. Cell doi: 10.1016/j.molcel.2008.02.027 – volume: 136 start-page: 322 year: 2009 ident: 10.1016/j.celrep.2015.05.027_bib20 article-title: A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons publication-title: Cell doi: 10.1016/j.cell.2008.11.050 – year: 2015 ident: 10.1016/j.celrep.2015.05.027_bib38 article-title: Targeting Cdc20 as a novel cancer therapeutic strategy publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2015.04.002 – volume: 17 start-page: 510 year: 2013 ident: 10.1016/j.celrep.2015.05.027_bib23 article-title: SOX2 targets fibronectin 1 to promote cell migration and invasion in ovarian cancer: new molecular leads for therapeutic intervention publication-title: OMICS doi: 10.1089/omi.2013.0058 – volume: 92 start-page: 362 year: 2012 ident: 10.1016/j.celrep.2015.05.027_bib13 article-title: SOX2 contributes to melanoma cell invasion publication-title: Lab. Invest. doi: 10.1038/labinvest.2011.188 – volume: 453 start-page: 599 year: 2008 ident: 10.1016/j.celrep.2015.05.027_bib25 article-title: Gene expression profiling in glioblastoma and immunohistochemical evaluation of IGFBP-2 and CDC20 publication-title: Virchows Arch. doi: 10.1007/s00428-008-0685-7 – volume: 4 start-page: 568 year: 2009 ident: 10.1016/j.celrep.2015.05.027_bib29 article-title: Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.03.014 – volume: 157 start-page: 580 year: 2014 ident: 10.1016/j.celrep.2015.05.027_bib33 article-title: Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells publication-title: Cell doi: 10.1016/j.cell.2014.02.030 – reference: 24726753 - Neoplasia. 2014 Mar;16(3):193-206, 206.e19-25 – reference: 20129251 - Cancer Cell. 2010 Jan 19;17(1):98-110 – reference: 21371437 - Biochem Biophys Res Commun. 2011 Mar 25;406(4):643-8 – reference: 21725312 - Nat Neurosci. 2011 Aug;14(8):973-83 – reference: 15549107 - Nature. 2004 Nov 18;432(7015):396-401 – reference: 21156286 - Cancer Cell. 2010 Dec 14;18(6):641-54 – reference: 24871945 - Dev Cell. 2014 May 27;29(4):377-91 – reference: 18669428 - N Engl J Med. 2008 Jul 31;359(5):492-507 – reference: 19575646 - Annu Rev Cell Dev Biol. 2009;25:377-406 – reference: 19733254 - Int J Biochem Cell Biol. 2010 Mar;42(3):421-4 – reference: 24659265 - Med Oncol. 2014 Apr;31(4):922 – reference: 9628895 - J Cell Biol. 1998 Jun 15;141(6):1393-406 – reference: 22184093 - Lab Invest. 2012 Mar;92(3):362-70 – reference: 20951947 - Cancer Cell. 2010 Oct 19;18(4):382-95 – reference: 17051156 - Nature. 2006 Dec 7;444(7120):756-60 – reference: 19497285 - Cell Stem Cell. 2009 Jun 5;4(6):568-80 – reference: 18772396 - Science. 2008 Sep 26;321(5897):1807-12 – reference: 16288884 - Methods. 2005 Oct;37(2):208-15 – reference: 19567251 - J Immunol Methods. 2009 Aug 15;347(1-2):70-8 – reference: 22069467 - PLoS One. 2011;6(11):e26740 – reference: 18024106 - Curr Opin Biotechnol. 2007 Oct;18(5):467-73 – reference: 18293417 - J Neurosci Res. 2008 Jun;86(8):1680-93 – reference: 22854781 - Nature. 2012 Aug 23;488(7412):522-6 – reference: 23972993 - Cell Rep. 2013 Aug 29;4(4):803-16 – reference: 16319895 - Nature. 2005 Dec 1;438(7068):690-5 – reference: 18471975 - Mol Cell. 2008 May 9;30(3):290-302 – reference: 19591226 - Stem Cells. 2009 Sep;27(9):2175-84 – reference: 16697959 - Cancer Cell. 2006 May;9(5):391-403 – reference: 22022424 - PLoS One. 2011;6(10):e25631 – reference: 21088844 - Acta Neuropathol. 2010 Dec;120(6):707-18 – reference: 25042802 - Mol Cell. 2014 Aug 21;55(4):537-51 – reference: 25850036 - Pharmacol Ther. 2015 Jul;151:141-51 – reference: 18953566 - Virchows Arch. 2008 Dec;453(6):599-609 – reference: 24726434 - Cell. 2014 Apr 24;157(3):580-94 – reference: 19228619 - N Engl J Med. 2009 Feb 19;360(8):765-73 – reference: 20945330 - Stem Cells. 2010 Dec;28(12):2141-50 – reference: 19167333 - Cell. 2009 Jan 23;136(2):322-36 – reference: 19900895 - Science. 2009 Oct 23;326(5952):575-8 – reference: 18948646 - Stem Cells. 2009 Jan;27(1):40-8 – reference: 23895273 - OMICS. 2013 Oct;17(10):510-8 – reference: 23993863 - Cancer Cell. 2013 Sep 9;24(3):331-46 – reference: 16896351 - Nat Rev Mol Cell Biol. 2006 Sep;7(9):644-56 – reference: 22912670 - PLoS One. 2012;7(8):e41335 – reference: 24842609 - FEBS Lett. 2014 Jun 27;588(14):2238-45 |
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| Snippet | Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard... Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard... Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard... |
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| SubjectTerms | Anaphase-Promoting Complex-Cyclosome - metabolism Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Brain Neoplasms - metabolism Brain Neoplasms - pathology Cdc20 Proteins - genetics Cdc20 Proteins - metabolism Cells, Cultured Glioblastoma - metabolism Glioblastoma - pathology Humans Mice Neoplastic Stem Cells - metabolism Neurons - metabolism Signal Transduction SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism |
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| Title | A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells |
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