应用群体药动学模型制订患儿抗癫痫给药方案的药学会诊实践
目的 为优化癫痫患儿卡马西平和丙戊酸给药方案提供参考。方法 药师参与1例脑外伤术后癫痫患儿的药学会诊，总结分析其使用卡马西平和丙戊酸血药浓度异常的原因，应用群体药动学模型为患儿调整给药剂量，并评价笔者团队所建模型的预测能力。结果 患儿病情得到了有效控制。结论 药师应用群体药动学模型优化抗癫痫药物治疗方案，为临床合理用药提供参考。...
Saved in:
| Published in | 药学实践杂志 Vol. 35; no. 6; pp. 559 - 561 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
厦门大学附属第一医院药学部,福建厦门361000
2017
福建医科大学附属第一医院药学部,福建福州350004%厦门大学附属第一医院药学部,福建厦门,361000%福建医科大学附属第一医院药学部,福建福州,350004 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1006-0111 |
| DOI | 10.3969/j.issn.1006-0111.2017.06.019 |
Cover
| Abstract | 目的 为优化癫痫患儿卡马西平和丙戊酸给药方案提供参考。方法 药师参与1例脑外伤术后癫痫患儿的药学会诊，总结分析其使用卡马西平和丙戊酸血药浓度异常的原因，应用群体药动学模型为患儿调整给药剂量，并评价笔者团队所建模型的预测能力。结果 患儿病情得到了有效控制。结论 药师应用群体药动学模型优化抗癫痫药物治疗方案，为临床合理用药提供参考。 |
|---|---|
| AbstractList | R742.1; 目的 为优化癫痫患儿卡马西平和丙戊酸给药方案提供参考.方法 药师参与1例脑外伤术后癫痫患儿的药学会诊,总结分析其使用卡马西平和丙戊酸血药浓度异常的原因,应用群体药动学模型为患儿调整给药剂量,并评价笔者团队所建模型的预测能力.结果 患儿病情得到了有效控制.结论 药师应用群体药动学模型优化抗癫痫药物治疗方案,为临床合理用药提供参考. 目的 为优化癫痫患儿卡马西平和丙戊酸给药方案提供参考。方法 药师参与1例脑外伤术后癫痫患儿的药学会诊，总结分析其使用卡马西平和丙戊酸血药浓度异常的原因，应用群体药动学模型为患儿调整给药剂量，并评价笔者团队所建模型的预测能力。结果 患儿病情得到了有效控制。结论 药师应用群体药动学模型优化抗癫痫药物治疗方案，为临床合理用药提供参考。 |
| Abstract_FL | Objective In order to provide a reference for optimizing the dosage regimen of carbamazepine and valproate in pediatric epilepsy patients .Methods Pharmacist consulted one pediatric epilepsy patient with traumatic brain injury for post operation epilepsy treatments .The abnormal plasma concentration of carbamazepine and valproic acid was analyzed with the population pharmacokinetic (PPK) model built by this team .New medication regimen was proposed and the predictive capabili-ty of this model was evaluated .Results Seizures in this patient have been effectively controlled .Conclusion Pharmacist can optimize the antiepileptic drug treatment with PPK model and achieve rational drug use clinically . |
| Author | 李彦萍;孙洲亮;林玮玮 |
| AuthorAffiliation | 厦门大学附属第一医院药学部,福建厦门361000;福建医科大学附属第一医院药学部,福建福州350004 |
| AuthorAffiliation_xml | – name: 厦门大学附属第一医院药学部,福建厦门361000;福建医科大学附属第一医院药学部,福建福州350004%厦门大学附属第一医院药学部,福建厦门,361000%福建医科大学附属第一医院药学部,福建福州,350004 |
| Author_FL | LIN Weiwei LI Yanping SUN Zhouliang |
| Author_FL_xml | – sequence: 1 fullname: LI Yanping – sequence: 2 fullname: SUN Zhouliang – sequence: 3 fullname: LIN Weiwei |
| Author_xml | – sequence: 1 fullname: 李彦萍;孙洲亮;林玮玮 |
| BookMark | eNo9kE1LAlEUhu_CICv_RAStZrpn7ty5c5chfYEQgXu5d0ZtpMZyiNJluBCjVZLoQrBCBFFXFX3_GefjZzRitHrh8JzncN4VlHDLbh6hDcAq4QbfKqmO57kqYGwoGABUDQNTsaFi4AmU_J8vo5TnORJTIIxSMJPoyH9vha1h-P00-7qLbqd-c-iPB8Gw7_du_MZLNHkIrh_9-k_QbIedUdgehR-dGAvu34J-I-zW5yvjweyzG02b_qQXvT6voaWCOPHyqb9cRdndnWx6X8kc7h2ktzOKRTlXhDQtXTDdJlJSKSQVoHEQhDLNxNTinOclM21pEM0G29TBAigwU-hMpxpwSlbR5kJ7KdyCcIu5Uvmi4sYHc9Urr1SrzRvARvx_TK4vSOu47BbPnZg9qzinolLNGYzEPh3r5Bcy4H3X |
| ClassificationCodes | R742.1 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3969/j.issn.1006-0111.2017.06.019 |
| DatabaseName | 维普_期刊 中文科技期刊数据库-CALIS站点 维普中文期刊数据库 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | Practice of pharmacy consultation on dosage regimen for pediatric epilepsy patient with PPK model |
| DocumentTitle_FL | Practice of pharmacy consultation on dosage regimen for pediatric epilepsy patient with PPK model |
| EndPage | 561 |
| ExternalDocumentID | yxsjzz201706019 673745404 |
| GroupedDBID | 2RA 92L ALMA_UNASSIGNED_HOLDINGS CDYEO CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| ID | FETCH-LOGICAL-c599-ab8c4a74d3bb5bab5a1291a3572805c999eb78db632d1d841c11f78a474521953 |
| ISSN | 1006-0111 |
| IngestDate | Thu May 29 04:07:36 EDT 2025 Wed Feb 14 09:57:13 EST 2024 |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 6 |
| Keywords | epilepsy 卡马西平 丙戊酸 群体药动学 valproic acid 癫痫 population pharmacokinetics carbamazepine |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c599-ab8c4a74d3bb5bab5a1291a3572805c999eb78db632d1d841c11f78a474521953 |
| Notes | 31-1685/R population pharmacokinetics carbamazepine valproic acid epilepsy Objective In order to provide a reference for optimizing the dosage regimen of carbamazepine and valproate in pediatric epilepsy patients.Methods Pharmacist consulted one pediatric epilepsy patient with traumatic brain injury for post operation epilepsy treatments. The abnormal plasma concentration of carbamazepine and valproic acid was analyzed with the population pharmacokinetic （PPK） model built by this team. New medication regimen was proposed and the predictive capability of this model was evaluated.Results Seizures in this patient have been effectively controlled. Conclusion Pharmacist can optimize the antiepileptic drug treatment with PPK model and achieve rational drug use clinically. |
| PageCount | 3 |
| ParticipantIDs | wanfang_journals_yxsjzz201706019 chongqing_primary_673745404 |
| PublicationCentury | 2000 |
| PublicationDate | 2017 |
| PublicationDateYYYYMMDD | 2017-01-01 |
| PublicationDate_xml | – year: 2017 text: 2017 |
| PublicationDecade | 2010 |
| PublicationTitle | 药学实践杂志 |
| PublicationTitleAlternate | The Journal of Pharmaceutical Practice |
| PublicationTitle_FL | Journal of Pharmaceutical Practice |
| PublicationYear | 2017 |
| Publisher | 厦门大学附属第一医院药学部,福建厦门361000 福建医科大学附属第一医院药学部,福建福州350004%厦门大学附属第一医院药学部,福建厦门,361000%福建医科大学附属第一医院药学部,福建福州,350004 |
| Publisher_xml | – name: 厦门大学附属第一医院药学部,福建厦门361000 – name: 福建医科大学附属第一医院药学部,福建福州350004%厦门大学附属第一医院药学部,福建厦门,361000%福建医科大学附属第一医院药学部,福建福州,350004 |
| SSID | ssib051375518 ssib006562796 ssib000270657 ssib017477785 ssib050280699 ssib001104385 ssib036440809 |
| Score | 2.0857596 |
| Snippet | 目的 为优化癫痫患儿卡马西平和丙戊酸给药方案提供参考。方法 药师参与1例脑外伤术后癫痫患儿的药学会诊，总结分析其使用卡马西平和丙戊酸血药浓度异常的原因，应用群体药... R742.1; 目的 为优化癫痫患儿卡马西平和丙戊酸给药方案提供参考.方法 药师参与1例脑外伤术后癫痫患儿的药学会诊,总结分析其使用卡马西平和丙戊酸血药浓度异常的原因,应用... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 559 |
| SubjectTerms | 丙戊酸 卡马西平 癫痫 群体药动学 |
| Title | 应用群体药动学模型制订患儿抗癫痫给药方案的药学会诊实践 |
| URI | http://lib.cqvip.com/qk/91926A/201706/673745404.html https://d.wanfangdata.com.cn/periodical/yxsjzz201706019 |
| Volume | 35 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate issn: 1006-0111 databaseCode: ABDBF dateStart: 20160101 customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn isFulltext: true dateEnd: 99991231 titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn omitProxy: true ssIdentifier: ssib050280699 providerName: EBSCOhost |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Na9RAFB9qC-JFFBW1Kj10jluTzEwyc0x2sxRBQajQW0mySYuHrdoWdI_SQ6l4sljaQ6EqpVDanlT8vvqHNLv7Z_jeZLqbfuAXLGH2zZv33ry32XkzmfmFkFEnchwvk2nFFcKt8IRblVjGrCKzzPKSOBWRhQeF795zxx_wO5NicuDMz9KupYX5eCxpnXqu5H-iCjSIK56S_YfI9oQCAcoQX7hChOH6VzGmoaCBTxWnoYdXX2IhCKkPFE6DGlWMhpLKGvXryCx9zSOoDxSXhi5-9W2kqJDKQPNIGrjYygc5DvJIh_pMV4HMuqaAUk8rVdQPdMEzhSBAYl-pS5VLA6V12SgcmX0UVTbM2APyq1iL2uuoBatCtA0oAQgX5WT6NAnH-bUBNewC-qpOVW_cPawJdU3RWlJlgcg-i5artPUBGOdoE8GJ4REpofEGyALth4XygkpxclT_-LUjQ61OabcVAYHoeaV-KNSKTgLbbN0h4KziBy2QuEEF5VTR3wUzxuqkP0AIQxVOVUuA0OlaaBX4Jy1hLj6IKQ1UxUqQGajMSFYAv5g7tjwsCYO6XmQ4ooC_Pz54MuUqPXiigrGeAtz-6GmMWzO2HYUnf_Z07mGr5RQwTIi_O-TgytggGfKDWlAvP-G2yk_YIe3krISbBPMKpwT9yFx8FXofWk7oLQD9qbOwmYdggnozg7H0LBk13bj9u04gisrMbHP6MeSG-qheM4ua06WscuICOW-mgyN-cW9fJAOtmUvkfv55pbOy3fn-7uDbq-7L_Xx5O9_dam9v5hsv8qUP3b037edv88Uf7eXVztpOZ3Wn82UN2NqvP7U3lzrri9hkd-vg63p3fznf2-h-fH-ZTNTDiep4xbz6pJIIpSpRLBMeebzB4ljEUSwiSMvtiAl8mZxIYFKXxp5sxC5zGnZDcjux7cyTEfc4pONKsCtksDnbTK-SkUhl3FapSHClRVqRtHnWYG6cWm4D8fmukeGeN6YeFQg3uNnTQ2hOfo2MGP9Mmf-9ualjEb_-Z5Zhcg7LxcrlDTI4_2QhvQm5_Hx8y_xMfgFOP7_0 |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E5%BA%94%E7%94%A8%E7%BE%A4%E4%BD%93%E8%8D%AF%E5%8A%A8%E5%AD%A6%E6%A8%A1%E5%9E%8B%E5%88%B6%E8%AE%A2%E6%82%A3%E5%84%BF%E6%8A%97%E7%99%AB%E7%97%AB%E7%BB%99%E8%8D%AF%E6%96%B9%E6%A1%88%E7%9A%84%E8%8D%AF%E5%AD%A6%E4%BC%9A%E8%AF%8A%E5%AE%9E%E8%B7%B5&rft.jtitle=%E8%8D%AF%E5%AD%A6%E5%AE%9E%E8%B7%B5%E6%9D%82%E5%BF%97&rft.au=%E6%9D%8E%E5%BD%A6%E8%90%8D&rft.au=%E5%AD%99%E6%B4%B2%E4%BA%AE&rft.au=%E6%9E%97%E7%8E%AE%E7%8E%AE&rft.date=2017&rft.pub=%E5%8E%A6%E9%97%A8%E5%A4%A7%E5%AD%A6%E9%99%84%E5%B1%9E%E7%AC%AC%E4%B8%80%E5%8C%BB%E9%99%A2%E8%8D%AF%E5%AD%A6%E9%83%A8%2C%E7%A6%8F%E5%BB%BA%E5%8E%A6%E9%97%A8361000&rft.issn=1006-0111&rft.volume=35&rft.issue=6&rft.spage=559&rft.epage=561&rft_id=info:doi/10.3969%2Fj.issn.1006-0111.2017.06.019&rft.externalDocID=yxsjzz201706019 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F91926A%2F91926A.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fyxsjzz%2Fyxsjzz.jpg |