组织型纤溶酶原激活剂的非溶栓效应

研究显示组织型纤溶酶原激活剂（tissue plasminogen activator,tPA）除了发挥溶栓作用外,还有一些非溶栓效应。目前认为tPA可以增加血脑屏障通透性和促进神经细胞死亡,发挥神经毒性作用。另一方面,基础和临床研究还显示tPA具有神经保护作用。此外,tPA对血管壁、血压都可能有正性或负性作用。对tPA溶栓作用外的病理生理作用的研究有助于其更好的临床应用。...

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Bibliographic Details
Published in中国卒中杂志 Vol. 12; no. 5; pp. 462 - 467
Main Author 左联 李刚
Format Journal Article
LanguageChinese
Published 200123,上海上海市东方医院(同济大学附属东方医院)神经内科 2017
Subjects
神经保护作用
神经毒性
组织型纤溶酶原激活剂
血管
血脑屏障
血脑屏障
血管
Neuroprotection
Neurotoxicity
神经毒性
Blood-brain barrier
组织型纤溶酶原激活剂
Tissue plasminogen activator
Blood vessel
神经保护作用
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ISSN1673-5765
DOI10.3969/j.issn.1673-5765.2017.05.019

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Summary:研究显示组织型纤溶酶原激活剂（tissue plasminogen activator,tPA）除了发挥溶栓作用外,还有一些非溶栓效应。目前认为tPA可以增加血脑屏障通透性和促进神经细胞死亡,发挥神经毒性作用。另一方面,基础和临床研究还显示tPA具有神经保护作用。此外,tPA对血管壁、血压都可能有正性或负性作用。对tPA溶栓作用外的病理生理作用的研究有助于其更好的临床应用。
Bibliography:11-5434/R
Tissue plasminogen activator;Blood-brain barrier;Blood vessel;Neurotoxicity;Neuroprotection
Some studies have showed non-thrombolytic effects of tissue plasminogen activator （tPA） more than thrombolysis. tPA was thought to exert neurotoxicity by increasing the permeability of blood-brain barrier and accelerating neuronal death. On the other hand, both fundamental and clinical studies have showed neuroprotective effects of tPA, and its positive/negative effects on blood vessel and blood pressure. Further research focusing on the pathophysiological mechnism of tPA other than thrombolysis is necessary for its more clinical application.
ZUO Lian, LI Gang（ Department of Neurology, East Hospital Affiliated to Tongji University, Shanghai 200123, China）
ISSN:1673-5765
DOI:10.3969/j.issn.1673-5765.2017.05.019