Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles - Gadala-Maria, Daniel; Yaari, Gur; Uduman, Mohamed; Kleinstein, Steven H. (Proceedings of the National Academy of Sciences - PNAS, 2015)
Keywords: adaptive immunity; Alleles; Automation; B-lymphocytes; B-Lymphocytes - metabolism; Base Sequence; Biological Sciences; Cells; Databases, Genetic; Gene Rearrangement, B-Lymphocyte; Genes; Genes, Immunoglobulin; Genotype; Genotype & phenotype; germ cells; high-throughput nucleotide sequencing; High-Throughput Nucleotide Sequencing - methods; Humans; Immunoglobulin Variable Region - genetics; Immunoglobulins; Mutation - genetics; Mutation Rate; PNAS Plus; Polymorphism; Polymorphism, Genetic; receptors; Software; V(D)J Recombination - genetics; somatic hypermutation; next-generation sequencing; adaptive immunity; variable gene segment; B-cell repertoire