Adipokines and the risk of fracture in older adults
Adiponectin and leptin are adipokines that influence bone metabolism in vitro and in animal models. However, less is known about the longitudinal association of leptin and adiponectin with fracture. We tested the hypothesis that low leptin and high adiponectin levels are each individually associated...
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| Published in | Journal of bone and mineral research Vol. 26; no. 7; pp. 1568 - 1576 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.07.2011
Wiley Oxford University Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0884-0431 1523-4681 1523-4681 |
| DOI | 10.1002/jbmr.361 |
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| Abstract | Adiponectin and leptin are adipokines that influence bone metabolism in vitro and in animal models. However, less is known about the longitudinal association of leptin and adiponectin with fracture. We tested the hypothesis that low leptin and high adiponectin levels are each individually associated with fracture risk in a prospective cohort study in Memphis and Pittsburgh among 3075 women and men aged 70 to 79 years from the Health Aging and Body Composition (Health ABC) study. There were 406 incident fractures (334 nonvertebral and 72 vertebral) over a mean of 6.5 ± 1.9 years. Cox regression was used to estimate the hazard ratios for fracture. Sex modified the association between adiponectin and fracture (p = .025 for interaction). Men with the highest adiponectin level (tertile 3) had a 94% higher risk of fracture [hazard ratio (HR) = 1.94; 95% confidence interval (CI) 1.20–3.16] compared with the lowest tertile (tertile 1; p = .007 for trend) after adjusting age, race, body mass index (BMI), education, diabetes, weight change, and hip bone mineral density (BMD). Among women, after adjusting for age and race, this association was no longer significant (p = .369 for trend). Leptin did not predict fracture risk in women (p = .544 for trend) or men (p = .118 for trend) in the multivariate models. Our results suggest that adiponectin, but not leptin, may be a novel risk factor for increased fracture risk independent of body composition and BMD and that these relationships may be influenced by sex. More research is needed to understand the physiologic basis underlying these sex differences. © 2011 American Society for Bone and Mineral Research. |
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| AbstractList | Adiponectin and leptin are adipokines that influence bone metabolism in vitro and in animal models. However, less is known about the longitudinal association of leptin and adiponectin with fracture. We tested the hypothesis that low leptin and high adiponectin levels are each individually associated with fracture risk in a prospective cohort study in Memphis and Pittsburgh among 3075 women and men aged 70 to 79 years from the Health Aging and Body Composition (Health ABC) study. There were 406 incident fractures (334 nonvertebral and 72 vertebral) over a mean of 6.5 ± 1.9 years. Cox regression was used to estimate the hazard ratios for fracture. Sex modified the association between adiponectin and fracture (p = .025 for interaction). Men with the highest adiponectin level (tertile 3) had a 94% higher risk of fracture [hazard ratio (HR) = 1.94; 95% confidence interval (CI) 1.20-3.16] compared with the lowest tertile (tertile 1; p = .007 for trend) after adjusting age, race, body mass index (BMI), education, diabetes, weight change, and hip bone mineral density (BMD). Among women, after adjusting for age and race, this association was no longer significant (p = .369 for trend). Leptin did not predict fracture risk in women (p = .544 for trend) or men (p = .118 for trend) in the multivariate models. Our results suggest that adiponectin, but not leptin, may be a novel risk factor for increased fracture risk independent of body composition and BMD and that these relationships may be influenced by sex. More research is needed to understand the physiologic basis underlying these sex differences.Adiponectin and leptin are adipokines that influence bone metabolism in vitro and in animal models. However, less is known about the longitudinal association of leptin and adiponectin with fracture. We tested the hypothesis that low leptin and high adiponectin levels are each individually associated with fracture risk in a prospective cohort study in Memphis and Pittsburgh among 3075 women and men aged 70 to 79 years from the Health Aging and Body Composition (Health ABC) study. There were 406 incident fractures (334 nonvertebral and 72 vertebral) over a mean of 6.5 ± 1.9 years. Cox regression was used to estimate the hazard ratios for fracture. Sex modified the association between adiponectin and fracture (p = .025 for interaction). Men with the highest adiponectin level (tertile 3) had a 94% higher risk of fracture [hazard ratio (HR) = 1.94; 95% confidence interval (CI) 1.20-3.16] compared with the lowest tertile (tertile 1; p = .007 for trend) after adjusting age, race, body mass index (BMI), education, diabetes, weight change, and hip bone mineral density (BMD). Among women, after adjusting for age and race, this association was no longer significant (p = .369 for trend). Leptin did not predict fracture risk in women (p = .544 for trend) or men (p = .118 for trend) in the multivariate models. Our results suggest that adiponectin, but not leptin, may be a novel risk factor for increased fracture risk independent of body composition and BMD and that these relationships may be influenced by sex. More research is needed to understand the physiologic basis underlying these sex differences. Adiponectin and leptin are adipokines that influence bone metabolism in vitro and in animal models. However, less is known about the longitudinal association of leptin and adiponectin with fracture. We tested the hypothesis that low leptin and high adiponectin levels are each individually associated with fracture risk in a prospective cohort study in Memphis and Pittsburgh among 3075 women and men aged 70 to 79 years from the Health Aging and Body Composition (Health ABC) study. There were 406 incident fractures (334 nonvertebral and 72 vertebral) over a mean of 6.5 plus or minus 1.9 years. Cox regression was used to estimate the hazard ratios for fracture. Sex modified the association between adiponectin and fracture (p = .025 for interaction). Men with the highest adiponectin level (tertile 3) had a 94% higher risk of fracture [hazard ratio (HR) = 1.94; 95% confidence interval (CI) 1.20-3.16] compared with the lowest tertile (tertile 1; p = .007 for trend) after adjusting age, race, body mass index (BMI), education, diabetes, weight change, and hip bone mineral density (BMD). Among women, after adjusting for age and race, this association was no longer significant (p = .369 for trend). Leptin did not predict fracture risk in women (p = .544 for trend) or men (p = .118 for trend) in the multivariate models. Our results suggest that adiponectin, but not leptin, may be a novel risk factor for increased fracture risk independent of body composition and BMD and that these relationships may be influenced by sex. More research is needed to understand the physiologic basis underlying these sex differences. Adiponectin and leptin are adipokines that influence bone metabolism in vitro and in animal models. However, less is known about the longitudinal association of leptin and adiponectin with fracture. We tested the hypothesis that low leptin and high adiponectin levels are each individually associated with fracture risk in a prospective cohort study in Memphis and Pittsburgh among 3075 women and men aged 70 to 79 years from the Health Aging and Body Composition (Health ABC) study. There were 406 incident fractures (334 nonvertebral and 72 vertebral) over a mean of 6.5±1.9 years. Cox regression was used to estimate the hazard ratios for fracture. Sex modified the association between adiponectin and fracture (p=.025 for interaction). Men with the highest adiponectin level (tertile 3) had a 94% higher risk of fracture [hazard ratio (HR)=1.94; 95% confidence interval (CI) 1.20-3.16] compared with the lowest tertile (tertile 1; p=.007 for trend) after adjusting age, race, body mass index (BMI), education, diabetes, weight change, and hip bone mineral density (BMD). Among women, after adjusting for age and race, this association was no longer significant (p=.369 for trend). Leptin did not predict fracture risk in women (p=.544 for trend) or men (p=.118 for trend) in the multivariate models. Our results suggest that adiponectin, but not leptin, may be a novel risk factor for increased fracture risk independent of body composition and BMD and that these relationships may be influenced by sex. More research is needed to understand the physiologic basis underlying these sex differences. © 2011 American Society for Bone and Mineral Research. Adiponectin and leptin are adipokines that influence bone metabolism in vitro and in animal models. However, less is known about the longitudinal association of leptin and adiponectin with fracture. We tested the hypothesis that low leptin and high adiponectin levels are each individually associated with fracture risk in a prospective cohort study in Memphis and Pittsburgh among 3075 women and men aged 70 to 79 years from the Health Aging and Body Composition (Health ABC) study. There were 406 incident fractures (334 nonvertebral and 72 vertebral) over a mean of 6.5 ± 1.9 years. Cox regression was used to estimate the hazard ratios for fracture. Sex modified the association between adiponectin and fracture (p = .025 for interaction). Men with the highest adiponectin level (tertile 3) had a 94% higher risk of fracture [hazard ratio (HR) = 1.94; 95% confidence interval (CI) 1.20-3.16] compared with the lowest tertile (tertile 1; p = .007 for trend) after adjusting age, race, body mass index (BMI), education, diabetes, weight change, and hip bone mineral density (BMD). Among women, after adjusting for age and race, this association was no longer significant (p = .369 for trend). Leptin did not predict fracture risk in women (p = .544 for trend) or men (p = .118 for trend) in the multivariate models. Our results suggest that adiponectin, but not leptin, may be a novel risk factor for increased fracture risk independent of body composition and BMD and that these relationships may be influenced by sex. More research is needed to understand the physiologic basis underlying these sex differences. Adiponectin and leptin are adipokines that influence bone metabolism in vitro and in animal models. However, less is known about the longitudinal association of leptin and adiponectin with fracture. We tested the hypothesis that low leptin and high adiponectin levels are each individually associated with fracture risk in a prospective cohort study in Memphis and Pittsburgh among 3075 women and men aged 70 to 79 years from the Health Aging and Body Composition (Health ABC) study. There were 406 incident fractures (334 nonvertebral and 72 vertebral) over a mean of 6.5 ± 1.9 years. Cox regression was used to estimate the hazard ratios for fracture. Sex modified the association between adiponectin and fracture (p = .025 for interaction). Men with the highest adiponectin level (tertile 3) had a 94% higher risk of fracture [hazard ratio (HR) = 1.94; 95% confidence interval (CI) 1.20–3.16] compared with the lowest tertile (tertile 1; p = .007 for trend) after adjusting age, race, body mass index (BMI), education, diabetes, weight change, and hip bone mineral density (BMD). Among women, after adjusting for age and race, this association was no longer significant (p = .369 for trend). Leptin did not predict fracture risk in women (p = .544 for trend) or men (p = .118 for trend) in the multivariate models. Our results suggest that adiponectin, but not leptin, may be a novel risk factor for increased fracture risk independent of body composition and BMD and that these relationships may be influenced by sex. More research is needed to understand the physiologic basis underlying these sex differences. © 2011 American Society for Bone and Mineral Research. Adiponectin and leptin are adipokines that influence bone metabolism in vitro and in animal models. However, less is known about the longitudinal association of leptin and adiponectin with fracture. We tested the hypothesis that low leptin and high adiponectin levels are each individually associated with fracture risk in a prospective cohort study in Memphis and Pittsburgh, among 3,075 women and men, aged 70–79, from the Health Aging and Body Composition (Health ABC) study. There were 406 incident fractures (334 non-vertebral and 72 vertebral) over a mean of 6.5 ± 1.9 years. Cox regression was used to estimate the hazard ratios for fracture. Sex modified the association between adiponectin and fracture (p for interaction=0.025). Men with the highest adiponectin level (tertile 3) had a 94 % higher risk of fracture (HR=1.94; 95% CI 1.20, 3.16) compared to the lowest tertile (tertile 1), p for trend=0.007 after adjusting age, race, BMI, education, diabetes weight change, and hip BMD. Among women, after adjusting for age and race this association was no longer significant (p for trend=0.369). Leptin did not predict fracture risk in women (p for trend=0.544) or men (p for trend=0.118) in the multivariate models. Our results suggest that adiponectin, but not leptin, may be a novel risk factor for increased fracture risk independent of body composition and BMD and that these relationships may be influenced by sex. More research is needed to understand the physiological basis underlying these sex differences. Adiponectin and leptin are adipokines that influence bone metabolism in vitro and in animal models. However, less is known about the longitudinal association of leptin and adiponectin with fracture. We tested the hypothesis that low leptin and high adiponectin levels are each individually associated with fracture risk in a prospective cohort study in Memphis and Pittsburgh among 3075 women and men aged 70 to 79 years from the Health Aging and Body Composition (Health ABC) study. There were 406 incident fractures (334 nonvertebral and 72 vertebral) over a mean of 6.5 plus or minus 1.9 years. Cox regression was used to estimate the hazard ratios for fracture. Sex modified the association between adiponectin and fracture (p=.025 for interaction). Men with the highest adiponectin level (tertile 3) had a 94% higher risk of fracture [hazard ratio (HR)=1.94; 95% confidence interval (CI) 1.20-3.16] compared with the lowest tertile (tertile 1; p=.007 for trend) after adjusting age, race, body mass index (BMI), education, diabetes, weight change, and hip bone mineral density (BMD). Among women, after adjusting for age and race, this association was no longer significant (p=.369 for trend). Leptin did not predict fracture risk in women (p=.544 for trend) or men (p=.118 for trend) in the multivariate models. Our results suggest that adiponectin, but not leptin, may be a novel risk factor for increased fracture risk independent of body composition and BMD and that these relationships may be influenced by sex. More research is needed to understand the physiologic basis underlying these sex differences. copyright 2011 American Society for Bone and Mineral Research. |
| Author | Barbour, Kamil E Evans, Rhobert W Harris, Tamara B Boudreau, Robert Zmuda, Joseph M Cauley, Jane A Kanaya, Alka M Strotmeyer, Elsa S Bauer, Douglas C Horwitz, Mara J |
| AuthorAffiliation | 1 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 5 University of California San Francisco, San Francisco, California 3 Division of General Internal Medicine, University of California, San Francisco, California 2 Division of Endocrinology and Metabolism at the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA 4 Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, Bethesda, Maryland |
| AuthorAffiliation_xml | – name: 4 Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, Bethesda, Maryland – name: 2 Division of Endocrinology and Metabolism at the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA – name: 3 Division of General Internal Medicine, University of California, San Francisco, California – name: 1 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA – name: 5 University of California San Francisco, San Francisco, California |
| Author_xml | – sequence: 1 givenname: Kamil E surname: Barbour fullname: Barbour, Kamil E email: barbourk@edc.pitt.edu – sequence: 2 givenname: Joseph M surname: Zmuda fullname: Zmuda, Joseph M – sequence: 3 givenname: Robert surname: Boudreau fullname: Boudreau, Robert – sequence: 4 givenname: Elsa S surname: Strotmeyer fullname: Strotmeyer, Elsa S – sequence: 5 givenname: Mara J surname: Horwitz fullname: Horwitz, Mara J – sequence: 6 givenname: Rhobert W surname: Evans fullname: Evans, Rhobert W – sequence: 7 givenname: Alka M surname: Kanaya fullname: Kanaya, Alka M – sequence: 8 givenname: Tamara B surname: Harris fullname: Harris, Tamara B – sequence: 9 givenname: Douglas C surname: Bauer fullname: Bauer, Douglas C – sequence: 10 givenname: Jane A surname: Cauley fullname: Cauley, Jane A |
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| Copyright | Copyright © 2011 American Society for Bone and Mineral Research 2015 INIST-CNRS Copyright © 2011 American Society for Bone and Mineral Research. |
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| Keywords | Human Diseases of the osteoarticular system Fracture Adipokine Trauma Adiponectin Osteoarticular system Vertebrata Mammalia Leptin INCIDENT FRACTURES MEN Elderly LONGITUDINAL |
| Language | English |
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| PublicationDate | July 2011 |
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| References | 2002; 17 2007; 18 2009; 24 2006; 91 2004; 61 2002; 295 2009; 160 2005; 63 1999; 140 2000; 92 2005; 20 2003; 59 2007; 92 2001; 28 2001; 29 1998; 63 2003; 73 2008; 93 2001; 104 2007; 59 2001; 86 2009; 30 2006; 89 2001; 7 2004; 19 2006; 21 2000; 32 2007; 298 2002; 87 2004; 35 2008; 26 2001; 55 2008; 83 2003; 124 2003; 40 2004; 117 2003; 88 1994; 10 Goldstone (2024020318030589800_bib6) 2002; 295 Scariano (2024020318030589800_bib4) 2003; 124 Kontogianni (2024020318030589800_bib19) 2004; 19 Thomas (2024020318030589800_bib13) 2001; 29 Spiegelman (2024020318030589800_bib1) 2001; 104 Zoico (2024020318030589800_bib9) 2003; 59 Jurimae (2024020318030589800_bib17) 2008; 26 Ainsworth (2024020318030589800_bib41) 2000; 32 Jurimae (2024020318030589800_bib12) 2009; 160 Blain (2024020318030589800_bib10) 2002; 87 Schett (2024020318030589800_bib34) 2004; 117 Martini (2024020318030589800_bib16) 2001; 28 Lorentzon (2024020318030589800_bib20) 2006; 21 Weiss (2024020318030589800_bib8) 2006; 21 Steppan (2024020318030589800_bib5) 2000; 92 Ruhl (2024020318030589800_bib22) 2002; 17 Yamauchi (2024020318030589800_bib14) 2001; 55 Gonnelli (2024020318030589800_bib31) 2008; 83 Araneta (2024020318030589800_bib36) 2009; 24 Morberg (2024020318030589800_bib15) 2003; 88 Sun (2024020318030589800_bib23) 2003; 40 Chanprasertyothin (2024020318030589800_bib24) 2006; 89 Michaelsson (2024020318030589800_bib30) 2008; 93 Huang (2024020318030589800_bib32) 2004; 61 Kanaya (2024020318030589800_bib38) 2006; 91 Hamrick (2024020318030589800_bib7) 2005; 20 Berner (2024020318030589800_bib26) 2004; 35 Richards (2024020318030589800_bib29) 2007; 92 Basurto (2024020318030589800_bib33) 2009; 160 Henry (2024020318030589800_bib2) 1999; 140 Yamauchi (2024020318030589800_bib25) 2001; 7 Pahor (2024020318030589800_bib40) 1994; 10 Jurimae (2024020318030589800_bib28) 2007; 18 Handschin (2024020318030589800_bib3) 2007; 59 Kanazawa (2024020318030589800_bib35) 2009; 160 Holden (2024020318030589800_bib37) 2009; 30 Mackey (2024020318030589800_bib39) 2007; 298 Luo (2024020318030589800_bib27) 2006; 21 Oh (2024020318030589800_bib21) 2005; 63 Johansson (2024020318030589800_bib42) 1998; 63 Blum (2024020318030589800_bib18) 2003; 73 Pasco (2024020318030589800_bib11) 2001; 86 Tworoger (2024020318030589800_bib43) 2007; 92 |
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| Snippet | Adiponectin and leptin are adipokines that influence bone metabolism in vitro and in animal models. However, less is known about the longitudinal association... Adiponectin and leptin are adipokines that influence bone metabolism in vitro and in animal models. However, less is known about the longitudinal association... |
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| SubjectTerms | Adiponectin Adiponectin - blood Adult Aged Biological and medical sciences Female Fractures, Bone - blood Fundamental and applied biological sciences. Psychology Humans Incident Fractures Leptin Leptin - blood Longitudinal Male Men Proportional Hazards Models Risk Factors Sex Characteristics Skeleton and joints Spinal Fractures - blood Vertebrates: osteoarticular system, musculoskeletal system |
| Title | Adipokines and the risk of fracture in older adults |
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