Efficacy of pectin solution for preventing gastro-esophageal reflux events in patients with percutaneous endoscopic gastrostomy

• Published in: Journal of Clinical Biochemistry and Nutrition Vol. 50; no. 3; pp. 190 - 194
• Main Authors: Kinoshita, Yoshikazu, Furuta, Kenji, Sumikawa, Masuko, Katoh, Kyoko, Aimi, Masahito, Hirata, Toshiaki, Sanpei, Mari, Ishine, Junichi, Adachi, Kyoichi, Fukazawa, Kousuke, Katoh, Setsushi, Ohara, Shunji, Shimura, Shino, Ohhata, Shuzo, Moriyama, Mika, Nakata, Shuji, Inoue, Yukiko, Ryuko, Kanji
• Format: Journal Article
• Language: English
• Published: Japan SOCIETY FOR FREE RADICAL RESEARCH JAPAN 01.05.2012; Japan Science and Technology Agency; the Society for Free Radical Research Japan
• Subjects: aspiration pneumonitis; half-solidification; impedance; Nutrients; Original; percutaneous endoscopic gastrostomy; pH monitoring; half-solidification; impedance; pH monitoring; percutaneous endoscopic gastrostomy; aspiration pneumonitis
• ISSN: 0912-0009; 1880-5086; 1880-5086
• DOI: 10.3164/jcbn.11-58

The aim of this study was to determine the efficacy of pectin solution, which increases the viscosity of liquid nutrient, for prevention of gastro-esophageal reflux in comparison with half-solid nutrient. The subjects were 10 elderly patients undergoing percutaneous endoscopic gastrostomy feeding. Twenty-four-hour esophageal multichannel intraluminal impedance and pH testing was performed during intake of half-solid nutrient and a combination of pectin solution and liquid nutrient. During 4 h after delivery, there was no significant difference in the total number of gastro-esophageal reflux events between the feeding of the half-solid nutrient and the combination of pectin solution and liquid nutrient (5.7 ± 1.2 vs 5.3 ± 1.0/4 h). Acidic reflux after delivery of the half-solid nutrient was significantly more frequent than that after delivery of the combination of pectin solution and liquid nutrient (80.7% vs 60.4%, p = 0.018). The incidence of gastro-esophageal reflux reaching the upper portion of the esophagus tended to be higher during delivery of the half-solid nutrient than during delivery of the combination of pectin solution and liquid nutrient (47.4% vs 34.0%, p = 0.153). In conclusion, the usage of pectin solution combined with liquid nutrient is effective for preventing acidic gastro-esophageal reflux and gastro-esophageal reflux reaching the upper portion of the esophagus.