促性腺激素释放激素类似物治疗中枢性性早熟女童及对骨代谢的影响
目的观察中枢性性早熟（CPP）女童给予促性腺激素释放激素类似物（Gn RHa）治疗前后骨代谢标志物的变化,探讨Gn RHa对CPP女童骨代谢的影响。方法选取2013年6月至2014年12月在该院小儿内分泌门诊就诊的初发特发性CPP女童30例（CPP组）,采用酶联免疫吸附试验（ELISA法）检测其Gn RHa治疗前和治疗6个月后血清N端中段骨钙素（N-MID）、β-胶原特殊序列（β-Crosslaps）、总Ⅰ型胶原氨基端延长肽（PINP）水平,并与30例同期进行健康体检的女童（对照组）进行比较。结果 （1）CPP组患儿Gn RHa治疗前血清N-MID、β-Crosslaps、PINP水平[（10...
Saved in:
| Published in | 现代医药卫生 Vol. 31; no. 21; pp. 3225 - 3226 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
福建医科大学附属协和医院儿内科,福建福州,350001
2015
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1009-5519 |
| DOI | 10.3969/j.issn.1009-5519.2015.21.007 |
Cover
| Abstract | 目的观察中枢性性早熟（CPP）女童给予促性腺激素释放激素类似物（Gn RHa）治疗前后骨代谢标志物的变化,探讨Gn RHa对CPP女童骨代谢的影响。方法选取2013年6月至2014年12月在该院小儿内分泌门诊就诊的初发特发性CPP女童30例（CPP组）,采用酶联免疫吸附试验（ELISA法）检测其Gn RHa治疗前和治疗6个月后血清N端中段骨钙素（N-MID）、β-胶原特殊序列（β-Crosslaps）、总Ⅰ型胶原氨基端延长肽（PINP）水平,并与30例同期进行健康体检的女童（对照组）进行比较。结果 （1）CPP组患儿Gn RHa治疗前血清N-MID、β-Crosslaps、PINP水平[（109.3±27.4）、（1.623±0.292）、（847.63±114.88）ng/m L]均显著高于对照组[（73.7±11.3）、（1.191±0.246）、（642.71±152.99）ng/m L],差异均有统计学意义（P〈0.05）。（2）CPP组女童Gn RHa治疗6个月后血清N-MID、β-Crosslaps、PINP水平分别为（77.4±11.7）、（1.204±0.248）、（617.89±163.38）ng/m L,较治疗前均显著降低,差异均有统计学意义（P〈0.05）,但与对照组比较,差异均无统计学意义（P〉0.05）。结论 Gn RHa治疗可抑制CPP女童成骨细胞及破骨细胞过度亢进,但短期治疗影响骨量积累的依据不足,长期治疗对骨代谢的影响仍需进一步观察。 |
|---|---|
| AbstractList | 目的观察中枢性性早熟（CPP）女童给予促性腺激素释放激素类似物（Gn RHa）治疗前后骨代谢标志物的变化,探讨Gn RHa对CPP女童骨代谢的影响。方法选取2013年6月至2014年12月在该院小儿内分泌门诊就诊的初发特发性CPP女童30例（CPP组）,采用酶联免疫吸附试验（ELISA法）检测其Gn RHa治疗前和治疗6个月后血清N端中段骨钙素（N-MID）、β-胶原特殊序列（β-Crosslaps）、总Ⅰ型胶原氨基端延长肽（PINP）水平,并与30例同期进行健康体检的女童（对照组）进行比较。结果 （1）CPP组患儿Gn RHa治疗前血清N-MID、β-Crosslaps、PINP水平[（109.3±27.4）、（1.623±0.292）、（847.63±114.88）ng/m L]均显著高于对照组[（73.7±11.3）、（1.191±0.246）、（642.71±152.99）ng/m L],差异均有统计学意义（P〈0.05）。（2）CPP组女童Gn RHa治疗6个月后血清N-MID、β-Crosslaps、PINP水平分别为（77.4±11.7）、（1.204±0.248）、（617.89±163.38）ng/m L,较治疗前均显著降低,差异均有统计学意义（P〈0.05）,但与对照组比较,差异均无统计学意义（P〉0.05）。结论 Gn RHa治疗可抑制CPP女童成骨细胞及破骨细胞过度亢进,但短期治疗影响骨量积累的依据不足,长期治疗对骨代谢的影响仍需进一步观察。 目的：观察中枢性性早熟（CPP）女童给予促性腺激素释放激素类似物（GnRHa）治疗前后骨代谢标志物的变化，探讨GnRHa对CPP女童骨代谢的影响。方法选取2013年6月至2014年12月在该院小儿内分泌门诊就诊的初发特发性CPP女童30例（CPP组），采用酶联免疫吸附试验（ELISA法）检测其GnRHa治疗前和治疗6个月后血清N端中段骨钙素（N-MID）、β-胶原特殊序列（β-Crosslaps）、总Ⅰ型胶原氨基端延长肽（PINP）水平，并与30例同期进行健康体检的女童（对照组）进行比较。结果（1）CPP组患儿GnRHa治疗前血清N-MID、β-Crosslaps、PINP水平[（109.3±27.4）、（1.623±0.292）、（847.63±114.88）ng/mL]均显著高于对照组[（73.7±11.3）、（1.191±0.246）、（642.71±152.99）ng/mL]，差异均有统计学意义（P＜0.05）。（2）CPP组女童GnRHa治疗6个月后血清N-MID、β-Crosslaps、PINP水平分别为（77.4±11.7）、（1.204±0.248）、（617.89±163.38）ng/mL，较治疗前均显著降低，差异均有统计学意义（P＜0.05），但与对照组比较，差异均无统计学意义（P＞0.05）。结论 GnRHa治疗可抑制CPP女童成骨细胞及破骨细胞过度亢进，但短期治疗影响骨量积累的依据不足，长期治疗对骨代谢的影响仍需进一步观察。 |
| Abstract_FL | Objective To observe the changes of bone metabolic markers in girls with central precocious puberty (CPP) treated by gonadotropin-releasing hormone analog(GnRHa) and to investigate its effect on bone metabolism. Methods 30 girls with first onset of idiopathic CPP(CPP group) in the pediatric endocrinology outpatient department of our hospital from June 2013 to December 2014 were selected. Serum levels of N-mid fragment of osteocalcin(N-MID),β-crosslaps and total procollagen type I N-terminal propeptide(PINP) before GnRHa treatment and after 6-month GnRHa treatment were measured with ELISA. The detec-tion results were compared with those in 30 age-matched girls undergoing physical examination(control group) at the same period. Results (1)The levels of serum N-MID,β-Crosslaps and PINP before GnRHa treatment in the CPP group were significantly higher than those in the control group,the differences were statistically significant[(109.3±27.4 )ng/mL vs.(73.7±11.3)ng/mL;(1.623 ±0.292)ng/mL vs. (1.191 ±0.246)ng/mL;(847.63 ±114.88)ng/mL vs. (642.71 ±152.99)ng/mL,P<0.05]. (2) The levels of serum N-MID,β-Crosslaps and PINP after 6-month GnRHa treatment in the CPP group were (77.4±11.7),(1.204±0.248),(617.89± 163.38)ng/mL respectively,which were significantly decreased compared with before treatment,the differences were statistically significant(P<0.05),but there were no statistical differences compared with those in the control group (P>0.05). Conclusion The GnRHa therapy can inhibit the excessive hyperfunction of osteoblasts and osteoclasts. But the evidence of short-term therapy influ-encing the bone quantity accumulation is lacked ,while the influence of long-term therapy on bone metabolism still needs to be further observed. |
| Author | 方昕 康惠敏 吕敏 |
| AuthorAffiliation | 福建医科大学附属协和医院儿内科,福建福州350001 |
| AuthorAffiliation_xml | – name: 福建医科大学附属协和医院儿内科,福建福州,350001 |
| Author_FL | Kang Huimin Lv Min Fang Xin |
| Author_FL_xml | – sequence: 1 fullname: Fang Xin – sequence: 2 fullname: Kang Huimin – sequence: 3 fullname: Lv Min |
| Author_xml | – sequence: 1 fullname: 方昕 康惠敏 吕敏 |
| BookMark | eNo9kMtKw0AUhmdRwap9CRFcJc4lyWSWUrxBwU1XbspkktQUTbVBancFb1gQF4oFFyqVolVEqy7UVvsyubRvYUpFOPAffj7OgW8CJNyiawEwg6BMmMbmCrLjea6MIGSSqiImY4hUGSMZQpoAyf9-HKQ8zzGgighVMEVJsOb39sLqXf_gK-xVo_ebwVEtPP8Z7VG743e70XErfO1EF3X_4ym8asTwcOqt6PA6aL5Fj83gtBY8fw4e7v3Obf-lEV3uB9_t4OxkCozZfMOzUn85CbKLC9n0spRZXVpJz2ckoTIqKQwTTaEQWpxDYmJu2EI1DWELbNkUUt3UKRaKhaEwGdd1jIngiDMLq5qBICGTYHZ0tsxdm7v5XKG4U3Ljh7lds1Ipe0MVODZAY3J6RIr1opvfdmJ2q-Rs8lIlp2maouuKopNfHMSFWQ |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3969/j.issn.1009-5519.2015.21.007 |
| DatabaseName | 维普期刊资源整合服务平台 中文科技期刊数据库-CALIS站点 维普中文期刊数据库 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | Gonadotropin-releasing hormone analog for treating girls with central precocious puberty and its influence on bone metabolism |
| DocumentTitle_FL | Gonadotropin-releasing hormone analog for treating girls with central precocious puberty and its influence on bone metabolism |
| EndPage | 3226 |
| ExternalDocumentID | xdyyws201521007 666488448 |
| GroupedDBID | -05 -0E -SE -S~ .5D 2B. 2C~ 2RA 5SA 5VR 92F 92I 92L 92M 93N 93R 9D9 9DE AAITT ABDBF ACGFS AFUIB ALMA_UNASSIGNED_HOLDINGS CAJEE CAJUS CCEZO CIEJG CQIGP CW7 CW9 EOJEC ESX FA0 J.9 JUIAU M~T M~X OBODZ PB1 PB7 Q-- Q-4 R-E RT5 S.. T8U TCJ TGQ U1F U1G U5E U5O W91 WFFXF ~WA 4A8 ABJNI ACUHS PSX |
| ID | FETCH-LOGICAL-c597-492364700eaa03d2abfc5dbcfc2ef7078d872c4e20cd9a88223ca1a9e256b1033 |
| ISSN | 1009-5519 |
| IngestDate | Thu May 29 03:59:47 EDT 2025 Wed Feb 14 10:28:18 EST 2024 |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 21 |
| Keywords | Osteocalcin 骨和骨组织/代谢 胶原 Bone and bones/metabolism 胶原Ⅰ型 儿童 Collagen type Puberty,preco-cious 青春期,早熟 促性腺素释放激素/类似物和衍生物 Collagen 骨钙素 Female Gonadotropin-releasing hormone/analogs&derivatives Child 女性 |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c597-492364700eaa03d2abfc5dbcfc2ef7078d872c4e20cd9a88223ca1a9e256b1033 |
| Notes | Gonadotropin-releasing hormone/analogs ＆ derivatives; Bone and bones/metabolism; Puberty; precocious; Osteocalcin; Collagen; Collagen type Ⅰ; Child; Female Fang Xin,Kang Huimin,Lv Min （ Department of Pediatrics ,Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China） Objective To observe the changes of bone metabolic markers in girls with central precocious puberty（CPP）treated by gonadotropin-releasing hormone analog（Gn RHa） and to investigate its effect on bone metabolism. Methods 30 girls with first onset of idiopathic CPP（CPP group） in the pediatric endocrinology outpatient department of our hospital from June 2013 to December 2014 were selected. Serum levels of N-mid fragment of osteocalcin（N-MID）,β-crosslaps and total procollagen type I N-terminal propeptide（PINP） before Gn RHa treatment and after 6-month Gn RHa treatment were measured with ELISA. The detection results were compared with those in 30 age-matched girls undergoing physical examination（control group） at the same p |
| PageCount | 2 |
| ParticipantIDs | wanfang_journals_xdyyws201521007 chongqing_primary_666488448 |
| PublicationCentury | 2000 |
| PublicationDate | 2015 |
| PublicationDateYYYYMMDD | 2015-01-01 |
| PublicationDate_xml | – year: 2015 text: 2015 |
| PublicationDecade | 2010 |
| PublicationTitle | 现代医药卫生 |
| PublicationTitleAlternate | Modern Medicine Health |
| PublicationTitle_FL | Journal of Modern Medicine & Health |
| PublicationYear | 2015 |
| Publisher | 福建医科大学附属协和医院儿内科,福建福州,350001 |
| Publisher_xml | – name: 福建医科大学附属协和医院儿内科,福建福州,350001 |
| SSID | ssib051374271 ssj0002402475 |
| Score | 2.004298 |
| Snippet | 目的观察中枢性性早熟（CPP）女童给予促性腺激素释放激素类似物（Gn RHa）治疗前后骨代谢标志物的变化,探讨Gn RHa对CPP女童骨代谢的影响。方法选取2013年6月至2014年12月在... 目的：观察中枢性性早熟（CPP）女童给予促性腺激素释放激素类似物（GnRHa）治疗前后骨代谢标志物的变化，探讨GnRHa对CPP女童骨代谢的影响。方法选取2013年6月至2014年12月... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 3225 |
| SubjectTerms | 促性腺素释放激素/类似物和衍生物 儿童 女性 早熟 胶原 胶原Ⅰ型 青春期 骨和骨组织/代谢 骨钙素 |
| Title | 促性腺激素释放激素类似物治疗中枢性性早熟女童及对骨代谢的影响 |
| URI | http://lib.cqvip.com/qk/91143A/201521/666488448.html https://d.wanfangdata.com.cn/periodical/xdyyws201521007 |
| Volume | 31 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate issn: 1009-5519 databaseCode: ABDBF dateStart: 20141215 customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn isFulltext: true dateEnd: 99991231 titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn omitProxy: true ssIdentifier: ssj0002402475 providerName: EBSCOhost |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR3LahRBsEk2IF5EMWKMSg7pk0yc7Z5H97Fnd5Yg6ClC8LLMMzltjEnQ5BTwhQHxoBjwoBIJGkU06kFNND-zu5P8hVU9k80cQlBhGGqqa6pqumarq3q6awkZFUEUVpM4NWJph4blOoERQCJhpFhNKoGANnZxN_LVa874devKpD3Z1z9YWrW0MB-ORUuH7iv5H6sCDuyKu2T_wbI9poAAGOwLZ7AwnP_KxtS3qNegglPfwSULyqW-oMKmnkIMNpnUd6lnUQWApJD5C90k4Ub_MBoAqtTzNOcaHoARkiqpiZlucqkEDq6mEVTVNUOfKlZSowQAJd4OfABuUN-mCjTkiFEewoARDa0YNDWoJ1FVpagSWgTQcHwuz9QiQLqiwkJir47aAiA5FfVynK3F-XjLAQeQUtP6QxfVURBi6qgD8rRAt_23T2vtaEUAEFTal7Q4Rb380bjuK2hDzXWbNPFiH1WeS8n3kRaOHz8SQfQoyyNDMT7lv4B8I3fh59ENlmIGuHQOG4-4dKQej1DGWE8Grii0x1gV67YfjMO91ZGQUYJbhby5nwwwnGaqkAHl1b3GvqO0q9y1WBHHY8iBn8gsXVS6J-MYGS0UuHyUeCwpMj3TmpqFQEnvW2ulQWuqFGJNnCQnitxoROUv-inStzR9mtxo79ztLr_dvf-zu7OcfXu993Cl--x3DmebW-3t7ezRRvfLVvZ8tf39Y_flGhDjsbqRPXjVWf-afVjvPFnpfPqx9_5de-vN7ue17MW9zq_NztPHg2Si4U_Uxo3iD0GMCPJeA2sJOpZrmkkQmDxmQZhGdhxGacSSFKtWxcJlkZUwM4plAKkj41FQDWQCYX1YNTk_QyqtmVZylowwW49kLHZwRl2koXR5FIWRTDHl4MEQGe51S_NmXvel2bPLEBkpOqpZeIO55p14cfH2HPYsw4VH545kMEyOI2U-lXeeVOZvLSQXILidDy8Wpv4D_jOLKw |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E4%BF%83%E6%80%A7%E8%85%BA%E6%BF%80%E7%B4%A0%E9%87%8A%E6%94%BE%E6%BF%80%E7%B4%A0%E7%B1%BB%E4%BC%BC%E7%89%A9%E6%B2%BB%E7%96%97%E4%B8%AD%E6%9E%A2%E6%80%A7%E6%80%A7%E6%97%A9%E7%86%9F%E5%A5%B3%E7%AB%A5%E5%8F%8A%E5%AF%B9%E9%AA%A8%E4%BB%A3%E8%B0%A2%E7%9A%84%E5%BD%B1%E5%93%8D&rft.jtitle=%E7%8E%B0%E4%BB%A3%E5%8C%BB%E8%8D%AF%E5%8D%AB%E7%94%9F&rft.au=%E6%96%B9%E6%98%95+%E5%BA%B7%E6%83%A0%E6%95%8F+%E5%90%95%E6%95%8F&rft.date=2015&rft.issn=1009-5519&rft.volume=31&rft.issue=21&rft.spage=3225&rft.epage=3226&rft_id=info:doi/10.3969%2Fj.issn.1009-5519.2015.21.007&rft.externalDocID=666488448 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F91143A%2F91143A.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fxdyyws%2Fxdyyws.jpg |