Pulmonary vascular changes in asthma and COPD

• Published in: Pulmonary pharmacology & therapeutics Vol. 29; no. 2; pp. 144 - 155
• Main Authors: Harkness, Louise M., Kanabar, Varsha, Sharma, Hari S., Westergren-Thorsson, Gunilla, Larsson-Callerfelt, Anna-Karin
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2014
• Subjects: Airway smooth muscle; Angiogenesis; Animals; Asthma; Asthma - pathology; Asthma - physiopathology; Basic Medicine; Cell and Molecular Biology; Cell- och molekylärbiologi; COPD; Humans; Lung - blood supply; Medical and Health Sciences; Medical Education; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Pulmonary Circulation - physiology; Pulmonary Disease, Chronic Obstructive - pathology; Pulmonary Disease, Chronic Obstructive - physiopathology; Pulmonary fibroblast; Pulmonary/Respiratory; Vascular endothelial growth factor; Vascular Remodeling - physiology; CRP; IL; FGF; VEGF; BALf; BM; Airway smooth muscle; COX; ECM; Asthma; Pulmonary fibroblast; PDE; Angiogenesis; VSM; TGF; PDGF; EPC; ASM; Vascular endothelial growth factor; VEGF165; IPF; COPD; basement membrane; C-reactive protein; platelet derived growth factor; endothelial progenitor cell; fibroblast growth factor; VEGF 165; interleukin; vascular smooth muscle; cyclooxygenase; idiopathic pulmonary fibrosis; VEGF-A isoform 165; bronchoalveolar lavage fluid; phosphodiesterase; transforming growth factor; extracellular matrix; chronic obstructive pulmonary disease
• ISSN: 1094-5539; 1522-9629; 1522-9629
• DOI: 10.1016/j.pupt.2014.09.003

In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease (COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels culminating to altered bronchial and pulmonary circulation. The involvement of residential cells such as endothelial cells, smooth muscle cells and pulmonary fibroblasts, all appear to have a crucial role in the progression of vascular inflammation and remodelling. The regulatory abnormalities, growth factors and mediators implicated in the pulmonary vascular changes of asthma and COPD subjects and potential therapeutic targets have been described in this review.