Activation of Pre-mRNA Splicing by Human RNPS1 Is Regulated by CK2 Phosphorylation
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from...
Saved in:
| Published in | Molecular and Cellular Biology Vol. 25; no. 4; pp. 1446 - 1457 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Society for Microbiology
01.02.2005
Taylor & Francis |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0270-7306 1098-5549 1098-5549 |
| DOI | 10.1128/MCB.25.4.1446-1457.2005 |
Cover
| Abstract | Article Usage Stats
Services
MCB
Citing Articles
Google Scholar
PubMed
Related Content
Social Bookmarking
CiteULike
Delicious
Digg
Facebook
Google+
Mendeley
Reddit
StumbleUpon
Twitter
current issue
Spotlights in the Current Issue
MCB
About
MCB
Subscribers
Authors
Reviewers
Advertisers
Inquiries from the Press
Permissions & Commercial Reprints
ASM Journals Public Access Policy
MCB
RSS Feeds
1752 N Street N.W. • Washington DC 20036
202.737.3600 • 202.942.9355 fax • journals@asmusa.org
Print ISSN:
0270-7306
Online ISSN:
1098-5549
Copyright © 2014
by the
American Society for Microbiology.
For an alternate route to
MCB
.asm.org, visit:
MCB
|
|---|---|
| AbstractList | Human RNPS1 was originally characterized as a pre-mRNA splicing activator in vitro and was shown to regulate alternative splicing in vivo. RNPS1 was also identified as a protein component of the splicing-dependent mRNP complex, or exon-exon junction complex (EJC), and a role for RNPS1 in postsplicing processes has been proposed. Here we demonstrate that RNPS1 incorporates into active spliceosomes, enhances the formation of the ATP-dependent A complex, and promotes the generation of both intermediate and final spliced products. RNPS1 is phosphorylated in vivo and interacts with the CK2 (casein kinase II) protein kinase. Serine 53 (Ser-53) of RNPS1 was identified as the major phosphorylation site for CK2 in vitro, and the same site is also phosphorylated in vivo. The phosphorylation status of Ser-53 significantly affects splicing activation in vitro, but it does not perturb the nuclear localization of RNPS1. In vivo experiments indicated that the phosphorylation of RNPS1 at Ser-53 influences the efficiencies of both splicing and translation. We propose that RNPS1 is a splicing regulator whose activator function is controlled in part by CK2 phosphorylation.Human RNPS1 was originally characterized as a pre-mRNA splicing activator in vitro and was shown to regulate alternative splicing in vivo. RNPS1 was also identified as a protein component of the splicing-dependent mRNP complex, or exon-exon junction complex (EJC), and a role for RNPS1 in postsplicing processes has been proposed. Here we demonstrate that RNPS1 incorporates into active spliceosomes, enhances the formation of the ATP-dependent A complex, and promotes the generation of both intermediate and final spliced products. RNPS1 is phosphorylated in vivo and interacts with the CK2 (casein kinase II) protein kinase. Serine 53 (Ser-53) of RNPS1 was identified as the major phosphorylation site for CK2 in vitro, and the same site is also phosphorylated in vivo. The phosphorylation status of Ser-53 significantly affects splicing activation in vitro, but it does not perturb the nuclear localization of RNPS1. In vivo experiments indicated that the phosphorylation of RNPS1 at Ser-53 influences the efficiencies of both splicing and translation. We propose that RNPS1 is a splicing regulator whose activator function is controlled in part by CK2 phosphorylation. Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology. For an alternate route to MCB .asm.org, visit: MCB Human RNPS1 was originally characterized as a pre-mRNA splicing activator in vitro and was shown to regulate alternative splicing in vivo. RNPS1 was also identified as a protein component of the splicing-dependent mRNP complex, or exon-exon junction complex (EJC), and a role for RNPS1 in postsplicing processes has been proposed. Here we demonstrate that RNPS1 incorporates into active spliceosomes, enhances the formation of the ATP-dependent A complex, and promotes the generation of both intermediate and final spliced products. RNPS1 is phosphorylated in vivo and interacts with the CK2 (casein kinase II) protein kinase. Serine 53 (Ser-53) of RNPS1 was identified as the major phosphorylation site for CK2 in vitro, and the same site is also phosphorylated in vivo. The phosphorylation status of Ser-53 significantly affects splicing activation in vitro, but it does not perturb the nuclear localization of RNPS1. In vivo experiments indicated that the phosphorylation of RNPS1 at Ser-53 influences the efficiencies of both splicing and translation. We propose that RNPS1 is a splicing regulator whose activator function is controlled in part by CK2 phosphorylation. |
| Author | Clive A. Slaughter Hitoshi Suzuki Akila Mayeda Sawako Tatsumi Eiji Sakashita Hitoshi Endo Vincent J. Kidd Pascal Loyer Janeen H. Trembley |
| AuthorAffiliation | Department of Genetics and Tumor Cell Biology, 1 Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, Tennessee, 5 Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida, 2 Department of Biochemistry, Jichi Medical School, Kawachi-gun, Tochigi, Japan, 3 INSERM U522, Hôpital Pontchaillou, Rennes, France 4 |
| AuthorAffiliation_xml | – name: Department of Genetics and Tumor Cell Biology, 1 Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, Tennessee, 5 Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida, 2 Department of Biochemistry, Jichi Medical School, Kawachi-gun, Tochigi, Japan, 3 INSERM U522, Hôpital Pontchaillou, Rennes, France 4 |
| Author_xml | – sequence: 1 givenname: Janeen H. surname: Trembley fullname: Trembley, Janeen H. organization: Department of Genetics and Tumor Cell Biology – sequence: 2 givenname: Sawako surname: Tatsumi fullname: Tatsumi, Sawako organization: Department of Biochemistry and Molecular Biology, University of Miami School of Medicine – sequence: 3 givenname: Eiji surname: Sakashita fullname: Sakashita, Eiji organization: Department of Biochemistry, Jichi Medical School – sequence: 4 givenname: Pascal surname: Loyer fullname: Loyer, Pascal organization: INSERM U522, Hôpital Pontchaillou – sequence: 5 givenname: Clive A. surname: Slaughter fullname: Slaughter, Clive A. organization: Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital – sequence: 6 givenname: Hitoshi surname: Suzuki fullname: Suzuki, Hitoshi organization: Department of Biochemistry and Molecular Biology, University of Miami School of Medicine – sequence: 7 givenname: Hitoshi surname: Endo fullname: Endo, Hitoshi organization: Department of Biochemistry, Jichi Medical School – sequence: 8 givenname: Vincent J. surname: Kidd fullname: Kidd, Vincent J. organization: Department of Genetics and Tumor Cell Biology – sequence: 9 givenname: Akila surname: Mayeda fullname: Mayeda, Akila email: mayeda@miami.edu organization: Department of Biochemistry and Molecular Biology, University of Miami School of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15684395$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNUU1z0zAU1DBlaNryF8BcuNnIsj6sA4c009IOpWTSctbIshyLkaUg2e3k32MnpYFTubx3eLs7-3ZPwJHzTgPwPodZnqPy07fFeYZIhrMcY5rmmLAMQUhegVkOeZkSgvkRmEHEYMoKSI_BSYw_IYSUw-INOM4JLXHByQys5qo3D7I33iW-SZZBp93qdp7cbaxRxq2TaptcDZ10yep2eZcn1zFZ6fVgZa_r6bb4ipJl6-Om9WFrdzpn4HUjbdRvn_Yp-HF5cb-4Sm--f7lezG9SRTjtUwk51VQqjUqGKakYUkwj2NQcIlhTWNeEI6QqyHDDajWOSmFaaM1qzhQnxSn4vNfdDFWna6VdH6QVm2A6GbbCSyP-vTjTirV_EAQzzsuR__GJH_yvQcdedCYqba102g9RUFZwTCB-EZgzNoa8c_Tub0fPVv7EPQLYHqCCjzHo5gCBYipWjMUKRAQWU7FiKlZMxR6efWYq0-_iHl8z9j_453u-cY0PnXz0wdail1vrQxOkUyaK4mWRD3uR1qzbRxO0kLETnaoO6OI3lC7JWw |
| CitedBy_id | crossref_primary_10_1007_s11010_008_9820_7 crossref_primary_10_1016_j_isci_2024_111400 crossref_primary_10_1016_j_cell_2010_09_014 crossref_primary_10_1016_j_cell_2010_09_036 crossref_primary_10_1038_nprot_2006_148 crossref_primary_10_3390_ijms17081153 crossref_primary_10_1128_MCB_06130_11 crossref_primary_10_1104_pp_109_138180 crossref_primary_10_1371_journal_ppat_1011036 crossref_primary_10_1111_j_1432_0436_2006_00060_x crossref_primary_10_1186_s40170_022_00295_8 crossref_primary_10_1186_s12711_021_00656_9 crossref_primary_10_1016_j_tig_2020_08_010 crossref_primary_10_1074_jbc_M708188200 crossref_primary_10_1038_sj_onc_1210882 crossref_primary_10_1007_s11010_022_04558_2 crossref_primary_10_1002_1873_3468_12531 crossref_primary_10_1093_nar_gkn1002 crossref_primary_10_15252_msb_202110820 crossref_primary_10_1021_acs_jproteome_0c00750 crossref_primary_10_1016_j_bbrc_2018_01_120 crossref_primary_10_1038_s41598_022_08461_0 crossref_primary_10_1002_iub_2686 crossref_primary_10_1016_j_ejmech_2021_114056 crossref_primary_10_1016_j_mcpro_2021_100119 crossref_primary_10_1016_j_febslet_2005_12_022 crossref_primary_10_1261_rna_028639_111 crossref_primary_10_1093_gbe_evv142 crossref_primary_10_3390_cells11223639 crossref_primary_10_1002_prca_201600155 crossref_primary_10_1261_rna_2304410 crossref_primary_10_1074_jbc_M110_192518 crossref_primary_10_1007_s12033_024_01062_4 crossref_primary_10_1083_jcb_201910207 crossref_primary_10_1016_j_semcdb_2020_04_016 |
| Cites_doi | 10.1038/418236a 10.1242/jcs.113.11.1841 10.1074/jbc.C400173200 10.1016/S1097-2765(03)00270-3 10.1016/0076-6879(91)01013-R 10.1016/S0960-9822(01)00036-7 10.1073/pnas.89.12.5547 10.1093/nar/16.8.3157 10.1017/S1355838200000960 10.1016/S0092-8674(02)00655-4 10.1074/jbc.M207518200 10.1242/jcs.00074 10.1038/35057062 10.1093/oso/9780199634187.003.0004 10.1016/S0021-9258(19)47159-7 10.2144/99264st03 10.1093/nar/gnf108 10.1017/S1355838299991501 10.1093/oso/9780199634187.003.0008 10.1073/pnas.1934877100 10.1242/jcs.115.15.3033 10.1146/annurev.genet.32.1.279 10.1038/sj.onc.1205690 10.1086/514856 10.1128/MCB.16.10.5400 10.1128/MCB.24.3.1174-1187.2004 10.1074/jbc.M109755200 10.1016/S0171-9335(98)80063-0 10.1126/science.1058040 10.1074/jbc.M205192200 10.1038/416499a 10.1146/annurev.bi.65.070196.002055 10.1126/science.1062786 10.1101/gad.12.1.55 10.1038/nature01031 10.1093/oso/9780199634187.003.0006 10.1073/pnas.0403533101 10.1016/S0168-9525(00)02176-4 10.1038/nrg775 10.1101/gad.1030602 10.1101/gad.1163204 10.1093/oso/9780199636518.003.0003 10.1242/jcs.111.11.1495 10.1093/emboj/19.24.6860 10.1038/nature03001 10.1128/MCB.23.8.2981-2990.2003 10.1074/jbc.M307692200 10.1093/emboj/18.16.4560 |
| ContentType | Journal Article |
| Copyright | Copyright © 2005, American Society for Microbiology 2005 |
| Copyright_xml | – notice: Copyright © 2005, American Society for Microbiology 2005 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7TM 7X8 5PM |
| DOI | 10.1128/MCB.25.4.1446-1457.2005 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Nucleic Acids Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Nucleic Acids Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Nucleic Acids Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry Biology |
| EISSN | 1098-5549 |
| EndPage | 1457 |
| ExternalDocumentID | PMC547998 15684395 10_1128_MCB_25_4_1446_1457_2005 12269580 mcb_25_4_1446 |
| Genre | Research Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S Journal Article |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: P30 CA021765 – fundername: NIGMS NIH HHS grantid: 5R01 GM44088-13 – fundername: NIGMS NIH HHS grantid: R01 GM044088 – fundername: NCI NIH HHS grantid: P30 CA21765-25 |
| GroupedDBID | --- -DZ -~X .55 .GJ 0R~ 123 18M 29M 2WC 39C 3O- 4.4 53G 5RE 5VS 9M8 ACGFO ACKIV ACNCT ADBBV ADIYS AENEX AEOZL AFFNX AGHSJ AGVNZ ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW C1A CS3 DIK DU5 E3Z EBS EJD F5P GX1 H13 HH5 HYE HZ~ IH2 KQ8 L7B M4Z MVM N9A O9- OK1 P2P RHF RHI RNS RPM RSF TDBHL TFL TFW TR2 UCJ UDS VQA W8F WH7 WHG WOQ X7M Y6R ZCA AAGFI AAYXX ABJNI ADXHL AMPGV CITATION ABRLO ABTAH CGR CUY CVF ECM EIF EMOBN NPM PKN YIN YYP ZGI ZXP ZY4 7TM TASJS 7X8 5PM |
| ID | FETCH-LOGICAL-c596t-a096e6ace287465b72c7e20fd9020d60dd5922cb074f7dc4f7bc463ee7d97c953 |
| ISSN | 0270-7306 1098-5549 |
| IngestDate | Thu Aug 21 18:28:31 EDT 2025 Fri Sep 05 07:06:00 EDT 2025 Fri Sep 05 04:30:15 EDT 2025 Wed Feb 19 01:43:22 EST 2025 Tue Jul 01 01:05:46 EDT 2025 Thu Apr 24 23:11:56 EDT 2025 Wed Dec 25 09:06:14 EST 2024 Wed May 18 15:26:12 EDT 2016 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c596t-a096e6ace287465b72c7e20fd9020d60dd5922cb074f7dc4f7bc463ee7d97c953 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, P.O. Box 016129, Miami, FL 33101-6129. Phone: (305) 243-4621. Fax: (305) 243-3065. E-mail: mayeda@miami.edu. Present address: Department of Bone and Joint Diseases, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8522, Japan. J.H.T. and S.T. contributed equally to this work. |
| OpenAccessLink | http://doi.org/10.1128/MCB.25.4.1446-1457.2005 |
| PMID | 15684395 |
| PQID | 17773095 |
| PQPubID | 23462 |
| PageCount | 12 |
| ParticipantIDs | crossref_citationtrail_10_1128_MCB_25_4_1446_1457_2005 proquest_miscellaneous_17773095 pubmedcentral_primary_oai_pubmedcentral_nih_gov_547998 highwire_asm_mcb_25_4_1446 pubmed_primary_15684395 crossref_primary_10_1128_MCB_25_4_1446_1457_2005 proquest_miscellaneous_67394504 informaworld_taylorfrancis_310_1128_MCB_25_4_1446_1457_2005 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2005-02-01 |
| PublicationDateYYYYMMDD | 2005-02-01 |
| PublicationDate_xml | – month: 02 year: 2005 text: 2005-02-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Molecular and Cellular Biology |
| PublicationTitleAlternate | Mol Cell Biol |
| PublicationYear | 2005 |
| Publisher | American Society for Microbiology Taylor & Francis |
| Publisher_xml | – name: American Society for Microbiology – name: Taylor & Francis |
| References | Mayeda A. (R29) 1999; 118 Misteli T (R30) 2000; 113 R21 R20 R22 R25 R24 R27 R26 Lykke-Andersen J (R23) 2001; 11 R1 R4 R6 R7 R8 R9 Hanamura A. (R12) 1998; 4 Moore M. J. (R31) 1998 R34 R33 R36 R35 R37 R39 Nasim M. T. (R32) 2002; 30 R41 R40 Mayeda A. (R28) 1999; 118 R43 R45 Wang Y.-C. (R49) 1997 R44 Schneider E. (R42) 2002; 21 R47 R46 R48 Brandner J. M. (R2) 1998; 75 Reed R. (R38) 1997 R50 R52 R51 R10 Cao W. (R5) 1997; 3 R11 Cáceres J. F. (R3) 1997 R14 R13 R16 R15 R18 R17 R19 15210956 - Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9666-70 1319065 - Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5547-51 12244125 - J Cell Sci. 2002 Oct 15;115(Pt 20):3873-8 8816452 - Mol Cell Biol. 1996 Oct;16(10):5400-8 9628316 - Eur J Cell Biol. 1998 Apr;75(4):295-308 8811184 - Annu Rev Biochem. 1996;65:367-409 12429741 - J Biol Chem. 2003 Jan 24;278(4):2265-70 10806095 - J Cell Sci. 2000 Jun;113 ( Pt 11):1841-9 9311728 - Am J Hum Genet. 1997 Aug;61(2):259-66 1943760 - Methods Enzymol. 1991;201:110-49 10449421 - EMBO J. 1999 Aug 16;18(16):4560-70 9630249 - RNA. 1998 Apr;4(4):430-44 10343905 - Biotechniques. 1999 Apr;26(4):680-2 12665594 - Mol Cell Biol. 2003 Apr;23(8):2981-90 12887888 - Mol Cell. 2003 Jul;12(1):5-14 14752011 - Genes Dev. 2004 Jan 15;18(2):210-22 12384611 - Nucleic Acids Res. 2002 Oct 15;30(20):e109 10580479 - RNA. 1999 Nov;5(11):1504-8 12226669 - Nature. 2002 Sep 12;419(6903):182-5 9928482 - Annu Rev Genet. 1998;32:279-305 10549534 - Methods Mol Biol. 1999;118:315-21 11909516 - Cell. 2002 Feb 22;108(4):439-51 11118221 - EMBO J. 2000 Dec 15;19(24):6860-9 11181995 - Science. 2001 Feb 16;291(5507):1304-51 11967553 - Nat Rev Genet. 2002 Apr;3(4):285-98 2584185 - J Biol Chem. 1989 Nov 25;264(33):19621-9 9580558 - J Cell Sci. 1998 Jun;111 ( Pt 11):1495-506 11237011 - Nature. 2001 Feb 15;409(6822):860-921 11709559 - J Biol Chem. 2002 Jan 25;277(4):2589-96 12118059 - J Cell Sci. 2002 Aug 1;115(Pt 15):3033-8 12138108 - J Biol Chem. 2002 Sep 27;277(39):36061-7 15184380 - J Biol Chem. 2004 Jul 23;279(30):31745-9 14625303 - J Biol Chem. 2004 Feb 20;279(8):7009-13 3375053 - Nucleic Acids Res. 1988 Apr 25;16(8):3157-64 12414731 - Genes Dev. 2002 Nov 1;16(21):2778-91 15496913 - Nature. 2004 Oct 21;431(7011):931-45 12140753 - Oncogene. 2002 Aug 1;21(33):5031-7 10999598 - RNA. 2000 Sep;6(9):1197-211 12972633 - Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11327-32 12110900 - Nature. 2002 Jul 11;418(6894):236-43 11173120 - Trends Genet. 2001 Feb;17(2):100-7 11546874 - Science. 2001 Sep 7;293(5536):1836-9 11932736 - Nature. 2002 Apr 4;416(6880):499-506 14729963 - Mol Cell Biol. 2004 Feb;24(3):1174-87 11231165 - Curr Biol. 2001 Feb 6;11(3):R88-91 9404896 - RNA. 1997 Dec;3(12):1456-67 9420331 - Genes Dev. 1998 Jan 1;12(1):55-66 10549533 - Methods Mol Biol. 1999;118:309-14 |
| References_xml | – ident: R26 doi: 10.1038/418236a – volume: 113 start-page: 1841 year: 2000 ident: R30 publication-title: J. Cell Sci. doi: 10.1242/jcs.113.11.1841 – ident: R19 doi: 10.1074/jbc.C400173200 – ident: R16 doi: 10.1016/S1097-2765(03)00270-3 – ident: R1 doi: 10.1016/0076-6879(91)01013-R – volume: 11 start-page: R88 year: 2001 ident: R23 publication-title: Curr. Biol. doi: 10.1016/S0960-9822(01)00036-7 – ident: R9 doi: 10.1073/pnas.89.12.5547 – ident: R41 doi: 10.1093/nar/16.8.3157 – ident: R10 doi: 10.1017/S1355838200000960 – ident: R34 doi: 10.1016/S0092-8674(02)00655-4 – ident: R45 doi: 10.1074/jbc.M207518200 – ident: R37 doi: 10.1242/jcs.00074 – ident: R14 doi: 10.1038/35057062 – start-page: 103 volume-title: Eukaryotic mRNA processing year: 1997 ident: R38 doi: 10.1093/oso/9780199634187.003.0004 – ident: R36 doi: 10.1016/S0021-9258(19)47159-7 – ident: R48 doi: 10.2144/99264st03 – volume: 30 start-page: e109 year: 2002 ident: R32 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gnf108 – ident: R8 doi: 10.1017/S1355838299991501 – start-page: 242 volume-title: Eukaryotic mRNA processing year: 1997 ident: R49 doi: 10.1093/oso/9780199634187.003.0008 – ident: R50 doi: 10.1073/pnas.1934877100 – ident: R47 doi: 10.1242/jcs.115.15.3033 – ident: R21 doi: 10.1146/annurev.genet.32.1.279 – volume: 118 start-page: 315 year: 1999 ident: R29 publication-title: Methods Mol. Biol. – volume: 21 start-page: 5031 year: 2002 ident: R42 publication-title: Oncogene doi: 10.1038/sj.onc.1205690 – ident: R7 doi: 10.1086/514856 – volume: 4 start-page: 430 year: 1998 ident: R12 publication-title: RNA – ident: R51 doi: 10.1128/MCB.16.10.5400 – volume: 118 start-page: 309 year: 1999 ident: R28 publication-title: Methods Mol. Biol. – ident: R40 doi: 10.1128/MCB.24.3.1174-1187.2004 – ident: R44 doi: 10.1074/jbc.M109755200 – volume: 75 start-page: 295 year: 1998 ident: R2 publication-title: Eur. J. Cell Biol. doi: 10.1016/S0171-9335(98)80063-0 – ident: R46 doi: 10.1126/science.1058040 – ident: R35 doi: 10.1074/jbc.M205192200 – ident: R25 doi: 10.1038/416499a – ident: R18 doi: 10.1146/annurev.bi.65.070196.002055 – ident: R24 doi: 10.1126/science.1062786 – ident: R4 doi: 10.1101/gad.12.1.55 – ident: R52 doi: 10.1038/nature01031 – start-page: 174 volume-title: Eukaryotic mRNA processing year: 1997 ident: R3 doi: 10.1093/oso/9780199634187.003.0006 – ident: R13 doi: 10.1073/pnas.0403533101 – ident: R11 doi: 10.1016/S0168-9525(00)02176-4 – ident: R6 doi: 10.1038/nrg775 – ident: R39 doi: 10.1101/gad.1030602 – ident: R33 doi: 10.1101/gad.1163204 – start-page: 75 volume-title: RNA-protein interactions: a practical approach year: 1998 ident: R31 doi: 10.1093/oso/9780199636518.003.0003 – volume: 3 start-page: 1456 year: 1997 ident: R5 publication-title: RNA – ident: R22 doi: 10.1242/jcs.111.11.1495 – ident: R20 doi: 10.1093/emboj/19.24.6860 – ident: R15 doi: 10.1038/nature03001 – ident: R43 doi: 10.1128/MCB.23.8.2981-2990.2003 – ident: R17 doi: 10.1074/jbc.M307692200 – ident: R27 doi: 10.1093/emboj/18.16.4560 – reference: 8816452 - Mol Cell Biol. 1996 Oct;16(10):5400-8 – reference: 10449421 - EMBO J. 1999 Aug 16;18(16):4560-70 – reference: 3375053 - Nucleic Acids Res. 1988 Apr 25;16(8):3157-64 – reference: 12414731 - Genes Dev. 2002 Nov 1;16(21):2778-91 – reference: 11237011 - Nature. 2001 Feb 15;409(6822):860-921 – reference: 14752011 - Genes Dev. 2004 Jan 15;18(2):210-22 – reference: 10343905 - Biotechniques. 1999 Apr;26(4):680-2 – reference: 12138108 - J Biol Chem. 2002 Sep 27;277(39):36061-7 – reference: 9404896 - RNA. 1997 Dec;3(12):1456-67 – reference: 10549534 - Methods Mol Biol. 1999;118:315-21 – reference: 2584185 - J Biol Chem. 1989 Nov 25;264(33):19621-9 – reference: 10806095 - J Cell Sci. 2000 Jun;113 ( Pt 11):1841-9 – reference: 11967553 - Nat Rev Genet. 2002 Apr;3(4):285-98 – reference: 12429741 - J Biol Chem. 2003 Jan 24;278(4):2265-70 – reference: 15496913 - Nature. 2004 Oct 21;431(7011):931-45 – reference: 12140753 - Oncogene. 2002 Aug 1;21(33):5031-7 – reference: 9420331 - Genes Dev. 1998 Jan 1;12(1):55-66 – reference: 11231165 - Curr Biol. 2001 Feb 6;11(3):R88-91 – reference: 12244125 - J Cell Sci. 2002 Oct 15;115(Pt 20):3873-8 – reference: 9928482 - Annu Rev Genet. 1998;32:279-305 – reference: 9311728 - Am J Hum Genet. 1997 Aug;61(2):259-66 – reference: 12118059 - J Cell Sci. 2002 Aug 1;115(Pt 15):3033-8 – reference: 11118221 - EMBO J. 2000 Dec 15;19(24):6860-9 – reference: 11181995 - Science. 2001 Feb 16;291(5507):1304-51 – reference: 1319065 - Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5547-51 – reference: 9628316 - Eur J Cell Biol. 1998 Apr;75(4):295-308 – reference: 11173120 - Trends Genet. 2001 Feb;17(2):100-7 – reference: 8811184 - Annu Rev Biochem. 1996;65:367-409 – reference: 10999598 - RNA. 2000 Sep;6(9):1197-211 – reference: 11909516 - Cell. 2002 Feb 22;108(4):439-51 – reference: 12887888 - Mol Cell. 2003 Jul;12(1):5-14 – reference: 12384611 - Nucleic Acids Res. 2002 Oct 15;30(20):e109 – reference: 10580479 - RNA. 1999 Nov;5(11):1504-8 – reference: 9630249 - RNA. 1998 Apr;4(4):430-44 – reference: 11709559 - J Biol Chem. 2002 Jan 25;277(4):2589-96 – reference: 12110900 - Nature. 2002 Jul 11;418(6894):236-43 – reference: 12226669 - Nature. 2002 Sep 12;419(6903):182-5 – reference: 11932736 - Nature. 2002 Apr 4;416(6880):499-506 – reference: 1943760 - Methods Enzymol. 1991;201:110-49 – reference: 15184380 - J Biol Chem. 2004 Jul 23;279(30):31745-9 – reference: 9580558 - J Cell Sci. 1998 Jun;111 ( Pt 11):1495-506 – reference: 15210956 - Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9666-70 – reference: 14729963 - Mol Cell Biol. 2004 Feb;24(3):1174-87 – reference: 12665594 - Mol Cell Biol. 2003 Apr;23(8):2981-90 – reference: 14625303 - J Biol Chem. 2004 Feb 20;279(8):7009-13 – reference: 10549533 - Methods Mol Biol. 1999;118:309-14 – reference: 11546874 - Science. 2001 Sep 7;293(5536):1836-9 – reference: 12972633 - Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11327-32 |
| SSID | ssj0006903 |
| Score | 1.999145 |
| Snippet | Article Usage Stats
Services
MCB
Citing Articles
Google Scholar
PubMed
Related Content
Social Bookmarking
CiteULike
Delicious
Digg
Facebook
Google+
Mendeley... Human RNPS1 was originally characterized as a pre-mRNA splicing activator in vitro and was shown to regulate alternative splicing in vivo. RNPS1 was also... |
| SourceID | pubmedcentral proquest pubmed crossref informaworld highwire |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1446 |
| SubjectTerms | Casein Kinase II - metabolism Cell Nucleus - metabolism Exons - genetics Gene Expression HeLa Cells Humans Phosphorylation Ribonucleoproteins - metabolism RNA Precursors - metabolism RNA Splicing - physiology Serine - metabolism Spliceosomes - metabolism |
| Title | Activation of Pre-mRNA Splicing by Human RNPS1 Is Regulated by CK2 Phosphorylation |
| URI | http://mcb.asm.org/content/25/4/1446.abstract https://www.tandfonline.com/doi/abs/10.1128/MCB.25.4.1446-1457.2005 https://www.ncbi.nlm.nih.gov/pubmed/15684395 https://www.proquest.com/docview/17773095 https://www.proquest.com/docview/67394504 https://pubmed.ncbi.nlm.nih.gov/PMC547998 |
| Volume | 25 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKEIIXBOPWccsDb1FK6thxLZ5KBdpAm8bWSXuzHMdRy9pmajOh8tP4dRw7cZJWYwNeojYXK8n3xT7n-Ph8CL0bkCiVUoWB5ikLCA55kIRaQWcIxjxPuJTSBPQPj-L9M_LlnJ53Or9aWUtXRdJTP69dV_I_qMI-wNWskv0HZOtGYQf8BnxhCwjD9q8wHionTmZT2ZY6mJ8cDf1TMydtQgBgWlZB-qPj075_YNaEWOn50uwcfcX-8SRfXU7y5XrWQOQEnpxyrp1gGOnZzP4p1Sub1Bu5MHle-z1_vNTzxM0Tm6CN_CEvcn8sC3gn09p0n36f-qfywog4FfWYcCxXNqSer6tsYReIoC532VHHzTC1000Pp005qVbPhlkYQNdS1cAue15T2BRsG97umss10RUFSaufNV7s9QMANosaDkcfe5j2iJm6joM-ocxGz9pXAJKXc8sL8GCBsaXU52ZB7q2Bsk5fnKtEYCqIMM3fQXcxA7vNJAR8ayrVx9yqctePWuUWwv29_8PdWYWo8lY2jSRXuHqrmu51PtF2am_LVho_Qg8rJ8cblox9jDp6sYvuVcTZRfdHTmXwCTppOOzlmec47DkOe8nasxz2LIe9g5VXc9gcAw57Wxx-is4-fxqP9oNK5yNQlMdFIMGN1rFU2mgvxDRhWDGNwyzl4MukcZimlGOsErB2M5Yq2CSKxJHWLOVMcRo9QzuLfKFfIE8TSZXsR0QpQqAZ2c94mCZ6oDH49Znsoti9WKGqIvhGi2UmrDOMBwLAabAVBhyj1Eq7KKwvvCzrwNx-yZ5DTsjVXGywpos-tLEUhY3PZaWYjohubfqtg14AXmaODz72_Gol-owB2_gNZ8Qs4oSGpIuel1RpnqdiH7ykDRLVJ5hS9JtHFtOJLUlPCeN8sHfTE79ED5pe4xXaKZZX-jUY9EXyxn45vwFlafA8 |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Activation+of+Pre-mRNA+Splicing+by+Human+RNPS1+Is+Regulated+by+CK2+Phosphorylation&rft.jtitle=Molecular+and+Cellular+Biology&rft.au=Janeen+H.+Trembley&rft.au=Sawako+Tatsumi&rft.au=Eiji+Sakashita&rft.au=Pascal+Loyer&rft.date=2005-02-01&rft.pub=American+Society+for+Microbiology&rft.issn=0270-7306&rft.eissn=1098-5549&rft.volume=25&rft.issue=4&rft.spage=1446&rft_id=info:doi/10.1128%2FMCB.25.4.1446-1457.2005&rft_id=info%3Apmid%2F15684395&rft.externalDBID=n%2Fa&rft.externalDocID=mcb_25_4_1446 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0270-7306&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0270-7306&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0270-7306&client=summon |