MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function - Miller, Brooke H.; Zeier, Zane; Xi, Li; Lanz, Thomas A.; Deng, Shibing; Strathmann, Julia; Willoughby, David; Kenny, Paul J.; Elsworth, John D.; Lawrence, Matthew S.; Roth, Robert H.; Edbauer, Dieter; et al. (Proceedings of the National Academy of Sciences - PNAS, 2012)
Keywords: Adolescence; Adult; adults; Animals; Antipsychotic Agents - pharmacology; Antipsychotic Agents - therapeutic use; behavior disorders; Biological Sciences; Bipolar Disorder - drug therapy; Bipolar Disorder - genetics; Bipolar Disorder - physiopathology; Brain; Brain - drug effects; Brain - growth & development; Brain - physiopathology; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Cerebral Cortex - physiopathology; Cognitive ability; cortex; Cortex (prefrontal); Cyclic AMP; Data processing; Databases, Genetic; Datasets; Demography; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases - metabolism; DNA microarrays; Down regulation; GATA2 Transcription Factor - metabolism; Gene expression; Gene expression regulation; Gene Expression Regulation - drug effects; genes; Glutamic acid receptors (ionotropic); HEK293 Cells; Humans; Mental disorders; Messenger RNA; Mice; MicroRNA; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Muscle Proteins - metabolism; N-Methyl-D-aspartic acid receptors; N-Methylaspartate - metabolism; nervous system diseases; neurodevelopment; Neurons; nucleotide sequences; Oligonucleotide Array Sequence Analysis; Open Reading Frames - genetics; Polymerase Chain Reaction; postpartum period; Rats; Receptors, N-Methyl-D-Aspartate - metabolism; Regulatory sequences; Reproducibility of Results; Ribonucleic acid; RNA; Rodents; Schizophrenia; Schizophrenia - drug therapy; Schizophrenia - genetics; Schizophrenia - physiopathology; Signal Transduction - drug effects; Untranslated regions; Up regulation