基于Oncomine数据库荟萃分析KIF23在非小细胞肺癌中的表达和意义
背景与目的 非小细胞肺癌（non-small cell lung cancer,NSCLC）是全球引起死亡的最重要原因之一。大多数患者发现时处于中晚期,预后较差。本研究拟探讨驱动蛋白超家族23（kinesin family member 23,KIF23）在NSCLC中的表达及意义。方法 收集Oncomine数据库中关于KIF23的信息,并对目前数据库中资料进行二次分析,对其在NSCLC中的作用进行荟萃分析。利用Kaplan-Meier Plotter进行患者生存周期分析。结果 Oncomine数据库中共收集了447项不同类型的研究结果,其中关于KIF23表达有统计学差异的研究结果有67个,K...
Saved in:
| Published in | 中国肺癌杂志 Vol. 20; no. 12; pp. 822 - 826 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
210006南京,南京医科大学金陵临床医学院呼吸内科
2017
210002南京,南京医科大学附属南京医院(南京市第一医院)呼吸内科%南京医科大学金陵临床医学院呼吸内科,南京,210006 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1009-3419 1999-6187 |
| DOI | 10.3779/j.issn.1009-3419.2017.12.05 |
Cover
| Abstract | 背景与目的 非小细胞肺癌（non-small cell lung cancer,NSCLC）是全球引起死亡的最重要原因之一。大多数患者发现时处于中晚期,预后较差。本研究拟探讨驱动蛋白超家族23（kinesin family member 23,KIF23）在NSCLC中的表达及意义。方法 收集Oncomine数据库中关于KIF23的信息,并对目前数据库中资料进行二次分析,对其在NSCLC中的作用进行荟萃分析。利用Kaplan-Meier Plotter进行患者生存周期分析。结果 Oncomine数据库中共收集了447项不同类型的研究结果,其中关于KIF23表达有统计学差异的研究结果有67个,KIF23表达增高的研究有64项、表达降低的研究有3项。共有16项研究涉及KIF23在NSCLC癌组织和正常组织中的表达,共包括1,189个样本,与对照组相比,KIF23在NSCLC细胞癌中高表达（P〈0.05）。不仅如此,KIF23表达量与NSCLC总体生存率存在相关性,高表达KIF23的患者总体生存率较差,低表达KIF23的患者预后较好（P〈0.05）。进一步亚组分析发现,KIF23表达水平对肺腺癌患者预后有显著影响,而在鳞癌患者中,其表达水平对预后无显著影响。结论 我们通过对Oncomine基因芯片数据库中肿瘤相关基因信息的深入挖掘,提出KIF23在NSLCL组织中高表达,且与NSCLC预后有关,可能为肿瘤药物的开发提供重要理论依据。 |
|---|---|
| AbstractList | 背景与目的 非小细胞肺癌（non-small cell lung cancer,NSCLC）是全球引起死亡的最重要原因之一。大多数患者发现时处于中晚期,预后较差。本研究拟探讨驱动蛋白超家族23（kinesin family member 23,KIF23）在NSCLC中的表达及意义。方法 收集Oncomine数据库中关于KIF23的信息,并对目前数据库中资料进行二次分析,对其在NSCLC中的作用进行荟萃分析。利用Kaplan-Meier Plotter进行患者生存周期分析。结果 Oncomine数据库中共收集了447项不同类型的研究结果,其中关于KIF23表达有统计学差异的研究结果有67个,KIF23表达增高的研究有64项、表达降低的研究有3项。共有16项研究涉及KIF23在NSCLC癌组织和正常组织中的表达,共包括1,189个样本,与对照组相比,KIF23在NSCLC细胞癌中高表达（P〈0.05）。不仅如此,KIF23表达量与NSCLC总体生存率存在相关性,高表达KIF23的患者总体生存率较差,低表达KIF23的患者预后较好（P〈0.05）。进一步亚组分析发现,KIF23表达水平对肺腺癌患者预后有显著影响,而在鳞癌患者中,其表达水平对预后无显著影响。结论 我们通过对Oncomine基因芯片数据库中肿瘤相关基因信息的深入挖掘,提出KIF23在NSLCL组织中高表达,且与NSCLC预后有关,可能为肿瘤药物的开发提供重要理论依据。 背景与目的 非小细胞肺癌(non-small cell lung cancer,NSCLC)是全球引起死亡的最重要原因之一.大多数患者发现时处于中晚期,预后较差.本研究拟探讨驱动蛋白超家族23(kinesin family member 23,KIF23)在NSCLC中的表达及意义.方法 收集Oncomine数据库中关于KIF23的信息,并对目前数据库中资料进行二次分析,对其在NSCLC中的作用进行荟萃分析.利用Kaplan-Meier Plotter进行患者生存周期分析.结果 Oncomine数据库中共收集了447项不同类型的研究结果,其中关于KIF23表达有统计学差异的研究结果有67个,KIF23表达增高的研究有64项、表达降低的研究有3项.共有16项研究涉及KIF23在NSCLC癌组织和正常组织中的表达,共包括1,189个样本,与对照组相比,KIF23在NSCLC细胞癌中高表达(P＜0.05).不仅如此,KIF23表达量与NSCLC总体生存率存在相关性,高表达KIF23的患者总体生存率较差,低表达KIF23的患者预后较好(P＜0.05).进一步亚组分析发现,KIF23表达水平对肺腺癌患者预后有显著影响,而在鳞癌患者中,其表达水平对预后无显著影响.结论 我们通过对Oncomine基因芯片数据库中肿瘤相关基因信息的深入挖掘,提出KIF23在NSLCL组织中高表达,且与NSCLC预后有关,可能为肿瘤药物的开发提供重要理论依据. |
| Abstract_FL | Background and objective Non-small cell lung cancer (NSCLC) is one of the most common cause of cancer-related death worldwide.As the overall prognosis for affected patients is still poor,there is a need for biomarkers for prediction of survival and guiding individual therapy.This study is to explore the expression and significance of kinesin family member 23 (KIF23) in NSCLC.Methods KIF23 data were retrieved from Oncomine NSCLC database.The prognostic value of KIF23 was retrieved from an online survival analysis tool "Kaplan-Meier Plotter" (KM plotter) database.Results In Oncomine database,there were 447 studies of different types concerning expression of KIF23,of which 67 studies were of statistically significance (64 up-regulated and 3 down-regulated).A total of 16 studies were involved KIF23 in NSCLC tissues and normal tissues,including a total of 1,189 samples.Overall,KIF23 expression in NSCLC is higher than that in normal tissues (P＜0.05).Moreover,Kaplan-Meier plots of overall survival indicated that KIF23 high expression is closely associated with poor survival in NSCLC (P＜0.05).Subgroup analysis revealed that KIF23 expression showed negative relation to the prognosis of pulmonary adenocarcinoma patients.Whereas,in those with squamous carcinoma KIF23 expression showed no effects on the prognosis of the patients.Conclusion KIF23 was found highly expressed in NSCLC,which might be a marker for NSCLC prognosis. |
| Author | 叶亮;李慧娟;张方;吕镗烽;刘红兵;宋勇 |
| AuthorAffiliation | 南京医科大学金陵临床医学院呼吸内科,南京210006;南京医科大学附属南京医院（南京市第一医院）呼吸内科,南京210002 |
| AuthorAffiliation_xml | – name: 210006南京,南京医科大学金陵临床医学院呼吸内科;210002南京,南京医科大学附属南京医院(南京市第一医院)呼吸内科%南京医科大学金陵临床医学院呼吸内科,南京,210006 |
| Author_FL | Hongbing LIU Yong SONG Liang YE Tangfeng LV Huijuan LI Fang ZHANG |
| Author_FL_xml | – sequence: 1 fullname: Liang YE – sequence: 2 fullname: Huijuan LI – sequence: 3 fullname: Fang ZHANG – sequence: 4 fullname: Tangfeng LV – sequence: 5 fullname: Hongbing LIU – sequence: 6 fullname: Yong SONG |
| Author_xml | – sequence: 1 fullname: 叶亮;李慧娟;张方;吕镗烽;刘红兵;宋勇 |
| BookMark | eNo1kM1KAlEAhS9hkFovUYtWM92_uTN3GZIlCUK4l-v82EjeKYeIXKZIgaYULYpS2rkpXNYEPo0zTm_RhLU6Z_FxDudkQEp60gZgC0GV6Drfqauu70sVQcgVQhFXMUS6irAKtRWQRpxzhSFDTyX-H1kDGd-vQ8gwJzQNjsJxMA9uS9L0Gq60o4dp1H8Pg_u4P46H7fC6G42Gh4U8JuHz5PtlFE4Hi69u3B7FV8HisTf_eFs8deLXSTybhXe9qDOYf96sg1VHnPj2xp9mQTm_V84dKMXSfiG3W1RMjTNFQMuwoGY5CJMqZ9QktkOqBsOYWVQIGxqQmZZmCqJzalNENMyFA3UNE4pNyyZZsL2MvRDSEbJWqXvnTZkUVlo1R7Rav1cgnAxNyM0laR57snbmJuxp022I5mWF6RQlmZyQHzuXef0 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3779/j.issn.1009-3419.2017.12.05 |
| DatabaseName | 维普期刊资源整合服务平台 中文科技期刊数据库-CALIS站点 维普中文期刊数据库 维普中文医药期刊数据库 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | Expression of KIF23 and Its Prognostic Role in Non-small Cell Lung Cancer： Analysis Based on the Data-mining of Oncomine |
| DocumentTitle_FL | Expression of KIF23 and Its Prognostic Role in Non-small Cell Lung Cancer:Analysis Based on the Data-mining of Oncomine |
| EISSN | 1999-6187 |
| EndPage | 826 |
| ExternalDocumentID | zgfazz201712006 674107593 |
| GrantInformation_xml | – fundername: 国家自然科学基金项目(No.81270079,No.81570025)资助 This study was supported by the grants from National Nature Science Foundation funderid: (No.81270079,No.81570025) |
| GroupedDBID | --- -05 04C 29R 2B. 2C~ 2RA 2WC 3V. 5GY 5VS 6PF 92F 92I 92L AAWTL ABUWG ACGFS AFKRA ALMA_UNASSIGNED_HOLDINGS BENPR BPHCQ BVBZV C1A CCEZO CCPQU CIEJG CQIGP CW9 DIK E3Z EBD EIHBH EMOBN EOJEC F5P GROUPED_DOAJ HYE IPNFZ KQ8 KWQ OBODZ OK1 PIMPY PQQKQ PROAC RIG RNS RPM TCJ TGQ U1G U5O W91 ~WA 4A8 93N PGMZT PHGZM PHGZT PMFND PSX |
| ID | FETCH-LOGICAL-c596-a0d8d05df123b964c3ef3b86226d4aae0806cd5ca3794e413529af0752342cde3 |
| ISSN | 1009-3419 |
| IngestDate | Thu May 29 03:56:18 EDT 2025 Wed Feb 14 10:03:26 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Keywords | 驱动蛋白超家族23 Kinesin family member 23 肺肿瘤 Oncomine Lung neoplasms |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c596-a0d8d05df123b964c3ef3b86226d4aae0806cd5ca3794e413529af0752342cde3 |
| Notes | Liang YE1,2, Huijuan LI1, Fang ZHANG1, Tangfeng LV1, Hongbing LIU1, Yong SONG1（1.Department of Respiratory Medicine, Jinling Clinical Medical College of Nanjing Medical University, Nanjing 210006, China; 2.Department of Respiratory Medicine, Najing Hospital Affiliated to Nanjing Medical University （Nanjing First Hospital）, Nanjing 210002, China） Lung neoplasms; Kinesin family member 23; Oncomine 12-1395/R Background and objective Non-small cell lung cancer （NSCLC） is one of the most common cause of cancer-related death worldwide. As the overall prognosis for affected patients is still poor, there is a need for biomarkers for prediction of survival and guiding individual therapy. This study is to explore the expression and significance of kinesin family member 23 （KIF23） in NSCLC. Methods KIF23 data were retrieved from Oncomine NSCLC database. ＂lhe prognostic value of KIF23 was retrieved from an online survival analysis tool ＂Kaplan-Meier Plotter＂ （KM plotter） database. Results In Oncomine database, there were 44 |
| PageCount | 5 |
| ParticipantIDs | wanfang_journals_zgfazz201712006 chongqing_primary_674107593 |
| PublicationCentury | 2000 |
| PublicationDate | 2017 |
| PublicationDateYYYYMMDD | 2017-01-01 |
| PublicationDate_xml | – year: 2017 text: 2017 |
| PublicationDecade | 2010 |
| PublicationTitle | 中国肺癌杂志 |
| PublicationTitleAlternate | Chinese Journal of Lung Cancer |
| PublicationTitle_FL | Chinese Journal of Lung Cancer |
| PublicationYear | 2017 |
| Publisher | 210006南京,南京医科大学金陵临床医学院呼吸内科 210002南京,南京医科大学附属南京医院(南京市第一医院)呼吸内科%南京医科大学金陵临床医学院呼吸内科,南京,210006 |
| Publisher_xml | – name: 210006南京,南京医科大学金陵临床医学院呼吸内科 – name: 210002南京,南京医科大学附属南京医院(南京市第一医院)呼吸内科%南京医科大学金陵临床医学院呼吸内科,南京,210006 |
| SSID | ssj0062934 ssib002262905 ssib044765436 ssib001103766 ssib038074678 ssib051369142 |
| Score | 2.121715 |
| Snippet | 背景与目的 非小细胞肺癌（non-small cell lung cancer,NSCLC）是全球引起死亡的最重要原因之一。大多数患者发现时处于中晚期,预后较差。本研究拟探讨驱动蛋白超家族23（kinesin family member 23,KIF23）在NSCLC中的表达及意义。方法... 背景与目的 非小细胞肺癌(non-small cell lung cancer,NSCLC)是全球引起死亡的最重要原因之一.大多数患者发现时处于中晚期,预后较差.本研究拟探讨驱动蛋白超家族23(kinesin family member 23,KIF23)在NSCLC中的表达及意义.方法... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 822 |
| SubjectTerms | Oncomine 肺肿瘤 驱动蛋白超家族23 |
| Title | 基于Oncomine数据库荟萃分析KIF23在非小细胞肺癌中的表达和意义 |
| URI | http://lib.cqvip.com/qk/91098A/201712/674107593.html https://d.wanfangdata.com.cn/periodical/zgfazz201712006 |
| Volume | 20 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR1Na9RAdKgtFC_iJ2q1FHSOqZtkZjJzTHazVKVVSoXelnxuT1s_2ssebSkKrS2KB0VbvPWi9Kgr9Ff4E7rb9V_43iSbDaX4BUsY3ryveS_Z92Yy80LIbTtOnFio0EiiJDaYmXADkiPTCDE62SzhSYRnh2fnxMwjdm-RL46c-VHatbS6Ek5H7VPPlfyPVwEGfsVTsv_g2YIpAKAN_oUreBiuf-Vj6nOq6tRzqc_wKv0HLZCDtUN9QRWnXgUbskZdH3EBRdnUlwgBOmioCpU2dkkACk3lA_D-3bqlwapKXUl9RVUNe3zNUgKpQz1PU0hkgF3QsLQqDlWKyqrWSVK3piGgHEMc19QMJfV8_KEISyMLREDOQAXkqpw1l1gBvke92mniBCoJQFSyTlURYPXwwEoit5LrD3syGl-L59R1EBf0U_UysQdG0IZUAnQr94D5wMpoHmg7qAsYw6uVl1KyM6P6trfwLYfQ6tQ0eqZOFW7zU4AIqaKVgSsopkytGxsoCT4VKFlmXQqt4PHcUh7L3S3dEp8SFSC72lJA61XzoQAhImtTDISWgha-4MK6fOWoZlXKT69VilEyOwg-SHeyggUnIynWodSRFCVMFxJwL6Sj18_5MIEotnW2m2nQbiOKmdXBH7McIaxRMub5cw_nh2k6Hk4tLxtYwlLDuIPfQID4XcQFxhw8AV3gc9MWymRFmTggznaPDLQcJ7fyIdz5zQCwmsrScqv5BHJEfWSvlQatZim7XDhPzuXTwik3e8YvkJH20kUyPptvfLlE5rt7naPOq8Hj3Xt70Nv60u286W_t9XfWui82ers7-qHtftj_-XG3e7B9_H2jv7bbf945frd59PXz8fv1_qf9_uFh9_Vmb3376NvLy2Sh7i9UZ4z8cyhGxJUwgkos4wqPU8g1QyVYZCepHUoBxotZECQw9RNRzKPAhhCbQG7KLRWkMCOwbGZFcWJfIaOt5VZylUxx6dhcCsZ5YLHETpE6hHkTBw4qTO1rZKKwTONxVvWmIWDuAdwU9E7ltmrk_4XPGic8f_3PKBPkLLaz1cwbZHTl6WpyE_L7lXAyv10m9frYL7ZXwxE |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E5%9F%BA%E4%BA%8EOncomine%E6%95%B0%E6%8D%AE%E5%BA%93%E8%8D%9F%E8%90%83%E5%88%86%E6%9E%90KIF23%E5%9C%A8%E9%9D%9E%E5%B0%8F%E7%BB%86%E8%83%9E%E8%82%BA%E7%99%8C%E4%B8%AD%E7%9A%84%E8%A1%A8%E8%BE%BE%E5%92%8C%E6%84%8F%E4%B9%89&rft.jtitle=%E4%B8%AD%E5%9B%BD%E8%82%BA%E7%99%8C%E6%9D%82%E5%BF%97&rft.au=%E5%8F%B6%E4%BA%AE&rft.au=%E6%9D%8E%E6%85%A7%E5%A8%9F&rft.au=%E5%BC%A0%E6%96%B9&rft.au=%E5%90%95%E9%95%97%E7%83%BD&rft.date=2017&rft.pub=210006%E5%8D%97%E4%BA%AC%2C%E5%8D%97%E4%BA%AC%E5%8C%BB%E7%A7%91%E5%A4%A7%E5%AD%A6%E9%87%91%E9%99%B5%E4%B8%B4%E5%BA%8A%E5%8C%BB%E5%AD%A6%E9%99%A2%E5%91%BC%E5%90%B8%E5%86%85%E7%A7%91&rft.issn=1009-3419&rft.volume=20&rft.issue=12&rft.spage=822&rft.epage=826&rft_id=info:doi/10.3779%2Fj.issn.1009-3419.2017.12.05&rft.externalDocID=zgfazz201712006 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F91098A%2F91098A.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzgfazz%2Fzgfazz.jpg |