高脂模型长爪沙鼠生化指标变化
目的观察高脂饲料喂养14周的长爪沙鼠生化指标变化。方法选取雄性长爪沙鼠20只,随机分为高脂饲料组和对照组,每组10只。对照组喂养普通饲料,高脂饲料组喂养含1.0%胆固醇、20.0%猪油的高脂饲料。14周后颌下静脉丛采血,检测血糖（GLU）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）等。结果高脂饲料组长爪沙鼠血清TC、LDL-C、TG、HDL-C水平[分别为（14.27±2.97）、（4.72±1.94）、（3.04±1.22）、（3.43±0.90）mmol/L]明显高于对照组[分别为（1.72±0.22）、（0.19±0.09）、（...
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| Published in | 现代医药卫生 Vol. 31; no. 24; pp. 3704 - 3705 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
广东医学院生物化学与分子生物学教研室,广东东莞,523808%东莞市慢性病防治院检验科,广东,523008
2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1009-5519 |
| DOI | 10.3969/j.issn.1009-5519.2015.24.006 |
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| Abstract | 目的观察高脂饲料喂养14周的长爪沙鼠生化指标变化。方法选取雄性长爪沙鼠20只,随机分为高脂饲料组和对照组,每组10只。对照组喂养普通饲料,高脂饲料组喂养含1.0%胆固醇、20.0%猪油的高脂饲料。14周后颌下静脉丛采血,检测血糖（GLU）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）等。结果高脂饲料组长爪沙鼠血清TC、LDL-C、TG、HDL-C水平[分别为（14.27±2.97）、（4.72±1.94）、（3.04±1.22）、（3.43±0.90）mmol/L]明显高于对照组[分别为（1.72±0.22）、（0.19±0.09）、（1.53±0.49）、（1.46±0.25）mmol/L],差异均有统计学意义（P〈0.01）。GLU水平[（6.47±0.55）mmol/L]低于对照组[（8.19±1.02）mmol/L],但差异无统计学意义（P〉0.05）。结论高脂饲料喂养能明显升高长爪沙鼠血脂水平,导致长爪沙鼠高脂血症。 |
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| AbstractList | 目的观察高脂饲料喂养14周的长爪沙鼠生化指标变化。方法选取雄性长爪沙鼠20只，随机分为高脂饲料组和对照组，每组10只。对照组喂养普通饲料，高脂饲料组喂养含1.0%胆固醇、20.0%猪油的高脂饲料。14周后颌下静脉丛采血，检测血糖（GLU）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）等。结果高脂饲料组长爪沙鼠血清TC、LDL-C、TG、HDL-C水平[分别为（14.27±2.97）、（4.72±1.94）、（3.04±1.22）、（3.43±0.90）mmol/L]明显高于对照组[分别为（1.72±0.22）、（0.19±0.09）、（1.53±0.49）、（1.46±0.25）mmol/L]，差异均有统计学意义（P<0.01）。GLU水平[（6.47±0.55）mmol/L]低于对照组[（8.19±1.02）mmol/L]，但差异无统计学意义（P＞0.05）。结论高脂饲料喂养能明显升高长爪沙鼠血脂水平，导致长爪沙鼠高脂血症。 目的观察高脂饲料喂养14周的长爪沙鼠生化指标变化。方法选取雄性长爪沙鼠20只,随机分为高脂饲料组和对照组,每组10只。对照组喂养普通饲料,高脂饲料组喂养含1.0%胆固醇、20.0%猪油的高脂饲料。14周后颌下静脉丛采血,检测血糖（GLU）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）等。结果高脂饲料组长爪沙鼠血清TC、LDL-C、TG、HDL-C水平[分别为（14.27±2.97）、（4.72±1.94）、（3.04±1.22）、（3.43±0.90）mmol/L]明显高于对照组[分别为（1.72±0.22）、（0.19±0.09）、（1.53±0.49）、（1.46±0.25）mmol/L],差异均有统计学意义（P〈0.01）。GLU水平[（6.47±0.55）mmol/L]低于对照组[（8.19±1.02）mmol/L],但差异无统计学意义（P〉0.05）。结论高脂饲料喂养能明显升高长爪沙鼠血脂水平,导致长爪沙鼠高脂血症。 |
| Abstract_FL | Objective To observe the change of serum biochemical indicators in Mongolian gerbils fed by 14-week high-fat diet. Methods 20 male Mongolian gerbils were selected and randomly divided into the high-fat fodder group and the control group,10 cases in each group. The control group was fed with common fodder ,while the high-fat fodder group was given the high-fat fodder containing 1.0%cholesterol and 20.0%lard. The venous blood was collected by submaxillary venous plexus after 14 weeks. The serum GLU,TG,TC,HDL-C and LDL-C,etc. were detected. Results The levels of serum TC,LDL-C,TG and HDL-C in the high-fat fodder group were (14.27±2.97),(4.72±1.94),(3.04±1.22),(3.43±0.90)mmol/L respectively,which were sig-nificantly higher than (1.72±0.22),(0.19±0.09),(1.53±0.49),(1.46±0.25) mmol/L in the control group respectively,the differ-ences were statistically significant(P<0.01),but the GLU level was lower than that in the control group without statistical difference [(6.47±0.55)mmol/L vs.(8.19±1.02)mmol/L,P>0.05]. Conclusion The high-fat fodder feeding can significantly increase serum lipid level in Mongolian gerbils and induces its hyperlipidemia. |
| Author | 唐菀泽 向乐 林东子 刘慧明 覃燕梅 丁航 |
| AuthorAffiliation | 广东医学院生物化学与分子生物学教研室,广东东莞523808 东莞市慢性病防治院检验科,广东523008 |
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| Author_FL | Tang Wanze Xiang Le Liu Huiming Ding Hang Lin Dongzi Qin Yanmei |
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| Keywords | 实验室技术和方法 沙鼠亚科 Laboratory techniques and procedures Gerbillinae 血清 Biological parameters 生化指标 Serum 疾病模型,动物 Disease models,animal |
| Language | Chinese |
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| Notes | Disease models; animal; Gerbillinae; Serum; Laboratory techniques and procedures; Biological parameters Tang Wanze,Xiang Le ,Lin Dongzi, Liu Huiming, Qin Yanmei, Ding Hang （ 1. Teaching and Researching Section of Biochemistry and Molec ular Biology, Guangdong Medical College, Dongguan, Guangdong 523808, China; 2. Department of Clinical Laboratory,Dongguan Municipal Hospital for Prevention and Treatment of Chronic Diseases, Guangdong 523008, China） Objective To observe the change of serum biochemical indicators in Mongolian gerbils fed by 14-week highfat diet. Methods 20 male Mongolian gerbils were selected and randomly divided into the high-fat fodder group and the control group,10 cases in each group. The control group was fed with common fodder,while the high-fat fodder group was given the highfat fodder containing 1.0% cholesterol and 20.0% lard. The venous blood was collected by submaxillary venous plexus after 14 weeks. The serum GLU,TG,TC,HDL-C and LDL-C,etc. were detected. Results The levels of serum TC, |
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| Publisher | 广东医学院生物化学与分子生物学教研室,广东东莞,523808%东莞市慢性病防治院检验科,广东,523008 |
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| Snippet | 目的观察高脂饲料喂养14周的长爪沙鼠生化指标变化。方法选取雄性长爪沙鼠20只,随机分为高脂饲料组和对照组,每组10只。对照组喂养普通饲料,高脂饲料组喂养含1.0%胆固醇、20.0%... 目的观察高脂饲料喂养14周的长爪沙鼠生化指标变化。方法选取雄性长爪沙鼠20只，随机分为高脂饲料组和对照组，每组10只。对照组喂养普通饲料，高脂饲料组喂养含1.0%胆固... |
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| SubjectTerms | 实验室技术和方法 沙鼠亚科 生化指标 疾病模型,动物 血清 |
| Title | 高脂模型长爪沙鼠生化指标变化 |
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