MDA5 variants trade antiviral activity for protection from autoimmune disease - Wallace, Chris; Singh, Rahul; Modis, Yorgo (BMC medical genomics, 2025)
Keywords: Analysis; Antiviral activity; Antiviral agents; Autoimmune disease; Autoimmune diseases; Autoimmune Diseases - genetics; Biomedical and Life Sciences; Biomedicine; Crohn's disease; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - genetics; Double-stranded RNA; Fitness trade-off; Gastrointestinal diseases; Gene Expression; Genes; Genetic analysis; Genetic aspects; Genetic diversity; Genetic Predisposition to Disease; Genetic research; Genome-wide association studies; Genome-wide association studies (GWAS); Genome-Wide Association Study; Genomics; Health aspects; Human genetic variants; Human Genetics; Humans; Hypothyroidism; Infections; Inflammation; Inflammatory bowel disease; Inflammatory bowel disease (IBD); Inflammatory bowel diseases; Inflammatory Bowel Diseases - genetics; Interferon-Induced Helicase, IFIH1 - genetics; Microarrays; Physiological aspects; Polymorphism, Single Nucleotide; Psoriasis; Psoriasis - genetics; Risk factors; RNA; RNA viruses; Thyroid hormones; Type 1 diabetes; Type 1 diabetes (T1D); Viral infections; White people; United Kingdom; Fitness trade-off; Autoimmune disease; Genome-wide association studies (GWAS); Inflammatory bowel disease (IBD); Human genetic variants; Type 1 diabetes (T1D)