Association of atherogenic indices and triglyceride-total cholesterol-body weight index (TCBI) with severity of stenosis in patients undergoing angiography: a case-control study

• Published in: BMC research notes Vol. 18; no. 1; pp. 180 - 9
• Main Authors: Imannezhad, Mobina, Kamrani, Farzam, Shariatikia, Ali, Nasrollahi, Mahsa, Mahaki, Hanie, Rezaee, Ali, Moohebati, Mohsen, Shahri, Seyed Hamed Hashemi, Darroudi, Susan
• Format: Journal Article
• Language: English
• Published: London BioMed Central 17.04.2025; BioMed Central Ltd; BMC
• Subjects: Aged; Angiography; Arteriosclerosis; Atherogenic indexes; Atherosclerosis; Atherosclerosis - blood; Atherosclerosis - diagnostic imaging; Biomedical and Life Sciences; Biomedicine; Body Weight; Cardiovascular disease; Case-Control Studies; Cholesterol; Cholesterol - blood; Constriction, Pathologic; Coronary Angiography; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - diagnostic imaging; Coronary Stenosis - blood; Coronary Stenosis - diagnostic imaging; Coronary vessels; Development and progression; Diabetes; Female; Health aspects; Heart diseases; High density lipoprotein; Humans; Life Sciences; Lipids; Male; Medical imaging; Medical research; Medicine, Experimental; Medicine/Public Health; Middle Aged; Nutritional index; Physiological aspects; Regression analysis; Research Note; Risk Factors; Sample size; Severity of Illness Index; Software; Statistical analysis; Stenosis; Triglycerides; Triglycerides - blood; Variance analysis; Womens health; Iran; Atherogenic indexes; Nutritional index; Angiography; Coronary artery disease; Atherosclerosis
• ISSN: 1756-0500; 1756-0500
• DOI: 10.1186/s13104-025-07203-5

Objectives Coronary artery disease, caused by atherosclerosis, necessitates assessing plaque formation risk using indices like the atherogenic index of plasma (AIP), Castelli’s risk indexes (CRI-I and CRI-II), the atherogenic coefficient (AC), and the triglyceride-total cholesterol-body weight index (TCBI). Although TCBI primarily assesses mortality risk, its relationship with stenosis severity is unclear. Utilizing data from a prior study, a case-control analysis was conducted on 1,187 subjects, which included 781 patients who underwent coronary angiography and 406 healthy controls. The indices were compared across varying degrees of arterial blockages. Results AIP significantly correlated with stenosis severity in women, increasing the risk of three-vessel stenosis by 2.5 times. AC raised the risk of single-vessel stenosis in men by 2.7 times. CRI-I and CRI-II showed a positive relationship with arterial stenosis in women, with CRI-I increasing the risk of two and three-vessel blockages by 21.9% and 22.4%, respectively. A one-unit increase in CRI-II raised the risk by 33.1% for two arteries and 25.3% for three. In conclusion, AIP, CRI-I, and CRI-II in women, along with AC in men, correlated with arterial stenosis severity, while TCBI did not. Further research is needed to determine which index is most effective in predicting CAD risk. Graphical Abstract