Drug repurposing for Alzheimer’s disease using a graph-of-thoughts based large language model to infer drug-disease relationships in a comprehensive knowledge graph - Wang, Zhiping Paul; Li, Xi; Matsumoto, Nicholas; Venkatesan, Mythreye; Chang, Jui-Hsuan; Moran, Jay; Choi, Hyunjun; Li, Binglan; Meng, Yufei; Hernandez, Miguel E.; Moore, Jason H. (BioData mining, 2025)
Keywords: Advances in Data Mining for Biomedical Informatics and Healthcare; Algorithms; Alzheimer's disease; Artificial intelligence; Bioinformatics; Biomedical and Life Sciences; Chatbots; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Data Mining and Knowledge Discovery; Drug development; Drug discovery; Drug therapy; Graphs; Knowledge bases (artificial intelligence); Knowledge representation; Large language models; Learning algorithms; Life Sciences; Machine learning; Methods; Neurodegenerative diseases; Patient outcomes; Performance enhancement; Performance evaluation; United States