原发不育及反复自然流产史夫妇单纯男方染色体异常核型分析
目的探讨男方染色体异常核型对原发不育及女方反复自然流产的影响。方法通过外周血淋巴细胞培养对2009年11月至2014年12月在该院就诊的1 170对原发不育及1 601对反复自然流产史夫妇的染色体进行G显带染色分析,排除女方染色体核型异常,对单纯男方染色体核型异常的患者进行核型分析。结果 （1）1 170对原发不育夫妇中,单纯男方染色体核型异常共147例,检出率为12.6%。其中数目异常22例（15.0%）,结构异常14例（9.5%）。同时检出染色体多态变异111例（75.5%）,其中大Y染色体43例（29.3%）,小Y染色体46例（31.3%）。（2）1 601对反复自然流产史夫妇中,单纯男...
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| Published in | 现代医药卫生 Vol. 32; no. 18; pp. 2796 - 2799 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
南京医科大学附属常州市妇幼保健院生殖健康实验室,江苏常州,213000
2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1009-5519 |
| DOI | 10.3969/j.issn.1009-5519.2016.18.005 |
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| Abstract | 目的探讨男方染色体异常核型对原发不育及女方反复自然流产的影响。方法通过外周血淋巴细胞培养对2009年11月至2014年12月在该院就诊的1 170对原发不育及1 601对反复自然流产史夫妇的染色体进行G显带染色分析,排除女方染色体核型异常,对单纯男方染色体核型异常的患者进行核型分析。结果 （1）1 170对原发不育夫妇中,单纯男方染色体核型异常共147例,检出率为12.6%。其中数目异常22例（15.0%）,结构异常14例（9.5%）。同时检出染色体多态变异111例（75.5%）,其中大Y染色体43例（29.3%）,小Y染色体46例（31.3%）。（2）1 601对反复自然流产史夫妇中,单纯男方染色体核型异常共180例,检出率为11.2%。其中数目异常5例（2.8%）,结构异常39例（21.7%）。同时检出染色体多态变异136例（75.6%）,其中大Y染色体52例（28.9%）,小Y染色体61例（33.9%）。（3）大Y染色体、小Y染色体在原发不育和反复自然流产史夫妇中的构成比比较,差异均无统计学意义（P〉0.05）;47,XXY核型在原发不育夫妇中的构成比（8.8%）高于反复自然流产史夫妇（0.6%）,差异有统计学意义（P〈0.05）;染色体结构异常在反复自然流产史夫妇中的构成比（21.7%）高于原发不育夫妇（9.5%）,差异有统计学意义P〈0.05）。结论男方染色体异常是导致原发不育和女方反复自然流产的重要因素,Y染色体数目与形态结构的异常对男性生育能力有重要影响。 |
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| AbstractList | 目的探讨男方染色体异常核型对原发不育及女方反复自然流产的影响。方法通过外周血淋巴细胞培养对2009年11月至2014年12月在该院就诊的1 170对原发不育及1 601对反复自然流产史夫妇的染色体进行G显带染色分析,排除女方染色体核型异常,对单纯男方染色体核型异常的患者进行核型分析。结果 （1）1 170对原发不育夫妇中,单纯男方染色体核型异常共147例,检出率为12.6%。其中数目异常22例（15.0%）,结构异常14例（9.5%）。同时检出染色体多态变异111例（75.5%）,其中大Y染色体43例（29.3%）,小Y染色体46例（31.3%）。（2）1 601对反复自然流产史夫妇中,单纯男方染色体核型异常共180例,检出率为11.2%。其中数目异常5例（2.8%）,结构异常39例（21.7%）。同时检出染色体多态变异136例（75.6%）,其中大Y染色体52例（28.9%）,小Y染色体61例（33.9%）。（3）大Y染色体、小Y染色体在原发不育和反复自然流产史夫妇中的构成比比较,差异均无统计学意义（P〉0.05）;47,XXY核型在原发不育夫妇中的构成比（8.8%）高于反复自然流产史夫妇（0.6%）,差异有统计学意义（P〈0.05）;染色体结构异常在反复自然流产史夫妇中的构成比（21.7%）高于原发不育夫妇（9.5%）,差异有统计学意义P〈0.05）。结论男方染色体异常是导致原发不育和女方反复自然流产的重要因素,Y染色体数目与形态结构的异常对男性生育能力有重要影响。 目的探讨男方染色体异常核型对原发不育及女方反复自然流产的影响。方法通过外周血淋巴细胞培养对2009年11月至2014年12月在该院就诊的1170对原发不育及1601对反复自然流产史夫妇的染色体进行G显带染色分析，排除女方染色体核型异常，对单纯男方染色体核型异常的患者进行核型分析。结果（1）1170对原发不育夫妇中，单纯男方染色体核型异常共147例，检出率为12.6%。其中数目异常22例（15.0％），结构异常14例（9.5％）。同时检出染色体多态变异111例（75.5％），其中大Y染色体43例（29.3%），小Y染色体46例（31.3%）。（2）1601对反复自然流产史夫妇中，单纯男方染色体核型异常共180例，检出率为11.2%。其中数目异常5例（2.8％），结构异常39例（21.7％）。同时检出染色体多态变异136例（75.6％），其中大Y染色体52例（28.9%），小Y染色体61例（33.9%）。（3）大Y染色体、小Y染色体在原发不育和反复自然流产史夫妇中的构成比比较，差异均无统计学意义（P>0.05）；47，XXY核型在原发不育夫妇中的构成比（8.8%）高于反复自然流产史夫妇（0.6%），差异有统计学意义（P<0.05）；染色体结构异常在反复自然流产史夫妇中的构成比（21.7%）高于原发不育夫妇（9.5%），差异有统计学意义P<0.05）。结论男方染色体异常是导致原发不育和女方反复自然流产的重要因素，Y染色体数目与形态结构的异常对男性生育能力有重要影响。 |
| Abstract_FL | Objective To investigate the effects of male chromosomal abnormal karyotype on primary infertility and re-current spontaneous abortion in the wife′s side. Methods The peripheral blood lymphocytes were cultured to perform the G banding chromosome analysis in 1 170 couples of primary infertility and the couples of recurrent spontaneous abortion in our hos-pital from November 2009 to December 2014 ,after excluding the female chromosomal abnormal karyotype ,the patients with pure male chromosomal abnormal karyotype were performed the karyotype analysis. Results (1)In 1 170 primary infertile couples, 147 cases were pure male chromosome abnormalities with the detection rate of 12.6%. Among them ,22 cases (15.0%) were num-ber abnormality and 14 cases (9.5%)were structural abnormality. At the same time ,111 cases (75.5%) of chromosome polymor-phic abnormality was detected,including 43 cases(29.3%) of large Y chromosome and 46 cases(31.3%) of small Y chromosome. (2)In 1 601 recurrent spontaneous abortion couples,180 cases were pure male karyotype abnormality,the detection rate was 11. 2%. Among them,5 cases(2.8%)were the number abnormality and 39 cases(21.7%)were structural abnormality. At the same time 136 cases(75.6%) of chromosomal polymorphism variation were detected,including 52 cases(28.9%) of large Y chromosome and 61 cases(33.9%) of small Y chromosome.(3)The constituent ratios of big Y chromosome and small Y chromosome had no statisti-cal difference between primary infertility couples and recurrent spontaneous abortion couples (P>0.05);the constituent ratio of 47, XXY karyotype in primary infertility couples was higher than that in recurrent abortion couples ,the difference was statistically significant(8.8%vs. 0.6%,P<0.05);the constituent ratio of chromosome structure abnormality in recurrent spontaneous abortion couples was 21.7%,which was higher than 9.5%in primary infertile couples,the difference was statistically significant(P<0.05). Conclusion The male chromosomal abnormality is an important factor leading to primary infertility and recurrent spontaneous abortion in the wife′s side. Y chromosome number and morphological and structural abnormalities have an important influence on male fertility ability. |
| Author | 朱自强 张峰 孔静 史烨 郑芳秀 虞斌 |
| AuthorAffiliation | 南京医科大学附属常州市妇幼保健院生殖健康实验室,江苏常州213000 |
| AuthorAffiliation_xml | – name: 南京医科大学附属常州市妇幼保健院生殖健康实验室,江苏常州,213000 |
| Author_FL | Zhang Feng Zhu Ziqiang Zheng Fangxiu Shi Ye Yu Bin Kong Jing |
| Author_FL_xml | – sequence: 1 fullname: Zhu Ziqiang – sequence: 2 fullname: Zhang Feng – sequence: 3 fullname: Kong Jing – sequence: 4 fullname: Shi Ye – sequence: 5 fullname: Zheng Fangxiu – sequence: 6 fullname: Yu Bin |
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| Keywords | 染色体畸变 Translocation,genetic 流产,习惯性 Abortion,habitual Infertility Karyotyping 不育 易位,遗传 核型分析 Chromosome aberrations |
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| Notes | Zhu Ziqiang,Zhang Feng,Kong Jing,Shi Ye ,Zheng Fangxiu, Yu Bin（Reproductive Health Laboratory,Affiliated Changzhou Municipal Women and Children Health Care Hospital, Nanjing Medical University, Changzhou , Jiangsu 213000, China） Objective To investigate the effects of male chromosomal abnormal karyotype on primary infertility and re-current spontaneous abortion in the wife′ s side. Methods The peripheral blood lymphocytes were cultured to perform the G banding chromosome analysis in 1 170 couples of primary infertility and the couples of recurrent spontaneous abortion in our hos-pital from November 2009 to December 2014,after excluding the female chromosomal abnormal karyotype,the patients with pure male chromosomal abnormal karyotype were performed the karyotype analysis. Results（1）In 1 170 primary infertile couples,147 cases were pure male chromosome abnormalities with the detection rate of 12.6%. Among them,22 cases（15.0%） were number abnormality and 14 cases（9.5%）were structural abnormality. At the same ti |
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| PublicationTitle | 现代医药卫生 |
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| Publisher | 南京医科大学附属常州市妇幼保健院生殖健康实验室,江苏常州,213000 |
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| Snippet | 目的探讨男方染色体异常核型对原发不育及女方反复自然流产的影响。方法通过外周血淋巴细胞培养对2009年11月至2014年12月在该院就诊的1 170对原发不育及1 601对反复自然流产... 目的探讨男方染色体异常核型对原发不育及女方反复自然流产的影响。方法通过外周血淋巴细胞培养对2009年11月至2014年12月在该院就诊的1170对原发不育及1601对反复自然流产史... |
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| SubjectTerms | 不育 易位,遗传 染色体畸变 核型分析 流产,习惯性 |
| Title | 原发不育及反复自然流产史夫妇单纯男方染色体异常核型分析 |
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