Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO
The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and the brain’s resident macrophages, microglia. Although initiation of an inflammatory response may be beneficial in response to injury of the n...
Saved in:
| Published in | Molecular imaging Vol. 17; p. 1536012118792317 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Los Angeles, CA
SAGE Publications
01.01.2018
Sage Publications Ltd SAGE Publishing |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1536-0121 1535-3508 1536-0121 |
| DOI | 10.1177/1536012118792317 |
Cover
| Abstract | The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and the brain’s resident macrophages, microglia. Although initiation of an inflammatory response may be beneficial in response to injury of the nervous system, chronic or maladaptive neuroinflammation can have harmful outcomes in many neurological diseases. An acute neuroinflammatory response is protective when activated neuroglia facilitate tissue repair by releasing anti-inflammatory cytokines and neurotrophic factors. On the other hand, chronic neuroglial activation is a major pathological mechanism in neurodegenerative diseases, likely contributing to neuronal dysfunction, injury, and disease progression. Therefore, the development of specific and sensitive probes for positron emission tomography (PET) studies of neuroinflammation is attracting immense scientific and clinical interest. An early phase of this research emphasized PET studies of the prototypical imaging biomarker of glial activation, translocator protein-18 kDa (TSPO), which presents difficulties for quantitation and lacks absolute cellular specificity. Many alternate molecular targets present themselves for PET imaging of neuroinflammation in vivo, including enzymes, intracellular signaling molecules as well as ionotropic, G-protein coupled, and immunoglobulin receptors. We now review the lead structures in radiotracer development for PET studies of neuroinflammation targets for neurodegenerative diseases extending beyond TSPO, including glycogen synthase kinase 3, monoamine oxidase-B, reactive oxygen species, imidazoline-2 binding sites, cyclooxygenase, the phospholipase A2/arachidonic acid pathway, sphingosine-1-phosphate receptor-1, cannabinoid-2 receptor, the chemokine receptor CX3CR1, purinergic receptors: P2X7 and P2Y12, the receptor for advanced glycation end products, Mer tyrosine kinase, and triggering receptor expressed on myeloid cells-1. We provide a brief overview of the cellular expression and function of these targets, noting their selectivity for astrocytes and/or microglia, and highlight the classes of PET radiotracers that have been investigated in early-stage preclinical or clinical research studies of neuroinflammation. |
|---|---|
| AbstractList | The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and the brain’s resident macrophages, microglia. Although initiation of an inflammatory response may be beneficial in response to injury of the nervous system, chronic or maladaptive neuroinflammation can have harmful outcomes in many neurological diseases. An acute neuroinflammatory response is protective when activated neuroglia facilitate tissue repair by releasing anti-inflammatory cytokines and neurotrophic factors. On the other hand, chronic neuroglial activation is a major pathological mechanism in neurodegenerative diseases, likely contributing to neuronal dysfunction, injury, and disease progression. Therefore, the development of specific and sensitive probes for positron emission tomography (PET) studies of neuroinflammation is attracting immense scientific and clinical interest. An early phase of this research emphasized PET studies of the prototypical imaging biomarker of glial activation, translocator protein-18 kDa (TSPO), which presents difficulties for quantitation and lacks absolute cellular specificity. Many alternate molecular targets present themselves for PET imaging of neuroinflammation in vivo, including enzymes, intracellular signaling molecules as well as ionotropic, G-protein coupled, and immunoglobulin receptors. We now review the lead structures in radiotracer development for PET studies of neuroinflammation targets for neurodegenerative diseases extending beyond TSPO, including glycogen synthase kinase 3, monoamine oxidase-B, reactive oxygen species, imidazoline-2 binding sites, cyclooxygenase, the phospholipase A2/arachidonic acid pathway, sphingosine-1-phosphate receptor-1, cannabinoid-2 receptor, the chemokine receptor CX3CR1, purinergic receptors: P2X7 and P2Y12, the receptor for advanced glycation end products, Mer tyrosine kinase, and triggering receptor expressed on myeloid cells-1. We provide a brief overview of the cellular expression and function of these targets, noting their selectivity for astrocytes and/or microglia, and highlight the classes of PET radiotracers that have been investigated in early-stage preclinical or clinical research studies of neuroinflammation. The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and the brain’s resident macrophages, microglia. Although initiation of an inflammatory response may be beneficial in response to injury of the nervous system, chronic or maladaptive neuroinflammation can have harmful outcomes in many neurological diseases. An acute neuroinflammatory response is protective when activated neuroglia facilitate tissue repair by releasing anti-inflammatory cytokines and neurotrophic factors. On the other hand, chronic neuroglial activation is a major pathological mechanism in neurodegenerative diseases, likely contributing to neuronal dysfunction, injury, and disease progression. Therefore, the development of specific and sensitive probes for positron emission tomography (PET) studies of neuroinflammation is attracting immense scientific and clinical interest. An early phase of this research emphasized PET studies of the prototypical imaging biomarker of glial activation, translocator protein-18 kDa (TSPO), which presents difficulties for quantitation and lacks absolute cellular specificity. Many alternate molecular targets present themselves for PET imaging of neuroinflammation in vivo, including enzymes, intracellular signaling molecules as well as ionotropic, G-protein coupled, and immunoglobulin receptors. We now review the lead structures in radiotracer development for PET studies of neuroinflammation targets for neurodegenerative diseases extending beyond TSPO, including glycogen synthase kinase 3, monoamine oxidase-B, reactive oxygen species, imidazoline-2 binding sites, cyclooxygenase, the phospholipase A2/arachidonic acid pathway, sphingosine-1-phosphate receptor-1, cannabinoid-2 receptor, the chemokine receptor CX3CR1, purinergic receptors: P2X 7 and P2Y 12 , the receptor for advanced glycation end products, Mer tyrosine kinase, and triggering receptor expressed on myeloid cells-1. We provide a brief overview of the cellular expression and function of these targets, noting their selectivity for astrocytes and/or microglia, and highlight the classes of PET radiotracers that have been investigated in early-stage preclinical or clinical research studies of neuroinflammation. The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and the brain's resident macrophages, microglia. Although initiation of an inflammatory response may be beneficial in response to injury of the nervous system, chronic or maladaptive neuroinflammation can have harmful outcomes in many neurological diseases. An acute neuroinflammatory response is protective when activated neuroglia facilitate tissue repair by releasing anti-inflammatory cytokines and neurotrophic factors. On the other hand, chronic neuroglial activation is a major pathological mechanism in neurodegenerative diseases, likely contributing to neuronal dysfunction, injury, and disease progression. Therefore, the development of specific and sensitive probes for positron emission tomography (PET) studies of neuroinflammation is attracting immense scientific and clinical interest. An early phase of this research emphasized PET studies of the prototypical imaging biomarker of glial activation, translocator protein-18 kDa (TSPO), which presents difficulties for quantitation and lacks absolute cellular specificity. Many alternate molecular targets present themselves for PET imaging of neuroinflammation in vivo, including enzymes, intracellular signaling molecules as well as ionotropic, G-protein coupled, and immunoglobulin receptors. We now review the lead structures in radiotracer development for PET studies of neuroinflammation targets for neurodegenerative diseases extending beyond TSPO, including glycogen synthase kinase 3, monoamine oxidase-B, reactive oxygen species, imidazoline-2 binding sites, cyclooxygenase, the phospholipase A2/arachidonic acid pathway, sphingosine-1-phosphate receptor-1, cannabinoid-2 receptor, the chemokine receptor CX3CR1, purinergic receptors: P2X and P2Y , the receptor for advanced glycation end products, Mer tyrosine kinase, and triggering receptor expressed on myeloid cells-1. We provide a brief overview of the cellular expression and function of these targets, noting their selectivity for astrocytes and/or microglia, and highlight the classes of PET radiotracers that have been investigated in early-stage preclinical or clinical research studies of neuroinflammation. The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and the brain's resident macrophages, microglia. Although initiation of an inflammatory response may be beneficial in response to injury of the nervous system, chronic or maladaptive neuroinflammation can have harmful outcomes in many neurological diseases. An acute neuroinflammatory response is protective when activated neuroglia facilitate tissue repair by releasing anti-inflammatory cytokines and neurotrophic factors. On the other hand, chronic neuroglial activation is a major pathological mechanism in neurodegenerative diseases, likely contributing to neuronal dysfunction, injury, and disease progression. Therefore, the development of specific and sensitive probes for positron emission tomography (PET) studies of neuroinflammation is attracting immense scientific and clinical interest. An early phase of this research emphasized PET studies of the prototypical imaging biomarker of glial activation, translocator protein-18 kDa (TSPO), which presents difficulties for quantitation and lacks absolute cellular specificity. Many alternate molecular targets present themselves for PET imaging of neuroinflammation in vivo, including enzymes, intracellular signaling molecules as well as ionotropic, G-protein coupled, and immunoglobulin receptors. We now review the lead structures in radiotracer development for PET studies of neuroinflammation targets for neurodegenerative diseases extending beyond TSPO, including glycogen synthase kinase 3, monoamine oxidase-B, reactive oxygen species, imidazoline-2 binding sites, cyclooxygenase, the phospholipase A2/arachidonic acid pathway, sphingosine-1-phosphate receptor-1, cannabinoid-2 receptor, the chemokine receptor CX3CR1, purinergic receptors: P2X7 and P2Y12, the receptor for advanced glycation end products, Mer tyrosine kinase, and triggering receptor expressed on myeloid cells-1. We provide a brief overview of the cellular expression and function of these targets, noting their selectivity for astrocytes and/or microglia, and highlight the classes of PET radiotracers that have been investigated in early-stage preclinical or clinical research studies of neuroinflammation.The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and the brain's resident macrophages, microglia. Although initiation of an inflammatory response may be beneficial in response to injury of the nervous system, chronic or maladaptive neuroinflammation can have harmful outcomes in many neurological diseases. An acute neuroinflammatory response is protective when activated neuroglia facilitate tissue repair by releasing anti-inflammatory cytokines and neurotrophic factors. On the other hand, chronic neuroglial activation is a major pathological mechanism in neurodegenerative diseases, likely contributing to neuronal dysfunction, injury, and disease progression. Therefore, the development of specific and sensitive probes for positron emission tomography (PET) studies of neuroinflammation is attracting immense scientific and clinical interest. An early phase of this research emphasized PET studies of the prototypical imaging biomarker of glial activation, translocator protein-18 kDa (TSPO), which presents difficulties for quantitation and lacks absolute cellular specificity. Many alternate molecular targets present themselves for PET imaging of neuroinflammation in vivo, including enzymes, intracellular signaling molecules as well as ionotropic, G-protein coupled, and immunoglobulin receptors. We now review the lead structures in radiotracer development for PET studies of neuroinflammation targets for neurodegenerative diseases extending beyond TSPO, including glycogen synthase kinase 3, monoamine oxidase-B, reactive oxygen species, imidazoline-2 binding sites, cyclooxygenase, the phospholipase A2/arachidonic acid pathway, sphingosine-1-phosphate receptor-1, cannabinoid-2 receptor, the chemokine receptor CX3CR1, purinergic receptors: P2X7 and P2Y12, the receptor for advanced glycation end products, Mer tyrosine kinase, and triggering receptor expressed on myeloid cells-1. We provide a brief overview of the cellular expression and function of these targets, noting their selectivity for astrocytes and/or microglia, and highlight the classes of PET radiotracers that have been investigated in early-stage preclinical or clinical research studies of neuroinflammation. |
| Author | Bernard-Gauthier, Vadim Dahl, Kenneth Vasdev, Neil Narayanaswami, Vidya Josephson, Lee Cumming, Paul |
| AuthorAffiliation | 3 Department of Radiology, Harvard Medical School, Boston, MA, USA 5 QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia 2 Azrieli Centre for Neuro-Radiochemistry, Research Imaging Centre, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada 1 Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, MA, USA 4 School of Psychology and Counselling and IHBI, Queensland University of Technology, Brisbane, Queensland, Australia |
| AuthorAffiliation_xml | – name: 5 QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia – name: 1 Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, MA, USA – name: 2 Azrieli Centre for Neuro-Radiochemistry, Research Imaging Centre, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada – name: 3 Department of Radiology, Harvard Medical School, Boston, MA, USA – name: 4 School of Psychology and Counselling and IHBI, Queensland University of Technology, Brisbane, Queensland, Australia |
| Author_xml | – sequence: 1 givenname: Vidya surname: Narayanaswami fullname: Narayanaswami, Vidya – sequence: 2 givenname: Kenneth surname: Dahl fullname: Dahl, Kenneth – sequence: 3 givenname: Vadim surname: Bernard-Gauthier fullname: Bernard-Gauthier, Vadim – sequence: 4 givenname: Lee surname: Josephson fullname: Josephson, Lee – sequence: 5 givenname: Paul surname: Cumming fullname: Cumming, Paul – sequence: 6 givenname: Neil surname: Vasdev fullname: Vasdev, Neil email: neil.vasdev@utoronto.ca |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30203712$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNUk1v1DAUjFARbRfunFAkLlwW_JHECQekUhZYqWIrWM7WS_wSvCT2Yiet9t_X2ZTSrgTiYNkaz8wbv-fT6MhYg1H0nJLXlArxhqY8I5RRmouCcSoeRScjNB-xo3vn4-jU-w0hjLCieBId83DigrKTaLfo0DXaNPHlYh1_BaVt76BC52MwKl6Da7D3cW1dvOxgT7R1_AUHZ7WpW-g66LU1sTYTqLBBgy6AVxh_0B7Bo38br4a-tfZn_B53drT9drl6Gj2uofX47HafRd8_Ltbnn-cXq0_L87OLeZUWST-vSFKkOecVTVWal5ATwJoUSmVZLlLByzIsVCzndUVJlhAoFeVU1UTVvEqAz6Ll5KssbOTW6Q7cTlrQcg9Y10hwva5alAg1CgKEFKASxkhJGAuAqEXJSAoYvOjkNZgt7K6hbe8MKZHjSOThSILm3aTZDmWHqkITGtw-CPLwxugfsrFXMqM8SYLHLHp1a-DsrwF9LzvtK2xbMGgHLxkloVCR52OtlwfUjR2cCe2VgcKFKPJ0ZL24n-guyu9fEQjZRKic9d5hLSvd7-ccAur2X28lB8L_aM98knho8E_cv_JvAD-l5eA |
| CitedBy_id | crossref_primary_10_1021_acs_jmedchem_1c01571 crossref_primary_10_3390_pharmaceutics12100925 crossref_primary_10_3389_fmed_2022_916693 crossref_primary_10_3390_ijms241311112 crossref_primary_10_1016_j_apsb_2020_08_006 crossref_primary_10_1007_s00259_022_06073_4 crossref_primary_10_1016_j_yexmp_2019_03_008 crossref_primary_10_1016_j_phro_2022_02_016 crossref_primary_10_2174_0929867329666221003101548 crossref_primary_10_1136_jnnp_2019_322402 crossref_primary_10_1016_j_tins_2020_08_008 crossref_primary_10_1016_j_ejmech_2021_113822 crossref_primary_10_1038_s41582_021_00537_1 crossref_primary_10_1111_pcn_13670 crossref_primary_10_1038_s41386_019_0561_y crossref_primary_10_3390_antiox10040528 crossref_primary_10_2478_afpuc_2021_0013 crossref_primary_10_1016_j_expneurol_2024_115071 crossref_primary_10_1038_s41380_024_02656_9 crossref_primary_10_1002_glia_23780 crossref_primary_10_3389_fneur_2020_505995 crossref_primary_10_1002_alz_12341 crossref_primary_10_1186_s13195_022_01016_5 crossref_primary_10_1097_j_pain_0000000000003247 crossref_primary_10_1038_s41598_024_65943_z crossref_primary_10_1002_alz_13678 crossref_primary_10_1038_s41380_021_01193_z crossref_primary_10_1002_jlcr_4019 crossref_primary_10_1007_s40211_023_00487_8 crossref_primary_10_1007_s11307_023_01875_w crossref_primary_10_1186_s13550_025_01202_0 crossref_primary_10_1177_1536012120927609 crossref_primary_10_1016_j_bbi_2023_07_023 crossref_primary_10_1186_s13550_022_00929_4 crossref_primary_10_1002_tcr_202300072 crossref_primary_10_1016_j_neubiorev_2021_06_027 crossref_primary_10_1002_ddr_22040 crossref_primary_10_1080_14787210_2020_1812384 crossref_primary_10_1192_bjo_2020_43 crossref_primary_10_1002_bkcs_12071 crossref_primary_10_1002_acn3_50837 crossref_primary_10_20900_jpbs_20230005 crossref_primary_10_3389_fncel_2020_00075 crossref_primary_10_1186_s13550_024_01085_7 crossref_primary_10_2147_JIR_S385825 crossref_primary_10_3390_biom13010164 crossref_primary_10_1016_j_cpet_2020_12_003 crossref_primary_10_1021_acschemneuro_4c00715 crossref_primary_10_1002_jlcr_3827 crossref_primary_10_1016_j_psychres_2020_113409 crossref_primary_10_2174_1381612828666220413094918 crossref_primary_10_1111_cei_13649 crossref_primary_10_3389_fnmol_2022_981442 crossref_primary_10_1016_j_nbd_2019_03_016 crossref_primary_10_1088_1361_6560_ad7221 crossref_primary_10_1016_j_critrevonc_2024_104266 crossref_primary_10_1136_bmj_n955 crossref_primary_10_1186_s13550_020_00617_1 crossref_primary_10_12688_wellcomeopenres_20153_1 crossref_primary_10_1016_j_semcdb_2019_01_011 crossref_primary_10_1021_acschemneuro_9b00081 crossref_primary_10_1016_j_tips_2019_11_005 crossref_primary_10_1016_S1474_4422_20_30139_3 crossref_primary_10_1021_acschemneuro_0c00802 crossref_primary_10_1016_j_bbr_2020_113004 crossref_primary_10_3390_ph15030276 crossref_primary_10_1016_j_expneurol_2024_114843 crossref_primary_10_1007_s00018_022_04211_7 crossref_primary_10_1007_s00259_021_05449_2 crossref_primary_10_7555_JBR_36_20220017 crossref_primary_10_1016_j_tins_2020_10_010 crossref_primary_10_1002_hlca_202400014 crossref_primary_10_1007_s13311_021_01027_4 crossref_primary_10_3390_molecules28030931 crossref_primary_10_1016_j_jneuroim_2018_11_010 crossref_primary_10_1097_WCO_0000000000001198 crossref_primary_10_1007_s10803_021_05095_5 crossref_primary_10_3390_ijms232315218 crossref_primary_10_1007_s11307_024_01972_4 crossref_primary_10_3389_fncel_2022_932572 crossref_primary_10_2214_AJR_21_26159 crossref_primary_10_3389_fnmol_2021_767041 crossref_primary_10_18203_2394_6040_ijcmph20243795 crossref_primary_10_3390_antiox12071411 crossref_primary_10_1038_s41598_021_82587_5 crossref_primary_10_3390_molecules25174017 crossref_primary_10_1007_s00259_021_05495_w crossref_primary_10_1007_s11030_024_10963_0 crossref_primary_10_3390_ijms23095023 crossref_primary_10_1016_j_radonc_2020_11_004 crossref_primary_10_62347_AICM8774 crossref_primary_10_1523_JNEUROSCI_1650_20_2020 crossref_primary_10_1007_s12035_022_03199_2 crossref_primary_10_3389_fnins_2020_00921 crossref_primary_10_3389_fmed_2019_00268 crossref_primary_10_1016_j_bionps_2023_100063 crossref_primary_10_1093_braincomms_fcac019 crossref_primary_10_1021_acscentsci_0c01076 crossref_primary_10_3390_molecules29174212 crossref_primary_10_1021_acschemneuro_0c00305 crossref_primary_10_3390_ijms21031029 crossref_primary_10_1016_S1470_2045_19_30461_9 crossref_primary_10_1002_hbm_25974 crossref_primary_10_1016_j_neuroimage_2021_117792 crossref_primary_10_3389_fmed_2024_1505440 crossref_primary_10_1016_j_bmcl_2019_04_036 crossref_primary_10_1039_D1MD00036E crossref_primary_10_1111_cei_13334 crossref_primary_10_3390_cells9122581 crossref_primary_10_3390_jpm11050371 crossref_primary_10_2174_0929867329666220329204054 crossref_primary_10_1038_s41380_020_0745_1 crossref_primary_10_1017_S003329171800421X crossref_primary_10_1038_s41582_020_00435_y crossref_primary_10_1002_jmri_29471 crossref_primary_10_2967_jnumed_119_229443 crossref_primary_10_1016_j_arr_2021_101544 crossref_primary_10_1093_braincomms_fcab011 crossref_primary_10_4103_amsr_amsr_52_23 crossref_primary_10_3390_nano12040600 crossref_primary_10_1002_jmri_28936 crossref_primary_10_1007_s00259_019_04462_w crossref_primary_10_1002_advs_202309021 crossref_primary_10_3389_fimmu_2020_00374 crossref_primary_10_23736_S0375_9393_22_16689_7 crossref_primary_10_3389_fnmol_2021_749737 crossref_primary_10_3390_molecules27238529 crossref_primary_10_1186_s13550_020_00683_5 crossref_primary_10_1002_alz_13699 crossref_primary_10_1097_j_pain_0000000000003342 |
| Cites_doi | 10.1016/j.tips.2009.05.005 10.1038/nrn3484 10.1016/j.bmcl.2014.11.048 10.1186/1742-2094-11-98 10.1016/j.diabres.2004.09.004 10.1021/acschemneuro.6b00056 10.1111/j.1471-4159.1990.tb03121.x 10.1002/glia.10180 10.1097/MNM.0000000000000660 10.1016/j.bcp.2012.05.005 10.2217/14796708.4.2.167 10.1016/j.drudis.2014.08.012 10.1007/s00259-010-1612-0 10.1016/j.biocel.2010.06.021 10.1016/S0169-328X(98)00040-0 10.1046/j.0953-816x.2001.01585.x 10.1016/j.cmet.2007.08.013 10.1016/j.expneurol.2007.07.004 10.1523/JNEUROSCI.04-02-00585.1984 10.1021/jm502021d 10.1111/j.1460-9568.2006.04671.x 10.1002/anie.201603797 10.1016/0024-3205(83)90062-0 10.1016/S1567-5769(01)00147-3 10.1002/glia.10293 10.1016/0166-2236(96)10049-7 10.1016/j.bmc.2013.08.019 10.1111/j.1471-4159.2007.05194.x 10.4161/cc.23067 10.1016/j.jneuroim.2017.11.002 10.3390/ijms18040785 10.1007/s12350-015-0391-1 10.1001/archneur.62.11.1734 10.1002/jlcr.3206 10.2337/diabetes.49.2.263 10.1371/journal.pone.0016964 10.1194/jlr.R046300 10.2967/jnumed.110.087031 10.1007/s13311-012-0118-9 10.3390/molecules23030607 10.1016/j.nbd.2003.07.002 10.1016/j.pharep.2015.07.006 10.1186/alzrt269 10.1073/pnas.1615413114 10.1186/1742-2094-8-76 10.1111/jnc.13607 10.1007/s00401-009-0556-6 10.1038/jcbfm.2014.34 10.1038/sj.bjp.0707505 10.1007/s00005-014-0275-0 10.1016/j.tins.2009.08.002 10.1186/s12974-015-0291-y 10.1212/WNL.47.2.425 10.1007/s11307-016-0944-y 10.1111/j.1471-4159.2004.02422.x 10.1186/s13024-017-0162-3 10.1016/j.bmc.2014.08.009 10.4236/pp.2013.48089 10.1007/s11307-005-0016-1 10.1016/j.bmcl.2010.11.026 10.1124/pr.107.07113 10.1111/j.1476-5381.2011.01302.x 10.1152/physrev.00011.2010 10.1038/jcbfm.2014.160 10.1016/j.neuroscience.2009.12.020 10.1016/S0896-6273(02)00794-8 10.2174/0929867323666160418114826 10.1016/j.bmcl.2015.06.004 10.1006/exnr.2001.7732 10.1021/acs.jmedchem.7b00058 10.1242/jcs.00384 10.1073/pnas.1316510111 10.1016/j.nucmedbio.2014.04.008 10.1186/1742-2094-5-17 10.1002/ana.410150302 10.1016/j.jneuroim.2012.12.005 10.1073/pnas.88.9.3637 10.1523/JNEUROSCI.23-35-11136.2003 10.1074/jbc.272.28.17810 10.1007/s11481-006-9021-7 10.1016/j.nucmedbio.2014.03.025 10.4049/jimmunol.163.3.1628 10.1016/S0092-8674(00)80801-6 10.1046/j.1471-4159.1994.63010245.x 10.1016/j.bmcl.2015.03.021 10.3390/molecules15118260 10.1016/j.yexcr.2014.11.020 10.1196/annals.1403.002 10.1016/j.neuroscience.2015.05.018 10.2174/1568026616666160315142457 10.1523/JNEUROSCI.23-04-01398.2003 10.1096/fj.07-9411com 10.1021/acschemneuro.5b00223 10.1038/nature17623 10.1111/j.1476-5381.1994.tb14842.x 10.1038/nn1472 10.1016/S1046-2023(02)00083-X 10.1021/acschemneuro.5b00319 10.1016/j.jalz.2017.07.671 10.1177/1536012117731258 10.1212/WNL.0b013e31820d5ec1 10.1212/NXI.0000000000000080 10.1146/annurev-physiol-021909-135843 10.1002/jlcr.1908 10.1016/S0197-4580(00)00124-X 10.1038/nm1425 10.1038/sj.jcbfm.9600493 10.1017/cjn.2015.19 10.1007/7657_2012_53 10.3390/ijms151223672 10.1126/science.aag2590 10.1021/acsmedchemlett.5b00044 10.1155/2013/484613 10.1111/j.1749-6632.1999.tb09388.x 10.1021/jm5001858 10.2967/jnumed.114.141713 10.4049/jimmunol.181.1.338 10.1093/jnen/63.9.901 10.1016/j.nucmedbio.2011.09.005 10.1111/j.1365-2990.2006.00795.x 10.1242/jcs.138057 10.1016/j.jns.2013.02.011 10.1007/s11302-009-9138-2 10.1016/j.jneuroim.2009.09.018 10.1016/j.bmcl.2015.05.085 10.1016/j.tips.2006.06.005 10.2174/138161208784480144 10.1111/jnc.12059 10.1016/j.nucmedbio.2017.05.011 10.1016/0896-6273(93)90192-T 10.1002/mds.26428 10.1038/nri2303 10.18632/aging.100021 10.1016/j.bmc.2011.03.041 10.1007/s00401-009-0619-8 10.1097/WAD.0b013e31815721c3 10.1021/acschemneuro.7b00385 10.1038/nrd3248 10.1038/nrn2398 10.1021/acsmedchemlett.6b00405 10.1016/j.pharmthera.2007.04.006 10.1517/14728222.9.5.887 10.1007/BF01059767 10.2353/ajpath.2009.080807 10.1002/jlcr.3158 10.1172/JCI118397 10.1016/B978-0-444-52001-2.00008-X 10.1016/S0896-6273(00)80781-3 10.1523/JNEUROSCI.6221-11.2012 10.2967/jnumed.116.181354 10.1074/jbc.M006993200 10.1523/JNEUROSCI.2121-13.2013 10.1016/j.molmed.2017.04.005 10.2967/jnumed.116.178996 10.2174/156720508785908937 10.1111/j.1399-0039.2011.01780.x 10.1016/j.biocel.2006.07.001 10.1111/j.1471-4159.2009.05984.x 10.1097/00005072-199911000-00003 10.1016/j.nucmedbio.2016.10.005 10.1016/j.brainresrev.2006.02.002 10.1016/j.tins.2010.12.001 10.1023/A:1007677003387 10.1021/ar500233s 10.1097/00001756-199605310-00013 10.1016/j.brainresbull.2007.02.015 10.1021/cr0782426 10.1002/mds.27271 10.1111/j.1476-5381.1983.tb08809.x 10.1523/JNEUROSCI.1487-12.2012 10.1016/j.febslet.2005.05.073 10.1146/annurev.immunol.021908.132528 10.1002/glia.23097 10.1038/nrd1415 10.2967/jnumed.107.049619 10.1038/nature07201 10.1038/nrn3880 10.1016/j.neuint.2010.10.013 10.1212/WNL.66.10_suppl_4.S24 10.1016/j.jneuroim.2014.07.012 10.2967/jnumed.113.131854 10.1136/jnnp.2005.063131 10.1016/j.nucmedbio.2011.03.003 10.1111/j.1471-4159.2010.06759.x 10.2967/jnumed.117.205492 10.1016/j.nucmedbio.2008.10.002 10.3389/fncel.2013.00026 10.1159/000067423 10.1016/j.cell.2010.02.016 10.1002/syn.20703 10.1038/nm1082 10.1038/nrneurol.2014.207 10.1038/382685a0 10.1038/nri1106 10.1002/jlcr.3008 10.1089/ars.2013.5745 10.1002/cne.903550208 10.1038/d41586-018-04930-7 10.1039/C5CC04536C 10.1126/science.1110647 10.1016/j.tips.2009.01.002 10.1002/glia.22361 10.1073/pnas.96.13.7563 10.1016/S0925-4439(00)00040-5 10.2967/jnumed.115.161083 10.1007/s00702-008-0069-9 10.1016/j.immuni.2005.10.001 10.1016/j.neuroimage.2017.10.009 10.1016/S0891-0618(99)00012-5 10.1038/nrd3295 10.1038/tp.2016.40 10.1016/0076-6879(91)00172-S 10.1007/s11910-017-0733-2 10.7150/thno.14334 10.1523/JNEUROSCI.1709-08.2008 10.4062/biomolther.2016.160 10.1039/C6CC00895J 10.1016/j.nbd.2011.09.002 10.1073/pnas.1014154108 10.1111/j.1476-5381.2010.00729.x 10.2967/jnumed.115.169995 10.1002/ana.410440724 10.1016/j.bmcl.2005.08.037 10.1016/j.brainres.2013.10.049 10.1177/0271678X17748786 10.1007/s00005-010-0069-y 10.1038/nrneurol.2010.17 10.1016/S0197-0186(96)00035-6 10.1021/jm3012273 10.1038/nature21029 10.1007/BF00964613 10.1017/CBO9780511575853 10.1016/0306-4522(89)90243-1 10.1186/s13195-017-0253-y 10.1016/j.jns.2008.06.031 10.1007/s00259-016-3457-7 10.2967/jnumed.115.166751 10.2967/jnumed.110.084046 10.1021/acsmedchemlett.5b00089 10.1016/S0014-5793(02)03413-0 10.1002/syn.21514 10.1016/j.pneurobio.2005.06.004 10.1016/j.brainresbull.2011.12.001 10.1523/JNEUROSCI.4178-07.2008 10.1002/jlcr.1492 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2018 The Author(s) 2018. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Author(s) 2018 2018 SAGE Publications Inc. |
| Copyright_xml | – notice: The Author(s) 2018 – notice: The Author(s) 2018. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: The Author(s) 2018 2018 SAGE Publications Inc. |
| DBID | AFRWT AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QO 7X7 7XB 88E 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BGLVJ BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ HCIFZ K9. L6V LK8 M0S M1P M7P M7S P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PTHSS 7X8 5PM ADTOC UNPAY DOA |
| DOI | 10.1177/1536012118792317 |
| DatabaseName | Openly Available Collection - Sage Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Biotechnology Research Abstracts ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Database ProQuest Central Technology Collection Natural Science Collection ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Engineering Collection Biological Sciences Health & Medical Collection (Alumni Edition) Medical Database Biological Science Database Engineering Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition Engineering Collection MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall DOAJ Open Access Full Text |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Technology Collection Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection ProQuest Engineering Collection Health Research Premium Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Engineering Database ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Materials Science & Engineering Collection Engineering Research Database ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database CrossRef MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository – sequence: 5 dbid: AFRWT name: Sage Journals GOLD Open Access 2024 url: http://journals.sagepub.com/ sourceTypes: Publisher – sequence: 6 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1536-0121 |
| ExternalDocumentID | oai_doaj_org_article_eafe70a009ad4220b022e707f7b205ae 10.1177/1536012118792317 PMC6134492 30203712 10_1177_1536012118792317 10.1177_1536012118792317 |
| Genre | Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: Center for Scientific Review grantid: R01AG054473 funderid: https://doi.org/10.13039/100005440 – fundername: ; grantid: R01AG054473 |
| GroupedDBID | --- 36B 53G 5VS 7X7 88E 8FI 8FJ AAFWJ AAJPV AASGM ABAWP ABDBF ABUWG ACGFS ACUHS ADBBV AENEX AEUYN AEWDL AFCOW AFKRA AFKRG AFPKN AFRWT AJUZI ALMA_UNASSIGNED_HOLDINGS AOIJS AUTPY AYAKG BCNDV BDDNI BENPR CCPQU CS3 DIK DU5 EAD EAP EBD EBS EMB EMK EMOBN EPL ESX F5P FYUFA GROUPED_DOAJ H13 HMCUK HYE I-F IPNFZ J8X K.F KQ8 M1P O9- OK1 PGMZT PHGZM PHGZT PIMPY PSQYO RBD ROL RPM SAUOL SCNPE SFC SV3 TUS UKHRP 0R~ AAYXX ABJCF ACHEB BGLVJ CITATION EJD M7P M7S PJZUB PPXIY PQGLB PTHSS PUEGO 123 4.4 CAG CGR COF CUY CVF EAS ECM EIF IL9 NPM OVD RIG TEORI 3V. 7QO 7XB 8FD 8FE 8FG 8FH 8FK AZQEC BBNVY BHPHI DWQXO FR3 GNUQQ HCIFZ K9. L6V LK8 P64 PKEHL PQEST PQQKQ PQUKI 7X8 5PM ADTOC UNPAY |
| ID | FETCH-LOGICAL-c594t-c0495833c15d58ba80aef09dd6687573bb73bed283fc10640abd131df0df3c4a3 |
| IEDL.DBID | UNPAY |
| ISSN | 1536-0121 1535-3508 |
| IngestDate | Tue Oct 14 18:56:02 EDT 2025 Sun Oct 26 03:11:52 EDT 2025 Tue Sep 30 16:56:55 EDT 2025 Thu Oct 02 05:59:39 EDT 2025 Tue Oct 07 07:04:31 EDT 2025 Mon Jul 21 06:04:29 EDT 2025 Wed Oct 01 06:48:35 EDT 2025 Thu Apr 24 22:56:38 EDT 2025 Tue Jun 17 22:49:13 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | neurodegenerative diseases astrocytes neuroinflammation microglia positron emission tomography (PET) imaging |
| Language | English |
| License | This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c594t-c0495833c15d58ba80aef09dd6687573bb73bed283fc10640abd131df0df3c4a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://proxy.k.utb.cz/login?url=https://journals.sagepub.com/doi/pdf/10.1177/1536012118792317 |
| PMID | 30203712 |
| PQID | 2313779857 |
| PQPubID | 4450583 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_eafe70a009ad4220b022e707f7b205ae unpaywall_primary_10_1177_1536012118792317 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6134492 proquest_miscellaneous_2102319887 proquest_journals_2313779857 pubmed_primary_30203712 crossref_citationtrail_10_1177_1536012118792317 crossref_primary_10_1177_1536012118792317 sage_journals_10_1177_1536012118792317 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2018 Jan-Dec |
| PublicationDateYYYYMMDD | 2018-01-01 |
| PublicationDate_xml | – month: 01 year: 2018 text: 2018 Jan-Dec |
| PublicationDecade | 2010 |
| PublicationPlace | Los Angeles, CA |
| PublicationPlace_xml | – name: Los Angeles, CA – name: England – name: Thousand Oaks – name: Sage CA: Los Angeles, CA |
| PublicationTitle | Molecular imaging |
| PublicationTitleAlternate | Mol Imaging |
| PublicationYear | 2018 |
| Publisher | SAGE Publications Sage Publications Ltd SAGE Publishing |
| Publisher_xml | – name: SAGE Publications – name: Sage Publications Ltd – name: SAGE Publishing |
| References | Hooper, Killick, Lovestone 2008; 104 Shukuri, Takashima-Hirano, Tokuda 2011; 52 Akiyama, Barger, Barnum 2000; 21 Nag, Varrone, Toth 2012; 66 Benito, Tolón, Pazos, Núñez, Castillo, Romero 2008; 153 Le Fur, Perrier, Vaucher 1983; 32 Choi, Aid, Bosetti 2009; 30 Lin, Bois, Holden 2017; 16 Mildner, Huang, Radke, Stenzel, Priller 2017; 65 Clarke, Barres 2013; 14 Seki, Maeda, Kataoka, Sugahara, Chiba 2013; 4 Takenouchi, Sekiyama, Sekigawa 2010; 58 Papadopoulos, Baraldi, Guilarte 2006; 27 Halldin, Gulyás, Langer, Farde 2001; 45 Warner, Giuliano, Vojnovic, Bukasa, Mitchell, Vane 1999; 96 Takabe, Paugh, Milstien, Spiegel 2008; 60 Choi, Aid, Caracciolo 2013; 124 Rudolph, Alcazar, Ameriks 2015; 25 Cole, Shao, Sherman 2014; 41 Lemke, Rothlin 2008; 8 Imbimbo, Solfrizzi, Panza 2010; 2 Vingill, Connor-Robson, Wade-Martins 2017 Grimsby, Chen, Wang, Lan, Shih 1991; 88 Johnson, Chaney 2017; 19 Crutcher, Gendelman, Kipnis 2006; 1 Minghetti 2004; 63 Vasdev, Sadovski, Garcia 2011; 54 Schain, Kreisl 2017; 17 Aid, Bosetti 2007; 73 Pike 2016; 23 Gao, Wang, Green, Hutchins, Zheng 2015; 25 Saint-Aubert, Lemoine, Chiotis, Leuzy, Rodriguez-Vieitez, Nordberg 2017; 12 Smith, Rottkamp, Nunomura 2000; 1502 Holland, Liang, Rotstein 2014; 57 Choi, Bosetti 2009; 1 Chalon, Vercouillie, Guilloteau, Suzenet, Routier 2015; 51 Cohen, Goedert 2004; 3 Robinson, Harp, Noronha, Miller 2014; 122 Shoulson 1998; 44 Ito, Imai, Ohsawa, Nakajima, Fukuuchi, Kohsaka 1998; 57 Doxey, Roach, Smith 1983; 78 De Sarno, Axtell, Raman, Roth, Alessi, Jope 2008; 181 Godyn, Jonczyk, Panek, Malawska 2016; 68 Yermakova, Rollins, Callahan, Rogers, O’Banion 1999; 58 Jin, Yang, Liu 2017; 24 Lue, Walker, Brachova 2001; 171 Colonna 2003; 3 Benito, Nunez, Tolon 2003; 23 Yamagata, Tagami, Torii 2003; 41 Nag, Lehmann, Kettschau 2013; 21 Saba, Valette, Peyronneau 2010; 64 Rojo, McBean, Cindric 2014; 21 Han, Liu, Liu 2017; 38 Wautier, Zoukourian, Chappey 1996; 97 Grimsby, Lan, Neve, Chen, Shih 1990; 55 Weinger, Omari, Marsden, Raine, Shafit-Zagardo 2009; 175 Kumata, Yui, Xie 2015; 25 Cortes, Singh, Morse 2015; 56 Puchałowicz, Tarnowski, Baranowska-Bosiacka, Chlubek, Dziedziejko 2014; 15 Coughlin, Slania, Du 2018 Lee, Yang 2012; 84 Hsieh, Yang 2013; 2013 Balsinde, Winstead, Dennis 2002; 531 Sheinerman, Umansky 2013; 12 Popovich, Longbrake 2008; 9 Nayak, Huo, Kwang 2010; 166 Singh, Cortes, Morse 2015; 56 Vivash, O’Brien 2016; 57 Hla, Brinkmann 2011; 76 Atwood, Mackie 2010; 160 Kettenmann, Hanisch, Noda, Verkhratsky 2011; 91 Sofroniew, Vinters 2010; 119 Bhat, Budd 2002; 11 Hu, Leak, Shi 2015; 11 Okada, Nakamura, Katoh 2006; 12 Olmos, Alemany, Escriba, García-Sevilla 1994; 111 Owens, Grabert, Davies 2017; 11 Lander, Tauras, Ogiste, Hori, Moss, Schmidt 1997; 272 Wolf, Yona, Kim, Jung 2013; 7 McGeer, Schulzer, McGeer 1996; 47 Liu, Jin, Yue 2016; 18 Pandey, DeGrado 2016; 6 Moore, Ase, Kinsara 2015; 2 Shrestha, Singh, Eldridge 2016; 57 Paliwal, Smith, Cox, Berardi, Dunn-Kucharski, Elta 1993; 21 Janssen, Vugts, Windhorst, Mach 2018; 23 DaRocha-Souto, Coma, Perez-Nievas 2012; 45 Zamanian, Xu, Foo 2012; 32 Park, Im 2017; 25 Evens, Vandeputte, Coolen 2012; 39 Kreutzberg 1996; 19 Herrmann, Imura, Song 2008; 28 Nimmerjahn, Kirchhoff, Helmchen 2005; 308 Ransohoff 2016; 353 Allaman, Belanger, Magistretti 2011; 34 Janssen, Vugts, Funke 2014; 57 Liu, Han, Jin 2017; 58 Bush, Puvanachandra, Horner 1999; 23 MacAulay, Doble, Patel 2007; 6 Sasaki, Hoshi, Akazawa 2003; 44 Ory, Celen, Gijsbers 2016; 57 Hofmann, Drury, Fu 1999; 97 Jeynes, Provias 2008; 5 Dupont, Largeau, Santiago Ribeiro, Guilloteau, Tronel, Arlicot 2017; 18 Skaper 2007; 1122 Nikoulina, Ciaraldi, Mudaliar, Mohideen, Carter, Henry 2000; 49 Monif, Burnstock, Williams 2010; 42 Piel, Vernaleken, Rosch 2014; 57 Constantinescu, Farooqi, O’Brien, Gran 2011; 164 Esposito, Giovacchini, Liow 2008; 49 Wojdasiewicz, Poniatowski, Kotela, Deszczyński, Kotela, Szukiewicz 2014; 62 Wiley, Sluyter, Gu, Stokes, Fuller 2011; 78 Vasdev, Garcia, Stableford 2005; 15 Shi, Gibson 2007; 21 Heppner, Ransohoff, Becher 2015; 16 Liang, Chen, Normandin 2016; 55 Kikuchi, Okada, Nengaki 2011; 19 Lue, Walker, Jacobson, Sabbagh 2009; 4 Cherry, Olschowka, O’Banion 2014; 11 Rusjan, Wilson, Miler 2014; 34 Savickas, Bongarzone, Luzi, Singh, Gee 2017; 13 Maciejewski-Lenoir, Chen, Feng, Maki, Bacon 1999; 163 Phillis, Horrocks, Farooqui 2006; 52 Rosenberg, Liu, Yue, Jin, Tu 2016; 57 Miller, Raff 1984; 4 Chesselet, Carmichael 2012; 9 Kihara, Mizuno, Chun 2015; 333 Craft, Watterson, Van Eldik 2005; 9 Luehmann, Detering, Fors 2016; 57 Vasdev, Sadovski, Moran 2011; 38 Albrecht, Granziera, Hooker, Loggia 2016; 7 Hu, Patnaik, Collier 2017; 8 Bramoullé, Saba, Valette 2008; 51 Choi, Gardell, Herr 2011; 108 Mintun, Raichle, Kilbourn, Wooten, Welch 1984; 15 Gonzalez, Elgueta, Montoya, Pacheco 2014; 274 Rupprecht, Papadopoulos, Rammes 2010; 9 Vincent 1989; 28 Ekblom, Jossan, Oreland, Walum, Aquilonius 1994; 41 Cary, Brooks, Fawaz 2016; 7 Hicks, Sadovski, Parkes 2015; 25 Liddelow, Guttenplan, Clarke 2017; 541 Masgrau, Guaza, Ransohoff, Galea 2017; 23 Medzhitov 2008; 454 Wanner, Anderson, Song 2013; 33 Savall, Wu, De Angelis 2015; 6 Schmid, Melchior, Masek 2009; 109 Halassa, Haydon 2010; 72 Leroy, Yilmaz, Brion 2007; 33 Huttunen, Kuja-Panula, Sorci, Agneletti, Donato, Rauvala 2000; 275 Ahmed 2005; 67 Molteni, Rossetti 2017; 313 Cahoy, Emery, Kaushal 2008; 28 Cumming, Burgher, Patkar 2018; 38 Valera, Masliah 2016; 31 Emanuele, D’Angelo, Tomaino 2005; 62 Mantovani, Sica, Locati 2005; 23 Cummings, Morstorf, Zhong 2014; 6 Shaikh, Schilson, Wagner 2015; 58 Reus, Fries, Stertz 2015; 300 Blaho, Hla 2014; 55 Groves, Kihara, Chun 2013; 328 Innis, Cunningham, Delforge 2007; 27 Carroll, Truillet, Shen 2016; 52 Wyss-Coray, Mucke 2002; 35 Pierce, Keating 2014; 1542 Michel, Ernsberger 1992; 13 Tansey, McCoy, Frank-Cannon 2007; 208 Yang, Chen 2008; 14 Maurer, Preiss, Brauns-Schubert, Schlicher, Charvet 2014; 127 Eng, Ghirnikar, Lee 2000; 25 Honer, Gobbi, Martarello, Comley 2014; 19 Ahmad, Postnov, Bormans, Versijpt, Vandenbulcke, Van Laere 2016; 10 Takahashi, Tomizawa, Kato 1994; 63 Li, Shao, Cole 2015; 6 Glass, Saijo, Winner, Marchetto, Gage 2010; 140 Andersson, Halldin 2013; 56 Carlisle, Marciano-Cabral, Staab, Ludwick, Cabral 2002; 2 Breder, Dewitt, Kraig 1995; 355 Ahmad, Postnov, Bormans 2016; 43 Gulyas, Pavlova, Kasa 2011; 58 Bhat, Budd Haeberlein, Avila 2004; 89 Jenner, Olanow 2006; 66 Combrinck, Williams, De Berardinis 2006; 77 Block, Hong 2005; 76 Walter, Franklin, Witting 2003; 23 Matousek, Hein, Shaftel, Olschowka, Kyrkanides, Kerry O’Banion 2010; 114 Kong, Guan 2016; 57 Suppl 2 Perry, Nicoll, Holmes 2010; 6 Valko, Leibfritz, Moncol, Cronin, Mazur, Telser 2007; 39 Carter, Scholl, Almkvist 2012; 53 Sanchez-Nogueiro, Marin-Garcia, Miras-Portugal 2005; 579 Cotrina, Nedergaard 2009; 5 Davalos, Grutzendler, Yang 2005; 8 Fowler, Logan, Volkow, Wang, MacGregor, Ding 2002; 27 Coughlin, Du, Rosenthal 2018; 165 Trkov, Stenovec, Kreft 2012; 60 Abbott 2018; 556 Kassenbrock, Vasdev, Liang 2016; 16 Streit, Braak, Xue, Bechmann 2009; 118 Aid, Langenbach, Bosetti 2008; 5 Brinkmann 2007; 115 Woodgett 1991; 200 Ametamey, Honer, Schubiger 2008; 108 Miron, Schubart, Antel 2008; 274 Bongarzone, Savickas, Luzi, Gee 2017; 60 Hou, Hsieh, Li 2018; 9 Rouach, Pebay, Meme 2006; 23 Kolahdooz, Nasoohi, Asle-Rousta, Ahmadiani, Dargahi 2015; 42 Sofroniew 2009; 32 Leroy, Brion 1999; 16 Llorens-Martín, Jurado, Hernández, Avila 2014; 7 Nag, Fazio, Lehmann 2016; 57 Van de Bittner, Ricq, Hooker 2014; 47 Nazem, Sankowski, Bacher, Al-Abed 2015; 12 Parker, Nabulsi, Holden 2014; 55 Wilms, Claasen, Röhl, Sievers, Deuschl, Lucius 2003; 14 Abe, Takai, Fukumoto 2014; 34 Rothhammer, Kenison, Tjon 2017; 114 Ikawa, Lohith, Shrestha 2017; 58 Drake, Brooks, Scott 2017; 58 Ma, Stankovich, Kilpatrick, Binder, Field 2011; 6 Basselin, Ramadan, Rapoport 2012; 87 Territo, Meyer, Peters 2017; 58 Anderson, Burda, Ren 2016; 532 DiSabato, Quan, Godbout 2016; 139 Fowler, Logan, Volkow, Wang 2005; 7 Horti, Dannals, Pomper 2017; 58 Coughlin, Wang, Ambinder 2016; 6 Lucas, Bensch, Eng 1980; 5 Gargalidis-Moudanos, Pizzinat, Javoy-Agid, Remaury, Parini 1997; 30 Pike 2009; 30 Yamagata, Andreasson, Kaufmann, Barnes, Worley 1993; 11 Kim, Shrestha, Eldridge 2017; 58 Hicks, VanBrocklin, Wilson, Houle, Vasdev 2010; 15 Prasad, Wagner, Keul 2014; 22 Vermeiren, Motte, Viot 2018; 33 Ng, Pascoal, Mathotaarachchi 2017; 9 Holland, Cumming, Vasdev 2013; 3 Martin-Gomez, Ruiz, Callado 1996; 7 Lavisse, Guillermier, Herard 2012; 32 Garcia-Sevilla, Escriba, Guimon 1999; 881 Haghikia, Gold 2010; 218 Noda, Takeuchi, Mizuno, Suzumura 2013; 256 Kawamura, Shimoda, Yui 2017; 45 Wang, Gao, Miller, Sledge, Hutchins, Zheng 2011; 21 Karlstrom, Nordvall, Sohn 2013; 56 Brinkmann, Billich, Baumruker 2010; 9 Ridderstad Wollberg, Ericsson-Dahlstrand, Jureus 2014; 111 Wang, Arcuino, Takano 2004; 10 Choi, Langenbach, Bosetti 2008; 22 Ohnishi, Senda, Yamane 2014; 41 Brooks, Shao, Quesada, Sherman, Scott, Kilbourn 2015; 6 Patel, Gibson 2008; 35 Pebay, Toutant, Premont 2001; 13 Wilson, Sadovski, Nobrega 2017; 53 Yan, Chen, Fu 1996; 382 Yokokura, Mori, Yagi 2011; 38 Ransohoff, Perry 2009; 27 Jackson, Giovannoni, Baker 2011; 8 Doble, Woodgett 2003; 116 Ghidoni, Benussi, Glionna 2008; 115 bibr76-1536012118792317 bibr109-1536012118792317 bibr25-1536012118792317 bibr41-1536012118792317 bibr212-1536012118792317 bibr92-1536012118792317 bibr125-1536012118792317 CHMP (bibr260-1536012118792317) bibr247-1536012118792317 bibr51-1536012118792317 bibr15-1536012118792317 bibr141-1536012118792317 bibr176-1536012118792317 bibr237-1536012118792317 bibr263-1536012118792317 bibr110-1536012118792317 bibr202-1536012118792317 bibr31-1536012118792317 bibr115-1536012118792317 bibr196-1536012118792317 bibr10-1536012118792317 bibr186-1536012118792317 Maciejewski-Lenoir D (bibr205-1536012118792317) 1999; 163 bibr96-1536012118792317 bibr100-1536012118792317 bibr257-1536012118792317 bibr131-1536012118792317 bibr105-1536012118792317 bibr55-1536012118792317 bibr172-1536012118792317 bibr226-1536012118792317 bibr71-1536012118792317 bibr242-1536012118792317 Imbimbo BP (bibr19-1536012118792317) 2010; 2 bibr268-1536012118792317 bibr217-1536012118792317 bibr21-1536012118792317 bibr62-1536012118792317 bibr111-1536012118792317 bibr267-1536012118792317 bibr181-1536012118792317 bibr129-1536012118792317 bibr97-1536012118792317 bibr46-1536012118792317 bibr20-1536012118792317 bibr233-1536012118792317 bibr82-1536012118792317 bibr253-1536012118792317 bibr187-1536012118792317 bibr66-1536012118792317 Ahmad R (bibr203-1536012118792317) 2016; 10 bibr145-1536012118792317 bibr206-1536012118792317 bibr222-1536012118792317 bibr192-1536012118792317 bibr130-1536012118792317 bibr9-1536012118792317 bibr40-1536012118792317 bibr114-1536012118792317 bibr156-1536012118792317 bibr248-1536012118792317 bibr35-1536012118792317 bibr42-1536012118792317 bibr213-1536012118792317 bibr256-1536012118792317 bibr238-1536012118792317 bibr77-1536012118792317 bibr108-1536012118792317 bibr264-1536012118792317 bibr221-1536012118792317 bibr34-1536012118792317 bibr32-1536012118792317 bibr116-1536012118792317 bibr246-1536012118792317 bibr75-1536012118792317 bibr159-1536012118792317 bibr24-1536012118792317 bibr124-1536012118792317 bibr167-1536012118792317 bibr211-1536012118792317 bibr85-1536012118792317 bibr16-1536012118792317 bibr59-1536012118792317 bibr67-1536012118792317 bibr50-1536012118792317 bibr93-1536012118792317 bibr183-1536012118792317 Kim M (bibr163-1536012118792317) 2017; 58 bibr149-1536012118792317 bibr175-1536012118792317 bibr262-1536012118792317 bibr26-1536012118792317 bibr18-1536012118792317 bibr173-1536012118792317 bibr83-1536012118792317 bibr157-1536012118792317 bibr170-1536012118792317 Horti A (bibr250-1536012118792317) 2017; 58 bibr270-1536012118792317 bibr165-1536012118792317 bibr191-1536012118792317 Drake L (bibr241-1536012118792317) 2017; 58 bibr91-1536012118792317 bibr138-1536012118792317 bibr251-1536012118792317 bibr121-1536012118792317 bibr64-1536012118792317 bibr37-1536012118792317 bibr154-1536012118792317 bibr208-1536012118792317 Kong YHF (bibr243-1536012118792317) 2016; 57 bibr45-1536012118792317 bibr216-1536012118792317 bibr7-1536012118792317 bibr197-1536012118792317 bibr29-1536012118792317 bibr72-1536012118792317 bibr189-1536012118792317 bibr224-1536012118792317 bibr80-1536012118792317 bibr146-1536012118792317 Janssen B (bibr218-1536012118792317) 2017 bibr140-1536012118792317 bibr240-1536012118792317 bibr119-1536012118792317 bibr132-1536012118792317 bibr53-1536012118792317 bibr219-1536012118792317 bibr232-1536012118792317 bibr135-1536012118792317 bibr127-1536012118792317 bibr143-1536012118792317 bibr56-1536012118792317 bibr227-1536012118792317 bibr61-1536012118792317 bibr4-1536012118792317 bibr48-1536012118792317 bibr235-1536012118792317 bibr68-1536012118792317 bibr239-1536012118792317 bibr117-1536012118792317 bibr17-1536012118792317 bibr168-1536012118792317 Ekblom J (bibr103-1536012118792317) 1994; 41 bibr84-1536012118792317 bibr255-1536012118792317 bibr230-1536012118792317 bibr204-1536012118792317 bibr94-1536012118792317 Llorens-Martín M (bibr86-1536012118792317) 2014; 7 bibr58-1536012118792317 bibr184-1536012118792317 bibr271-1536012118792317 bibr229-1536012118792317 Vingill S (bibr65-1536012118792317) 2017 bibr33-1536012118792317 bibr220-1536012118792317 bibr133-1536012118792317 Michel MC (bibr134-1536012118792317) 1992; 13 bibr107-1536012118792317 bibr123-1536012118792317 bibr210-1536012118792317 Majno G (bibr2-1536012118792317) 2004 bibr23-1536012118792317 bibr102-1536012118792317 bibr188-1536012118792317 bibr249-1536012118792317 bibr13-1536012118792317 bibr265-1536012118792317 bibr99-1536012118792317 bibr113-1536012118792317 bibr199-1536012118792317 bibr178-1536012118792317 bibr78-1536012118792317 bibr180-1536012118792317 bibr198-1536012118792317 bibr234-1536012118792317 bibr38-1536012118792317 bibr209-1536012118792317 bibr89-1536012118792317 bibr12-1536012118792317 Shrestha S (bibr160-1536012118792317) 2016; 57 bibr47-1536012118792317 bibr200-1536012118792317 bibr164-1536012118792317 bibr225-1536012118792317 Kumar V (bibr1-1536012118792317) 2003 bibr88-1536012118792317 bibr259-1536012118792317 bibr137-1536012118792317 bibr63-1536012118792317 bibr179-1536012118792317 Johnson EMA (bibr254-1536012118792317) 2017; 19 bibr6-1536012118792317 bibr27-1536012118792317 bibr153-1536012118792317 Singh P (bibr161-1536012118792317) 2015; 56 Owens R (bibr252-1536012118792317) 2017; 11 Cortes M (bibr162-1536012118792317) 2015; 56 Liu H (bibr195-1536012118792317) 2017; 58 bibr245-1536012118792317 bibr106-1536012118792317 bibr90-1536012118792317 bibr69-1536012118792317 bibr122-1536012118792317 bibr43-1536012118792317 bibr214-1536012118792317 bibr74-1536012118792317 bibr148-1536012118792317 Matousek SB (bibr151-1536012118792317) 2010; 114 bibr261-1536012118792317 bibr142-1536012118792317 bibr193-1536012118792317 bibr3-1536012118792317 bibr185-1536012118792317 Holland JP (bibr54-1536012118792317) 2013; 3 bibr177-1536012118792317 Halldin C (bibr52-1536012118792317) 2001; 45 bibr150-1536012118792317 bibr215-1536012118792317 bibr44-1536012118792317 bibr223-1536012118792317 bibr228-1536012118792317 bibr57-1536012118792317 bibr128-1536012118792317 bibr5-1536012118792317 bibr60-1536012118792317 bibr73-1536012118792317 bibr36-1536012118792317 bibr236-1536012118792317 bibr49-1536012118792317 bibr136-1536012118792317 bibr70-1536012118792317 bibr126-1536012118792317 bibr231-1536012118792317 bibr144-1536012118792317 bibr152-1536012118792317 bibr118-1536012118792317 bibr139-1536012118792317 bibr244-1536012118792317 bibr39-1536012118792317 bibr104-1536012118792317 bibr147-1536012118792317 bibr112-1536012118792317 bibr98-1536012118792317 bibr155-1536012118792317 bibr269-1536012118792317 bibr8-1536012118792317 bibr171-1536012118792317 bibr81-1536012118792317 bibr11-1536012118792317 bibr28-1536012118792317 bibr120-1536012118792317 bibr207-1536012118792317 Rosenberg A (bibr194-1536012118792317) 2016; 57 bibr87-1536012118792317 bibr174-1536012118792317 bibr258-1536012118792317 bibr95-1536012118792317 bibr166-1536012118792317 bibr266-1536012118792317 bibr158-1536012118792317 bibr182-1536012118792317 bibr14-1536012118792317 bibr30-1536012118792317 bibr79-1536012118792317 bibr190-1536012118792317 bibr101-1536012118792317 bibr22-1536012118792317 bibr169-1536012118792317 bibr201-1536012118792317 |
| References_xml | – volume: 56 start-page: 1092 issue: suppl 3 year: 2015 article-title: Synthesis of PET radioligands as potential probes for imaging COX-2 in neuroinflammation publication-title: J Nucl Med – volume: 58 start-page: 60 issue: 1 year: 2011 end-page: 68 article-title: Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]- -deprenyl using whole hemisphere autoradiography publication-title: Neurochem Int – volume: 21 start-page: 1766 issue: 12 year: 2014 end-page: 1801 article-title: Redox control of microglial function: molecular mechanisms and functional significance publication-title: Antioxid Redox Signal – volume: 25 start-page: 1965 issue: 9 year: 2015 end-page: 1970 article-title: Synthesis of [(11)C]GSK1482160 as a new PET agent for targeting P2X(7) receptor publication-title: Bioorg Med Chem Lett – volume: 11 start-page: 251 issue: 5 year: 2002 end-page: 261 article-title: GSK3beta signalling: casting a wide net in Alzheimer’s disease publication-title: Neurosignals – volume: 2013 start-page: 484613 year: 2013 article-title: Role of redox signaling in neuroinflammation and neurodegenerative diseases publication-title: Biomed Res Int – volume: 333 start-page: 171 issue: 2 year: 2015 end-page: 177 article-title: Lysophospholipid receptors in drug discovery publication-title: Exp Cell Res – volume: 8 start-page: 287 issue: 3 year: 2017 end-page: 292 article-title: Development of [(18)F]Maleimide-based glycogen synthase kinase-3beta ligands for positron emission tomography imaging publication-title: ACS Med Chem Lett – volume: 208 start-page: 1 issue: 1 year: 2007 end-page: 25 article-title: Neuroinflammatory mechanisms in Parkinson’s disease: potential environmental triggers, pathways, and targets for early therapeutic intervention publication-title: Exp Neurol – volume: 28 start-page: 189 issue: 1 year: 1989 end-page: 199 article-title: Histochemical localization of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine oxidation in the mouse brain publication-title: Neuroscience – volume: 91 start-page: 461 issue: 2 year: 2011 end-page: 553 article-title: Physiology of microglia publication-title: Physiol Rev – volume: 84 start-page: 581 issue: 5 year: 2012 end-page: 590 article-title: Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases publication-title: Biochem Pharmacol – volume: 44 start-page: S160 issue: 3 suppl 1 year: 1998 end-page: S166 article-title: DATATOP: a decade of neuroprotective inquiry. Parkinson study group. deprenyl and tocopherol antioxidative therapy of parkinsonism publication-title: Ann Neurol – volume: 58 start-page: 551 issue: suppl 1 year: 2017 article-title: Imaging the receptor for advanced glycation endproducts with [18F]RAGER publication-title: J Nucl Med – volume: 108 start-page: 1501 issue: 5 year: 2008 end-page: 1516 article-title: Molecular imaging with PET publication-title: Chem Rev – volume: 76 start-page: S3 issue: 8 suppl 3 year: 2011 end-page: S8 article-title: Sphingosine 1-phosphate (S1P): physiology and the effects of S1P receptor modulation publication-title: Neurology – volume: 41 start-page: 199 issue: 2 year: 2003 end-page: 206 article-title: Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes publication-title: Glia – volume: 67 start-page: 3 issue: 1 year: 2005 end-page: 21 article-title: Advanced glycation endproducts – role in pathology of diabetic complications publication-title: Diabetes Res Clin Pract – volume: 57 start-page: 165 issue: 2 year: 2016 end-page: 168 article-title: Imaging microglial activation with TSPO PET: lighting up neurologic diseases? publication-title: J Nucl Med – volume: 114 start-page: 2012 issue: 8 year: 2017 end-page: 2017 article-title: Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation publication-title: Proc Natl Acad Sci U S A – volume: 23 start-page: 1398 issue: 4 year: 2003 end-page: 1405 article-title: Nonpsychotropic cannabinoid receptors regulate microglial cell migration publication-title: J Neurosci – volume: 63 start-page: 245 issue: 1 year: 1994 end-page: 255 article-title: Localization and developmental changes of tau protein kinase I/glycogen synthase kinase-3 beta in rat brain publication-title: J Neurochem – volume: 21 start-page: 245 issue: 1 year: 2011 end-page: 249 article-title: The first synthesis of [(11)C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3) publication-title: Bioorg Med Chem Lett – volume: 1502 start-page: 139 issue: 1 year: 2000 end-page: 144 article-title: Oxidative stress in Alzheimer’s disease publication-title: Biochim Biophys Acta – volume: 5 start-page: 17 year: 2008 article-title: Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2 publication-title: J Neuroinflammation – volume: 308 start-page: 1314 issue: 5726 year: 2005 end-page: 1318 article-title: Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo publication-title: Science – volume: 56 start-page: 196 issue: 3-4 year: 2013 end-page: 206 article-title: PET radioligands targeting the brain GABAA /benzodiazepine receptor complex publication-title: J Labelled Comp Radiopharm – volume: 68 start-page: 127 issue: 1 year: 2016 end-page: 138 article-title: Therapeutic strategies for Alzheimer’s disease in clinical trials publication-title: Pharmacol Rep – volume: 34 start-page: 76 issue: 2 year: 2011 end-page: 87 article-title: Astrocyte–neuron metabolic relationships: for better and for worse publication-title: Trends Neurosci – volume: 139 start-page: 136 issue: suppl 2 year: 2016 end-page: 153 article-title: Neuroinflammation: the devil is in the details publication-title: J Neurochem – volume: 39 start-page: 44 issue: 1 year: 2007 end-page: 84 article-title: Free radicals and antioxidants in normal physiological functions and human disease publication-title: Int J Biochem Cell Biol – volume: 6 start-page: 37 issue: 4 year: 2014 article-title: Alzheimer’s disease drug-development pipeline: few candidates, frequent failures publication-title: Alzheimers Res Ther – volume: 4 start-page: 585 issue: 2 year: 1984 end-page: 592 article-title: Fibrous and protoplasmic astrocytes are biochemically and developmentally distinct publication-title: J Neurosci – volume: 52 start-page: 4888 year: 2016 end-page: 4890 article-title: [(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography publication-title: Chem Commun (Camb) – volume: 77 start-page: 85 issue: 1 year: 2006 end-page: 88 article-title: Levels of CSF prostaglandin E2, cognitive decline, and survival in Alzheimer’s disease publication-title: J Neurol Neurosurg Psychiatry – volume: 10 start-page: 821 issue: 8 year: 2004 end-page: 827 article-title: P2X7 receptor inhibition improves recovery after spinal cord injury publication-title: Nat Med – volume: 31 start-page: 225 issue: 2 year: 2016 end-page: 234 article-title: Combination therapies: the next logical step for the treatment of synucleinopathies? publication-title: Mov Disord – volume: 9 start-page: 971 issue: 12 year: 2010 end-page: 988 article-title: Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders publication-title: Nat Rev Drug Discov – volume: 49 start-page: 1414 issue: 9 year: 2008 end-page: 1421 article-title: Imaging neuroinflammation in Alzheimer’s disease with radiolabeled arachidonic acid and PET publication-title: J Nucl Med – volume: 57 start-page: 9232 issue: 22 year: 2014 end-page: 9258 article-title: Positron emission tomography in CNS drug discovery and drug monitoring publication-title: J Med Chem – volume: 87 start-page: 154 issue: 2-3 year: 2012 end-page: 171 article-title: Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans publication-title: Brain Res Bull – volume: 5 start-page: 247 issue: 3 year: 1980 end-page: 255 article-title: In vitro polymerization of glial fibrillary acidic (GFA) protein extracted from multiple sclerosis (MS) brain publication-title: Neurochem Res – volume: 89 start-page: 1313 issue: 6 year: 2004 end-page: 1317 article-title: Glycogen synthase kinase 3: a drug target for CNS therapies publication-title: J Neurochem – volume: 21 start-page: 383 issue: 3 year: 2000 end-page: 421 article-title: Inflammation and Alzheimer’s disease publication-title: Neurobiol Aging – volume: 15 start-page: 5270 issue: 23 year: 2005 end-page: 5273 article-title: Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): a radiolabelled glycogen synthase kinase-3beta specific inhibitor for PET studies publication-title: Bioorg Med Chem Lett – volume: 579 start-page: 3783 issue: 17 year: 2005 end-page: 3788 article-title: Characterization of a functional P2X(7)-like receptor in cerebellar granule neurons from P2X(7) knockout mice publication-title: FEBS Lett – year: 2018 article-title: (18)F-XTRA PET for enhanced imaging of the extrathalamic alpha4beta2 nicotinic acetylcholine receptor [published online ahead of print March 1, 2018] publication-title: J Nucl Med – volume: 175 start-page: 283 issue: 1 year: 2009 end-page: 293 article-title: Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions publication-title: Am J Pathol – volume: 54 start-page: 678 issue: 10 year: 2011 end-page: 680 article-title: Radiosynthesis of [11C]SL25.1188 via [11C]CO fixation for imaging monoamine oxidase B publication-title: J Label Compd Radiopharm – volume: 122 start-page: 173 year: 2014 end-page: 189 article-title: The Experimental Autoimmune Encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment publication-title: Handb Clin Neurol – volume: 58 start-page: 10 issue: suppl 1 year: 2017 article-title: Optimization of S1P1-specific PET radioligands for imaging neuroinflammation publication-title: J Nucl Med – volume: 3 start-page: 445 issue: 6 year: 2003 end-page: 453 article-title: TREMs in the immune system and beyond publication-title: Nat Rev Immunol – volume: 163 start-page: 1628 issue: 3 year: 1999 end-page: 1635 article-title: Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia publication-title: J Immunol – volume: 16 start-page: 358 issue: 6 year: 2015 end-page: 372 article-title: Immune attack: the role of inflammation in Alzheimer disease publication-title: Nat Rev Neurosci – volume: 58 start-page: 3471 issue: 8 year: 2015 end-page: 3484 article-title: Synthesis and evaluation of fluorinated fingolimod (FTY720) analogues for sphingosine-1-phosphate receptor molecular imaging by positron emission tomography publication-title: J Med Chem – volume: 355 start-page: 296 issue: 2 year: 1995 end-page: 315 article-title: Characterization of inducible cyclooxygenase in rat brain publication-title: J Comp Neurol – volume: 25 start-page: 288 issue: 2 year: 2015 end-page: 291 article-title: Radiosynthesis and ex vivo evaluation of [(18)F]-(S)-3-(6-(3-fluoropropoxy)benzo[d]isoxazol-3-yl)-5-(methoxymethyl)oxazoli din-2-one for imaging MAO-B with PET publication-title: Bioorg Med Chem Lett – volume: 57 start-page: 1 issue: suppl 2 year: 2016 article-title: Development and in vivo evaluation of three F-18 labeled S1P1 ligands as PET tracers for MS publication-title: J Nucl Med – volume: 16 start-page: 1536012117731258 year: 2017 article-title: The search for a subtype-selective PET imaging agent for the GABAA receptor complex: evaluation of the radiotracer [(11)C]ADO in nonhuman primates publication-title: Mol Imaging – volume: 34 start-page: 1907 issue: 12 year: 2014 end-page: 1913 article-title: In vivo imaging of reactive oxygen species in mouse brain by using [ H]hydromethidine as a potential radical trapping radiotracer publication-title: J Cereb Blood Flow Metab – volume: 272 start-page: 17810 issue: 28 year: 1997 end-page: 17814 article-title: Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress publication-title: J Biol Chem – volume: 45 start-page: 139 issue: 2 year: 2001 end-page: 152 article-title: Brain radioligands – state of the art and new trends publication-title: Q J Nucl Med – volume: 127 start-page: 1369 issue: Pt 7 year: 2014 end-page: 1378 article-title: GSK-3 – at the crossroads of cell death and survival publication-title: J Cell Sci – volume: 60 start-page: 1406 issue: 9 year: 2012 end-page: 1416 article-title: Fingolimod – a sphingosine-like molecule inhibits vesicle mobility and secretion in astrocytes publication-title: Glia – volume: 23 start-page: 11136 issue: 35 year: 2003 end-page: 11141 article-title: Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer’s disease brains publication-title: J Neurosci – volume: 42 start-page: 1753 issue: 11 year: 2010 end-page: 1756 article-title: Microglia: proliferation and activation driven by the P2X7 receptor publication-title: Int J Biochem Cell Biol – volume: 7 start-page: 470 issue: 4 year: 2016 end-page: 483 article-title: In vivo imaging of human neuroinflammation publication-title: ACS Chem Neurosci – volume: 60 start-page: 181 issue: 2 year: 2008 end-page: 195 article-title: “Inside-out” signaling of sphingosine-1-phosphate: therapeutic targets publication-title: Pharmacol Rev – volume: 1 start-page: 195 issue: 3 year: 2006 end-page: 211 article-title: Debate: “is increasing neuroinflammation beneficial for neural repair?” publication-title: J Neuroimmune Pharmacol – volume: 64 start-page: 61 issue: 1 year: 2010 end-page: 69 article-title: [(11)C]SL25.1188, a new reversible radioligand to study the monoamine oxidase type B with PET: preclinical characterisation in nonhuman primate publication-title: Synapse – volume: 8 start-page: 327 issue: 5 year: 2008 end-page: 336 article-title: Immunobiology of the TAM receptors publication-title: Nat Rev Immunol – volume: 27 start-page: 263 issue: 3 year: 2002 end-page: 277 article-title: Monoamine oxidase: radiotracer development and human studies publication-title: Methods – volume: 532 start-page: 195 issue: 7598 year: 2016 end-page: 200 article-title: Astrocyte scar formation aids central nervous system axon regeneration publication-title: Nature – volume: 57 start-page: 509 issue: 8 year: 2014 end-page: 516 article-title: Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [(1)(1)C]A-740003 as a novel tracer of neuroinflammation publication-title: J Labelled Comp Radiopharm – volume: 43 start-page: 2219 issue: 12 year: 2016 end-page: 2227 article-title: Decreased in vivo availability of the cannabinoid type 2 receptor in Alzheimer’s disease publication-title: Eur J Nucl Med Mol Imaging – volume: 15 start-page: 23672 issue: 12 year: 2014 end-page: 23704 article-title: P2X and P2Y receptors-role in the pathophysiology of the nervous system publication-title: Int J Mol Sci – volume: 55 start-page: 9601 issue: 33 year: 2016 end-page: 9605 article-title: Discovery of a highly selective glycogen synthase kinase-3 inhibitor (PF-04802367) that modulates tau phosphorylation in the brain: translation for PET neuroimaging publication-title: Angew Chem Int Ed Engl – volume: 35 start-page: 805 issue: 8 year: 2008 end-page: 815 article-title: In vivo site-directed radiotracers: a mini-review publication-title: Nucl Med Biol – volume: 6 start-page: 1965 issue: 12 year: 2015 end-page: 1971 article-title: In vivo metabolic trapping radiotracers for imaging monoamine oxidase-A and -B enzymatic activity publication-title: ACS Chem Neurosci – volume: 353 start-page: 777 issue: 6301 year: 2016 end-page: 783 article-title: How neuroinflammation contributes to neurodegeneration publication-title: Science – volume: 1122 start-page: 23 year: 2007 end-page: 34 article-title: The brain as a target for inflammatory processes and neuroprotective strategies publication-title: Ann N Y Acad Sci – volume: 58 start-page: 203 issue: suppl 1 year: 2017 article-title: Novel PET radioligands show that, in rhesus monkeys, COX-1 is constitutively expressed and COX-2 is induced by inflammation publication-title: J Nucl Med – volume: 454 start-page: 428 issue: 7203 year: 2008 end-page: 435 article-title: Origin and physiological roles of inflammation publication-title: Nature – volume: 32 start-page: 638 issue: 12 year: 2009 end-page: 647 article-title: Molecular dissection of reactive astrogliosis and glial scar formation publication-title: Trends Neurosci – volume: 25 start-page: 1439 issue: 9-10 year: 2000 end-page: 1451 article-title: Glial fibrillary acidic protein: GFAP-thirty-one years (1969–2000) publication-title: Neurochem Res – volume: 34 start-page: 883 issue: 5 year: 2014 end-page: 889 article-title: Kinetic modeling of the monoamine oxidase B radioligand [(1)(1)C]SL25.1188 in human brain with high-resolution positron emission tomography publication-title: J Cereb Blood Flow Metab – volume: 38 start-page: 343 issue: 2 year: 2011 end-page: 351 article-title: In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease publication-title: Eur J Nucl Med Mol Imaging – volume: 39 start-page: 389 issue: 3 year: 2012 end-page: 399 article-title: Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer publication-title: Nucl Med Biol – volume: 25 start-page: 3157 issue: 16 year: 2015 end-page: 3163 article-title: Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8 H)-yl)methanones are P2X7 antagonists publication-title: Bioorg Med Chem Lett – volume: 23 start-page: 1818 issue: 18 year: 2016 end-page: 1869 article-title: Considerations in the development of reversibly binding PET radioligands for brain imaging publication-title: Curr Med Chem – volume: 114 start-page: 247 issue: 1 year: 2010 end-page: 258 article-title: Cyclooxygenase-1 mediates prostaglandin E(2) elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1beta expression publication-title: J Neurochem – volume: 15 start-page: 217 issue: 3 year: 1984 end-page: 227 article-title: A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography publication-title: Ann Neurol – volume: 66 start-page: 323 issue: 4 year: 2012 end-page: 330 article-title: In vivo evaluation in cynomolgus monkey brain and metabolism of [(1)(8)F]fluorodeprenyl: a new MAO-B pet radioligand publication-title: Synapse – volume: 16 start-page: 279 issue: 4 year: 1999 end-page: 293 article-title: Developmental expression and localization of glycogen synthase kinase-3beta in rat brain publication-title: J Chem Neuroanat – volume: 57 start-page: 1 issue: 1 year: 1998 end-page: 9 article-title: Microglia-specific localisation of a novel calcium binding protein, Iba1 publication-title: Brain Res Mol Brain Res – volume: 57 start-page: 323 issue: 4 year: 2014 end-page: 331 article-title: Alternative approaches for PET radiotracer development in Alzheimer’s disease: imaging beyond plaque publication-title: J Labelled Comp Radiopharm – volume: 23 start-page: 486 issue: 6 year: 2017 end-page: 500 article-title: Should we stop saying ‘glia’ and ‘neuroinflammation’? publication-title: Trends Mol Med – volume: 62 start-page: 1734 issue: 11 year: 2005 end-page: 1736 article-title: Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementia publication-title: Arch Neurol – volume: 45 start-page: 425 issue: 1 year: 2012 end-page: 437 article-title: Activation of glycogen synthase kinase-3 beta mediates beta-amyloid induced neuritic damage in Alzheimer’s disease publication-title: Neurobiol Dis – volume: 30 start-page: 174 issue: 4 year: 2009 end-page: 181 article-title: The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research publication-title: Trends Pharmacol Sci – volume: 18 start-page: 724 issue: 5 year: 2016 end-page: 732 article-title: PET imaging study of S1PR1 expression in a rat model of multiple sclerosis publication-title: Mol Imaging Biol – volume: 881 start-page: 392 year: 1999 end-page: 409 article-title: Imidazoline receptors and human brain disorders publication-title: Ann N Y Acad Sci – volume: 12 start-page: 19 issue: 1 year: 2017 article-title: Tau PET imaging: present and future directions publication-title: Mol Neurodegener – volume: 7 start-page: 1393 issue: 8 year: 1996 end-page: 1396 article-title: Increased density of I2-imidazoline receptors in human glioblastomas publication-title: Neuroreport – volume: 108 start-page: 751 issue: 2 year: 2011 end-page: 756 article-title: FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation publication-title: Proc Natl Acad Sci U S A – volume: 55 start-page: 1166 issue: 4 year: 1990 end-page: 1169 article-title: Tissue distribution of human monoamine oxidase A and B mRNA publication-title: J Neurochem – volume: 96 start-page: 7563 issue: 13 year: 1999 end-page: 7568 article-title: Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis publication-title: Proc Natl Acad Sci U S A – volume: 9 start-page: 481 year: 2008 end-page: 493 article-title: Can the immune system be harnessed to repair the CNS? publication-title: Nat Rev Neurosci – volume: 7 start-page: 377 issue: 6 year: 2005 end-page: 387 article-title: Translational neuroimaging: positron emission tomography studies of monoamine oxidase publication-title: Mol Imaging Biol – volume: 9 start-page: 883 issue: 11 year: 2010 end-page: 897 article-title: Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis publication-title: Nat Rev Drug Discov – volume: 115 start-page: 84 issue: 1 year: 2007 end-page: 105 article-title: Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology publication-title: Pharmacol Ther – volume: 11 start-page: 98 year: 2014 article-title: Neuroinflammation and M2 microglia: the good, the bad, and the inflamed publication-title: J Neuroinflammation – volume: 300 start-page: 141 year: 2015 end-page: 154 article-title: The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders publication-title: Neuroscience – volume: 32 start-page: 1839 issue: 16 year: 1983 end-page: 1847 article-title: Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide. I. In vitro studies publication-title: Life Sci – volume: 28 start-page: 264 issue: 1 year: 2008 end-page: 278 article-title: A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function publication-title: J Neurosci – volume: 541 start-page: 481 issue: 7638 year: 2017 end-page: 487 article-title: Neurotoxic reactive astrocytes are induced by activated microglia publication-title: Nature – volume: 14 start-page: 311 issue: 5 year: 2013 end-page: 321 article-title: Emerging roles of astrocytes in neural circuit development publication-title: Nat Rev Neurosci – volume: 38 start-page: 204 issue: 2 year: 2018 end-page: 224 article-title: Sifting through the surfeit of neuroinflammation tracers publication-title: J Cereb Blood Flow Metab – volume: 53 start-page: 14 year: 2017 end-page: 20 article-title: Evaluation of a novel radiotracer for positron emission tomography imaging of reactive oxygen species in the central nervous system publication-title: Nucl Med Biol – volume: 13 start-page: 2067 issue: 12 year: 2001 end-page: 2076 article-title: Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades publication-title: Eur J Neurosci – volume: 17 start-page: 25 issue: 3 year: 2017 article-title: Neuroinflammation in neurodegenerative disorders – a review publication-title: Curr Neurol Neurosci Rep – volume: 28 start-page: 7231 issue: 28 year: 2008 end-page: 7243 article-title: STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury publication-title: J Neurosci – volume: 58 start-page: 91 issue: 2 year: 2010 end-page: 96 article-title: P2X7 receptor signaling pathway as a therapeutic target for neurodegenerative diseases publication-title: Arch Immunol Ther Exp (Warsz) – volume: 13 start-page: 369 issue: 10 year: 1992 end-page: 370 article-title: Keeping an eye on the I site: imidazoline-preferring receptors publication-title: Trends Pharmacol Sci – volume: 11 start-page: 56 issue: 1 year: 2015 end-page: 64 article-title: Microglial and macrophage polarization – new prospects for brain repair publication-title: Nat Rev Neurol – volume: 12 start-page: 1 issue: 1 year: 2013 end-page: 2 article-title: Early detection of neurodegenerative diseases: circulating brain-enriched microRNA publication-title: Cell Cycle – volume: 63 start-page: 901 issue: 9 year: 2004 end-page: 910 article-title: Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases publication-title: J Neuropathol Exp Neurol – volume: 32 start-page: 6391 issue: 18 year: 2012 end-page: 6410 article-title: Genomic analysis of reactive astrogliosis publication-title: J Neurosci – volume: 41 start-page: 594 issue: 7 year: 2014 end-page: 599 article-title: Human whole-body biodistribution and dosimetry of a new PET tracer, [(11)C]ketoprofen methyl ester, for imagings of neuroinflammation publication-title: Nucl Med Biol – volume: 19 start-page: 1936 issue: 12 year: 2014 end-page: 1944 article-title: Radioligand development for molecular imaging of the central nervous system with positron emission tomography publication-title: Drug Discov Today – volume: 7 start-page: 26 year: 2013 article-title: Microglia, seen from the CX3CR1 angle publication-title: Front Cell Neurosci – volume: 49 start-page: 263 issue: 2 year: 2000 end-page: 271 article-title: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes publication-title: Diabetes – volume: 256 start-page: 13 issue: 1-2 year: 2013 end-page: 18 article-title: Fingolimod phosphate promotes the neuroprotective effects of microglia publication-title: J Neuroimmunol – volume: 52 start-page: 1094 issue: 7 year: 2011 end-page: 1101 article-title: In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester publication-title: J Nucl Med – volume: 6 start-page: 548 issue: 5 year: 2015 end-page: 552 article-title: Synthesis and initial in vivo studies with [(11)C]SB-216763: the first radiolabeled brain penetrative inhibitor of GSK-3 publication-title: ACS Med Chem Lett – volume: 57 start-page: 315 issue: 2 year: 2016 end-page: 320 article-title: In vivo and in vitro characterization of a novel MAO-B inhibitor radioligand, F-labeled deuterated fluorodeprenyl publication-title: J Nucl Med – volume: 8 start-page: 76 year: 2011 article-title: Fingolimod modulates microglial activation to augment markers of remyelination publication-title: J Neuroinflammation – volume: 140 start-page: 918 issue: 6 year: 2010 end-page: 934 article-title: Mechanisms underlying inflammation in neurodegeneration publication-title: Cell – volume: 55 start-page: 838 issue: 5 year: 2014 end-page: 844 article-title: Evaluation of 11C-BU99008, a PET ligand for the imidazoline2 binding sites in rhesus brain publication-title: J Nucl Med – volume: 165 start-page: 118 year: 2018 end-page: 124 article-title: The distribution of the alpha7 nicotinic acetylcholine receptor in healthy aging: an in vivo positron emission tomography study with [(18)F]ASEM publication-title: Neuroimage – volume: 2 start-page: 19 year: 2010 article-title: Are NSAIDs useful to treat Alzheimer’s disease or mild cognitive impairment? publication-title: Front Aging Neurosci – volume: 6 start-page: 193 issue: 4 year: 2010 end-page: 201 article-title: Microglia in neurodegenerative disease publication-title: Nat Rev Neurol – volume: 10 start-page: 431 year: 2016 article-title: Synthesis, biodistribution and in vitro evaluation of brain permeable high affinity type 2 cannabinoid receptor agonists [(11)C]MA2 and [(18)F]MA3 publication-title: Front Neurosci – volume: 13 start-page: P1536 issue: 7 year: 2017 end-page: P1537 article-title: Development and evaluation of a novel positron emission tomography radiotracer for imaging the receptor for advanced glycation endproducts in Alzheimer’s disease publication-title: Alzheimer’s Dementia – volume: 38 start-page: 372 year: 2017 end-page: 382 article-title: Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response publication-title: Nucl Med Commun – volume: 8 start-page: 752 issue: 6 year: 2005 end-page: 758 article-title: ATP mediates rapid microglial response to local brain injury in vivo publication-title: Nat Neurosci – volume: 218 start-page: 1 issue: 1-2 year: 2010 end-page: 2 article-title: Sphingosine-1-phosphate and its receptors as a possible therapeutic target in autoimmune diseases of the nervous system publication-title: J Neuroimmunol – volume: 274 start-page: 1 issue: 1-2 year: 2014 end-page: 13 article-title: Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases publication-title: J Neuroimmunol – volume: 23 start-page: 344 issue: 4 year: 2005 end-page: 346 article-title: Macrophage polarization comes of age publication-title: Immunity – volume: 274 start-page: 13 issue: 1-2 year: 2008 end-page: 17 article-title: Central nervous system-directed effects of FTY720 (fingolimod) publication-title: J Neurol Sci – volume: 531 start-page: 2 issue: 1 year: 2002 end-page: 6 article-title: Phospholipase A(2) regulation of arachidonic acid mobilization publication-title: FEBS Lett – volume: 44 start-page: 242 issue: 3 year: 2003 end-page: 250 article-title: Selective expression of Gi/o-coupled ATP receptor P2Y12 in microglia in rat brain publication-title: Glia – volume: 6 start-page: e777 year: 2016 article-title: In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [(11)C]DPA-713 PET and analysis of CSF and plasma publication-title: Transl Psychiatry – volume: 2 start-page: 69 issue: 1 year: 2002 end-page: 82 article-title: Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation publication-title: Int Immunopharmacol – volume: 124 start-page: 59 issue: 1 year: 2013 end-page: 68 article-title: Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer’s disease publication-title: J Neurochem – volume: 4 start-page: 167 issue: 2 year: 2009 end-page: 177 article-title: Receptor for advanced glycation end products: its role in Alzheimer’s disease and other neurological diseases publication-title: Future Neurol – volume: 30 start-page: 431 issue: 8 year: 2009 end-page: 440 article-title: PET radiotracers: crossing the blood–brain barrier and surviving metabolism publication-title: Trends Pharmacol Sci – volume: 33 start-page: 273 issue: 2 year: 2018 end-page: 281 article-title: The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases publication-title: Mov Disord – volume: 24 start-page: 558 issue: 2 year: 2017 end-page: 570 article-title: A promising carbon-11-labeled sphingosine-1-phosphate receptor 1-specific PET tracer for imaging vascular injury publication-title: J Nucl Cardiol – volume: 2 start-page: e80 issue: 2 year: 2015 article-title: P2Y12 expression and function in alternatively activated human microglia publication-title: Neurol Neuroimmunol Neuroinflamm – volume: 1542 start-page: 206 year: 2014 end-page: 220 article-title: TAM receptor tyrosine kinases: expression, disease and oncogenesis in the central nervous system publication-title: Brain Res – volume: 18 issue: 4 year: 2017 article-title: Translocator protein-18 kDa (TSPO) positron emission tomography (PET) imaging and its clinical impact in neurodegenerative diseases publication-title: Int J Mol Sci – volume: 111 start-page: 997 issue: 4 year: 1994 end-page: 1002 article-title: The effects of chronic imidazoline drug treatment on glial fibrillary acidic protein concentrations in rat brain publication-title: Br J Pharmacol – volume: 109 start-page: 117 issue: suppl 1 year: 2009 end-page: 125 article-title: Differential gene expression in LPS/IFNgamma activated microglia and macrophages: in vitro versus in vivo publication-title: J Neurochem – volume: 33 start-page: 12870 issue: 31 year: 2013 end-page: 12886 article-title: Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury publication-title: J Neurosci – volume: 116 start-page: 1175 issue: Pt 7 year: 2003 end-page: 1186 article-title: GSK-3: tricks of the trade for a multi-tasking kinase publication-title: J Cell Sci – volume: 9 start-page: 25 issue: 1 year: 2017 article-title: Monoamine oxidase B inhibitor, selegiline, reduces (18)F-THK5351 uptake in the human brain publication-title: Alzheimers Res Ther – volume: 382 start-page: 685 issue: 6593 year: 1996 end-page: 691 article-title: RAGE and amyloid-beta peptide neurotoxicity in Alzheimer’s disease publication-title: Nature – volume: 53 start-page: 37 issue: 1 year: 2012 end-page: 46 article-title: Evidence for astrocytosis in prodromal Alzheimer disease provided by C-deuterium- -deprenyl: a multitracer PET paradigm combining C-Pittsburgh compound B and F-FDG publication-title: J Nucl Med – volume: 14 start-page: 417 issue: 3 year: 2003 end-page: 424 article-title: Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro publication-title: Neurobiol Dis – volume: 153 start-page: 277 issue: 2 year: 2008 end-page: 285 article-title: Cannabinoid CB2 receptors in human brain inflammation publication-title: Br J Pharmacol – volume: 181 start-page: 338 issue: 1 year: 2008 end-page: 345 article-title: Lithium prevents and ameliorates experimental autoimmune encephalomyelitis publication-title: J Immunol – volume: 5 start-page: 223 issue: 2 year: 2009 end-page: 232 article-title: Physiological and pathological functions of P2X7 receptor in the spinal cord publication-title: Purinergic Signal – volume: 27 start-page: 119 year: 2009 end-page: 145 article-title: Microglial physiology: unique stimuli, specialized responses publication-title: Annu Rev Immunol – volume: 97 start-page: 238 year: 1996 end-page: 243 article-title: Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats publication-title: J Clin Invest – volume: 21 start-page: 145 issue: 2 year: 1993 end-page: 161 article-title: Stereoselective, competitive, and nonlinear plasma protein binding of ibuprofen enantiomers as determined in vivo in healthy subjects publication-title: J Pharmacokinet Biopharm – volume: 5 start-page: 432 issue: 5 year: 2008 end-page: 437 article-title: Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis publication-title: Curr Alzheimer Res – volume: 57 start-page: 115 issue: suppl 2 year: 2016 article-title: A novel PET radioligand, [11C]PS13, successfully images COX-1, a potential biomarker for neuroinflammation publication-title: J Nucl Med – volume: 25 start-page: 3230 issue: 16 year: 2015 end-page: 3233 article-title: Radiosynthesis and preliminary PET evaluation of glycogen synthase kinase 3beta (GSK-3beta) inhibitors containing [(11)C]methylsulfanyl, [(11)C]methylsulfinyl or [(11)C]methylsulfonyl groups publication-title: Bioorg Med Chem Lett – volume: 88 start-page: 3637 issue: 9 year: 1991 end-page: 3641 article-title: Human monoamine oxidase A and B genes exhibit identical exon–intron organization publication-title: Proc Natl Acad Sci U S A – volume: 111 start-page: 5409 issue: 14 year: 2014 end-page: 5414 article-title: Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis publication-title: Proc Natl Acad Sci U S A – volume: 3 start-page: 479 issue: 6 year: 2004 end-page: 487 article-title: GSK3 inhibitors: development and therapeutic potential publication-title: Nat Rev Drug Discov – volume: 60 start-page: 7213 issue: 17 year: 2017 end-page: 7232 article-title: Targeting the receptor for advanced glycation endproducts (RAGE): a medicinal chemistry perspective publication-title: J Med Chem – volume: 21 start-page: 6634 issue: 21 year: 2013 end-page: 6641 article-title: Development of a novel fluorine-18 labeled deuterated fluororasagiline ([(18)F]fluororasagiline-D2) radioligand for PET studies of monoamino oxidase B (MAO-B) publication-title: Bioorg Med Chem – volume: 6 start-page: e16964 issue: 2 year: 2011 article-title: Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility publication-title: PLoS One – volume: 3 start-page: 194 issue: 3 year: 2013 end-page: 216 article-title: PET radiopharmaceuticals for probing enzymes in the brain publication-title: Am J Nucl Med Mol Imaging – volume: 52 start-page: 201 issue: 2 year: 2006 end-page: 243 article-title: Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders publication-title: Brain Res Rev – volume: 556 start-page: 426 issue: 7702 year: 2018 end-page: 428 article-title: Is ‘friendly fire’ in the brain provoking Alzheimer’s disease? publication-title: Nature – volume: 22 start-page: 5168 issue: 19 year: 2014 end-page: 5181 article-title: Synthesis of fluorinated analogues of sphingosine-1-phosphate antagonists as potential radiotracers for molecular imaging using positron emission tomography publication-title: Bioorg Med Chem – volume: 164 start-page: 1079 issue: 4 year: 2011 end-page: 1106 article-title: Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS) publication-title: Br J Pharmacol – volume: 32 start-page: 10809 issue: 32 year: 2012 end-page: 10818 article-title: Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging publication-title: J Neurosci – volume: 78 start-page: 489 issue: 3 year: 1983 end-page: 505 article-title: Studies on RX 781094: a selective, potent and specific antagonist of alpha 2-adrenoceptors publication-title: Br J Pharmacol – volume: 30 start-page: 31 issue: 1 year: 1997 end-page: 36 article-title: I2-imidazoline binding sites and monoamine oxidase activity in human postmortem brain from patients with Parkinson’s disease publication-title: Neurochem Int – volume: 47 start-page: 3127 issue: 10 year: 2014 end-page: 3134 article-title: A philosophy for CNS radiotracer design publication-title: Acc Chem Res – volume: 313 start-page: 109 year: 2017 end-page: 115 article-title: Neurodegenerative diseases: the immunological perspective publication-title: J Neuroimmunol – volume: 6 start-page: 329 issue: 4 year: 2007 end-page: 337 article-title: Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism publication-title: Cell Metab – volume: 16 start-page: 1830 issue: 16 year: 2016 end-page: 1842 article-title: Selected PET radioligands for ion channel linked neuroreceptor imaging: focus on GABA, NMDA and nACh receptors publication-title: Curr Top Med Chem – volume: 58 start-page: 209 issue: suppl 1 year: 2017 article-title: . [18F]JHU16907 for PET imaging of MER tyrosine kinase (MERTK) publication-title: J Nucl Med – volume: 51 start-page: 14826 issue: 80 year: 2015 end-page: 14831 article-title: PET tracers for imaging brain alpha7 nicotinic receptors: an update publication-title: Chem Commun (Camb) – volume: 58 start-page: 1135 issue: 11 year: 1999 end-page: 1146 article-title: Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons publication-title: J Neuropathol Exp Neurol – volume: 73 start-page: 108 issue: 1-3 year: 2007 end-page: 113 article-title: Gene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal aging publication-title: Brain Res Bull – volume: 57 start-page: 1436 issue: 9 year: 2016 end-page: 1441 article-title: Preclinical evaluation of a P2X7 receptor-selective radiotracer: PET studies in a rat model with local overexpression of the human P2X7 receptor and in nonhuman primates publication-title: J Nucl Med – volume: 11 start-page: 56 year: 2017 article-title: Divergent neuroinflammatory regulation of microglial TREM expression and involvement of NF-kappaB publication-title: Front Cell Neurosci – year: 2017 article-title: Are rodent models of Parkinson’s disease behaving as they should? publication-title: Behav Brain Res – volume: 58 start-page: 320 issue: 2 year: 2017 end-page: 325 article-title: 11C-ER176, a radioligand for 18-kDa translocator protein, has adequate sensitivity to robustly image all three affinity genotypes in human brain publication-title: J Nucl Med – volume: 9 start-page: 887 issue: 5 year: 2005 end-page: 900 article-title: Neuroinflammation: a potential therapeutic target publication-title: Expert Opin Ther Targets – volume: 115 start-page: 1047 issue: 7 year: 2008 end-page: 1050 article-title: Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment publication-title: J Neural Transm (Vienna) – volume: 56 start-page: 1091 issue: suppl 2 year: 2015 article-title: [18F]PS-2 as a candidate radioligand for imaging COX-1 expression in brain: radiosynthesis and monkey PET imaging publication-title: J Nucl Med – volume: 4 start-page: 628 issue: 8 year: 2013 end-page: 637 article-title: Role of sphingosine 1-phosphate (S1P) receptor 1 in experimental autoimmune encephalomyelitis publication-title: Pharmacol Pharm – volume: 23 issue: 3 year: 2018 article-title: PET imaging of microglial activation-beyond targeting TSPO publication-title: Molecules – volume: 166 start-page: 132 issue: 1 year: 2010 end-page: 144 article-title: Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia publication-title: Neuroscience – volume: 65 start-page: 375 issue: 2 year: 2017 end-page: 387 article-title: P2Y12 receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases publication-title: Glia – volume: 38 start-page: 933 issue: 7 year: 2011 end-page: 943 article-title: Development of new radiopharmaceuticals for imaging monoamine oxidase B publication-title: Nucl Med Biol – volume: 45 start-page: 1 year: 2017 end-page: 7 article-title: A useful PET probe [(11)C]BU99008 with ultra-high specific radioactivity for small animal PET imaging of I2-imidazoline receptors in the hypothalamus publication-title: Nucl Med Biol – volume: 9 start-page: 241 issue: 2 year: 2012 end-page: 244 article-title: Animal models of neurological disorders publication-title: Neurotherapeutics – volume: 328 start-page: 9 issue: 1-2 year: 2013 end-page: 18 article-title: Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy publication-title: J Neurol Sci – volume: 35 start-page: 419 issue: 3 year: 2002 end-page: 432 article-title: Inflammation in neurodegenerative disease – a double-edged sword publication-title: Neuron – volume: 23 start-page: 297 issue: 2 year: 1999 end-page: 308 article-title: Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice publication-title: Neuron – volume: 33 start-page: 43 issue: 1 year: 2007 end-page: 55 article-title: Increased level of active GSK-3beta in Alzheimer’s disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration publication-title: Neuropathol Appl Neurobiol – volume: 62 start-page: 395 issue: 5 year: 2014 end-page: 403 article-title: The chemokine CX3CL1 (fractalkine) and its receptor CX3CR1: occurrence and potential role in osteoarthritis publication-title: Arch Immunol Ther Exp (Warsz) – volume: 104 start-page: 1433 issue: 6 year: 2008 end-page: 1439 article-title: The GSK3 hypothesis of Alzheimer’s disease publication-title: J Neurochem – volume: 47 start-page: 425 issue: 2 year: 1996 end-page: 432 article-title: Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer’s disease: a review of 17 epidemiologic studies publication-title: Neurology – volume: 51 start-page: 153 issue: 3 year: 2008 end-page: 158 article-title: Radiosynthesis of (S)-5-methoxymethyl-3-[6-(4,4,4-trifluorobutoxy)benzo[d]isoxazol-3-yl] oxazolidin-2-[11C]one ([11C]SL25.1188), a novel radioligand for imaging monoamine oxidase-B with PET publication-title: J Label Compd Radiopharm – volume: 76 start-page: 77 issue: 2 year: 2005 end-page: 98 article-title: Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism publication-title: Prog Neurobio.l – volume: 41 start-page: 253 year: 1994 end-page: 258 article-title: Reactive gliosis and monoamine oxidase B publication-title: J Neural Transm Suppl – volume: 275 start-page: 40096 issue: 51 year: 2000 end-page: 40105 article-title: Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation publication-title: J Biol Chem – volume: 9 start-page: 578 issue: 3 year: 2018 end-page: 586 article-title: Development of a positron emission tomography radiotracer for imaging elevated levels of superoxide in neuroinflammation publication-title: ACS Chem Neurosci – volume: 19 start-page: 312 issue: 8 year: 1996 end-page: 318 article-title: Microglia: a sensor for pathological events in the CNS publication-title: Trends Neurosci – volume: 118 start-page: 475 issue: 4 year: 2009 end-page: 485 article-title: Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease publication-title: Acta Neuropathol – volume: 14 start-page: 1443 issue: 14 year: 2008 end-page: 1451 article-title: Cyclooxygenase-2 in synaptic signaling publication-title: Curr Pharm Des – volume: 23 start-page: 1453 issue: 6 year: 2006 end-page: 1464 article-title: S1P inhibits gap junctions in astrocytes: involvement of G and Rho GTPase/ROCK publication-title: Eur J Neurosci – volume: 27 start-page: 1533 issue: 9 year: 2007 end-page: 1539 article-title: Consensus nomenclature for in vivo imaging of reversibly binding radioligands publication-title: J Cereb Blood Flow Metab – volume: 7 start-page: 391 year: 2016 end-page: 398 article-title: Synthesis and evaluation of [(18)F]RAGER: a first generation small-molecule PET radioligand targeting the receptor for advanced glycation endproducts publication-title: ACS Chem Neurosci – volume: 72 start-page: 335 year: 2010 end-page: 355 article-title: Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior publication-title: Annu Rev Physiol – volume: 41 start-page: 507 issue: 6 year: 2014 end-page: 512 article-title: Synthesis and evaluation of [(11)C]PyrATP-1, a novel radiotracer for PET imaging of glycogen synthase kinase-3beta (GSK-3beta) publication-title: Nucl Med Biol – volume: 57 Suppl 2 start-page: 1049 year: 2016 article-title: RAGE-specific probe 18F -FPS-ZM1 may be a promising biomarker for early detection of diabetes with Alzheimer’s disease publication-title: J Nucl Med – volume: 42 start-page: 195 issue: 3 year: 2015 end-page: 202 article-title: Sphingosin-1-phosphate receptor 1: a potential target to inhibit neuroinflammation and restore the sphingosin-1-phosphate metabolism publication-title: Can J Neurol Sci – volume: 119 start-page: 7 issue: 1 year: 2010 end-page: 35 article-title: Astrocytes: biology and pathology publication-title: Acta Neuropathol – volume: 19 start-page: 5518 issue: Suppl 1 year: 2017 end-page: 5758 article-title: Development and evaluation of the first TREM1-specific PET tracer for imaging maladaptive inflammation in a mouse model of lipopolysaccharide-induced sepsis publication-title: Mol Imaging Biol – volume: 6 start-page: 571 issue: 4 year: 2016 end-page: 593 article-title: Glycogen synthase kinase-3 (GSK-3)-targeted therapy and imaging publication-title: Theranostics – volume: 6 start-page: 671 issue: 6 year: 2015 end-page: 676 article-title: Synthesis, SAR, and pharmacological characterization of brain penetrant P2X7 receptor antagonists publication-title: ACS Med Chem Lett – volume: 22 start-page: 1491 issue: 5 year: 2008 end-page: 1501 article-title: Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury publication-title: FASEB J – volume: 97 start-page: 889 issue: 7 year: 1999 end-page: 901 article-title: RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides publication-title: Cell – volume: 12 start-page: 74 year: 2015 article-title: Rodent models of neuroinflammation for Alzheimer’s disease publication-title: J Neuroinflammation – volume: 200 start-page: 564 year: 1991 end-page: 577 article-title: cDNA cloning and properties of glycogen synthase kinase-3 publication-title: Methods Enzymol – volume: 11 start-page: 371 issue: 2 year: 1993 end-page: 386 article-title: Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids publication-title: Neuron – volume: 19 start-page: 3265 issue: 10 year: 2011 end-page: 3273 article-title: Efficient synthesis and chiral separation of C-labeled ibuprofen assisted by DMSO for imaging of in vivo behavior of the individual isomers by positron emission tomography publication-title: Bioorg Med Chem – volume: 25 start-page: 80 issue: 1 year: 2017 end-page: 90 article-title: Sphingosine 1-phosphate receptor modulators and drug discovery publication-title: Biomol Ther (Seoul) – volume: 21 start-page: 276 issue: 4 year: 2007 end-page: 291 article-title: Oxidative stress and transcriptional regulation in Alzheimer disease publication-title: Alzheimer Dis Assoc Disord – volume: 171 start-page: 29 issue: 1 year: 2001 end-page: 45 article-title: Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer’s disease: identification of a cellular activation mechanism publication-title: Exp Neurol – volume: 12 start-page: 829 issue: 7 year: 2006 end-page: 834 article-title: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury publication-title: Nat Med – volume: 7 start-page: 46 year: 2014 article-title: GSK-3beta, a pivotal kinase in Alzheimer disease publication-title: Front Mol Neurosci – volume: 27 start-page: 402 issue: 8 year: 2006 end-page: 409 article-title: Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function publication-title: Trends Pharmacol Sci – volume: 160 start-page: 467 issue: 3 year: 2010 end-page: 479 article-title: CB2: a cannabinoid receptor with an identity crisis publication-title: Br J Pharmacol – volume: 56 start-page: 3177 issue: 8 year: 2013 end-page: 3190 article-title: Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1) publication-title: J Med Chem – volume: 55 start-page: 1596 issue: 8 year: 2014 end-page: 1608 article-title: An update on the biology of sphingosine 1-phosphate receptors publication-title: J Lipid Res – volume: 57 start-page: 1124 issue: 7 year: 2016 end-page: 1129 article-title: PET/CT imaging of chemokine receptors in inflammatory atherosclerosis using targeted nanoparticles publication-title: J Nucl Med – volume: 58 start-page: 458 issue: 3 year: 2017 end-page: 465 article-title: Characterization of (11)C-GSK1482160 for targeting the P2X7 receptor as a biomarker for neuroinflammation publication-title: J Nucl Med – volume: 1 start-page: 234 issue: 2 year: 2009 end-page: 244 article-title: Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid publication-title: Aging (Albany NY) – volume: 66 start-page: S24 issue: 10 suppl 4 year: 2006 end-page: S36 article-title: The pathogenesis of cell death in Parkinson’s disease publication-title: Neurology – volume: 78 start-page: 321 issue: 5 year: 2011 end-page: 332 article-title: The human P2X7 receptor and its role in innate immunity publication-title: Tissue Antigens – volume: 15 start-page: 8260 issue: 11 year: 2010 end-page: 8278 article-title: Radiolabeled small molecule protein kinase inhibitors for imaging with PET or SPECT publication-title: Molecules – ident: bibr58-1536012118792317 doi: 10.1016/j.tips.2009.05.005 – ident: bibr22-1536012118792317 doi: 10.1038/nrn3484 – ident: bibr119-1536012118792317 doi: 10.1016/j.bmcl.2014.11.048 – ident: bibr46-1536012118792317 doi: 10.1186/1742-2094-11-98 – ident: bibr229-1536012118792317 doi: 10.1016/j.diabres.2004.09.004 – ident: bibr261-1536012118792317 doi: 10.1021/acschemneuro.6b00056 – ident: bibr101-1536012118792317 doi: 10.1111/j.1471-4159.1990.tb03121.x – ident: bibr175-1536012118792317 doi: 10.1002/glia.10180 – ident: bibr224-1536012118792317 doi: 10.1097/MNM.0000000000000660 – ident: bibr124-1536012118792317 doi: 10.1016/j.bcp.2012.05.005 – ident: bibr235-1536012118792317 doi: 10.2217/14796708.4.2.167 – volume: 45 start-page: 139 issue: 2 year: 2001 ident: bibr52-1536012118792317 publication-title: Q J Nucl Med – ident: bibr56-1536012118792317 doi: 10.1016/j.drudis.2014.08.012 – ident: bibr263-1536012118792317 doi: 10.1007/s00259-010-1612-0 – ident: bibr216-1536012118792317 doi: 10.1016/j.biocel.2010.06.021 – ident: bibr44-1536012118792317 doi: 10.1016/S0169-328X(98)00040-0 – ident: bibr173-1536012118792317 doi: 10.1046/j.0953-816x.2001.01585.x – ident: bibr78-1536012118792317 doi: 10.1016/j.cmet.2007.08.013 – ident: bibr8-1536012118792317 doi: 10.1016/j.expneurol.2007.07.004 – ident: bibr191-1536012118792317 – ident: bibr24-1536012118792317 doi: 10.1523/JNEUROSCI.04-02-00585.1984 – ident: bibr190-1536012118792317 doi: 10.1021/jm502021d – ident: bibr174-1536012118792317 doi: 10.1111/j.1460-9568.2006.04671.x – volume: 56 start-page: 1092 issue: 3 year: 2015 ident: bibr162-1536012118792317 publication-title: J Nucl Med – ident: bibr98-1536012118792317 doi: 10.1002/anie.201603797 – ident: bibr66-1536012118792317 doi: 10.1016/0024-3205(83)90062-0 – ident: bibr197-1536012118792317 doi: 10.1016/S1567-5769(01)00147-3 – ident: bibr227-1536012118792317 doi: 10.1002/glia.10293 – volume: 57 start-page: 1049 year: 2016 ident: bibr243-1536012118792317 publication-title: J Nucl Med – ident: bibr34-1536012118792317 doi: 10.1016/0166-2236(96)10049-7 – ident: bibr112-1536012118792317 doi: 10.1016/j.bmc.2013.08.019 – ident: bibr91-1536012118792317 doi: 10.1111/j.1471-4159.2007.05194.x – ident: bibr259-1536012118792317 doi: 10.4161/cc.23067 – ident: bibr13-1536012118792317 doi: 10.1016/j.jneuroim.2017.11.002 – ident: bibr74-1536012118792317 doi: 10.3390/ijms18040785 – ident: bibr192-1536012118792317 doi: 10.1007/s12350-015-0391-1 – ident: bibr238-1536012118792317 doi: 10.1001/archneur.62.11.1734 – ident: bibr211-1536012118792317 doi: 10.1002/jlcr.3206 – ident: bibr82-1536012118792317 doi: 10.2337/diabetes.49.2.263 – ident: bibr249-1536012118792317 doi: 10.1371/journal.pone.0016964 – ident: bibr176-1536012118792317 doi: 10.1194/jlr.R046300 – ident: bibr105-1536012118792317 doi: 10.2967/jnumed.110.087031 – ident: bibr63-1536012118792317 doi: 10.1007/s13311-012-0118-9 – ident: bibr264-1536012118792317 doi: 10.3390/molecules23030607 – volume-title: Cells, Tissues, and Disease: Principles of General Pathology year: 2004 ident: bibr2-1536012118792317 – ident: bibr70-1536012118792317 doi: 10.1016/j.nbd.2003.07.002 – ident: bibr257-1536012118792317 doi: 10.1016/j.pharep.2015.07.006 – ident: bibr256-1536012118792317 doi: 10.1186/alzrt269 – ident: bibr187-1536012118792317 doi: 10.1073/pnas.1615413114 – ident: bibr180-1536012118792317 doi: 10.1186/1742-2094-8-76 – ident: bibr4-1536012118792317 doi: 10.1111/jnc.13607 – ident: bibr45-1536012118792317 doi: 10.1007/s00401-009-0556-6 – ident: bibr118-1536012118792317 doi: 10.1038/jcbfm.2014.34 – ident: bibr196-1536012118792317 doi: 10.1038/sj.bjp.0707505 – ident: bibr206-1536012118792317 doi: 10.1007/s00005-014-0275-0 – ident: bibr25-1536012118792317 doi: 10.1016/j.tins.2009.08.002 – ident: bibr64-1536012118792317 doi: 10.1186/s12974-015-0291-y – ident: bibr18-1536012118792317 doi: 10.1212/WNL.47.2.425 – ident: bibr193-1536012118792317 doi: 10.1007/s11307-016-0944-y – ident: bibr79-1536012118792317 doi: 10.1111/j.1471-4159.2004.02422.x – ident: bibr120-1536012118792317 doi: 10.1186/s13024-017-0162-3 – ident: bibr189-1536012118792317 doi: 10.1016/j.bmc.2014.08.009 – ident: bibr184-1536012118792317 doi: 10.4236/pp.2013.48089 – ident: bibr108-1536012118792317 doi: 10.1007/s11307-005-0016-1 – ident: bibr94-1536012118792317 doi: 10.1016/j.bmcl.2010.11.026 – ident: bibr167-1536012118792317 doi: 10.1124/pr.107.07113 – ident: bibr185-1536012118792317 doi: 10.1111/j.1476-5381.2011.01302.x – ident: bibr33-1536012118792317 doi: 10.1152/physrev.00011.2010 – ident: bibr130-1536012118792317 doi: 10.1038/jcbfm.2014.160 – volume: 13 start-page: 369 issue: 10 year: 1992 ident: bibr134-1536012118792317 publication-title: Trends Pharmacol Sci – ident: bibr172-1536012118792317 doi: 10.1016/j.neuroscience.2009.12.020 – ident: bibr16-1536012118792317 doi: 10.1016/S0896-6273(02)00794-8 – ident: bibr59-1536012118792317 doi: 10.2174/0929867323666160418114826 – ident: bibr219-1536012118792317 doi: 10.1016/j.bmcl.2015.06.004 – ident: bibr236-1536012118792317 doi: 10.1006/exnr.2001.7732 – ident: bibr244-1536012118792317 doi: 10.1021/acs.jmedchem.7b00058 – ident: bibr75-1536012118792317 doi: 10.1242/jcs.00384 – ident: bibr209-1536012118792317 doi: 10.1073/pnas.1316510111 – ident: bibr159-1536012118792317 doi: 10.1016/j.nucmedbio.2014.04.008 – ident: bibr152-1536012118792317 doi: 10.1186/1742-2094-5-17 – ident: bibr60-1536012118792317 doi: 10.1002/ana.410150302 – ident: bibr182-1536012118792317 doi: 10.1016/j.jneuroim.2012.12.005 – ident: bibr100-1536012118792317 doi: 10.1073/pnas.88.9.3637 – ident: bibr200-1536012118792317 doi: 10.1523/JNEUROSCI.23-35-11136.2003 – ident: bibr230-1536012118792317 doi: 10.1074/jbc.272.28.17810 – ident: bibr5-1536012118792317 doi: 10.1007/s11481-006-9021-7 – ident: bibr95-1536012118792317 doi: 10.1016/j.nucmedbio.2014.03.025 – volume: 163 start-page: 1628 issue: 3 year: 1999 ident: bibr205-1536012118792317 publication-title: J Immunol doi: 10.4049/jimmunol.163.3.1628 – ident: bibr231-1536012118792317 doi: 10.1016/S0092-8674(00)80801-6 – ident: bibr89-1536012118792317 doi: 10.1046/j.1471-4159.1994.63010245.x – ident: bibr222-1536012118792317 doi: 10.1016/j.bmcl.2015.03.021 – ident: bibr53-1536012118792317 doi: 10.3390/molecules15118260 – ident: bibr179-1536012118792317 doi: 10.1016/j.yexcr.2014.11.020 – ident: bibr9-1536012118792317 doi: 10.1196/annals.1403.002 – ident: bibr40-1536012118792317 doi: 10.1016/j.neuroscience.2015.05.018 – ident: bibr267-1536012118792317 doi: 10.2174/1568026616666160315142457 – ident: bibr199-1536012118792317 doi: 10.1523/JNEUROSCI.23-04-01398.2003 – ident: bibr149-1536012118792317 doi: 10.1096/fj.07-9411com – volume: 41 start-page: 253 year: 1994 ident: bibr103-1536012118792317 publication-title: J Neural Transm Suppl – ident: bibr113-1536012118792317 doi: 10.1021/acschemneuro.5b00223 – ident: bibr30-1536012118792317 doi: 10.1038/nature17623 – volume: 7 start-page: 46 year: 2014 ident: bibr86-1536012118792317 publication-title: Front Mol Neurosci – ident: bibr135-1536012118792317 doi: 10.1111/j.1476-5381.1994.tb14842.x – ident: bibr36-1536012118792317 doi: 10.1038/nn1472 – ident: bibr109-1536012118792317 doi: 10.1016/S1046-2023(02)00083-X – ident: bibr240-1536012118792317 doi: 10.1021/acschemneuro.5b00319 – ident: bibr242-1536012118792317 doi: 10.1016/j.jalz.2017.07.671 – ident: bibr268-1536012118792317 doi: 10.1177/1536012117731258 – ident: bibr169-1536012118792317 doi: 10.1212/WNL.0b013e31820d5ec1 – ident: bibr226-1536012118792317 doi: 10.1212/NXI.0000000000000080 – ident: bibr23-1536012118792317 doi: 10.1146/annurev-physiol-021909-135843 – ident: bibr116-1536012118792317 doi: 10.1002/jlcr.1908 – ident: bibr20-1536012118792317 doi: 10.1016/S0197-4580(00)00124-X – ident: bibr28-1536012118792317 doi: 10.1038/nm1425 – ident: bibr61-1536012118792317 doi: 10.1038/sj.jcbfm.9600493 – ident: bibr181-1536012118792317 doi: 10.1017/cjn.2015.19 – ident: bibr51-1536012118792317 doi: 10.1007/7657_2012_53 – ident: bibr210-1536012118792317 doi: 10.3390/ijms151223672 – ident: bibr14-1536012118792317 doi: 10.1126/science.aag2590 – ident: bibr93-1536012118792317 doi: 10.1021/acsmedchemlett.5b00044 – ident: bibr123-1536012118792317 doi: 10.1155/2013/484613 – ident: bibr136-1536012118792317 doi: 10.1111/j.1749-6632.1999.tb09388.x – ident: bibr57-1536012118792317 doi: 10.1021/jm5001858 – ident: bibr67-1536012118792317 doi: 10.2967/jnumed.114.141713 – ident: bibr84-1536012118792317 doi: 10.4049/jimmunol.181.1.338 – ident: bibr154-1536012118792317 doi: 10.1093/jnen/63.9.901 – ident: bibr201-1536012118792317 doi: 10.1016/j.nucmedbio.2011.09.005 – volume: 19 start-page: 5518 issue: 1 year: 2017 ident: bibr254-1536012118792317 publication-title: Mol Imaging Biol – ident: bibr85-1536012118792317 doi: 10.1111/j.1365-2990.2006.00795.x – ident: bibr81-1536012118792317 doi: 10.1242/jcs.138057 – ident: bibr177-1536012118792317 doi: 10.1016/j.jns.2013.02.011 – ident: bibr212-1536012118792317 doi: 10.1007/s11302-009-9138-2 – ident: bibr170-1536012118792317 doi: 10.1016/j.jneuroim.2009.09.018 – ident: bibr96-1536012118792317 doi: 10.1016/j.bmcl.2015.05.085 – ident: bibr68-1536012118792317 doi: 10.1016/j.tips.2006.06.005 – ident: bibr144-1536012118792317 doi: 10.2174/138161208784480144 – volume: 57 start-page: 1 issue: 2 year: 2016 ident: bibr194-1536012118792317 publication-title: J Nucl Med – ident: bibr150-1536012118792317 doi: 10.1111/jnc.12059 – ident: bibr131-1536012118792317 doi: 10.1016/j.nucmedbio.2017.05.011 – ident: bibr143-1536012118792317 doi: 10.1016/0896-6273(93)90192-T – ident: bibr262-1536012118792317 doi: 10.1002/mds.26428 – ident: bibr245-1536012118792317 doi: 10.1038/nri2303 – ident: bibr148-1536012118792317 doi: 10.18632/aging.100021 – ident: bibr155-1536012118792317 doi: 10.1016/j.bmc.2011.03.041 – ident: bibr43-1536012118792317 doi: 10.1007/s00401-009-0619-8 – ident: bibr127-1536012118792317 doi: 10.1097/WAD.0b013e31815721c3 – volume: 57 start-page: 115 issue: 2 year: 2016 ident: bibr160-1536012118792317 publication-title: J Nucl Med – ident: bibr132-1536012118792317 doi: 10.1021/acschemneuro.7b00385 – volume: 56 start-page: 1091 issue: 2 year: 2015 ident: bibr161-1536012118792317 publication-title: J Nucl Med – ident: bibr178-1536012118792317 doi: 10.1038/nrd3248 – volume: 58 start-page: 209 issue: 1 year: 2017 ident: bibr250-1536012118792317 publication-title: J Nucl Med – ident: bibr6-1536012118792317 doi: 10.1038/nrn2398 – ident: bibr97-1536012118792317 doi: 10.1021/acsmedchemlett.6b00405 – ident: bibr168-1536012118792317 doi: 10.1016/j.pharmthera.2007.04.006 – ident: bibr17-1536012118792317 doi: 10.1517/14728222.9.5.887 – ident: bibr157-1536012118792317 doi: 10.1007/BF01059767 – ident: bibr248-1536012118792317 doi: 10.2353/ajpath.2009.080807 – ident: bibr55-1536012118792317 doi: 10.1002/jlcr.3158 – volume: 58 start-page: 551 issue: 1 year: 2017 ident: bibr241-1536012118792317 publication-title: J Nucl Med – ident: bibr233-1536012118792317 doi: 10.1172/JCI118397 – ident: bibr83-1536012118792317 doi: 10.1016/B978-0-444-52001-2.00008-X – ident: bibr26-1536012118792317 doi: 10.1016/S0896-6273(00)80781-3 – ident: bibr41-1536012118792317 doi: 10.1523/JNEUROSCI.6221-11.2012 – ident: bibr223-1536012118792317 doi: 10.2967/jnumed.116.181354 – ident: bibr232-1536012118792317 doi: 10.1074/jbc.M006993200 – ident: bibr29-1536012118792317 doi: 10.1523/JNEUROSCI.2121-13.2013 – ident: bibr255-1536012118792317 doi: 10.1016/j.molmed.2017.04.005 – ident: bibr73-1536012118792317 doi: 10.2967/jnumed.116.178996 – ident: bibr237-1536012118792317 doi: 10.2174/156720508785908937 – ident: bibr228-1536012118792317 – ident: bibr215-1536012118792317 doi: 10.1111/j.1399-0039.2011.01780.x – ident: bibr125-1536012118792317 doi: 10.1016/j.biocel.2006.07.001 – ident: bibr7-1536012118792317 doi: 10.1111/j.1471-4159.2009.05984.x – ident: bibr146-1536012118792317 doi: 10.1097/00005072-199911000-00003 – ident: bibr140-1536012118792317 doi: 10.1016/j.nucmedbio.2016.10.005 – ident: bibr142-1536012118792317 doi: 10.1016/j.brainresrev.2006.02.002 – ident: bibr21-1536012118792317 doi: 10.1016/j.tins.2010.12.001 – ident: bibr47-1536012118792317 doi: 10.1023/A:1007677003387 – ident: bibr49-1536012118792317 doi: 10.1021/ar500233s – ident: bibr137-1536012118792317 doi: 10.1097/00001756-199605310-00013 – ident: bibr147-1536012118792317 doi: 10.1016/j.brainresbull.2007.02.015 – ident: bibr50-1536012118792317 doi: 10.1021/cr0782426 – volume: 10 start-page: 431 year: 2016 ident: bibr203-1536012118792317 publication-title: Front Neurosci – ident: bibr121-1536012118792317 doi: 10.1002/mds.27271 – ident: bibr133-1536012118792317 doi: 10.1111/j.1476-5381.1983.tb08809.x – ident: bibr71-1536012118792317 doi: 10.1523/JNEUROSCI.1487-12.2012 – ident: bibr213-1536012118792317 doi: 10.1016/j.febslet.2005.05.073 – ident: bibr38-1536012118792317 doi: 10.1146/annurev.immunol.021908.132528 – ident: bibr225-1536012118792317 doi: 10.1002/glia.23097 – ident: bibr80-1536012118792317 doi: 10.1038/nrd1415 – volume: 2 start-page: 19 year: 2010 ident: bibr19-1536012118792317 publication-title: Front Aging Neurosci – ident: bibr166-1536012118792317 doi: 10.2967/jnumed.107.049619 – ident: bibr3-1536012118792317 doi: 10.1038/nature07201 – ident: bibr31-1536012118792317 doi: 10.1038/nrn3880 – ident: bibr106-1536012118792317 doi: 10.1016/j.neuint.2010.10.013 – ident: bibr128-1536012118792317 doi: 10.1212/WNL.66.10_suppl_4.S24 – ident: bibr12-1536012118792317 doi: 10.1016/j.jneuroim.2014.07.012 – ident: bibr138-1536012118792317 doi: 10.2967/jnumed.113.131854 – ident: bibr153-1536012118792317 doi: 10.1136/jnnp.2005.063131 – year: 2017 ident: bibr65-1536012118792317 publication-title: Behav Brain Res – ident: bibr114-1536012118792317 doi: 10.1016/j.nucmedbio.2011.03.003 – volume: 114 start-page: 247 issue: 1 year: 2010 ident: bibr151-1536012118792317 publication-title: J Neurochem doi: 10.1111/j.1471-4159.2010.06759.x – ident: bibr270-1536012118792317 doi: 10.2967/jnumed.117.205492 – ident: bibr62-1536012118792317 doi: 10.1016/j.nucmedbio.2008.10.002 – ident: bibr204-1536012118792317 doi: 10.3389/fncel.2013.00026 – ident: bibr88-1536012118792317 doi: 10.1159/000067423 – ident: bibr11-1536012118792317 doi: 10.1016/j.cell.2010.02.016 – volume: 58 start-page: 203 issue: 1 year: 2017 ident: bibr163-1536012118792317 publication-title: J Nucl Med – volume: 11 start-page: 56 year: 2017 ident: bibr252-1536012118792317 publication-title: Front Cell Neurosci – volume: 3 start-page: 194 issue: 3 year: 2013 ident: bibr54-1536012118792317 publication-title: Am J Nucl Med Mol Imaging – ident: bibr117-1536012118792317 doi: 10.1002/syn.20703 – ident: bibr214-1536012118792317 doi: 10.1038/nm1082 – volume-title: Robbins Basic Pathology year: 2003 ident: bibr1-1536012118792317 – ident: bibr37-1536012118792317 doi: 10.1038/nrneurol.2014.207 – ident: bibr234-1536012118792317 doi: 10.1038/382685a0 – ident: bibr251-1536012118792317 doi: 10.1038/nri1106 – ident: bibr265-1536012118792317 doi: 10.1002/jlcr.3008 – ident: bibr126-1536012118792317 doi: 10.1089/ars.2013.5745 – ident: bibr145-1536012118792317 doi: 10.1002/cne.903550208 – ident: bibr258-1536012118792317 doi: 10.1038/d41586-018-04930-7 – ident: bibr266-1536012118792317 doi: 10.1039/C5CC04536C – ident: bibr32-1536012118792317 doi: 10.1126/science.1110647 – ident: bibr141-1536012118792317 doi: 10.1016/j.tips.2009.01.002 – ident: bibr183-1536012118792317 doi: 10.1002/glia.22361 – ident: bibr158-1536012118792317 doi: 10.1073/pnas.96.13.7563 – ident: bibr104-1536012118792317 doi: 10.1016/S0925-4439(00)00040-5 – ident: bibr111-1536012118792317 doi: 10.2967/jnumed.115.161083 – ident: bibr239-1536012118792317 doi: 10.1007/s00702-008-0069-9 – ident: bibr39-1536012118792317 doi: 10.1016/j.immuni.2005.10.001 – ident: bibr269-1536012118792317 doi: 10.1016/j.neuroimage.2017.10.009 – ident: bibr77-1536012118792317 doi: 10.1016/S0891-0618(99)00012-5 – ident: bibr69-1536012118792317 doi: 10.1038/nrd3295 – ident: bibr271-1536012118792317 doi: 10.1038/tp.2016.40 – ident: bibr76-1536012118792317 doi: 10.1016/0076-6879(91)00172-S – ident: bibr253-1536012118792317 – ident: bibr15-1536012118792317 doi: 10.1007/s11910-017-0733-2 – ident: bibr87-1536012118792317 doi: 10.7150/thno.14334 – ident: bibr27-1536012118792317 doi: 10.1523/JNEUROSCI.1709-08.2008 – ident: bibr188-1536012118792317 doi: 10.4062/biomolther.2016.160 – ident: bibr129-1536012118792317 doi: 10.1039/C6CC00895J – ident: bibr90-1536012118792317 doi: 10.1016/j.nbd.2011.09.002 – ident: bibr186-1536012118792317 doi: 10.1073/pnas.1014154108 – ident: bibr198-1536012118792317 doi: 10.1111/j.1476-5381.2010.00729.x – ident: bibr221-1536012118792317 doi: 10.2967/jnumed.115.169995 – ident: bibr107-1536012118792317 doi: 10.1002/ana.410440724 – volume-title: Novel PET Tracers Targeting Purinergic Receptors for in Vivo Imaging of Microglial Activation year: 2017 ident: bibr218-1536012118792317 – ident: bibr92-1536012118792317 doi: 10.1016/j.bmcl.2005.08.037 – ident: bibr246-1536012118792317 doi: 10.1016/j.brainres.2013.10.049 – ident: bibr72-1536012118792317 doi: 10.1177/0271678X17748786 – ident: bibr217-1536012118792317 doi: 10.1007/s00005-010-0069-y – ident: bibr35-1536012118792317 doi: 10.1038/nrneurol.2010.17 – ident: bibr139-1536012118792317 doi: 10.1016/S0197-0186(96)00035-6 – volume: 58 start-page: 10 issue: 1 year: 2017 ident: bibr195-1536012118792317 publication-title: J Nucl Med – ident: bibr208-1536012118792317 doi: 10.1021/jm3012273 – ident: bibr42-1536012118792317 doi: 10.1038/nature21029 – ident: bibr48-1536012118792317 doi: 10.1007/BF00964613 – ident: bibr99-1536012118792317 doi: 10.1017/CBO9780511575853 – ident: bibr102-1536012118792317 doi: 10.1016/0306-4522(89)90243-1 – ident: bibr122-1536012118792317 doi: 10.1186/s13195-017-0253-y – ident: bibr171-1536012118792317 doi: 10.1016/j.jns.2008.06.031 – ident: bibr202-1536012118792317 doi: 10.1007/s00259-016-3457-7 – ident: bibr207-1536012118792317 doi: 10.2967/jnumed.115.166751 – ident: bibr156-1536012118792317 doi: 10.2967/jnumed.110.084046 – ident: bibr220-1536012118792317 doi: 10.1021/acsmedchemlett.5b00089 – ident: bibr164-1536012118792317 doi: 10.1016/S0014-5793(02)03413-0 – ident: bibr110-1536012118792317 doi: 10.1002/syn.21514 – ident: bibr10-1536012118792317 doi: 10.1016/j.pneurobio.2005.06.004 – ident: bibr165-1536012118792317 doi: 10.1016/j.brainresbull.2011.12.001 – ident: bibr247-1536012118792317 doi: 10.1523/JNEUROSCI.4178-07.2008 – ident: bibr115-1536012118792317 doi: 10.1002/jlcr.1492 – volume-title: Concept Paper on No Need for Revision of the Guideline on Medicinal Products for the Treatment of Alzheimer’s Disease and Other Dementias ident: bibr260-1536012118792317 |
| SSID | ssj0020299 |
| Score | 2.5393598 |
| SecondaryResourceType | review_article |
| Snippet | The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and... |
| SourceID | doaj unpaywall pubmedcentral proquest pubmed crossref sage |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1536012118792317 |
| SubjectTerms | Activation Advanced glycosylation end products Amine oxidase (flavin-containing) Animals Arachidonic acid Astrocytes Binding sites Biomarkers Brain - diagnostic imaging Brain - pathology Cannabinoids Central nervous system Chemokines CX3CR1 protein Cytokines Emission analysis Glia Glycogen Glycogen synthase kinase 3 Glycosylation Humans Imidazoline Immunoglobulin receptors Inflammation Inflammation - diagnostic imaging Inflammatory response Intracellular signalling Kinases Macrophages Medical imaging Microglia Myeloid cells Nervous system Neurodegenerative diseases Neurodegenerative Diseases - diagnostic imaging Neuroglia Neuroimaging Neurological diseases Phospholipase Phospholipase A2 Positron emission Positron emission tomography Prostaglandin endoperoxide synthase Proteins Quantitation Radioactive tracers Radiopharmaceuticals - chemistry Reactive oxygen species Receptors Receptors, GABA - metabolism Review Selectivity Target recognition Tomography Tyrosine |
| SummonAdditionalLinks | – databaseName: DOAJ Open Access Full Text dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQD8AF8WahICMhJJCidWIncbjxaFWQSivYSr1FtseBlZZsxe4K9d8zY3uzXV69cMjFcRxnPGN_zni-YeyZ1B4K60UGutQZ4v8iM6rIMyDyNFl0GhQFCh9-rA5O1IfT8vRCqi86ExbpgaPgxt50vhYGoYABVRTC4qKDBXVX20KUxtPsK3Sz3kylrZbAWXbjlByjWVeBzEwTXV5ITrZZhAJX_58A5u_nJFMk_rVVf2bOf5jZ7MJatH-T3Uggkr-Onb_Frvj-Nrt6mNzkd9g5_Wqi7EP8eG_CPxmYzrFlh0iPmx74JJz-XnDEq_z9t5CmiM87Hng6UOFQR2I8I5_2sRD8l8BOTVMjfxddOotX_Gi1nCFG5zEKhk8-Hx_dZSf7e5O3B1nKsZC5slHLzOEOgQKvXF5Cqa3RwvhONABVRVT30lq8cDi17FxOXj9jIZc5dAI66ZSR99hOP-_9A8bR9qvGaNUosDgtWGOxCaclgLbO-mLExmuhty4RkFMejFmbJ87xX4dpxF4MT5xF8o1_1H1D4zjUI9rsUIDK1CZlai9TphHbXWtBm2x50WLrxMqoS3zH0-E2WiG5Vkzv5yusQwwYeYMz9ojdj0oz9ESSs7fO8fvrLXXa6ur2nX76NTB9I9ZSqsEnn5Pibbr0dyG8HFTzUok9_B8Se8SuI4TU8afULttZfl_5xwjTlvZJsMifF3s0pg priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3db9MwELdGJwEviG8CAxkJIYEUNXGcxEFCiEGngbSuGp20t8hfGZVKUtZWaP89d46TUj7GQ14cx3Lsu_PPPt_vCHmRCGuYslFoRCpCwP8slJzFoUHytIRVwnAMFD4aZ4en_PNZerZDxl0sDF6r7GyiM9Sm0XhGPgQcgtx4Is3fLb6HmDUKvatdCg3pUyuYt45i7BrZZciMNSC7-6Px5KTfgkXMZZQENU_DBLDJxnE5hLLMEZ4JpNRzCcw2C5Xj8_8bCP3zLqWP1r-xrhfy8oecz39Zrw5uk1seaNL3rWTcITu2vkuuH3lX-j1yicdRmKGITkZTeiLNrIGWNaBBKmtDp-6G-JICpqWfvrlURrSpqOPyAKEEOWpjHumsbguNPXcM1mg-6cfW7bN8Q4_XqzngeNpGytDpl8nxfXJ6MJp-OAx9HoZQpwVfhRp2ERicpePUpEJJEUlbRYUxWYZ0-IlS8MCUi6TSMXoGpTJxEpsqMlWiuUwekEHd1PYRoWAfskIKXnCjwHQoqaAJLRJjhNLKsoAMu0EvtScpx1wZ8zL2vOS_T1NAXvVfLFqCjivq7uM89vWQWtsVNBfnpdfU0srK5pEE7CkNZyxSgHKgIK9yxaJU2oDsdVJQen1flhvpDMjz_jVoKrpfZG2bNdRBloy4AKsekIet0PQ9SdAhnMfw__mWOG11dftNPfvq2MABj3FewJcvUfA2Xfr3ILzuRfO_I_b46p99Qm4CgBTtkdQeGawu1vYpgLSVeuY17yd0_jRZ priority: 102 providerName: ProQuest – databaseName: Openly Available Collection - Sage Journals dbid: AFRWT link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELbKVgIuFc-yUJCREBJIYfNwEocLKtBVQSqtSip6i_xKWWk3qbqJqv33zDhOylJeh1wcZ-w4M85nj-cbQl5E3OhQGt_TPOYe4P_QEywMPI3kaVFYcs0wUPjgS7J_wj6fxqcbpOpjYdwILt_gsSrokZ2s0bpxN3rinIwTMNPEkpNxpL8L0ndtsyi63e4-qQaWoHu6XaBnW-F5yJXXR7fdIJthCiujEdncnR5_y4clmh_ajJMo38MGrhyb19pc-5FZvv_fgdTrZy1dNP-ttjoXq0sxn__0P5veIVsOiNLdTnPukg1T3SM3D5yr_T5Z4XYVZjCiR3s5PRZ6VoNkBWiRikrT3J4gX1LAvPTTwqY6onVJLdcHKC3oWRcTSWdVV6jNmWW4xumVfuzcQsu39LBt5oDzaRdJQ_OvR4cPyMl0L_-w77k8DZ6KM9Z4ClYZGLylgljHXAruC1P6mdZJgnT5kZRwgUrwqFQBeg6F1EEU6NLXZaSYiB6SUVVX5hGhMH8kmeAsY1rC1CKFBBGKR1pzqaQJx2TSD3qhHIk55tKYF4HjLf_1M43Jq-GJ847A4y913-N3HOoh9bYtqC_OCmfJhRGlSX0B2FRoFoa-BBQEBWmZytCPhRmTnV4Lil6bC5COzI48hjaeD7fBktE9IypTt1AHWTSCDGb9MdnulGboSYQO4zSA90_X1Gmtq-t3qtl3yxYOeI2xDJ58iYp31aU_D8LrQTX_OWKP_1fqE3IboCbvNq92yKi5aM1TgHONfOZs8Afy6UDf priority: 102 providerName: SAGE Publications |
| Title | Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO |
| URI | https://journals.sagepub.com/doi/full/10.1177/1536012118792317 https://www.ncbi.nlm.nih.gov/pubmed/30203712 https://www.proquest.com/docview/2313779857 https://www.proquest.com/docview/2102319887 https://pubmed.ncbi.nlm.nih.gov/PMC6134492 https://journals.sagepub.com/doi/pdf/10.1177/1536012118792317 https://doaj.org/article/eafe70a009ad4220b022e707f7b205ae |
| UnpaywallVersion | publishedVersion |
| Volume | 17 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1536-0121 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0020299 issn: 1536-0121 databaseCode: KQ8 dateStart: 20020101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1536-0121 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0020299 issn: 1536-0121 databaseCode: DOA dateStart: 20020101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 1536-0121 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0020299 issn: 1536-0121 databaseCode: ABDBF dateStart: 20020101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1536-0121 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0020299 issn: 1536-0121 databaseCode: DIK dateStart: 20020101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 1536-0121 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0020299 issn: 1536-0121 databaseCode: RPM dateStart: 20160101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1536-0121 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0020299 issn: 1536-0121 databaseCode: 7X7 dateStart: 20180101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1536-0121 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0020299 issn: 1536-0121 databaseCode: BENPR dateStart: 20180101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELdYKwEvfMMKozISQgIpa77j8NZBy0BaV5VWlKfIjp2toiTVmgiNv547x83oxofgoa3kXBzbPZ9_8fl-R8hzjynpCmVbkgXMAvzvWtx3HUsieZrnZkz6GCh8NAoPZ_6HeTA3Z3MwFsaM4Hofj1VBi7Sxxtm9klnP-Bh7MEtDzU3GkP3OiXZIOwwAirdIezYa9z_XHKmB5QU6Ix2KWyh_4aa8UsXWsqTZ-38FOa-enDSx-TeqfMXPv_Hl8qfVaXi7TsG61qSGeCjly35VQpe-X6J8_O-O3yG3DG6l_VrR7pJrKr9Hrh8Zz_x9co67W5jwiI4HUzrhclFA01MAl5Tnkk71gfM1BYhM33_VmZFokVFNDQI6DmpZh1DSRV4XSnWiCbHRGtO3tRdp_ZoeV-USXgtoHXhDpx_Hxw_IbDiYvjm0TFoHKw1iv7RSeCnBWK_UCWTABGc2V5kdSxmGyK7vCQEf0CDmZamDjkYupOM5MrNl5qU-9x6SVl7kapdQMDdhzJkf-1KAJRJcQBUp86RkIhXK7ZDe5l9NUsN5jqk3loljaM4vj2iHvGzuWNV8H3-QPUBFaeSQqVsXFGcniZn4ieKZimwOUJZL33VtAaAJCqIsEq4dcNUhexs1SzY6kEDtSATJAnjGs-YyTHz05vBcFRXIIOmGE8Mi0SGPaq1sWuKhfzlyoP_Rlr5uNXX7Sr441eTiAO98P4Y7X6AiXjTp94PwqtH9v47Y438RfkJuAjpl9X7XHmmVZ5V6CgiwFF2yE80j-GbDd13S7g8nn6bwezAYjSddvavSNZbgByE9Uv8 |
| linkProvider | Unpaywall |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLbGJrG9IK6jMMBIgARS1MR2GgdpQox1atnaVSOT9hbs2NkqlaSsrab-OX4bx46bUi7jaQ95cWzLl-Pjzz4-30HoFeVaEal9T_GQe4D_iScYCTxlyNMoyblixlG41291Ttnns_BsDf1Y-MKYZ5ULnWgVtSozc0feBBxiuPF4GH0Yf_dM1ChjXV2E0BAutILatRRjzrHjUM-v4Ag32e3uw3y_JuSgnXzqeC7KgJeFMZt6GWBk43qUBaEKuRTcFzr3Y6VaLUP2TqWEDzrEaZ4Fxu4lpApooHJf5TRjgkK9t9AGoyyGw9_GXrs_OKmPfD6xESxBrYQeBSy0NJQ2Ia1lCda4ofCzAdOWG6ONH_A30Pvn203HDrA5K8ZifiVGo1_2x4O76I4DtvhjJYn30Jou7qPbPWe6f4Dm5vrLRETCg3aCT4QallBzBugTi0LhxL5In2DA0Lj7zYZOwmWOLXcILAKQ28rHEg-LKlHpc8uYbdQ13q_MTJP3-Hg2HcG5AVeeOTj5Mjh-iE5vZEYeofWiLPRjhEEftWLBWcyUBFUlhYQqMk6V4jKTmjRQczHoaeZI0U1sjlEaOB7036epgd7WJcYVIcg1effMPNb5DJW3TSgvz1OnGVItch35ArCuUIwQXwKqgoQojyTxQ6EbaGchBanTL5N0uRoa6GX9GzSDMfeIQpczyGNYOYIYdpEG2q6Epm4JNQboKID-RyvitNLU1T_F8MKyjwP-YyyGkm-M4C2b9O9BeFeL5n9H7Mn1nX2BNjtJ7yg96vYPn6ItAK-8ug7bQevTy5l-BgBxKp-7VYjR15te-D8B7kVxwQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELdgkwYviG8KGxgJIYEUGsdO4uxtX9UGbKtGpu0tsmNnVCpJtbZC---5c9yMMr4e8uLYF8e-u_yc8_1MyBsurYm0DQMjYxkA_o8CJSIWGCRP41EljcBE4cOjZP9UfDyPz_3eHMyF8SM4_YDbqqBHzlmjdU9M1fcxxj5YaeK4ySSy37H0NlmFVQ2Htdfq1uDkLO9WXGHkDpDE-gE2uI5T3pCx9F1y9P2_w5w3t0765Pw783qirr6r8finz9PgPrnncSXdahXhAbll64dk7dBHzh-RK_z7hAcS0eFeTk-UGTUguQTwR1VtaO42hE8pQFh68M2dXESbijrqDtBBUJs2xZGO6rbQ2AtHWI3eku62UZ7pJj2ez8YA22mbGEPzL8Pjx-R0sJfv7Af-2IWgjDMxC0pYNGAuVsliE0utZKhsFWbGJAmy33Ot4YIZlrwqGQYClTaMM1OFpuKlUPwJWamb2j4jFNxBkikpMmE0eAqtNIgoJTdG6lLbqEf6i0EvSs9JjkdjjAvmach_naYeede1mLR8HH-pu43z2NVDJm1X0FxeFN4wC6sqm4YKoKYyIopCDaAGCtIq1VEYK9sj6wstKBbKWYB0JGqUMTzjdXcbDBOjLaq2zRzqICkGy8CJ98jTVmm6nnCM_6YM3j9dUqelri7fqUdfHfk3wC8hMmj5FhXvukt_HoT3nWr-c8Se_6_UV2RtuDsoPh8cfXpB7gKIlO1vqXWyMruc2w0AajP90pvjDxkJL1Y |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLagk4AX7pfCQEZCSCBlTWIncXgbsGkgbauglcZTZMfOqChJtSZC49dzju1mdOMieOiLc-Lazmf7S47Pdwh5xoTRsTJhoEUiAuD_cSB5HAUaxdNYXAnNMVB4_yDdm_L3R8mRP5uDsTB-BJdbeKwKWmQXa5zdC12NvI9xBLM0tdpkAtXvouwy2UgToOIDsjE9GG9_chqpScASm5EOzQO0P3NTXqhibVuy6v2_opwXT0762PyrXb2Qp9_kfP7T7rR7w6VgXVpRQzyU8mWra6FL389JPv53x2-S65630m0HtFvkkqlvkyv73jN_h5zi1y1MeETHOxP6QepZA00vgVxSWWs6sQfOlxQoMn331WZGok1FrTQIYBxg6UIo6ax2hdocW0FsXI3pW-dFWr6ih107h9cC6gJv6OTj-PAume7uTN7sBT6tQ1AmOW-DEl5KMNarjBKdCCVFKE0V5lqnKarrM6XgBwgSrCojdDRKpSMW6SrUFSu5ZPfIoG5q84BQWG7SXAqec61gJVJSQRWlYFoLVSoTD8lo9VSL0mueY-qNeRF5mfPzIzokL_o7Fk7v4w-2rxEovR0qdduC5uS48BO_MLIyWSiBykrN4zhUQJqgIKsyFYeJNEOyuYJZscJAAbWjEKRI4D-e9pdh4qM3R9am6cAGRTeiHDaJIbnvUNm3hKF_OYug_9kaXteaun6lnn224uJA7zjP4c7nCMSzJv1-EF722P_riD38F-NH5BqwU-G-d22SQXvSmcfAAFv1xM_zH5EFTPw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Emerging+PET+Radiotracers+and+Targets+for+Imaging+of+Neuroinflammation+in+Neurodegenerative+Diseases%3A+Outlook+Beyond+TSPO&rft.jtitle=Molecular+imaging&rft.au=Narayanaswami%2C+Vidya&rft.au=Dahl%2C+Kenneth&rft.au=Bernard-Gauthier%2C+Vadim&rft.au=Josephson%2C+Lee&rft.date=2018-01-01&rft.eissn=1536-0121&rft.volume=17&rft.spage=1536012118792317&rft_id=info:doi/10.1177%2F1536012118792317&rft_id=info%3Apmid%2F30203712&rft.externalDocID=30203712 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1536-0121&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1536-0121&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1536-0121&client=summon |