DNA damage and health effects in juvenile haddock (Melanogrammus aeglefinus) exposed to PAHs associated with oil-polluted sediment or produced water

The research objective was to study the presence of DNA damages in haddock exposed to petrogenic or pyrogenic polyaromatic hydrocarbons (PAHs) from different sources: 1) extracts of oil produced water (PW), dominated by 2-ring PAHs; 2) distillation fractions of crude oil (representing oil-based dril...

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Published in	PloS one Vol. 15; no. 10; p. e0240307
Main Authors	Meier, Sonnich, Karlsen, Ørjan, Le Goff, Jeremie, Sørensen, Lisbet, Sørhus, Elin, Pampanin, Daniela M., Donald, Carey E., Fjelldal, Per Gunnar, Dunaevskaya, Evgenia, Romano, Marta, Caliani, Ilaria, Casini, Silvia, Bogevik, André S., Olsvik, Pål A., Myers, Mark, Grøsvik, Bjørn Einar
Format	Journal Article
Language	English
Published	United States Public Library of Science 22.10.2020 Public Library of Science (PLoS)
Subjects	Adducts Administration, Oral Analysis Animals Aryl Hydrocarbon Hydroxylases - genetics Bile Biological effects Biology and Life Sciences Crude oil CYP1A protein Cytochrome P450 Damage Deoxyribonucleic acid Detoxification Distillation Distilled water DNA DNA adducts DNA Damage Drilling Drilling muds Earth Sciences Engineering and Technology Environmental aspects Environmental engineering Environmental science Exposure Fish Fisheries Gadiformes - genetics Gadiformes - growth & development Gadinae Gene expression Gene Expression Regulation, Developmental - drug effects Haddock Health aspects Histopathology Hydrocarbons Infusions, Parenteral Injection Intestine Intestines - chemistry Lipid peroxidation Lipids Liver Liver - chemistry Medicine and Health Sciences Melanogrammus aeglefinus Metabolites Norway Oil Oil fields Oil pollution Peroxidation Petroleum Petroleum Pollution Physical Sciences Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - administration & dosage Polycyclic Aromatic Hydrocarbons - toxicity Recovery Sediment pollution Soil Pollutants - administration & dosage Soil Pollutants - toxicity Water Pollutants, Chemical - administration & dosage Water Pollutants, Chemical - toxicity Water pollution Norway Italy North Sea
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ISSN	1932-6203 1932-6203
DOI	10.1371/journal.pone.0240307

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Abstract	The research objective was to study the presence of DNA damages in haddock exposed to petrogenic or pyrogenic polyaromatic hydrocarbons (PAHs) from different sources: 1) extracts of oil produced water (PW), dominated by 2-ring PAHs; 2) distillation fractions of crude oil (representing oil-based drilling mud), dominated by 3-ring PAHs; 3) heavy pyrogenic PAHs, mixture of 4/5/6-ring PAHs. The biological effect of the different PAH sources was studied by feeding juvenile haddock with low doses of PAHs (0.3-0.7 mg PAH/kg fish/day) for two months, followed by a two-months recovery. In addition to the oral exposure, a group of fish was exposed to 12 single compounds of PAHs (4/5/6-ring) via intraperitoneal injection. The main endpoint was the analysis of hepatic and intestinal DNA adducts. In addition, PAH burden in liver, bile metabolites, gene and protein expression of CYP1A, GST activity, lipid peroxidation, skeletal deformities and histopathology of livers were evaluated. Juvenile haddock responded quickly to both intraperitoneal injection and oral exposure of 4/5/6-ring PAHs. High levels of DNA adducts were detected in livers three days after the dose of the single compound exposure. Fish had also high levels of DNA adducts in liver after being fed with extracts dominated by 2-ring PAHs (a PW exposure scenario) and 3-ring PAHs (simulating an oil exposure scenario). Elevated levels of DNA adducts were observed in the liver of all exposed groups after the 2 months of recovery. High levels of DNA adduct were found also in the intestines of individuals exposed to oil or heavy PAHs, but not in the PW or control groups. This suggests that the intestinal barrier is very important for detoxification of orally exposures of PAHs.
AbstractList	The research objective was to study the presence of DNA damages in haddock exposed to petrogenic or pyrogenic polyaromatic hydrocarbons (PAHs) from different sources: 1) extracts of oil produced water (PW), dominated by 2-ring PAHs; 2) distillation fractions of crude oil (representing oil-based drilling mud), dominated by 3-ring PAHs; 3) heavy pyrogenic PAHs, mixture of 4/5/6-ring PAHs. The biological effect of the different PAH sources was studied by feeding juvenile haddock with low doses of PAHs (0.3–0.7 mg PAH/kg fish/day) for two months, followed by a two-months recovery. In addition to the oral exposure, a group of fish was exposed to 12 single compounds of PAHs (4/5/6-ring) via intraperitoneal injection. The main endpoint was the analysis of hepatic and intestinal DNA adducts. In addition, PAH burden in liver, bile metabolites, gene and protein expression of CYP1A, GST activity, lipid peroxidation, skeletal deformities and histopathology of livers were evaluated. Juvenile haddock responded quickly to both intraperitoneal injection and oral exposure of 4/5/6-ring PAHs. High levels of DNA adducts were detected in livers three days after the dose of the single compound exposure. Fish had also high levels of DNA adducts in liver after being fed with extracts dominated by 2-ring PAHs (a PW exposure scenario) and 3-ring PAHs (simulating an oil exposure scenario). Elevated levels of DNA adducts were observed in the liver of all exposed groups after the 2 months of recovery. High levels of DNA adduct were found also in the intestines of individuals exposed to oil or heavy PAHs, but not in the PW or control groups. This suggests that the intestinal barrier is very important for detoxification of orally exposures of PAHs. The research objective was to study the presence of DNA damages in haddock exposed to petrogenic or pyrogenic polyaromatic hydrocarbons (PAHs) from different sources: 1) extracts of oil produced water (PW), dominated by 2-ring PAHs; 2) distillation fractions of crude oil (representing oil-based drilling mud), dominated by 3-ring PAHs; 3) heavy pyrogenic PAHs, mixture of 4/5/6-ring PAHs. The biological effect of the different PAH sources was studied by feeding juvenile haddock with low doses of PAHs (0.3-0.7 mg PAH/kg fish/day) for two months, followed by a two-months recovery. In addition to the oral exposure, a group of fish was exposed to 12 single compounds of PAHs (4/5/6-ring) via intraperitoneal injection. The main endpoint was the analysis of hepatic and intestinal DNA adducts. In addition, PAH burden in liver, bile metabolites, gene and protein expression of CYP1A, GST activity, lipid peroxidation, skeletal deformities and histopathology of livers were evaluated. Juvenile haddock responded quickly to both intraperitoneal injection and oral exposure of 4/5/6-ring PAHs. High levels of DNA adducts were detected in livers three days after the dose of the single compound exposure. Fish had also high levels of DNA adducts in liver after being fed with extracts dominated by 2-ring PAHs (a PW exposure scenario) and 3-ring PAHs (simulating an oil exposure scenario). Elevated levels of DNA adducts were observed in the liver of all exposed groups after the 2 months of recovery. High levels of DNA adduct were found also in the intestines of individuals exposed to oil or heavy PAHs, but not in the PW or control groups. This suggests that the intestinal barrier is very important for detoxification of orally exposures of PAHs.The research objective was to study the presence of DNA damages in haddock exposed to petrogenic or pyrogenic polyaromatic hydrocarbons (PAHs) from different sources: 1) extracts of oil produced water (PW), dominated by 2-ring PAHs; 2) distillation fractions of crude oil (representing oil-based drilling mud), dominated by 3-ring PAHs; 3) heavy pyrogenic PAHs, mixture of 4/5/6-ring PAHs. The biological effect of the different PAH sources was studied by feeding juvenile haddock with low doses of PAHs (0.3-0.7 mg PAH/kg fish/day) for two months, followed by a two-months recovery. In addition to the oral exposure, a group of fish was exposed to 12 single compounds of PAHs (4/5/6-ring) via intraperitoneal injection. The main endpoint was the analysis of hepatic and intestinal DNA adducts. In addition, PAH burden in liver, bile metabolites, gene and protein expression of CYP1A, GST activity, lipid peroxidation, skeletal deformities and histopathology of livers were evaluated. Juvenile haddock responded quickly to both intraperitoneal injection and oral exposure of 4/5/6-ring PAHs. High levels of DNA adducts were detected in livers three days after the dose of the single compound exposure. Fish had also high levels of DNA adducts in liver after being fed with extracts dominated by 2-ring PAHs (a PW exposure scenario) and 3-ring PAHs (simulating an oil exposure scenario). Elevated levels of DNA adducts were observed in the liver of all exposed groups after the 2 months of recovery. High levels of DNA adduct were found also in the intestines of individuals exposed to oil or heavy PAHs, but not in the PW or control groups. This suggests that the intestinal barrier is very important for detoxification of orally exposures of PAHs.
Audience	Academic
Author	Pampanin, Daniela M. Dunaevskaya, Evgenia Grøsvik, Bjørn Einar Le Goff, Jeremie Karlsen, Ørjan Donald, Carey E. Bogevik, André S. Meier, Sonnich Sørhus, Elin Caliani, Ilaria Romano, Marta Myers, Mark Casini, Silvia Olsvik, Pål A. Fjelldal, Per Gunnar Sørensen, Lisbet
AuthorAffiliation	3 SINTEF Ocean AS, Environment and New Resources, Trondheim, Norway 4 Department of Chemistry Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway 5 NORCE, Randaberg, Norway 8 Nord Univ, Fac Biosci & Aquaculture, Bodo, Norway 2 ADn’tox, Bâtiment Recherche, Centre François Baclesse, Caen, France University of Louisville School of Medicine, UNITED STATES 7 Nofima AS – Norwegian Institute of Food, Fisheries Aquaculture Research, Fyllingsdalen, Norway 1 Institute of Marine Research, Bergen, Norway 9 Myers Ecotoxicology Services, LLC, Shoreline, Washington, United States of America 6 Department of Physical, Earth and Environmental Sciences, University of Siena, Siena, Italy
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/33091018$$D View this record in MEDLINE/PubMed
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Copyright	COPYRIGHT 2020 Public Library of Science 2020 Meier et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2020 Meier et al 2020 Meier et al
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SubjectTerms	Adducts Administration, Oral Analysis Animals Aryl Hydrocarbon Hydroxylases - genetics Bile Biological effects Biology and Life Sciences Crude oil CYP1A protein Cytochrome P450 Damage Deoxyribonucleic acid Detoxification Distillation Distilled water DNA DNA adducts DNA Damage Drilling Drilling muds Earth Sciences Engineering and Technology Environmental aspects Environmental engineering Environmental science Exposure Fish Fisheries Gadiformes - genetics Gadiformes - growth & development Gadinae Gene expression Gene Expression Regulation, Developmental - drug effects Haddock Health aspects Histopathology Hydrocarbons Infusions, Parenteral Injection Intestine Intestines - chemistry Lipid peroxidation Lipids Liver Liver - chemistry Medicine and Health Sciences Melanogrammus aeglefinus Metabolites Norway Oil Oil fields Oil pollution Peroxidation Petroleum Petroleum Pollution Physical Sciences Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - administration & dosage Polycyclic Aromatic Hydrocarbons - toxicity Recovery Sediment pollution Soil Pollutants - administration & dosage Soil Pollutants - toxicity Water Pollutants, Chemical - administration & dosage Water Pollutants, Chemical - toxicity Water pollution
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Title	DNA damage and health effects in juvenile haddock (Melanogrammus aeglefinus) exposed to PAHs associated with oil-polluted sediment or produced water
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