Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging
Wallerian degeneration plays a significant role in many central nervous system (CNS) diseases. Tracking the progression of Wallerian degeneration may provide better understanding of the evolution of many CNS diseases. In this study, a 28-day longitudinal in vivo DTI of optic nerve (ON) and optic tra...
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| Published in | NeuroImage (Orlando, Fla.) Vol. 40; no. 1; pp. 1 - 10 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.03.2008
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1053-8119 1095-9572 |
| DOI | 10.1016/j.neuroimage.2007.11.049 |
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| Abstract | Wallerian degeneration plays a significant role in many central nervous system (CNS) diseases. Tracking the progression of Wallerian degeneration may provide better understanding of the evolution of many CNS diseases. In this study, a 28-day longitudinal
in vivo DTI of optic nerve (ON) and optic tract (OT) was conducted to evaluate the temporal and spatial evolution of Wallerian degeneration resulting from the transient retinal ischemia. At 3–28 days after ischemia, ipsilateral ON and contralateral OT showed significant reduction in axial diffusivity (32–40% and 21–29% respectively) suggestive of axonal damage. Both ON and OT showed significant increase in radial diffusivity, 200–290% and 58–65% respectively, at 9–28 days suggestive of myelin damage. Immunohistochemistry of phosphorylated neurofilament (pNF) and myelin basic protein (MBP) was performed to assess axonal and myelin integrities validating the DTI findings. Both DTI and immunohistochemistry detected that transient retinal ischemia caused more severe damage to ON than to OT. The current results suggest that axial and radial diffusivities are capable of reflecting the severity of axonal and myelin damage in mice as assessed using immunohistochemistry. |
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| AbstractList | Wallerian degeneration plays a significant role in many central nervous system (CNS) diseases. Tracking the progression of Wallerian degeneration may provide better understanding of the evolution of many CNS diseases. In this study, a 28-day longitudinal
in vivo DTI of optic nerve (ON) and optic tract (OT) was conducted to evaluate the temporal and spatial evolution of Wallerian degeneration resulting from the transient retinal ischemia. At 3–28 days after ischemia, ipsilateral ON and contralateral OT showed significant reduction in axial diffusivity (32–40% and 21–29% respectively) suggestive of axonal damage. Both ON and OT showed significant increase in radial diffusivity, 200–290% and 58–65% respectively, at 9–28 days suggestive of myelin damage. Immunohistochemistry of phosphorylated neurofilament (pNF) and myelin basic protein (MBP) was performed to assess axonal and myelin integrities validating the DTI findings. Both DTI and immunohistochemistry detected that transient retinal ischemia caused more severe damage to ON than to OT. The current results suggest that axial and radial diffusivities are capable of reflecting the severity of axonal and myelin damage in mice as assessed using immunohistochemistry. Wallerian degeneration plays a significant role in many central nervous system (CNS) diseases. Tracking the progression of Wallerian degeneration may provide better understanding of the evolution of many CNS diseases. In this study, a 28-day longitudinal in vivo DTI of optic nerve (ON) and optic tract (OT) was conducted to evaluate the temporal and spatial evolution of Wallerian degeneration resulting from the transient retinal ischemia. At 3-28 days after ischemia, ipsilateral ON and contralateral OT showed significant reduction in axial diffusivity (32-40% and 21-29% respectively) suggestive of axonal damage. Both ON and OT showed significant increase in radial diffusivity, 200-290% and 58-65% respectively, at 9-28 days suggestive of myelin damage. Immunohistochemistry of phosphorylated neurofilament (pNF) and myelin basic protein (MBP) was performed to assess axonal and myelin integrities validating the DTI findings. Both DTI and immunohistochemistry detected that transient retinal ischemia caused more severe damage to ON than to OT. The current results suggest that axial and radial diffusivities are capable of reflecting the severity of axonal and myelin damage in mice as assessed using immunohistochemistry. Wallerian degeneration plays a significant role in many central nervous system (CNS) diseases. Tracking the progression of Wallerian degeneration may provide better understanding of the evolution of many CNS diseases. In this study, a 28-day longitudinal in vivo DTI of optic nerve (ON) and optic tract (OT) was conducted to evaluate the temporal and spatial evolution of Wallerian degeneration resulting from the transient retinal ischemia. At 3 − 28 days after ischemia, ipsilateral ON and contralateral OT showed significant reduction in axial diffusivity ( 32 − 40% and 21 − 29% respectively) suggestive of axonal damage. Both ON and OT showed significant increase in radial diffusivity, 200 − 290% and 58 − 65% in ON and OT respectively, at 9 − 28 days suggestive of myelin damage. Immuohistochmistry of phosphorylated neurofilament (pNF) and myelin basic protein (MBP) was performed to assess axonal and myelin integrities validating the DTI findings. Both DTI and immunohistochemistry detected that transient retinal ischemia caused more severe damage to ON than to OT. The current results suggest that axial and radial diffusivities are capable of reflecting the severity of axonal and myelin damage in mice as assessed using immunohistochemistry. Wallerian degeneration plays a significant role in many central nervous system (CNS) diseases. Tracking the progression of Wallerian degeneration may provide better understanding of the evolution of many CNS diseases. In this study, a 28-day longitudinalin vivoDTI of optic nerve (ON) and optic tract (OT) was conducted to evaluate the temporal and spatial evolution of Wallerian degeneration resulting from the transient retinal ischemia. At 3-28 days after ischemia, ipsilateral ON and contralateral OT showed significant reduction in axial diffusivity (32-40% and 21-29% respectively) suggestive of axonal damage. Both ON and OT showed significant increase in radial diffusivity, 200-290% and 58-65% respectively, at 9-28 days suggestive of myelin damage. Immunohistochemistry of phosphorylated neurofilament (pNF) and myelin basic protein (MBP) was performed to assess axonal and myelin integrities validating the DTI findings. Both DTI and immunohistochemistry detected that transient retinal ischemia caused more severe damage to ON than to OT. The current results suggest that axial and radial diffusivities are capable of reflecting the severity of axonal and myelin damage in mice as assessed using immunohistochemistry. Wallerian degeneration plays a significant role in many central nervous system (CNS) diseases. Tracking the progression of Wallerian degeneration may provide better understanding of the evolution of many CNS diseases. In this study, a 28-day longitudinal in vivo DTI of optic nerve (ON) and optic tract (OT) was conducted to evaluate the temporal and spatial evolution of Wallerian degeneration resulting from the transient retinal ischemia. At 3-28 days after ischemia, ipsilateral ON and contralateral OT showed significant reduction in axial diffusivity (32-40% and 21-29% respectively) suggestive of axonal damage. Both ON and OT showed significant increase in radial diffusivity, 200-290% and 58-65% respectively, at 9-28 days suggestive of myelin damage. Immunohistochemistry of phosphorylated neurofilament (pNF) and myelin basic protein (MBP) was performed to assess axonal and myelin integrities validating the DTI findings. Both DTI and immunohistochemistry detected that transient retinal ischemia caused more severe damage to ON than to OT. The current results suggest that axial and radial diffusivities are capable of reflecting the severity of axonal and myelin damage in mice as assessed using immunohistochemistry.Wallerian degeneration plays a significant role in many central nervous system (CNS) diseases. Tracking the progression of Wallerian degeneration may provide better understanding of the evolution of many CNS diseases. In this study, a 28-day longitudinal in vivo DTI of optic nerve (ON) and optic tract (OT) was conducted to evaluate the temporal and spatial evolution of Wallerian degeneration resulting from the transient retinal ischemia. At 3-28 days after ischemia, ipsilateral ON and contralateral OT showed significant reduction in axial diffusivity (32-40% and 21-29% respectively) suggestive of axonal damage. Both ON and OT showed significant increase in radial diffusivity, 200-290% and 58-65% respectively, at 9-28 days suggestive of myelin damage. Immunohistochemistry of phosphorylated neurofilament (pNF) and myelin basic protein (MBP) was performed to assess axonal and myelin integrities validating the DTI findings. Both DTI and immunohistochemistry detected that transient retinal ischemia caused more severe damage to ON than to OT. The current results suggest that axial and radial diffusivities are capable of reflecting the severity of axonal and myelin damage in mice as assessed using immunohistochemistry. |
| Author | Cross, Anne H. Liang, Hsiao-Fang Song, Sheng-Kwei Sun, Shu-Wei |
| AuthorAffiliation | 1 Departments of Radiology, Washington University School of Medicine, St. Louis, MO, USA 2 Neurology, Washington University School of Medicine, St. Louis, MO, USA |
| AuthorAffiliation_xml | – name: 2 Neurology, Washington University School of Medicine, St. Louis, MO, USA – name: 1 Departments of Radiology, Washington University School of Medicine, St. Louis, MO, USA |
| Author_xml | – sequence: 1 givenname: Shu-Wei surname: Sun fullname: Sun, Shu-Wei organization: Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA – sequence: 2 givenname: Hsiao-Fang surname: Liang fullname: Liang, Hsiao-Fang organization: Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA – sequence: 3 givenname: Anne H. surname: Cross fullname: Cross, Anne H. organization: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA – sequence: 4 givenname: Sheng-Kwei surname: Song fullname: Song, Sheng-Kwei email: ssong@wustl.edu organization: Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18187343$$D View this record in MEDLINE/PubMed |
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| References | Arfanakis, Haughton, Carew, Rogers, Dempsey, Meyerand (bib3) 2002; 23 Lambot, Depasse, Noel, Vanderhaeghen (bib27) 2005; 25 Boretius, Wurfel, Zipp, Frahm, Michaelis (bib9) 2007; 161 Kim, Ronen, Ugurbil, Kim (bib25) 2006; 32 Khong, Zhou, Ooi, Chung, Cheung, Wong (bib22) 2004; 18 Loy, Kim, Xie, Schmidt, Trinkaus, Song (bib28) 2007; 24 Song, Sun, Ramsbottom, Chang, Russell, Cross (bib35) 2002; 17 Bjartmar, Battistuta, Terada, Dupree, Trapp (bib8) 2002; 51 Basser, Pierpaoli (bib4) 1996; 111 Guilfoyle, Helpern, Lim (bib16) 2003; 16 Kim, Budde, Liang, Klein, Russell, Cross, Song (bib23) 2006; 21 Kim, Loy, Liang, Trinkaus, Schmidt, Song (bib24) 2007; 58 Sun, Liang, Schmidt, Cross, Song (bib39) 2007; 28 Gonen, Catalaa, Babb, Ge, Mannon, Kolson, Grossman (bib15) 2000; 54 Pierpaoli, Barnett, Pajevic, Chen, Penix, Virta, Basser (bib32) 2001; 13 Ciccarelli, Werring, Barker, Griffin, Wheeler-Kingshott, Miller, Thompson (bib11) 2003; 250 Harsan, Poulet, Guignard, Parizel, Skoff, Ghandour (bib18) 2007; 85 Sun, Liang, Le, Armstrong, Cross, Song (bib38) 2006; 32 Thomalla, Glauche, Koch, Beaulieu, Weiller, Rother (bib42) 2004; 22 Beaulieu, Does, Snyder, Allen (bib5) 1996; 36 Nair, Tanahashi, Low, Billings-Gagliardi, Schwartz, Duong (bib30) 2005; 28 Song, Yoshino, Le, Lin, Sun, Cross, Armstrong (bib36) 2005; 26 Hess, Mukherjee, Han, Xu, Vigneron (bib21) 2006; 56 Beirowski, Adalbert, Wagner, Grumme, Addicks, Ribchester, Coleman (bib6) 2005; 6 Franklin, Paxinos (bib14) 1997 Harsan, Poulet, Guignard, Steibel, Parizel, de Sousa, Boehm, Grucker, Ghandour (bib19) 2006; 83 Budde, Kim, Liang, Schmidt, Russell, Cross, Song (bib10) 2007; 57 Sawlani, Gupta, Singh, Kohli (bib33) 1997; 146 Hasan, Parker, Alexander (bib20) 2001; 13 Kuhn, Johnson, Davis (bib26) 1988; 168 Ahmad, Lope-Piedrafita, Bi, Hicks, Yao, Yu, Chaitkin, Howison, Weberg, Trouard (bib2) 2005; 82 Sow, Lamant, Bonny, Larvaron, Piaud, Lecureuil, Fontaine, Saleh, Garcia Otin, Renou (bib37) 2006; 83 Coleman (bib12) 2005; 6 Sun, Liang, Trinkaus, Cross, Armstrong, Song (bib40) 2006; 55 Thomalla, Glauche, Weiller, Rother (bib43) 2005; 76 Meier, Weiner, Khoury, Guttmann (bib29) 2004; 14 Narayanan, Francis, Sled, Santos, Antel, Levesque, Brass, Lapierre, Sappey-Marinier, Pike (bib31) 2006; 29 Song, Sun, Ju, Lin, Cross, Neufeld (bib34) 2003; 20 Sun, Neil, Song (bib41) 2003; 50 Beirowski, Berek, Adalbert, Wagner, Grumme, Addicks, Ribchester, Coleman (bib7) 2004; 134 Gupta, Saksena, Hasan, Agarwal, Haris, Pandey, Narayana (bib17) 2006; 24 De Stefano, Matthews, Narayanan, Francis, Antel, Arnold (bib13) 1997; 49 Aboul-Enein, Weiser, Hoftberger, Lassmann, Bradl (bib1) 2006; 111 |
| References_xml | – volume: 14 start-page: 46S year: 2004 end-page: 53S ident: bib29 article-title: Magnetic resonance imaging surrogates of multiple sclerosis pathology and their relationship to central nervous system atrophy publication-title: J. Neuroimaging – volume: 28 start-page: 165 year: 2005 end-page: 174 ident: bib30 article-title: Myelination and long diffusion times alter diffusion-tensor-imaging contrast in myelin-deficient shiverer mice publication-title: NeuroImage – volume: 21 start-page: 626 year: 2006 end-page: 632 ident: bib23 article-title: Detecting axon damage in spinal cord from a mouse model of multiple sclerosis publication-title: Neurobiol. Dis. – volume: 20 start-page: 1714 year: 2003 end-page: 1722 ident: bib34 article-title: Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia publication-title: NeuroImage – volume: 85 start-page: 935 year: 2007 end-page: 944 ident: bib18 article-title: Astrocytic hypertrophy in dysmyelination influences the diffusion anisotropy of white matter publication-title: J. Neurosci. Res. – volume: 18 start-page: 240 year: 2004 end-page: 247 ident: bib22 article-title: The evaluation of Wallerian degeneration in chronic paediatric middle cerebral artery infarction using diffusion tensor MR imaging publication-title: Cerebrovasc. Dis. – volume: 58 start-page: 253 year: 2007 end-page: 260 ident: bib24 article-title: Noninvasive diffusion tensor imaging of evolving white matter pathology in a mouse model of acute spinal cord injury publication-title: Magn. Reson. Med. – volume: 36 start-page: 627 year: 1996 end-page: 631 ident: bib5 article-title: Changes in water diffusion due to Wallerian degeneration in peripheral nerve publication-title: Magn. Reson. Med. – volume: 134 start-page: 23 year: 2004 end-page: 35 ident: bib7 article-title: Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice publication-title: J. Neurosci. Methods – volume: 57 start-page: 688 year: 2007 end-page: 695 ident: bib10 article-title: Toward accurate diagnosis of white matter pathology using diffusion tensor imaging publication-title: Magn. Reson. Med. – volume: 25 start-page: 7232 year: 2005 end-page: 7237 ident: bib27 article-title: Mapping labels in the human developing visual system and the evolution of binocular vision publication-title: J. Neurosci. – volume: 23 start-page: 794 year: 2002 end-page: 802 ident: bib3 article-title: Diffusion tensor MR imaging in diffuse axonal injury publication-title: AJNR Am. J. Neuroradiol. – year: 1997 ident: bib14 article-title: The Mouse Brain in Stereotaxic Coordinates – volume: 161 start-page: 112 year: 2007 end-page: 117 ident: bib9 article-title: High-field diffusion tensor imaging of mouse brain publication-title: J. Neurosci. Methods – volume: 28 start-page: 30 year: 2007 end-page: 38 ident: bib39 article-title: Selective vulnerability of cerebral white matter in a murine model of multiple sclerosis detected using diffusion tensor imaging publication-title: Neurobiol. Dis. – volume: 6 start-page: 889 year: 2005 end-page: 898 ident: bib12 article-title: Axon degeneration mechanisms: commonality amid diversity publication-title: Nat. Rev., Neurosci. – volume: 51 start-page: 51 year: 2002 end-page: 58 ident: bib8 publication-title: Ann. Neurol. – volume: 13 start-page: 769 year: 2001 end-page: 780 ident: bib20 article-title: Comparison of gradient encoding schemes for diffusion-tensor MRI publication-title: J. Magn. Reson. Imaging – volume: 24 start-page: 979 year: 2007 end-page: 990 ident: bib28 article-title: Diffusion tensor imaging predicts hyperacute spinal cord injury severity publication-title: J. Neurotrauma – volume: 82 start-page: 811 year: 2005 end-page: 821 ident: bib2 article-title: Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of Niemann-Pick C mice publication-title: J. Neurosci. Res. – volume: 16 start-page: 77 year: 2003 end-page: 81 ident: bib16 article-title: Diffusion tensor imaging in fixed brain tissue at 7.0 T publication-title: NMR Biomed. – volume: 111 start-page: 209 year: 1996 end-page: 219 ident: bib4 article-title: Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI publication-title: J. Magn. Reson., B – volume: 250 start-page: 287 year: 2003 end-page: 292 ident: bib11 article-title: A study of the mechanisms of normal-appearing white matter damage in multiple sclerosis using diffusion tensor imaging—evidence of Wallerian degeneration publication-title: J. Neurol. – volume: 22 start-page: 1767 year: 2004 end-page: 1774 ident: bib42 article-title: Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke publication-title: NeuroImage – volume: 32 start-page: 1243 year: 2006 end-page: 1249 ident: bib25 article-title: Spatial resolution dependence of DTI tractography in human occipito-callosal region publication-title: NeuroImage – volume: 29 start-page: 637 year: 2006 end-page: 642 ident: bib31 article-title: Axonal injury in the cerebral normal-appearing white matter of patients with multiple sclerosis is related to concurrent demyelination in lesions but not to concurrent demyelination in normal-appearing white matter publication-title: NeuroImage – volume: 111 start-page: 539 year: 2006 end-page: 547 ident: bib1 article-title: Transient axonal injury in the absence of demyelination: a correlate of clinical disease in acute experimental autoimmune encephalomyelitis publication-title: Acta Neuropathol. (Berl.) – volume: 76 start-page: 266 year: 2005 end-page: 268 ident: bib43 article-title: Time course of Wallerian degeneration after ischaemic stroke revealed by diffusion tensor imaging publication-title: J. Neurol. Neurosurg. Psychiatry – volume: 17 start-page: 1429 year: 2002 end-page: 1436 ident: bib35 article-title: Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water publication-title: NeuroImage – volume: 83 start-page: 403 year: 2006 end-page: 414 ident: bib37 article-title: Oligodendrocyte differentiation is increased in transferrin transgenic mice publication-title: J. Neurosci. Res. – volume: 54 start-page: 15 year: 2000 end-page: 19 ident: bib15 article-title: Total brain publication-title: Neurology – volume: 49 start-page: 1138 year: 1997 end-page: 1141 ident: bib13 article-title: Axonal dysfunction and disability in a relapse of multiple sclerosis: longitudinal study of a patient publication-title: Neurology – volume: 26 start-page: 132 year: 2005 end-page: 140 ident: bib36 article-title: Demyelination increases radial diffusivity in corpus callosum of mouse brain publication-title: NeuroImage – volume: 55 start-page: 302 year: 2006 end-page: 308 ident: bib40 article-title: Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum publication-title: Magn. Reson. Med. – volume: 50 start-page: 743 year: 2003 end-page: 748 ident: bib41 article-title: Relative indices of water diffusion anisotropy are equivalent in live and formalin-fixed mouse brains publication-title: Magn. Reson. Med. – volume: 168 start-page: 199 year: 1988 end-page: 202 ident: bib26 article-title: Wallerian degeneration: evaluation with MR imaging publication-title: Radiology – volume: 32 start-page: 1195 year: 2006 end-page: 1204 ident: bib38 article-title: Differential sensitivity of publication-title: NeuroImage – volume: 6 start-page: 6 year: 2005 ident: bib6 article-title: The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves publication-title: BMC Neurosci. – volume: 13 start-page: 1174 year: 2001 end-page: 1185 ident: bib32 article-title: Water diffusion changes in Wallerian degeneration and their dependence on white matter architecture publication-title: NeuroImage – volume: 146 start-page: 103 year: 1997 end-page: 108 ident: bib33 article-title: MRI demonstration of Wallerian degeneration in various intracranial lesions and its clinical implications publication-title: J. Neurol. Sci. – volume: 83 start-page: 392 year: 2006 end-page: 402 ident: bib19 article-title: Brain dysmyelination and recovery assessment by noninvasive publication-title: J. Neurosci. Res. – volume: 56 start-page: 104 year: 2006 end-page: 117 ident: bib21 article-title: Q-ball reconstruction of multimodal fiber orientations using the spherical harmonic basis publication-title: Magn. Reson. Med. – volume: 24 start-page: 549 year: 2006 end-page: 555 ident: bib17 article-title: Focal Wallerian degeneration of the corpus callosum in large middle cerebral artery stroke: serial diffusion tensor imaging publication-title: J. Magn. Reson. Imaging |
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| Snippet | Wallerian degeneration plays a significant role in many central nervous system (CNS) diseases. Tracking the progression of Wallerian degeneration may provide... |
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| SubjectTerms | Algorithms Animals Axons - pathology Biomarkers Brain Cell Count Cell Death Diffusion Diffusion Magnetic Resonance Imaging Immunohistochemistry Ischemia Male Mice Myelin Basic Protein - metabolism Myelin Sheath - pathology Neurofilament Proteins - metabolism Optic nerve Optic Nerve - pathology Phosphorylation Retinal Ganglion Cells - pathology Retinal Vessels - pathology Studies Visual Pathways - pathology Wallerian Degeneration - pathology |
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| Title | Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging |
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