中药治疗非酒精性脂肪性肝纤维化的研究现状
非酒精性脂肪性肝纤维化是非酒精性脂肪性肝炎（NASH）进展为终末期肝病的关键病理阶段,其有效治疗亟待解决。中药具有多组分及多途径、多靶点作用的特点,对非酒精性脂肪性肝纤维化具有综合治疗的优势,可通过调节肝脏脂质代谢、抑制氧化应激反应及肝细胞凋亡、调节炎症、纤维化相关基因的表达等阻止肝脂肪变、炎症及纤维化的发生与进展。...
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| Published in | 临床肝胆病杂志 Vol. 29; no. 4; pp. 249 - 252 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
河北医科大学第三医院中西医结合肝病科,石家庄,050051
2013
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 |
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| Abstract | 非酒精性脂肪性肝纤维化是非酒精性脂肪性肝炎（NASH）进展为终末期肝病的关键病理阶段,其有效治疗亟待解决。中药具有多组分及多途径、多靶点作用的特点,对非酒精性脂肪性肝纤维化具有综合治疗的优势,可通过调节肝脏脂质代谢、抑制氧化应激反应及肝细胞凋亡、调节炎症、纤维化相关基因的表达等阻止肝脂肪变、炎症及纤维化的发生与进展。 |
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| AbstractList | R575; 非酒精性脂肪性肝纤维化是非酒精性脂肪性肝炎(NASH)进展为终末期肝病的关键病理阶段,其有效治疗亟待解决.中药具有多组分及多途径、多靶点作用的特点,对非酒精性脂肪性肝纤维化具有综合治疗的优势,可通过调节肝脏脂质代谢、抑制氧化应激反应及肝细胞凋亡、调节炎症、纤维化相关基因的表达等阻止肝脂肪变、炎症及纤维化的发生与进展. 非酒精性脂肪性肝纤维化是非酒精性脂肪性肝炎（NASH）进展为终末期肝病的关键病理阶段,其有效治疗亟待解决。中药具有多组分及多途径、多靶点作用的特点,对非酒精性脂肪性肝纤维化具有综合治疗的优势,可通过调节肝脏脂质代谢、抑制氧化应激反应及肝细胞凋亡、调节炎症、纤维化相关基因的表达等阻止肝脂肪变、炎症及纤维化的发生与进展。 |
| Author | 南月敏 李文聪 |
| AuthorAffiliation | 河北医科大学第三医院中西医结合肝病科,石家庄050051 |
| AuthorAffiliation_xml | – name: 河北医科大学第三医院中西医结合肝病科,石家庄,050051 |
| Author_FL | LI Wencong NAN Yuemin |
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| Author_xml | – sequence: 1 fullname: 南月敏 李文聪 |
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| DocumentTitleAlternate | Traditional Chinese medicines for treatment of non - alcoholic fibrosing steatohepatitis |
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| EndPage | 252 |
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| Keywords | 脂肪肝 肝硬化 中草药 |
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| Notes | fatty liver ; liver cirrhosis ; drugs, Chinese herbal The incidence of non - alcoholic fatty liver disease （NAFLD） continues to rise globally. Later stages of NAFLD are characterized by severe structural and functional perturbations in the liver, with the progressive clinical manifestations being fibrosis and cirrhosis, leading to end - stage liver disease. Thus, the pathogenic process of hepatic fibrosis has been a principal target of efforts to develop therapeutic inter- ventions capable of suppressing NAFLD progression, with tile aim of protecting liver function and ultimately promoting patient quality of life and survival. Extensive research has uncovered several of the molecular factors and signaling pathways leading to the excessive synthesis and deposition of extracellular matrix （ECM） or collagen, including those of inflammation, oxidative stress and apoptosis. In this review, we dis- cuss the potential of traditional Chinese medicine （TCM） herbs for inhibiting or resolving fibrosis by interacting with |
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| PublicationTitle | 临床肝胆病杂志 |
| PublicationTitleAlternate | Chinese Journal of Clinical Hepatology |
| PublicationTitle_FL | Journal of Clinical Hepatology |
| PublicationYear | 2013 |
| Publisher | 河北医科大学第三医院中西医结合肝病科,石家庄,050051 |
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| Snippet | 非酒精性脂肪性肝纤维化是非酒精性脂肪性肝炎（NASH）进展为终末期肝病的关键病理阶段,其有效治疗亟待解决。中药具有多组分及多途径、多靶点作用的特点,对非酒精性脂肪性肝... R575; 非酒精性脂肪性肝纤维化是非酒精性脂肪性肝炎(NASH)进展为终末期肝病的关键病理阶段,其有效治疗亟待解决.中药具有多组分及多途径、多靶点作用的特点,对非酒精性脂肪... |
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| StartPage | 249 |
| SubjectTerms | 中草药 肝硬化 脂肪肝 |
| Title | 中药治疗非酒精性脂肪性肝纤维化的研究现状 |
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