Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets - Maurer, Jacoba M.; Schellekens, Reinout C. A.; van Rieke, Hèlen M.; Wanke, Christoph; Iordanov, Ventzeslav; Stellaard, Frans; Wutzke, Klaus D.; Dijkstra, Gerard; van der Zee, Margot; Woerdenbag, Herman J.; Frijlink, Henderik W.; Kosterink, Jos G. W. (PloS one, 2015)
Keywords: Administration, Oral; Adolescent; Adult; Aged; Bioavailability; Biological Availability; Colon; Colon - chemistry; Colon - metabolism; Drug Carriers - administration & dosage; Drug Carriers - chemistry; Drug Carriers - pharmacokinetics; Drug delivery systems; Drug dosages; Drug Liberation; Excretion; Feasibility studies; Female; Gastroenterology; Gastrointestinal Transit; Healthy Volunteers; Humans; Hydrogen ions; Hydrogen-Ion Concentration; Ileum; Ileum - chemistry; Ileum - metabolism; In vivo methods and tests; Inflammatory bowel disease; Intestine; Kinetics; Laboratories; Lag time; Male; Medical equipment; Middle Aged; Organ Specificity; pH effects; Pharmaceutical sciences; Pharmacology; Pharmacy; Small intestine; Statistical analysis; Statistical methods; Tablets; Transit time; Travel time; Urea; Urine; Young Adult