Marine Hydroquinone Zonarol Prevents Inflammation and Apoptosis in Dextran Sulfate Sodium-Induced Mice Ulcerative Colitis
We previously identified an anti-inflammatory compound, zonarol, a hydroquinone isolated from the brown algae Dictyopteris undulata as a marine natural product. To ascertain the in vivo functions of zonarol, we examined the pharmacological effects of zonarol administration on dextran sulfate sodium...
Saved in:
| Published in | PloS one Vol. 9; no. 11; p. e113509 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
19.11.2014
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0113509 |
Cover
| Abstract | We previously identified an anti-inflammatory compound, zonarol, a hydroquinone isolated from the brown algae Dictyopteris undulata as a marine natural product. To ascertain the in vivo functions of zonarol, we examined the pharmacological effects of zonarol administration on dextran sulfate sodium (DSS)-induced inflammation in a mouse model of ulcerative colitis (UC). Our goal is to establish a safe and effective cure for inflammatory bowel disease (IBD) using zonarol.
We subjected Slc:ICR mice to the administration of 2% DSS in drinking water for 14 days. At the same time, 5-aminosalicylic acid (5-ASA) at a dose of 50 mg/kg (positive control) and zonarol at doses of 10 and 20 mg/kg, were given orally once a day. DSS-treated animals developed symptoms similar to those of human UC, such as severe bloody diarrhea, which were evaluated by the disease activity index (DAI). Treatment with 20 mg/kg of zonarol, as well as 5-ASA, significantly suppressed the DAI score, and also led to a reduced colonic ulcer length and/or mucosal inflammatory infiltration by various immune cells, especially macrophages. Zonarol treatment significantly reduced the expression of pro-inflammatory signaling molecules, and prevented the apoptosis of intestinal epithelial cells. Finally, zonarol protected against in vitro lipopolysaccharide (LPS)-induced activation in the RAW264.7 mouse macrophage cell line.
This is the first report that a marine bioproduct protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazine, a well-known prodrug that releases 5-ASA. We believe that the oral administration of zonarol might offer a better treatment for human IBDs than 5-ASA, or may be useful as an alternative/additive therapeutic strategy against UC, without any evidence of side effects. |
|---|---|
| AbstractList | Background and Aim We previously identified an anti-inflammatory compound, zonarol, a hydroquinone isolated from the brown algae Dictyopteris undulata as a marine natural product. To ascertain the in vivo functions of zonarol, we examined the pharmacological effects of zonarol administration on dextran sulfate sodium (DSS)-induced inflammation in a mouse model of ulcerative colitis (UC). Our goal is to establish a safe and effective cure for inflammatory bowel disease (IBD) using zonarol. Methods and Results We subjected Slc:ICR mice to the administration of 2% DSS in drinking water for 14 days. At the same time, 5-aminosalicylic acid (5-ASA) at a dose of 50 mg/kg (positive control) and zonarol at doses of 10 and 20 mg/kg, were given orally once a day. DSS-treated animals developed symptoms similar to those of human UC, such as severe bloody diarrhea, which were evaluated by the disease activity index (DAI). Treatment with 20 mg/kg of zonarol, as well as 5-ASA, significantly suppressed the DAI score, and also led to a reduced colonic ulcer length and/or mucosal inflammatory infiltration by various immune cells, especially macrophages. Zonarol treatment significantly reduced the expression of pro-inflammatory signaling molecules, and prevented the apoptosis of intestinal epithelial cells. Finally, zonarol protected against in vitro lipopolysaccharide (LPS)-induced activation in the RAW264.7 mouse macrophage cell line. Conclusions This is the first report that a marine bioproduct protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazine, a well-known prodrug that releases 5-ASA. We believe that the oral administration of zonarol might offer a better treatment for human IBDs than 5-ASA, or may be useful as an alternative/additive therapeutic strategy against UC, without any evidence of side effects. Background and Aim We previously identified an anti-inflammatory compound, zonarol, a hydroquinone isolated from the brown algae Dictyopteris undulata as a marine natural product. To ascertain the in vivo functions of zonarol, we examined the pharmacological effects of zonarol administration on dextran sulfate sodium (DSS)-induced inflammation in a mouse model of ulcerative colitis (UC). Our goal is to establish a safe and effective cure for inflammatory bowel disease (IBD) using zonarol. Methods and Results We subjected Slc:ICR mice to the administration of 2% DSS in drinking water for 14 days. At the same time, 5-aminosalicylic acid (5-ASA) at a dose of 50 mg/kg (positive control) and zonarol at doses of 10 and 20 mg/kg, were given orally once a day. DSS-treated animals developed symptoms similar to those of human UC, such as severe bloody diarrhea, which were evaluated by the disease activity index (DAI). Treatment with 20 mg/kg of zonarol, as well as 5-ASA, significantly suppressed the DAI score, and also led to a reduced colonic ulcer length and/or mucosal inflammatory infiltration by various immune cells, especially macrophages. Zonarol treatment significantly reduced the expression of pro-inflammatory signaling molecules, and prevented the apoptosis of intestinal epithelial cells. Finally, zonarol protected against in vitro lipopolysaccharide (LPS)-induced activation in the RAW264.7 mouse macrophage cell line. Conclusions This is the first report that a marine bioproduct protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazine, a well-known prodrug that releases 5-ASA. We believe that the oral administration of zonarol might offer a better treatment for human IBDs than 5-ASA, or may be useful as an alternative/additive therapeutic strategy against UC, without any evidence of side effects. We previously identified an anti-inflammatory compound, zonarol, a hydroquinone isolated from the brown algae Dictyopteris undulata as a marine natural product. To ascertain the in vivo functions of zonarol, we examined the pharmacological effects of zonarol administration on dextran sulfate sodium (DSS)-induced inflammation in a mouse model of ulcerative colitis (UC). Our goal is to establish a safe and effective cure for inflammatory bowel disease (IBD) using zonarol.We subjected Slc:ICR mice to the administration of 2% DSS in drinking water for 14 days. At the same time, 5-aminosalicylic acid (5-ASA) at a dose of 50 mg/kg (positive control) and zonarol at doses of 10 and 20 mg/kg, were given orally once a day. DSS-treated animals developed symptoms similar to those of human UC, such as severe bloody diarrhea, which were evaluated by the disease activity index (DAI). Treatment with 20 mg/kg of zonarol, as well as 5-ASA, significantly suppressed the DAI score, and also led to a reduced colonic ulcer length and/or mucosal inflammatory infiltration by various immune cells, especially macrophages. Zonarol treatment significantly reduced the expression of pro-inflammatory signaling molecules, and prevented the apoptosis of intestinal epithelial cells. Finally, zonarol protected against in vitro lipopolysaccharide (LPS)-induced activation in the RAW264.7 mouse macrophage cell line.This is the first report that a marine bioproduct protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazine, a well-known prodrug that releases 5-ASA. We believe that the oral administration of zonarol might offer a better treatment for human IBDs than 5-ASA, or may be useful as an alternative/additive therapeutic strategy against UC, without any evidence of side effects. We previously identified an anti-inflammatory compound, zonarol, a hydroquinone isolated from the brown algae Dictyopteris undulata as a marine natural product. To ascertain the in vivo functions of zonarol, we examined the pharmacological effects of zonarol administration on dextran sulfate sodium (DSS)-induced inflammation in a mouse model of ulcerative colitis (UC). Our goal is to establish a safe and effective cure for inflammatory bowel disease (IBD) using zonarol. We subjected Slc:ICR mice to the administration of 2% DSS in drinking water for 14 days. At the same time, 5-aminosalicylic acid (5-ASA) at a dose of 50 mg/kg (positive control) and zonarol at doses of 10 and 20 mg/kg, were given orally once a day. DSS-treated animals developed symptoms similar to those of human UC, such as severe bloody diarrhea, which were evaluated by the disease activity index (DAI). Treatment with 20 mg/kg of zonarol, as well as 5-ASA, significantly suppressed the DAI score, and also led to a reduced colonic ulcer length and/or mucosal inflammatory infiltration by various immune cells, especially macrophages. Zonarol treatment significantly reduced the expression of pro-inflammatory signaling molecules, and prevented the apoptosis of intestinal epithelial cells. Finally, zonarol protected against in vitro lipopolysaccharide (LPS)-induced activation in the RAW264.7 mouse macrophage cell line. This is the first report that a marine bioproduct protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazine, a well-known prodrug that releases 5-ASA. We believe that the oral administration of zonarol might offer a better treatment for human IBDs than 5-ASA, or may be useful as an alternative/additive therapeutic strategy against UC, without any evidence of side effects. We previously identified an anti-inflammatory compound, zonarol, a hydroquinone isolated from the brown algae Dictyopteris undulata as a marine natural product. To ascertain the in vivo functions of zonarol, we examined the pharmacological effects of zonarol administration on dextran sulfate sodium (DSS)-induced inflammation in a mouse model of ulcerative colitis (UC). Our goal is to establish a safe and effective cure for inflammatory bowel disease (IBD) using zonarol.BACKGROUND AND AIMWe previously identified an anti-inflammatory compound, zonarol, a hydroquinone isolated from the brown algae Dictyopteris undulata as a marine natural product. To ascertain the in vivo functions of zonarol, we examined the pharmacological effects of zonarol administration on dextran sulfate sodium (DSS)-induced inflammation in a mouse model of ulcerative colitis (UC). Our goal is to establish a safe and effective cure for inflammatory bowel disease (IBD) using zonarol.We subjected Slc:ICR mice to the administration of 2% DSS in drinking water for 14 days. At the same time, 5-aminosalicylic acid (5-ASA) at a dose of 50 mg/kg (positive control) and zonarol at doses of 10 and 20 mg/kg, were given orally once a day. DSS-treated animals developed symptoms similar to those of human UC, such as severe bloody diarrhea, which were evaluated by the disease activity index (DAI). Treatment with 20 mg/kg of zonarol, as well as 5-ASA, significantly suppressed the DAI score, and also led to a reduced colonic ulcer length and/or mucosal inflammatory infiltration by various immune cells, especially macrophages. Zonarol treatment significantly reduced the expression of pro-inflammatory signaling molecules, and prevented the apoptosis of intestinal epithelial cells. Finally, zonarol protected against in vitro lipopolysaccharide (LPS)-induced activation in the RAW264.7 mouse macrophage cell line.METHODS AND RESULTSWe subjected Slc:ICR mice to the administration of 2% DSS in drinking water for 14 days. At the same time, 5-aminosalicylic acid (5-ASA) at a dose of 50 mg/kg (positive control) and zonarol at doses of 10 and 20 mg/kg, were given orally once a day. DSS-treated animals developed symptoms similar to those of human UC, such as severe bloody diarrhea, which were evaluated by the disease activity index (DAI). Treatment with 20 mg/kg of zonarol, as well as 5-ASA, significantly suppressed the DAI score, and also led to a reduced colonic ulcer length and/or mucosal inflammatory infiltration by various immune cells, especially macrophages. Zonarol treatment significantly reduced the expression of pro-inflammatory signaling molecules, and prevented the apoptosis of intestinal epithelial cells. Finally, zonarol protected against in vitro lipopolysaccharide (LPS)-induced activation in the RAW264.7 mouse macrophage cell line.This is the first report that a marine bioproduct protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazine, a well-known prodrug that releases 5-ASA. We believe that the oral administration of zonarol might offer a better treatment for human IBDs than 5-ASA, or may be useful as an alternative/additive therapeutic strategy against UC, without any evidence of side effects.CONCLUSIONSThis is the first report that a marine bioproduct protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazine, a well-known prodrug that releases 5-ASA. We believe that the oral administration of zonarol might offer a better treatment for human IBDs than 5-ASA, or may be useful as an alternative/additive therapeutic strategy against UC, without any evidence of side effects. |
| Author | Yamada, Sohsuke Shimizu, Hiroya Noguchi, Hirotsugu Nawata, Aya Koyama, Tomoyuki Kitsuyama, Ryo Wang, Ke-Yong Sasaguri, Yasuyuki Satoh, Takumi Nakayama, Toshiyuki Ueda, Yuki Tanimoto, Akihide |
| AuthorAffiliation | 4 Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan Future University in Egypt (FUE), Egypt 1 Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan 3 Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka 020-8551, Japan 2 Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo 108-8477, Japan 6 Laboratory of Pathology, Fukuoka Wajiro Hospital, Fukuoka 811-0213, Japan 5 Shared-Use Research Center, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan 7 Department of Anti-Aging Food Research, School of Bioscience and Biotechnology, Tokyo University of Technology, Hachioji 192-0982, Japan |
| AuthorAffiliation_xml | – name: 1 Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan – name: 3 Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka 020-8551, Japan – name: 5 Shared-Use Research Center, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan – name: 7 Department of Anti-Aging Food Research, School of Bioscience and Biotechnology, Tokyo University of Technology, Hachioji 192-0982, Japan – name: 2 Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo 108-8477, Japan – name: 6 Laboratory of Pathology, Fukuoka Wajiro Hospital, Fukuoka 811-0213, Japan – name: Future University in Egypt (FUE), Egypt – name: 4 Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan |
| Author_xml | – sequence: 1 givenname: Sohsuke surname: Yamada fullname: Yamada, Sohsuke – sequence: 2 givenname: Tomoyuki surname: Koyama fullname: Koyama, Tomoyuki – sequence: 3 givenname: Hirotsugu surname: Noguchi fullname: Noguchi, Hirotsugu – sequence: 4 givenname: Yuki surname: Ueda fullname: Ueda, Yuki – sequence: 5 givenname: Ryo surname: Kitsuyama fullname: Kitsuyama, Ryo – sequence: 6 givenname: Hiroya surname: Shimizu fullname: Shimizu, Hiroya – sequence: 7 givenname: Akihide surname: Tanimoto fullname: Tanimoto, Akihide – sequence: 8 givenname: Ke-Yong surname: Wang fullname: Wang, Ke-Yong – sequence: 9 givenname: Aya surname: Nawata fullname: Nawata, Aya – sequence: 10 givenname: Toshiyuki surname: Nakayama fullname: Nakayama, Toshiyuki – sequence: 11 givenname: Yasuyuki surname: Sasaguri fullname: Sasaguri, Yasuyuki – sequence: 12 givenname: Takumi surname: Satoh fullname: Satoh, Takumi |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25409433$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9Uk1v1DAQjVAR_YB_gMASFy672HGcxByQqqXQlVqBVHrhYk3sSfHKsRc7WbH_vtkv1FaIk63xe2-eZ95pduSDxyx7zeiU8Yp9WIQhenDT5VieUsa4oPJZdsIkzydlTvnRg_txdprSglLB67J8kR3noqCy4PwkW19DtB7J5drE8HuwmybkZ_AQgyPfI67Q94nMfeug66C3wRPwhpwvw7IPySZiPfmMf_oIntwMroUeyU0wdugmc28GjYZcW43k1mmMI3-FZBac7W16mT1vwSV8tT_PstsvFz9ml5Orb1_ns_OriRYy7ycVRYaCVkYApbwxUGIpGoa5aUDWlaEoGBMgjCwZaCG4bOtWg2lkxZsKND_L3u50ly4ktZ9aUqzMS1bRIi9HxHyHMAEWahltB3GtAli1LYR4pyD2VjtUNUAheaHbnFUFtqVkdV4wIUqoJeVSjFqf9t2GpkOjx_FFcI9EH794-0vdhZUqcl4VPB8F3u8FNvvA1KvOJo3OgccwbH1XtKI1lSP03RPov3_35qGjv1YOGRgBH3cAHUNKEVulbb9d9WjQOsWo2gTuIK42gVP7wI3k4gn5oP9f2j2XXt69 |
| CitedBy_id | crossref_primary_10_1016_j_phymed_2016_06_010 crossref_primary_10_1021_acs_jnatprod_5b01067 crossref_primary_10_1155_2018_3048532 crossref_primary_10_1016_j_jtcme_2023_03_007 crossref_primary_10_3390_md14080149 crossref_primary_10_3390_md16090292 crossref_primary_10_3390_molecules23051214 crossref_primary_10_1007_s10787_022_01093_w crossref_primary_10_1016_j_phymed_2019_153016 crossref_primary_10_12688_f1000research_12111_1 crossref_primary_10_1039_C9FO00664H crossref_primary_10_3390_molecules25010076 crossref_primary_10_1080_10408398_2021_1915242 crossref_primary_10_3389_fnut_2022_794169 crossref_primary_10_1093_ecco_jcc_jjx043 crossref_primary_10_1016_j_bmc_2016_05_047 crossref_primary_10_1016_j_carbpol_2021_118214 crossref_primary_10_3390_ijms26030885 crossref_primary_10_3390_antiox6010021 crossref_primary_10_1016_j_lfs_2020_118356 crossref_primary_10_3390_nu13103455 crossref_primary_10_1093_bbb_zbae038 crossref_primary_10_3748_wjg_v23_i1_76 crossref_primary_10_1002_adhm_201700276 crossref_primary_10_3390_md22080336 crossref_primary_10_1016_j_acthis_2016_06_004 crossref_primary_10_2174_0115672018260113231023064614 crossref_primary_10_3389_fphar_2021_735194 crossref_primary_10_1016_j_intimp_2015_08_029 crossref_primary_10_1111_pin_12423 crossref_primary_10_1016_j_bjp_2018_01_005 crossref_primary_10_1021_acs_jafc_4c01758 crossref_primary_10_3390_antibiotics12061013 crossref_primary_10_1021_acs_jafc_2c06578 crossref_primary_10_3390_antiox11020343 crossref_primary_10_1016_j_bbrc_2015_01_059 crossref_primary_10_1038_s41598_017_11408_5 crossref_primary_10_1155_2017_6742652 crossref_primary_10_22144_ctu_jvn_2022_120 |
| Cites_doi | 10.1016/S0002-9343(00)00480-0 10.1016/j.bbagen.2005.08.001 10.1016/j.crohns.2012.03.005 10.1016/j.bbrc.2011.12.087 10.1007/BF01945759 10.1189/jlb.0311168 10.1016/j.bbrc.2005.09.107 10.1002/mnfr.200800446 10.1172/JCI42917 10.1046/j.1365-2249.1999.00878.x 10.2331/suisan.59.339 10.3748/wjg.14.4280 10.1021/jo00953a022 10.1016/j.intimp.2012.10.022 10.1056/NEJMoa050516 10.1002/ibd.21697 10.1016/j.ajpath.2013.11.030 10.1097/01.MIB.0000217334.30689.3e 10.1016/j.pcl.2011.06.007 10.1111/j.1471-4159.2007.05039.x 10.2353/ajpath.2008.070604 10.1093/carcin/bgq248 10.1016/j.ajpath.2012.10.008 10.1038/sj.ejcn.1601049 10.1136/gut.2003.036632 10.1056/NEJMra020831 10.3109/00365521.2012.725092 10.1161/ATVBAHA.111.227140 10.1007/BF00049065 10.1271/bbb.130018 10.1002/bscb.19860950906 10.1080/00365520701409035 10.1038/nature06005 10.1089/ars.2012.4946 10.1371/journal.pone.0071843 10.1517/14740338.2011.529898 |
| ContentType | Journal Article |
| Copyright | 2014 Yamada et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 Yamada et al 2014 Yamada et al |
| Copyright_xml | – notice: 2014 Yamada et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2014 Yamada et al 2014 Yamada et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0113509 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database Health & Medical Collection (Alumni) Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Agricultural Science Database MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| DocumentTitleAlternate | Role of Zonarol in UC |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1626170426 oai_doaj_org_article_8aa4934cf2174ef6918241556a890395 PMC4237432 3501855701 25409433 10_1371_journal_pone_0113509 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Japan |
| GeographicLocations_xml | – name: Japan |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO PTHSS PYCSY RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM CGR CUY CVF ECM EIF IPNFZ NPM PJZUB PPXIY PQGLB PV9 RIG RZL 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 ESTFP PUEGO 5PM - 02 AAPBV ABPTK ADACO BBAFP BBORY KM |
| ID | FETCH-LOGICAL-c592t-70e1e507d5a003bda6e65b1e2dba987d0e5115a5d961ac5539f8fcadb973b7ac3 |
| IEDL.DBID | M48 |
| ISSN | 1932-6203 |
| IngestDate | Fri Nov 26 17:14:11 EST 2021 Wed Aug 27 01:27:21 EDT 2025 Thu Aug 21 18:11:55 EDT 2025 Mon Sep 08 14:42:13 EDT 2025 Fri Jul 25 10:24:18 EDT 2025 Mon Jul 21 05:45:46 EDT 2025 Tue Jul 01 01:54:29 EDT 2025 Thu Apr 24 23:12:38 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c592t-70e1e507d5a003bda6e65b1e2dba987d0e5115a5d961ac5539f8fcadb973b7ac3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: SY TK TS. Performed the experiments: SY TK YU RK HS TS. Analyzed the data: SY TK HN YS TS. Contributed reagents/materials/analysis tools: AT KYW AN TN. Wrote the paper: SY TK TS. Contributed excellent technical assistance and helpful comments: AT TN YS. Competing Interests: The authors have declared that no competing interests exist. |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0113509 |
| PMID | 25409433 |
| PQID | 1626170426 |
| PQPubID | 1436336 |
| ParticipantIDs | plos_journals_1626170426 doaj_primary_oai_doaj_org_article_8aa4934cf2174ef6918241556a890395 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4237432 proquest_miscellaneous_1627070809 proquest_journals_1626170426 pubmed_primary_25409433 crossref_citationtrail_10_1371_journal_pone_0113509 crossref_primary_10_1371_journal_pone_0113509 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2014-11-19 |
| PublicationDateYYYYMMDD | 2014-11-19 |
| PublicationDate_xml | – month: 11 year: 2014 text: 2014-11-19 day: 19 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2014 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | KH Kwon (ref5) 2005; 337 R Opheim (ref10) 2012; 47 K Mori (ref16) 1986; 95 KH Katsanos (ref7) 2012; 6 A Nabeshima (ref23) 2013; 19 HS Oz (ref31) 2013; 4 S Yamada (ref26) 2008; 172 F Sanchez-Munoz (ref3) 2008; 14 F Ishibashi (ref20) 2013; 77 T Satoh (ref27) 2008; 104 P Kubes (ref36) 2000; 109 T Koyama (ref13) 2010; 6 W Qiu (ref37) 2011; 121 JA Skyberg (ref32) 2011; 90 O Schreiber (ref35) 2013; 8 W Reinisch (ref33) 2012; 18 M Yanagitai (ref29) 2012; 418 V Linares (ref8) 2011; 10 T Olsen (ref4) 2007; 42 T Tasaki (ref24) 2013; 182 T Takenouchi (ref28) 2005; 1726 JH Lee (ref17) 2013 DK Podolsky (ref1) 2002; 347 BJ Geerling (ref12) 2000; 54 S Yamada (ref25) 2011; 31 AMS Mayer (ref18) 1993; 260/261 E Szigethy (ref11) 2011; 58 K Taniguchi (ref19) 1993; 59 G Cimino (ref15) 1975; 31 H Noguchi (ref22) 2014; 184 M Larrosa (ref30) 2009; 53 P Rutgeerts (ref34) 2005; 353 KL Edelblum (ref39) 2006; 12 F Obermeier (ref6) 1999; 116 T Sha (ref21) 2013; 15 RJ Xavier (ref2) 2007; 448 W Fenical (ref14) 1973; 38 S Zeissig (ref38) 2004; 53 DC Montrose (ref9) 2011; 32 |
| References_xml | – volume: 109 start-page: 150 year: 2000 ident: ref36 article-title: Nitric oxide and intestinal inflammation publication-title: Am J Med doi: 10.1016/S0002-9343(00)00480-0 – volume: 1726 start-page: 177 year: 2005 ident: ref28 article-title: Inhibitory effects of U73122 and U73343 on Ca2+ influx and pore formation induced by the activation of P2X7 nucleotide receptors in mouse microglial cell line publication-title: Biochim Biophys Acta doi: 10.1016/j.bbagen.2005.08.001 – volume: 6 start-page: 735 year: 2012 ident: ref7 article-title: Inflammatory bowel disease and lupus: a systematic review of the literature publication-title: J Crohns Colitis doi: 10.1016/j.crohns.2012.03.005 – volume: 418 start-page: 22 year: 2012 ident: ref29 article-title: Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2011.12.087 – volume: 31 start-page: 1250 year: 1975 ident: ref15 article-title: Zonaroic acid from the brown seaweed Dictyopteris undulate (which is the same as zonarioides) publication-title: Experientia doi: 10.1007/BF01945759 – volume: 90 start-page: 1043 year: 2011 ident: ref32 article-title: Apple polyphenols require T cells to ameliorate dextran sulfate sodium-induced colitis and dampen proinflammatory cytokine expression publication-title: J Leukoc Biol doi: 10.1189/jlb.0311168 – volume: 337 start-page: 647 year: 2005 ident: ref5 article-title: Interleukin-1beta targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2005.09.107 – volume: 53 start-page: 1044 year: 2009 ident: ref30 article-title: Polyphenol metabolites from colonic microbiota exert anti-inflammatory activity on different inflammation models publication-title: Mol Nutr Food Res doi: 10.1002/mnfr.200800446 – volume: 121 start-page: 1722 year: 2011 ident: ref37 article-title: PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice publication-title: J Clin Invest doi: 10.1172/JCI42917 – volume: 116 start-page: 238 year: 1999 ident: ref6 article-title: Interferon-gamma (IFN-gamma)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice publication-title: Clin Exp Immunol doi: 10.1046/j.1365-2249.1999.00878.x – volume: 59 start-page: 339 year: 1993 ident: ref19 article-title: Feeding-deterrents from the brown alga Dictyopteris undulata against the abalone Haliotis discus hannai publication-title: Nippon Suisan Gakkaishi (in Japanese) doi: 10.2331/suisan.59.339 – volume: 14 start-page: 4280 year: 2008 ident: ref3 article-title: Role of cytokines in inflammatory bower disease publication-title: World J Gastroenterol doi: 10.3748/wjg.14.4280 – volume: 4 start-page: e132 year: 2013 ident: ref31 article-title: Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in Colitis Models publication-title: Front Immunol – volume: 38 start-page: 2383 year: 1973 ident: ref14 article-title: Zonarol and isozonarol, fungitoxic hydroquinones from the brown seaweed Dictyopteris zonarioides publication-title: J Org Chem doi: 10.1021/jo00953a022 – volume: 15 start-page: 23 year: 2013 ident: ref21 article-title: Establishment and validation of a new semi-chronic dextran sulfate sodium-induced model of colitis in mice publication-title: Int Immunopharmacol doi: 10.1016/j.intimp.2012.10.022 – volume: 353 start-page: 2462 year: 2005 ident: ref34 article-title: Infliximab for induction and maintenance therapy for ulcerative colitis publication-title: N Engl J Med doi: 10.1056/NEJMoa050516 – volume: 18 start-page: 201 year: 2012 ident: ref33 article-title: Long-term infliximab maintenance therapy for ulcerative colitis: the ACT-1 and -2 extension studies publication-title: Inflamm Bowel Dis doi: 10.1002/ibd.21697 – volume: 184 start-page: 644 year: 2014 ident: ref22 article-title: Depletion of apoptosis signal-regulating kinase 1 prevents bile duct ligation-induced necro-inflammation and subsequent peribiliary fibrosis publication-title: Am J Pathol doi: 10.1016/j.ajpath.2013.11.030 – volume: 12 start-page: 413 year: 2006 ident: ref39 article-title: Regulation of apoptosis during homeostasis and disease in the intestinal epithelium publication-title: Inflamm Bowel Dis doi: 10.1097/01.MIB.0000217334.30689.3e – volume: 58 start-page: 903 year: 2011 ident: ref11 article-title: Inflammatory bowel disease publication-title: Pediatr Clin North Am doi: 10.1016/j.pcl.2011.06.007 – volume: 104 start-page: 1116 year: 2008 ident: ref27 article-title: Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1 publication-title: J Neurochem doi: 10.1111/j.1471-4159.2007.05039.x – volume: 172 start-page: 1419 year: 2008 ident: ref26 article-title: Matrix metalloproteinase 12 accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks to fibrous plaques in transgenic rabbits publication-title: Am J Pathol doi: 10.2353/ajpath.2008.070604 – volume: 32 start-page: 343 year: 2011 ident: ref9 article-title: Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis publication-title: Carcinogenesis doi: 10.1093/carcin/bgq248 – volume: 182 start-page: 597 year: 2013 ident: ref24 article-title: Apoptosis signal-regulating kinase 1 deficiency attenuates vascular injury-induced neointimal hyperplasia by suppressing apoptosis in smooth muscle cells publication-title: Am J Pathol doi: 10.1016/j.ajpath.2012.10.008 – volume: 54 start-page: 514 year: 2000 ident: ref12 article-title: Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls publication-title: Eur J Clin Nutr doi: 10.1038/sj.ejcn.1601049 – volume: 6 start-page: 109 year: 2010 ident: ref13 article-title: New value and functionality found in undeveloped food materials publication-title: J Jpn Soc Med Use Func Foods (In Japanese) – volume: 53 start-page: 1295 year: 2004 ident: ref38 article-title: Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment publication-title: Gut doi: 10.1136/gut.2003.036632 – volume: 347 start-page: 417 year: 2002 ident: ref1 article-title: Inflammatory bowel disease publication-title: N Engl J Med doi: 10.1056/NEJMra020831 – volume: 47 start-page: 1436 year: 2012 ident: ref10 article-title: Use of complementary and alternative medicine in patients with inflammatory bowel disease: results of a cross-sectional study in Norway publication-title: Scand J Gastroenterol doi: 10.3109/00365521.2012.725092 – volume: 31 start-page: 1555 year: 2011 ident: ref25 article-title: Apoptosis signal-regulating kinase 1 deficiency accelerates hyperlipidemia-induced atheromatous plaques via suppression of macrophage apoptosis publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.111.227140 – volume: 260/261 start-page: 521 year: 1993 ident: ref18 article-title: Phospholipase A2 inhibitors from marine algae publication-title: Hydrobiologia doi: 10.1007/BF00049065 – volume: 77 start-page: 1120 year: 2013 ident: ref20 article-title: Algicidal sesquiterpene hydroquinones from the brown alga Dictyopteris undulata publication-title: Biosci Biotech Biochem doi: 10.1271/bbb.130018 – volume: 95 start-page: 771 year: 1986 ident: ref16 article-title: Synthesis and absolute configuration of zonarol, a fungitoxic hydroquinone from the brown seaweed Dictyopteris zonarioides publication-title: Bulletin des Societes Chimiques Belges doi: 10.1002/bscb.19860950906 – volume: 42 start-page: 1312 year: 2007 ident: ref4 article-title: Tissue levels of tumor necrosis factor-alpha correlates with grade of inflammation in untreated ulcerative colitis publication-title: Scand J Gastroenterol doi: 10.1080/00365520701409035 – volume: 448 start-page: 427 year: 2007 ident: ref2 article-title: Unravelling the pathogenesis of inflammatory bowel disease publication-title: Nature doi: 10.1038/nature06005 – volume: 19 start-page: 1983 year: 2013 ident: ref23 article-title: Peroxiredoxin 4 protects against nonalcoholic steatohepatitis and type 2 diabetes in a nongenetic mouse model publication-title: Antioxid Redox Signal doi: 10.1089/ars.2012.4946 – volume: 8 start-page: e71843 year: 2013 ident: ref35 article-title: iNOS-dependent increase in colonic mucus thickness in DSS-colitic rats publication-title: PLoS One doi: 10.1371/journal.pone.0071843 – volume: 10 start-page: 253 year: 2011 ident: ref8 article-title: Oxidative stress as a mechanism underlying sulfasalazine-induced toxicity publication-title: Expert Opin Drug Saf doi: 10.1517/14740338.2011.529898 – year: 2013 ident: ref17 article-title: Evaluation of antioxidant activity of marine algae-extracts from Korea publication-title: J Aquatic Food Product Technol |
| SSID | ssj0053866 |
| Score | 2.3483663 |
| Snippet | We previously identified an anti-inflammatory compound, zonarol, a hydroquinone isolated from the brown algae Dictyopteris undulata as a marine natural... Background and Aim We previously identified an anti-inflammatory compound, zonarol, a hydroquinone isolated from the brown algae Dictyopteris undulata as a... Background and Aim We previously identified an anti-inflammatory compound, zonarol, a hydroquinone isolated from the brown algae Dictyopteris undulata as a... |
| SourceID | plos doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e113509 |
| SubjectTerms | Administration, Oral Algae Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Apoptosis Apoptosis - drug effects Biology and Life Sciences Cell activation Cell Line Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Colitis, Ulcerative - pathology Colon Colon - pathology Dextran Dextran sulfate Dextran Sulfate - toxicity Diarrhea Dictyopteris undulata Disease Models, Animal Drinking water Epithelial cells Hydroquinone Hydroquinones - chemistry Hydroquinones - pharmacology Hydroquinones - therapeutic use Immune system Infiltration Inflammation - prevention & control Inflammatory bowel diseases Interleukin-6 - analysis Interleukin-6 - genetics Intestine Lipopolysaccharides Lipopolysaccharides - toxicity Macrophages Male Medical treatment Medicine and Health Sciences Mesalamine - therapeutic use Mice Mice, Inbred ICR Mucosa Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Oral administration Phaeophyceae - chemistry Phaeophyceae - metabolism Pharmacology Polyphenols Rodents Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use Side effects Signaling Sodium Sulfasalazine Sulfate Sulfates Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - genetics Ulcerative colitis |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Na9wwEBUlp15K06-4TYsKObQHJ5ZlSdaxDQ2hkJ4ayM3IkkwWXNvE60P66zsjaZfdEsglV0tr6-ON5s1q9ETICYc5ZR3zuVUa_60CGBsmZc45eDtuitb6oPb5S15eVz9vxM3OVV-YExblgePAndXGVJpXtkPu7DupgRCjE5Sm1gXXQb0U3NgmmIprMFixlOmgHFfsLM3L6TQO_hQQzQUmIO44oqDXj_qm_Tg_xDX_T5nc8UEXL8mLRB7pt9joQ_LMD6_IYTLPmX5JGtJfX5P7K4PH-ujtvcOPrCDI9_QvsO67sadTlG2aKaALABEPL1IzOGqmcVqP8wqLqIN1GzwZnZe-A0ZK59Gtlj85BPEAB0fxHnu69NZH7XBqQybd_IZcX_z4fX6Zp1sWcit0uc5V4ZkHVuiEAQtvnZFeipb50rVG18oVHjiZMMJpyYwVguuu7qxxrVa8Vcbyt-QAO3FEqKy6ooU3SWVxR5UbiEVMWZRt2UHkVImM8M2QNzZJkONNGH0T9tUUhCJxIBucqCZNVEby7a-mKMHxSP3vOJvbuiigHR4ArJoEq-YxWGXkCLGw-cDcMBm064HQZOR4g4-Hiz9vi8FUcf_FDH5cQh0FK2yNTXwX4bRtJMTpmOPJM6L2gLbXi_2SYXUb5MAxsani5fun6PYH8hwYYYWHLZk-Jgfru8V_BNa1bj8FA_sHSc0syA priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Technology Collection dbid: 8FG link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3Nb9MwFLdgXLigja8VBjISBzhkS-LYjk9oDEpBGpdRaeISObYDkUKSNe1h_z3vOU5Z0QTX2qmdvG_7vd8j5DUDmiZV4iIjFZ5WARvrRIiIMbB2TMelcR7t86tYLLMvl_wyHLgNIa1y0oleUdvO4Bn5SSI8djgYlHf9VYRdo_B2NbTQuEvuJSmsipXi80-TJgZZFiKUyzGZnATqHPdd646BrxnHNMQb5sij9iPKadMNt3mcfydO3rBE833yILiQ9HSk-QG549qH5CAI6UDfBCTpt4_I9bnG4j66uLa4SA2hvqPfwfdedQ0N4E0D_dxWwBZjCSPVraWnfdevu6EeaN3SD6C9wZ7Ri01TgV9KLzpbb35F2PLDOEvPQdHQZWPciCBOz3w-3fCYLOcfv50totBrITJcpetIxi5x4BtarkHOS6uFE7xMXGpLrXJpYweeGdfcKpFowzlTVV4ZbUslWSm1YU_IHr7EIaEiq-IS_klIg_eqTENEotM4LdMK4qeMzwibPnlhAhA59sNoCn-7JiEgGT9kgYQqAqFmJNo-1Y9AHP-Z_x6puZ2LMNr-h271owhSWeRaZ4plpsLAzFVCQbSFHpbQuYqZgq0eIi9MCwzFHy6ckaOJP24ffrUdBoHFWxjdum7j50jQszlu8enITttNQrSOmZ5sRuQOo-28xe5IW__0oOCY3pSx9Nm_t_Wc3AePL8NiykQdkb31auNegFe1Ll960fkNuOskXw priority: 102 providerName: ProQuest |
| Title | Marine Hydroquinone Zonarol Prevents Inflammation and Apoptosis in Dextran Sulfate Sodium-Induced Mice Ulcerative Colitis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/25409433 https://www.proquest.com/docview/1626170426 https://www.proquest.com/docview/1627070809 https://pubmed.ncbi.nlm.nih.gov/PMC4237432 https://doaj.org/article/8aa4934cf2174ef6918241556a890395 http://dx.doi.org/10.1371/journal.pone.0113509 |
| Volume | 9 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVFSB databaseName: Free Full-Text Journals in Chemistry customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: HH5 dateStart: 20060101 isFulltext: true titleUrlDefault: http://abc-chemistry.org/ providerName: ABC ChemistRy – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KQ8 dateStart: 20060101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KQ8 dateStart: 20061001 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: ABDBF dateStart: 20080101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVBFR databaseName: Free Medical Journals - Free Access to All customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DIK dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: GX1 dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: RPM dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Technology Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8FG dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/technologycollection1 providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 1932-6203 dateEnd: 20250930 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M48 dateStart: 20061201 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nj9MwELWW3QsXxPK1haUyEgc4pEri2I4PCO2WLQWpK8RSqeISOY6zRApJaVqJ_ntmnKSiqAiJSw6xnTj2jOdN7HlDyEsGcxrkgfWMVPi3CsRYB0J4jIG1Y9pPjXVsn9diOo8-LvjiiPQ5W7sBbA66dphPar4qRz9_bN-Cwr9xWRtk0DcaLevKjkBeGceIvhOwTSHK-Sza7SuAdgvRBdD9rSXSA3P0ehjbs1WO0h8pUMu6OQRH_zxV-ZuZmtwn9zp8SS9agTglR7Z6QE47DW7oq45m-vVDsp1pjPyj022GLykq6B39CsB8VZe0Y3Zq6IcqB5lp4xuprjJ6sayX67opGlpU9B0s7WDs6M2mzAG00ps6KzbfPcwHYmxGZ7AK0XlpbEsvTsfusF3ziMwnV1_GU69LxOAZrsK1J30bWACOGdewCKSZFlbwNLBhlmoVy8y3ANu45pkSgTacM5XHudFZqiRLpTbsMTnGjzgjVES5n8KThDS46co0uCs69MM0zMG5iviAsH7IE9OxlGOyjDJxW28SvJV2IBOcs6SbswHxdq2WLUvHP-pf4mzu6iLHtrtRr26TTmWTWOtIscjk6LXZXChwxRB-CR0rnyno6hnKQv-CJgmEo7cHzDMg5718HC5-sSsGbcYtGl3ZeuPqSFiEY-zik1acdp3spXJA5J6g7X3FfklVfHOM4Xj2KWLh0_9u-YzcBaQYYRBmoM7J8Xq1sc8Bja3TIbkjFxKu8TjA6-T9kJxcXl1_-jx0_zeGTgF_AfLnPLI |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Nb9MwFLfGOMAFMb5WGGAkkOCQLYljpzkgNDamlq27bJUqLpljOyxSloSmFeo_xd_Ie4kTVjTBadfaTZy8n99H_N7vEfKWgUy91DOOCiP8WgUwlp4QDmNg7Zh0E2Uats9TMZoGX2d8tkF-dbUwmFbZ6cRGUetS4TfyPU803OFgUD5VPxzsGoWnq10LjRYWx2b1E0K2-uP4EOT7zvePvpwfjBzbVcBRPPIXTugaz4AXpLkERCdaCiN44hlfJxICcO0a8EG45DoSnlScsygdpkrqJApZEkrF4Lp3yN2AuQFy9YezPsAD3SGELc9jobdn0bBblYXZhX3EOKY9XjN_TZcAZFXNy_omD_fvRM1rlu_oIXlgXVa632Jsi2yY4hHZskqhpu8tc_WHx2Q1kVhMSEcrjTfJClgS_Qa-_rzMqSWLqum4SAGGbckklYWm-1VZLco6q2lW0EOwFmA_6dkyT8EPpmelzpZXDrYYUUbTCSg2Os2VaRnL6UGTv1c_IdNbkcJTsokPsU2oCFI3gSuJUOE5LpMQAUnf9RM_hXgt4APCulceK0t8jv038rg5zQshAGpfZIyCiq2gBsTp_1W1xB__mf8ZpdnPRdru5ody_j22WiAeShlELFApBoImFRFEd-jRCTmMXBbBUrcRC90N6vgP6gdkp8PHzcNv-mFQEHjqIwtTLps5Iej1IS7xWQunfpE-x_CesQEJ14C29hTrI0V22ZCQYzpVwPzn_17Wa3JvdD45iU_Gp8cvyH3wNgMs5PSiHbK5mC_NS_DoFsmrZhtRcnHb-_Y3xBFicw |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLbGkBAviHFbYYCRQIKHrEkc280DQmOlahmbkEalipfg2A5EKklpWqH-NX4d5yROWNEET3uNncTx-c4tPhdCnjOgaZAF1tMyxr9VAGMVCOExBtqOKT_Vtq72eSbG0-j9jM92yK82FwbDKluZWAtqU2r8R94PRF07HBRKP3NhER-HozeLHx52kMKT1radRgORE7v5Ce5b9XoyBFq_CMPRu0_HY891GPA0j8OVJ30bWLCIDFeA7tQoYQVPAxuaVIEzbnwL9ghX3MQiUJpzFmeDTCuTxpKlUmkGz71GrksWMQwnk7PO2QM5IoRL1WMy6DtkHC7Kwh4CTzGOIZAXVGHdMQArrM7L6jJr9--gzQtacHSb3HLmKz1q8LZHdmxxh-w5AVHRl66K9au7ZHOqMLGQjjcGX5IXsCT6Gez-ZTmnrnBURSdFBpBs0iepKgw9WpSLVVnlFc0LOoTtB11Kz9fzDGxiel6afP3dw3Yj2hp6CkKOTufaNtXL6XEdy1fdI9MrocJ9sosfsU-oiDI_hScJqfFMlynwhlToh2mYge8W8R5h7ZYn2hVBx14c86Q-2ZPgDDUbmSChEkeoHvG6uxZNEZD_zH-L1OzmYgnv-kK5_Jo4iZAMlIpiFukMnUKbiRg8PbTuhBrEPothqfuIhfYFVfKHA3rkoMXH5cPPumEQFngCpApbrus5EmT8AJf4oIFTt8iQo6vPWI_ILaBtfcX2SJF_qwuSY2hVxMKH_17WU3IDODb5MDk7eURuguEZYU5nEB-Q3dVybR-DcbdKn9RcRMmXq2bb3xqCZq4 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Marine+Hydroquinone+Zonarol+Prevents+Inflammation+and+Apoptosis+in+Dextran+Sulfate+Sodium-Induced+Mice+Ulcerative+Colitis&rft.jtitle=PloS+one&rft.au=Yamada%2C+Sohsuke&rft.au=Koyama%2C+Tomoyuki&rft.au=Noguchi%2C+Hirotsugu&rft.au=Ueda%2C+Yuki&rft.date=2014-11-19&rft.pub=Public+Library+of+Science&rft.eissn=1932-6203&rft.volume=9&rft.issue=11&rft_id=info:doi/10.1371%2Fjournal.pone.0113509&rft_id=info%3Apmid%2F25409433&rft.externalDocID=PMC4237432 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |